PKC Differentially Translocates during Spaced and Massed Training in Aplysia

The molecular biology of memory storage: a dialogue between genes and synapses

Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917 · see citing works

Genetic dissection of consolidated memory in Drosophila

Tully, T., Preat, T., Boynton, S. C., & Del Vecchio, M. (1994) · Cell · doi:10.1016/0092-8674(94)90398-0 · Cited by 924 · see citing works

Presynaptic facilitation revisited: state and time dependence

Byrne, J., & Kandel, E. R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-02-00425.1996 · Cited by 544 · see citing works

Spatially Resolved Dynamics of cAMP and Protein Kinase A Subunits in Aplysia Sensory Neurons

Bacskai, B. J., Hochner, B., Mahaut‐Smith, M. P., Adams, S., Kaang, B., Kandel, E. R., & Tsien, R. Y. (1993) · Science · doi:10.1126/science.7682336 · Cited by 540 · see citing works

Exclusive Consolidated Memory Phases in Drosophila

Isabel, G., Pascual, A., & Préat, T. (2004) · Science · doi:10.1126/science.1094932 · Cited by 285 · see citing works

Clathrin‐Dependent Mechanisms of G Protein‐coupled Receptor Endocytosis

Wolfe, B. L., & Trejo, J. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00551.x · Cited by 242 · see citing works

Molecular Mechanisms of Memory Storage inAplysia

Hawkins, R. D., Kandel, E. R., & Bailey, C. H. (2006) · Biological Bulletin · doi:10.2307/4134556 · Cited by 231 · see citing works

Synapse- and Stimulus-Specific Local Translation During Long-Term Neuronal Plasticity

Wang, D. O., Kim, S. M., Zhao, Y., Hwang, H., Miura, S. K., Sossin, W. S., & Martin, K. C. (2009) · Science · doi:10.1126/science.1173205 · Cited by 226 · see citing works

Facilitatory transmitter causes a selective and prolonged increase in adenosine 3':5'-monophosphate in sensory neurons mediating the gill and siphon withdrawal reflex in Aplysia

Bernier, L., Castellucci, V. F., Kandel, E. R., & Schwartz, J. H. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-12-01682.1982 · Cited by 212 · see citing works

Inhibitor of adenosine 3':5'-monophosphate-dependent protein kinase blocks presynaptic facilitation in Aplysia

Castellucci, V. F., Nairn, A. C., Greengard, P., Schwartz, J. H., & Kandel, E. R. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-12-01673.1982 · Cited by 204 · see citing works

Mechanisms for Generating the Autonomous cAMP-Dependent Protein Kinase Required for Long-Term Facilitation in Aplysia

Chain, D. G., Casadio, A., Schacher, S., Hegde, A. N., Valbrun, M., Yamamoto, N., Goldberg, A. L., Bartsch, D., Kandel, E. R., & Schwartz, J. H. (1999) · Neuron · doi:10.1016/s0896-6273(00)80686-8 · Cited by 186 · see citing works

Role of Transforming Growth Factor-β in Long-Term Synaptic Facilitation in Aplysia

Zhang, F., Endo, S., Cleary, L. J., Eskin, A., & Byrne, J. H. (1997) · Science · doi:10.1126/science.275.5304.1318 · Cited by 180 · see citing works

Molecular Mechanisms Underlying a Unique Intermediate Phase of Memory in Aplysia

Sutton, M. A., Masters, S. E., Bagnall, M. W., & Carew, T. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00342-7 · Cited by 177 · see citing works

Parallel Molecular Pathways Mediate Expression of Distinct Forms of Intermediate-Term Facilitation at Tail Sensory–Motor Synapses in Aplysia

Sutton, M. A., & Carew, T. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)81152-6 · Cited by 137 · see citing works

Differential Induction of Long-Term Synaptic Facilitation by Spaced and Massed Applications of Serotonin at Sensory Neuron Synapses of <i>Aplysia californica</i>

Mauelshagen, J., Sherff, C. M., & Carew, T. J. (1998) · Learning &amp; Memory · doi:10.1101/lm.5.3.246 · Cited by 129 · see citing works

Serotonin Induces Temporally and Mechanistically Distinct Phases of Persistent PKA Activity in Aplysia Sensory Neurons

Müller, U., & Carew, T. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80660-1 · Cited by 128 · see citing works

Interaction between Amount and Pattern of Training in the Induction of Intermediate- and Long-Term Memory for Sensitization in <i>Aplysia</i>

Sutton, M. A., Ide, J., Masters, S. E., & Carew, T. J. (2002) · Learning &amp; Memory · doi:10.1101/lm.44802 · Cited by 125 · see citing works

Isoform specificity of protein kinase Cs in synaptic plasticityPreprint

Sossin, W. S. (2007) · Learning & Memory · doi:10.1101/lm.469707 · Cited by 102 · see citing works

Serotonin Stimulates Phosphorylation ofAplysiaSynapsin and Alters Its Subcellular Distribution in Sensory Neurons

Angers, A., Fioravante, D., Chin, J., Cleary, L. J., Bean, A. J., & Byrne, J. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05412.2002 · Cited by 89 · see citing works

Ca2+-Independent Protein Kinase C Apl II Mediates the Serotonin-Induced Facilitation at DepressedAplysiaSensorimotor Synapses

Manseau, F., Fan, X., Hueftlein, T., Sossin, W. S., & Castellucci, V. F. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01247.2001 · Cited by 76 · see citing works

5-HT and cAMP induce the formation of coated pits and vesicles and increase the expression of clathrin light chain in sensory neurons of aplysia

Hu, Y., Barzilai, A., Chen, M., Bailey, C. H., & Kandel, E. R. (1993) · Neuron · doi:10.1016/0896-6273(93)90207-8 · Cited by 75 · see citing works

Ubiquitin‐proteasome‐mediated CREB repressor degradation during induction of long‐term facilitation

Upadhya, S. C., Smith, T. K., & Hegde, A. N. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02707.x · Cited by 73 · see citing works

Postsynaptic Regulation of Long-Term Facilitation in Aplysia

Cai, D., Chen, S., & Glanzman, D. L. (2008) · Current Biology · doi:10.1016/j.cub.2008.05.038 · Cited by 68 · see citing works

Biochemical Pathways by Which Serotonin Regulates Translation in the Nervous System of Aplysia

Yanow, S. K., Manseau, F., Hislop, J., Castellucci, V. F., & Sossin, W. S. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70020572.x · Cited by 64 · see citing works

Isoform Specificity of PKC Translocation in LivingAplysiaSensory Neurons and a Role for Ca2+-Dependent PKC APL I in the Induction of Intermediate-Term Facilitation

Zhao, Y., Leal, K., Farah, C. A., Martin, K. C., Sossin, W. S., & Klein, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1919-06.2006 · Cited by 64 · see citing works

Serotonergic Modulation in Aplysia. I. Distributed Serotonergic Network Persistently Activated by Sensitizing Stimuli

Marinesco, S., Kolkman, K. E., & Carew, T. J. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00209.2004 · Cited by 64 · see citing works

Two Signaling Pathways Regulate the Expression and Secretion of a Neuropeptide Required for Long-Term Facilitation inAplysia

Hu, J., Wu, F., & Schacher, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4258-05.2006 · Cited by 57 · see citing works

Role of Protein Kinase C in the Induction and Maintenance of Serotonin-Dependent Enhancement of the Glutamate Response in Isolated Siphon Motor Neurons ofAplysia californica

Villareal, G., Li, Q., Cai, D., Fink, A. E., Lim, T., Bougie, J. K., Sossin, W. S., & Glanzman, D. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4149-08.2009 · Cited by 57 · see citing works

Modulation of a cAMP/Protein Kinase A Cascade by Protein Kinase C in Sensory Neurons ofAplysia

Sugita, S., Baxter, D. A., & Byrne, J. H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-19-07237.1997 · Cited by 56 · see citing works

Chapter 17 New tricks for an old slug: The critical role of postsynaptic mechanisms in learning and memory in Aplysia

Glanzman, D. L. (2008) · Progress in brain research · doi:10.1016/s0079-6123(07)00017-9 · Cited by 48 · see citing works

Serotonin Increases Phosphorylation of Synaptic 4EBP through TOR, but Eukaryotic Initiation Factor 4E Levels Do Not Limit Somatic Cap-Dependent Translation in Aplysia Neurons

Carroll, M., Dyer, J., & Sossin, W. S. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00955-06 · Cited by 33 · see citing works

Serotonin Receptor Antagonists Discriminate Between PKA- and PKC-Mediated Plasticity inAplysiaSensory Neurons

Dumitriu, B. C., Cohen, J. E., Wan, Q., Negroiu, A. M., & Abrams, T. W. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00642.2005 · Cited by 26 · see citing works

Chapter 1 Molecular memory traces

Sossin, W. S. (2008) · Progress in brain research · doi:10.1016/s0079-6123(07)00001-5 · Cited by 25 · see citing works

Regulation of Eukaryotic Initiation Factor 4E Phosphorylation in the Nervous System of Aplysia californica

Dyer, J. R., & Sossin, W. S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750872.x · Cited by 24 · see citing works

Molecular pharmacology of protein kinases

Hidaka, H., Hagiwara, M., & Chijiwa, T. (1990) · Neurochemical Research · doi:10.1007/bf00969929 · Cited by 24 · see citing works

An autonomous kinase generated during long-term facilitation in Aplysia is related to the Ca(2+)-independent protein kinase C Apl II.Preprint

Sossin, W. S. (1997) · Learning & Memory · doi:10.1101/lm.3.5.389 · Cited by 24 · see citing works

Physiological Role for Phosphatidic Acid in the Translocation of the Novel Protein Kinase C Apl II inAplysiaNeurons

Farah, C. A., Nagakura, I., Weatherill, D., Fan, X., & Sossin, W. S. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00178-08 · Cited by 23 · see citing works

Serotonin induces selective cleavage of the PKA RI subunit but not RII subunit in Aplysia neurons

Kurosu, T., Hernandez, A. I., & Schwartz, J. H. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.146 · Cited by 10 · see citing works

The right time to learn: Mechanisms and optimization of spaced learning

Smolen, P., Zhang, Y., & Byrne, J. H. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.18 · Cited by 326 · see citing works

A new chapter in the field of memory: adult hippocampal neurogenesis

Koehl, M., & Abrous, D. N. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07609.x · Cited by 183 · see citing works

The Role of C2 Domains in PKC Signaling

Farah, C. A., & Sossin, W. S. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2888-2_29 · Cited by 61 · see citing works

Molecular Determinants of the Spacing Effect

Naqib, F., Sossin, W. S., & Farah, C. A. (2012) · Neural Plasticity · doi:10.1155/2012/581291 · Cited by 49 · see citing works

Sustained Hypoxia Elicits Competing Spinal Mechanisms of Phrenic Motor Facilitation

Devinney, M. J., Nichols, N. L., & Mitchell, G. S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4122-15.2016 · Cited by 45 · see citing works

The Interval Between VNS-Tone Pairings Determines the Extent of Cortical Map Plasticity

Borland, M. S., Engineer, C. T., Vrana, W. A., Moreno, N. A., Engineer, N. D., Vanneste, S., Sharma, P., Pantalia, M., Lane, M. C., Rennaker, R. L., et al. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.11.004 · Cited by 39 · see citing works

Bidirectional Regulation of eEF2 Phosphorylation Controls Synaptic Plasticity by Decoding Neuronal Activity Patterns

McCamphill, P. K., Farah, C. A., Anadolu, M. N., Hoque, S., & Sossin, W. S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2376-14.2015 · Cited by 38 · see citing works

Pattern and predictability in memory formation: From molecular mechanisms to clinical relevance

Philips, G. T., Kopec, A. M., & Carew, T. J. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.05.003 · Cited by 33 · see citing works

The massed-spaced learning effect in non-neural human cells

Kukushkin, N. V., Carney, R. M., Tabassum, T., & Carew, T. J. (2024) · Nature Communications · doi:10.1038/s41467-024-53922-x · Cited by 32 · see citing works

PKA and PKC are required for long-term but not short-term in vivo operant memory in AplysiaPreprint

Michel, M., Green, C. L., & Lyons, L. C. (2010) · Learning & Memory · doi:10.1101/lm.2026311 · Cited by 30 · see citing works

Differential effects of spaced vs. massed training in long-term object-identity and object-location recognition memory

Bello-Medina, P. C., Carrasco, L., González-Ornelas, N. R., Jeffery, K. J., & Ramı́rez-Amaya, V. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.04.047 · Cited by 27 · see citing works

Massed Training-Induced Intermediate-Term Operant Memory inAplysiaRequires Protein Synthesis and Multiple Persistent Kinase Cascades

Michel, M., Green, C. L., Gardner, J. S., Organ, C. L., & Lyons, L. C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6264-11.2012 · Cited by 24 · see citing works

Making a lecture stick: The Effect of spaced instruction on knowledge retention in medical education

Timmer, M. C. J., Steendijk, P., Arend, S. M., & Versteeg, M. (2020) · Medical Science Educator · doi:10.1007/s40670-020-00995-0 · Cited by 20 · see citing works

Aplysia Cell Adhesion Molecule and a Novel Protein Kinase C Activity in the Postsynaptic Neuron Are Required for Presynaptic Growth and Initial Formation of Specific Synapses

Hu, J., Chen, Y., Bougie, J. K., Sossin, W. S., & Schacher, S. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0546-10.2010 · Cited by 21 · see citing works

Evolutionary Conservation of the Signaling Proteins Upstream of Cyclic AMP-Dependent Kinase and Protein Kinase C in Gastropod Mollusks

Sossin, W. S., & Abrams, T. W. (2009) · Brain Behavior and Evolution · doi:10.1159/000258666 · Cited by 18 · see citing works

Transforming growth factor β recruits persistent MAPK signaling to regulate long-term memory consolidation in Aplysia californicaPreprint

Shobe, J. L., Philips, G. T., & Carew, T. J. (2016) · Learning & Memory · doi:10.1101/lm.040915.115 · Cited by 18 · see citing works

The Rates of Protein Synthesis and Degradation Account for the Differential Response of Neurons to Spaced and Massed Training Protocols

Naqib, F., Farah, C. A., Pack, C. C., & Sossin, W. S. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002324 · Cited by 17 · see citing works

Histone deacetylase inhibition facilitates massed pattern-induced synaptic plasticity and memoryPreprint

Pandey, K. R., Sharma, K. P., & Sharma, S. K. (2015) · Learning & Memory · doi:10.1101/lm.039289.115 · Cited by 16 · see citing works

Quantitative description of the interactions among kinase cascades underlying long-term plasticity of Aplysia sensory neurons

Zhang, Y., Smolen, P. D., Cleary, L. J., & Byrne, J. H. (2021) · Scientific Reports · doi:10.1038/s41598-021-94393-0 · Cited by 16 · see citing works

Role for protein kinase C in controlling Aplysia bag cell neuron excitability

Tam, A. K. H., Gardam, K. E., Lamb, S., Kachoei, B. A., & Magoski, N. S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.01.037 · Cited by 16 · see citing works

Protein Phosphatase-Dependent Circadian Regulation of Intermediate-Term Associative Memory

Michel, M., Gardner, J. S., Green, C. L., Organ, C. L., & Lyons, L. C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4534-12.2013 · Cited by 14 · see citing works

Live-imaging of PKC Translocation in Sf9 Cells and in Aplysia Sensory Neurons

Farah, C. A., & Sossin, W. S. (2011) · Journal of Visualized Experiments · doi:10.3791/2516 · Cited by 14 · see citing works

Expression, phosphorylation, and glycosylation of CNS proteins in aversive operant conditioning associated memory in Lymnaea stagnalis

Silverman‐Gavrila, L. B., Senzel, A., Charlton, M. P., & Feng, Z.-P. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.04.027 · Cited by 14 · see citing works

Delayed intensive acquisition training alleviates the lesion-induced place learning deficits after fimbria–fornix transection in the rat

Malá, H., Castro, M. R., Pearce, H. L., Kingod, S. C., Nedergaard, S., Scharff, Z., Zandersen, M., & Mogensen, J. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.035 · Cited by 12 · see citing works

Role of protein kinases C (PKC) in the relationship between the neuroendocrine and immune systems in marine mussels: The model ofMytilus galloprovincialisLamark (1819)

Ramos-Martı́nez, J. I., González-Riopedre, M., & Barcia, R. (2011) · The European Zoological Journal · doi:10.1080/11250003.2011.600729 · Cited by 11 · see citing works

Isolation of the differential effects of chronic and acute stress in a manner that is not confounded by stress severity

Conoscenti, M. A., Weatherill, D. B., Huang, Y., Tordjman, R., & Fanselow, M. S. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100616 · Cited by 10 · see citing works

Intermittent apnea elicits inactivity-induced phrenic motor facilitation via a retinoic acid- and protein synthesis-dependent pathway

Baertsch, N. A., & Baker, T. L. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00212.2017 · Cited by 9 · see citing works

Neurotropic and modulatory effects of insulin-like growth factor II in Aplysia

Kukushkin, N. V., Williams, S. P., & Carew, T. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-50923-5 · Cited by 9 · see citing works

Autophosphorylation of the C2 domain inhibits translocation of the novel protein kinase C ( nPKC ) Apl II

Farah, C. A., Lindeman, A. A., Siu, V., Gupta, M. D., & Sossin, W. S. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07930.x · Cited by 7 · see citing works

A first partial Aplysia californica proteome

Sun, Y., Monje, F. J., Pollak, D. D., & Lübec, G. (2010) · Amino Acids · doi:10.1007/s00726-010-0795-9 · Cited by 6 · see citing works

Synapse formation changes the rules for desensitization of PKC translocation inAplysia

Farah, C. A., Naqib, F., Weatherill, D. B., Pack, C. C., & Sossin, W. S. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12794 · Cited by 4 · see citing works

Rictor regulates phosphorylation of the novel protein kinase C Apl II in Aplysia sensory neurons

Labban, M., Dyer, J. R., & Sossin, W. S. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07865.x · Cited by 3 · see citing works

Roles of Protein Kinase C and Protein Kinase M in Aplysia Learning

Hastings, M. H., Farah, C. A., & Sossin, W. S. (2013) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-415823-8.00018-6 · Cited by 3 · see citing works

Decline in the Recovery from Synaptic Depression in Heavier Aplysia Results from Decreased Serotonin-Induced Novel PKC Activation

Dunn, T. W., & Sossin, W. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136907 · Cited by 2 · see citing works

Preface to Molluscan Neurobiology: Recent Advances and New Vistas

Katz, P. S. (2009) · Brain Behavior and Evolution · doi:10.1159/000258663 · Cited by 2 · see citing works

Activity-dependent inhibitory gating in molecular signaling cascades induces a novel form of intermediate-term synaptic facilitation in Aplysia californicaPreprint

Fischbach, S., Kopec, A. M., & Carew, T. J. (2014) · Learning & Memory · doi:10.1101/lm.033894.113 · Cited by 2 · see citing works

The Putative Role of m6A-RNA Methylation in Memory Consolidation

Novikov, D. A., Beletskiy, A., & Kolosov, P. M. (2021) · Neurochemical Journal · doi:10.1134/s1819712421020112 · Cited by 1 · see citing works

Network motifs exhibiting a differential response to spaced and massed inputsPreprint

Sreejan, A., Saxena, P., & Gadgil, C. J. (2024) · Learning & Memory · doi:10.1101/lm.054012.124

The rates of protein synthesis and degradation account for the differential response of neurons to spaced and massed training protocols,” PLoS

Naqib, F., Farah, C. A., Pack, C. C., & Sossin, W. S. (2013)

The Rates of Protein Synthesis and Degradation Account for the Differential Response of Neurons to Spaced and Massed Training Protocols

Naqib, F., Farah, C. A., Pack, C. C., & Sossin, W. S. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002324 · Cited by 17 · see citing works

Synapse formation changes the rules for desensitization of PKC translocation inAplysia

Farah, C. A., Naqib, F., Weatherill, D. B., Pack, C. C., & Sossin, W. S. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12794 · Cited by 4 · see citing works

Transient Mitogen-Activated Protein Kinase Activation Is Confined to a Narrow Temporal Window Required for the Induction of Two-Trial Long-Term Memory in<i>Aplysia</i>

Philips, G. T., Tzvetkova, E. I., & Carew, T. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4262-07.2007 · Cited by 67 · see citing works

Massed Training-Induced Intermediate-Term Operant Memory inAplysiaRequires Protein Synthesis and Multiple Persistent Kinase Cascades

Michel, M., Green, C. L., Gardner, J. S., Organ, C. L., & Lyons, L. C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6264-11.2012 · Cited by 24 · see citing works