Cited by 235Neuroscience and Neuropharmacology ResearchIon channel regulation and functionNicotinic Acetylcholine Receptors Study

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Multiple Structural Elements Determine Subunit Specificity of Mg2+Block in NMDA Receptor Channels

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Kuner, Thomas, Schoepfer, Ralf·1996·The Journal of Neuroscience

DOI 10.1523/jneurosci.16-11-03549.1996PMC PMC6578835

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Abstract

In NMDA receptor channels, subtype-specific differences of Mg 2+block are determined by the NR2 subunits. Channels assembled from the NR1-NR2A or NR1-NR2B subunits are blocked more strongly than channels formed by the NR1-NR2C or NR1-NR2D subunits, predominantly reflecting a difference in voltage dependence. A determinant of Mg 2+block common to the NR2 subunits is located in the M2 domain (N-site or Q/R/N-site). However, subunit-specific differences of block suggested that additional structural elements exist. Chimeric NR2 subunits were constructed by replacing segments of the least sensitive NR2C subunit with homologous segments of the most sensitive NR2B subunit. Mutant NR2 subunits were coexpressed with wild-type NR1 in Xenopus oocytes, and Mg 2+block was quantified. Replacement of the entire M1–M4 region resulted in a chimera with a sensitivity of Mg 2+block similar to that of the NR2B wild type. Replacing smaller segments or introducing point mutations did not generate channels with Mg 2+block characteristic of NR2B wild type. However, combining in a single chimera three small segments (M1, M2–M3 linker, M4), each independently mediating an increase in Mg 2+block, produced channels close to NR2B wild type. Thus, differences in Mg 2+block as controlled by the NR2 subunits cannot be explained by a single structural determinant in addition to the N-site. Moreover, three elements of the NR2 subunit are the major determinants of subtype-specific differences of Mg 2+block in heteromeric NMDA receptor channels.

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A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Glutamate neurotoxicity and diseases of the nervous system
Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,188
Magnesium gates glutamate-activated channels in mouse central neurones
Nowak, L. M., Bregestovski, P. D., Ascher, P., Herbet, A., & Prochiantz, A. (1984) · Nature · doi:10.1038/307462a0 · Cited by 4,116
Cloned Glutamate Receptors
Hollmann, M., & Heinemann, S. F. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.000335 · Cited by 4,056
Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90210-0 · Cited by 3,535
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
Mayer, M. L., Westbrook, G. L., & Guthrie, P. B. (1984) · Nature · doi:10.1038/309261a0 · Cited by 2,941
Heteromeric NMDA receptors: molecular and functional distinction of subtypes
Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakmann, B., & Seeburg, P. H. (1992) · Science · doi:10.1126/science.256.5060.1217 · Cited by 2,541
Self-citation
Molecular cloning and characterization of the rat NMDA receptor
Moriyoshi, K., Masu, M., Ishii, T., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1991) · Nature · doi:10.1038/354031a0 · Cited by 1,771
Ionic Blockage of Sodium Channels in Nerve
Woodhull, A. M. (1973) · The Journal of General Physiology · doi:10.1085/jgp.61.6.687 · Cited by 1,581
Molecular diversity of the NMDA receptor channel
Kutsuwada, T., Kashiwabuchi, N., Mori, H., Sakimura, K., Kushiya, E., Araki, K., Meguro, H., Hisashi, M., Kumanishi, T., Arakawa, M., et al. (1992) · Nature · doi:10.1038/358036a0 · Cited by 1,352

Show all 49 references

Research works printed but not linked: 3

Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (1995) Mutagenesis of cloned DNA. In: Current protocols in molecular biology, Chap 8. (Janssen K, ed). New York: Wiley.
Kuner, 1995, Probing the cytoplasmic face of the NMDA receptor channel pore in cysteine-substitution mutants., Soc Neurosci Abstr, 21, 85
Schoepfer, 1994, Single channel properties of recombinant NMDA receptors expressed in Xenopus oocytes., Soc Neurosci Abstr, 20, 309.2

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Authors: Kuner, T., & Schoepfer, R.
Affiliations: Heidelberg University (DE)
ORCID: Kuner, Thomas
Schoepfer, Ralf
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 1996-06-01
Volume: 16
Issue: 11
Pages: 3549-3558
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.16-11-03549.1996
PMC: PMC6578835
OpenAlex: W1530479094
Cited by: 235
References: 49
Citations by year: 2026: 3 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 10 · 2015: 3 · 2014: 8 · 2013: 9 · 2012: 10
FWCI: 4.60
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Max Planck Digital Library (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: NMDA receptor channels, Mg2+ block, NR2 subunits, subunit specificity, NR2B, NR2C, NR1, chimeric subunits, voltage dependence, heteromeric channels, ion channel structure
MeSH terms: Amino Acid Sequence, Animals, Female, Ion Channels, Magnesium, Microelectrodes, Molecular Sequence Data, Oocytes, Recombinant Fusion Proteins, Sensitivity and Specificity, Xenopus, Receptors, N-Methyl-D-Aspartate, Patch-Clamp Techniques

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Multiple Structural Elements Determine Subunit Specificity of Mg2+Block in NMDA Receptor Channels

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