The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
The Leaving or Q Fraction of the Murine Cerebral Proliferative Epithelium: A General Model of Neocortical Neuronogenesis
Open accessAbstract
Neurons of neocortical layers II–VI in the dorsomedial cortex of the mouse arise in the pseudostratified ventricular epithelium (PVE) through 11 cell cycles over the six embryonic days 11–17 (E11–E17). The present experiments measure the proportion of daughter cells that leave the cycle (quiescent or Q fraction or Q) during a single cell cycle and the complementary proportion that continues to proliferate (proliferative or P fraction or P; P = 1 − Q). Q and P for the PVE become 0.5 in the course of the eighth cycle, occurring on E14, and Q rises to ∼0.8 (and P falls to ∼0.2) in the course of the 10th cycle occurring on E16. This indicates that early in neuronogenesis, neurons are produced relatively slowly and the PVE expands rapidly but that the reverse happens in the final phase of neuronogenesis. The present analysis completes a cycle of analyses that have determined the four fundamental parameters of cell proliferation: growth fraction, lengths of cell cycle, and phases Q and P. These parameters are the basis of a coherent neuronogenetic model that characterizes patterns of growth of the PVE and mathematically relates the size of the initial proliferative population to the neuronal population of the adult neocortex.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Specification of Cerebral Cortical Areas
Rakic, P. (1988) · Science · doi:10.1126/science.3291116 · Cited by 3,127 · cited 2×
“…a corresponding reduction in the factor P. Proliferative fates: symmetric and asymmetric cell divisions With respect to proliferative fate, a cell division may be “symmetric,” where both daughter cells are either Q or P, or it may be “asymmetric,” with one daughter cell Q and one P (Rakic, 1988).”
BackgroundNeuronal migration, with special reference to developing human brain: a review
Sidman, R. L., & Rakic, P. (1973) · Brain Research · doi:10.1016/0006-8993(73)90617-3 · Cited by 1,255
Linked Regularities in the Development and Evolution of Mammalian Brains
Finlay, B. L., & Darlington, R. B. (1995) · Science · doi:10.1126/science.7777856 · Cited by 1,217
Rakic, P. (1974) · Science · doi:10.1126/science.183.4123.425 · Cited by 1,161
THE BASIC UNIFORMITY IN STRUCTURE OF THE NEOCORTEX
ROCKEL, A. J., HIORNS, R. W., & POWELL, T. P. S. (1980) · Brain · doi:10.1093/brain/103.2.221 · Cited by 896
Chenn, A., & McConnell, S. K. (1995) · Cell · doi:10.1016/0092-8674(95)90035-7 · Cited by 766
Sauer, F. C. (1935) · Journal of Comparative Neurology · doi:10.1002/cne.900620207 · Cited by 712
The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall
Takahashi, T., Nowakowski, R., & Caviness, V. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-09-06046.1995 · Cited by 673
Self-citationCaviness, V. S. (1982) · Developmental Brain Research · doi:10.1016/0165-3806(82)90141-9 · Cited by 639
Self-citationWidespread Dispersion of Neuronal Clones Across Functional Regions of the Cerebral Cortex
Walsh, C., & Cepko, C. L. (1992) · Science · doi:10.1126/science.1734520 · Cited by 612
Cited by
Noctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R. (2004) · Nature Neuroscience · doi:10.1038/nn1172 · Cited by 2,229
The cell biology of neurogenesis
Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130
Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors
Chenn, A., & Walsh, C. A. (2002) · Science · doi:10.1126/science.1074192 · Cited by 1,431
Asymmetric Inheritance of Radial Glial Fibers by Cortical Neurons
Miyata, T., Kawaguchi, A., Okano, H., & Ogawa, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00420-2 · Cited by 892
Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses
Shi, Y., Kirwan, P., Smith, J., Robinson, H. P. C., & Livesey, F. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3041 · Cited by 813
Metadata
- Authors
- Takahashi, T., Nowakowski, R. S., & Caviness, V. S.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1996-10-01
- Volume
- 16
- Issue
- 19
- Pages
- 6183-6196
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1559406855
- Cited by
- 332
- References
- 41
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Leaving or Q Fraction of the Murine Cerebral Proliferative Epithelium: A General Model of Neocortical Neuronogenesis. https://app.cochat.ai/papers/10.1523/jneurosci.16-19-06183.1996
- The paper
- Takahashi, T., Nowakowski, R. S., & Caviness, V. S. (1996). The Leaving or Q Fraction of the Murine Cerebral Proliferative Epithelium: A General Model of Neocortical Neuronogenesis. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.16-19-06183.1996
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
