Cited by 1,097Nerve injury and regenerationNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

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Distribution of Brain-Derived Neurotrophic Factor (BDNF) Protein and mRNA in the Normal Adult Rat CNS: Evidence for Anterograde Axonal Transport

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Conner, James M., Lauterborn, Julie C., Yan, Qiao, Gall, Christine M., Varon, Silvio·1997·The Journal of Neuroscience

DOI 10.1523/jneurosci.17-07-02295.1997PMC PMC6573520

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Abstract

A sensitive immunohistochemical technique was used, along with highly specific affinity-purified antibodies to brain-derived neurotrophic factor (BDNF), to generate a detailed mapping of BDNF immunoreactivity (BDNF-ir) throughout the adult rat CNS. A parallel analysis of sites of BDNF synthesis was performed with in situ hybridization techniques using a cRNA probe to the exon encoding mature rat BDNF protein. These combined data revealed (1) groups of cell bodies containing diffuse BDNF-ir throughout the CNS that were strongly correlated with fields of cells containing BDNF mRNA; (2) varying degrees of BDNF-ir outside of cell bodies, in what appeared to be fibers and/or terminals; and (3) many regions containing extremely heavy BDNF-immunoreactive fiber/terminal labeling that lacked BDNF mRNA (e.g., medial habenula, central nucleus of the amygdala, bed nucleus of stria terminalis, lateral septum, and spinal cord). The latter observation suggested that in these regions BDNF was derived from anterograde axonal transport by afferent systems. In the two cases in which this hypothesis was tested by the elimination of select afferents, BDNF immunostaining was completely eliminated. These data, along with the observation that BDNF-ir was rarely found within dendrites or fibers en passage, suggest that BDNF protein produced in adult CNS neurons is polarized primarily along axonal processes and is preferentially stored in terminals within the innervation target.

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Authors: Conner, J. M., Lauterborn, J. C., Yan, Q., Gall, C. M., & Varon, S.
Affiliations: University of California San Diego (US)
University of California, Irvine (US)
Amgen (United States) (US)
ORCID: Conner, James M.
Lauterborn, Julie C.
Gall, Christine M.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 1997-04-01
Volume: 17
Issue: 7
Pages: 2295-2313
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.17-07-02295.1997
PMC: PMC6573520
OpenAlex: W2117830068
Cited by: 1,097
References: 57
Citations by year: 2026: 10 · 2025: 12 · 2024: 25 · 2023: 23 · 2022: 41 · 2021: 38 · 2020: 32 · 2019: 39 · 2018: 40 · 2017: 42 · 2016: 49 · 2015: 58 · 2014: 44 · 2013: 52 · 2012: 48
FWCI: 13.92
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ns016349-16, 5k02mh000974-03, 5r01ns026748-10)
National Institute of Mental Health (MH00974)
National Institute of Neurological Disorders and Stroke (NS-26748, NS 16349)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: brain-derived neurotrophic factor, anterograde axonal transport, BDNF mRNA, central nervous system, afferent systems, medial habenula, central amygdala, bed nucleus of the stria terminalis, lateral septum, spinal cord
MeSH terms: Animals, Axonal Transport, Brain, Female, Immunohistochemistry, Male, Nerve Fibers, Neurons, Organ Specificity, Reference Values, RNA, Messenger, Spinal Cord, Rats, Sprague-Dawley, In Situ Hybridization, DNA, Complementary, Brain-Derived Neurotrophic Factor, Rats

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Distribution of Brain-Derived Neurotrophic Factor (BDNF) Protein and mRNA in the Normal Adult Rat CNS: Evidence for Anterograde Axonal Transport

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