The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Distribution of Brain-Derived Neurotrophic Factor (BDNF) Protein and mRNA in the Normal Adult Rat CNS: Evidence for Anterograde Axonal Transport
Open accessAbstract
A sensitive immunohistochemical technique was used, along with highly specific affinity-purified antibodies to brain-derived neurotrophic factor (BDNF), to generate a detailed mapping of BDNF immunoreactivity (BDNF-ir) throughout the adult rat CNS. A parallel analysis of sites of BDNF synthesis was performed with in situ hybridization techniques using a cRNA probe to the exon encoding mature rat BDNF protein. These combined data revealed (1) groups of cell bodies containing diffuse BDNF-ir throughout the CNS that were strongly correlated with fields of cells containing BDNF mRNA; (2) varying degrees of BDNF-ir outside of cell bodies, in what appeared to be fibers and/or terminals; and (3) many regions containing extremely heavy BDNF-immunoreactive fiber/terminal labeling that lacked BDNF mRNA (e.g., medial habenula, central nucleus of the amygdala, bed nucleus of stria terminalis, lateral septum, and spinal cord). The latter observation suggested that in these regions BDNF was derived from anterograde axonal transport by afferent systems. In the two cases in which this hypothesis was tested by the elimination of select afferents, BDNF immunostaining was completely eliminated. These data, along with the observation that BDNF-ir was rarely found within dendrites or fibers en passage, suggest that BDNF protein produced in adult CNS neurons is polarized primarily along axonal processes and is preferentially stored in terminals within the innervation target.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“BDNF is involved in multiple levels of neuroplasticity like synaptic modulation, adult neurogenesis, and dendritic growth (29–32).”
From Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics. (2021) · cites this paper as [29]
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,501
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,015
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8856 · Cited by 1,426
Long-Lasting Neurotrophin-Induced Enhancement of Synaptic Transmission in the Adult Hippocampus
Kang, H., & Schuman, E. M. (1995) · Science · doi:10.1126/science.7886457 · Cited by 1,354
Maisonpierre, P. C., Belluscio, L., Friedman, B., Alderson, R. F., Wiegand, S. J., Furth, M. E., Lindsay, R. M., & Yancopoulos, G. D. (1990) · Neuron · doi:10.1016/0896-6273(90)90089-x · Cited by 1,250
Korsching, S. I., Auburger, G. W. J., Heumann, R., Scott, J., & Thoenen, H. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03791.x · Cited by 938
Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB
Berkemeier, L. R., Winslow, J. W., Kaplan, D. R., Nikolics, K., Goeddel, D. V., & Rosenthal, A. (1991) · Neuron · doi:10.1016/0896-6273(91)90287-a · Cited by 836
Ernfors, P., Wetmore, C., Olson, L., & Persson, H. (1990) · Neuron · doi:10.1016/0896-6273(90)90090-3 · Cited by 819
Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF
Lohof, A. M., Ip, N. Y., & Poo, M.-M. (1993) · Nature · doi:10.1038/363350a0 · Cited by 755
Isackson, P. J., Huntsman, M. M., Murray, K. D., & Gall, C. M. (1991) · Neuron · doi:10.1016/0896-6273(91)90234-q · Cited by 711 · cited 1×
“This cRNA probe contains 384 bases complementary to the mRNA encoding mature rat BDNF protein (Isackson et al., 1991).”
BackgroundSelf-citationLimbic Seizures Increase Neuronal Production of Messenger RNA for Nerve Growth Factor
Gall, C. M., & Isackson, P. J. (1989) · Science · doi:10.1126/science.2549634 · Cited by 616
Self-citationWidespread Expression of BDNF But Not NT3 by Target Areas of Basal Forebrain Cholinergic Neurons
PHILLIPS, H. S., Hains, J. M., Laramee, G. R., Rosenthal, A., & Winslow, J. W. (1990) · Science · doi:10.1126/science.1688328 · Cited by 539
Sutherland, R. J. (1982) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(82)90003-3 · Cited by 537
Shelton, D. L., & Reichardt, L. F. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.8.2714 · Cited by 532
Whittemore, S. R., Ebendal, T., Lärkfors, L., Olson, L., Seiger, Å., Strömberg, I., & Persson, H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.3.817 · Cited by 522
Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system
Yan, Q., Rosenfeld, R. D., Matheson, C. R., Hawkins, N., Lopez, O. T., Bennett, L., & Welcher, A. A. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00613-6 · Cited by 498
Self-citationPolarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture
Dotti, C. G., & Simons, K. (1990) · Cell · doi:10.1016/0092-8674(90)90240-f · Cited by 427
Bernard, J. F., Alden, M., & Besson, J. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903290205 · Cited by 411
Neurotrophin-6 is a new member of the nerve growth factor family
Götz, R., Köster, R. W., Winkler, C., Raulf, F., Lottspeich, F., Schartl, M., & Thoenen, H. (1994) · Nature · doi:10.1038/372266a0 · Cited by 410
Goodman, L. J., Valverde, J., Lim, F., Geschwind, M. D., Federoff, H. J., Geller, A. I., & Hefti, F. F. (1996) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0017 · Cited by 323
Blöchl, A., & Thoenen, H. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01112.x · Cited by 319
Anterograde transport of neurotrophins and axodendritic transfer in the developing visual system
von Bartheld, C. S., Byers, M. R., Williams, R., & Bothwell, M. A. (1996) · Nature · doi:10.1038/379830a0 · Cited by 284
Endogenous brain-derived neurotrophic factor is anterogradely transported in primary sensory neurons
Zhou, X., & Rush, R. A. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00237-0 · Cited by 277
Timmusk, T., Belluardo, N., METSIS, M. L., & Persson, H. (1993) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1993.tb00526.x · Cited by 254
Nerve growth factor in Alzheimer's disease: defective retrograde transport to nucleus basalis
Mufson, E., Conner, J., & Kordower, J. (1995) · NeuroReport · doi:10.1097/00001756-199505090-00028 · Cited by 221
Self-citationCells that Express Brain‐Derived Neurotrophic Factor mRNA in the Developing Postnatal Rat Brain
Friedman, W., Olson, L., & Persson, H. (1991) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1991.tb00854.x · Cited by 209
Wetmore, C., Olson, L., & Bean, A. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01688.1994 · Cited by 207
Ċastrén, E., Thoenen, H., & Lindholm, D. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00386-j · Cited by 173
Blöchl, A., & Thoenen, H. (1996) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0014 · Cited by 156
Alden, M., Besson, J., & Bernard, J. (1994) · Journal of Comparative Neurology · doi:10.1002/cne.903410302 · Cited by 147
Wetmore, C., Cao, Y. H., Pettersson, R. F., & Olson, L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.21.9843 · Cited by 141
Nerve growth factor mRNA and protein increase in hypothalamus in a mouse model of aggression.
Spillantini, M. G., Aloe, L., Alleva, E., De Simone, R., Goedert, M., & Levi-Montalcini, R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.21.8555 · Cited by 136
Humpel, C., Wetmore, C., & Olson, L. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90476-v · Cited by 133
Ceccatelli, S., Ernfors, P., Villar, M. J., Persson, H., & Hökfelt, T. G. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10352 · Cited by 129
Gall, C. M., Gold, S. J., Isackson, P. J., & Seroogy, K. B. (1992) · Molecular and Cellular Neuroscience · doi:10.1016/1044-7431(92)90009-q · Cited by 121
Self-citationConner, J. M., Muir, D., Varon, S. S., Hagg, T., & Manthorpe, M. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903190310 · Cited by 105
Self-citationImmunohistochemical Visualization of Brain‐derived Neurotrophic Factor in the Rat Brain
Dugich‐Djordjevic, M. M., Peterson, C. M., Isono, F., Ohsawa, F., Widmer, H. R., Denton, T. L., Bennett, G. L., & Hefti, F. F. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb00703.x · Cited by 97
Guthrie, K. M., & Gall, C. M. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903130107 · Cited by 92
Self-citationLauterborn, J. C., Isackson, P. J., & Gall, C. M. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903060308 · Cited by 84
Self-citationStructure–function relationships in the neurotrophin family
Ibáñez, C. F. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251104 · Cited by 83
Selective inhibition of axon outgrowth by antibodies to NGF in a model of temporal lobe epilepsy
Holtzman, D. M., & Lowenstein, D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07062.1995 · Cited by 78
Cellular Localization of NGF and NT-3 mRNAs in Postnatal Rat Forebrain
Lauterborn, J. C., Isackson, P. J., & Gall, C. M. (1994) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1994.1005 · Cited by 78
Self-citationConner, J. M., & Varon, S. S. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903260304 · Cited by 76
Self-citationExpression of Neurotrophins by Midbrain Dopaminergic Neurons
Seroogy, K. B., & Gall, C. M. (1993) · Experimental Neurology · doi:10.1006/exnr.1993.1182 · Cited by 71
Self-citationNarhi, L. O., Rosenfeld, R., Talvenheimo, J., Prestrelski, S. J., Arakawa, T., Lary, J. W., Kolvenbach, C. G., Hecht, R. M., Boone, T., & Miller, J. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38653-3 · Cited by 68
Conner, J. M., Fass-Holmes, B., & Varon, S. S. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903450307 · Cited by 65
Self-citationMufson, E. J., Conner, J. M., Varon, S. S., & Kordower, J. H. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903410407 · Cited by 59
Self-citationNGF modulates sympathetic innervation of lymphoid tissues
Carlson, S. L., Albers, K. M., Beiting, D., Parish, M., Conner, J. R., & Davis, B. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-09-05892.1995 · Cited by 53
Self-citationPolarity signals in epithelial cells
Rodriguez-Boulan, E. J., & Zurzolo, C. (1993) · Journal of Cell Science · doi:10.1242/jcs.1993.supplement_17.2 · Cited by 46
Ma, W., Ribeiro‐da‐Silva, A., Noël, G. P. J. C., Julien, J., & Cuello, A. C. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb00625.x · Cited by 44
NGF mRNA is expressed by GABAergic but not cholinergic neurons in rat basal forebrain
Lauterborn, J. C., Bizon, J. L., Tran, T. M., & Gall, C. M. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903600307 · Cited by 40
Self-citationDistribution of brain-derived neurotrophic factor in the rat pituitary gland
Conner, J. M., Yan, Q., & Varon, S. S. (1996) · Neuroreport · doi:10.1097/00001756-199608120-00014 · Cited by 36
Self-citationWetmore, C., Cao, Y., Pettersson, R. F., & Olson, L. (1993) · Journal of Histochemistry & Cytochemistry · doi:10.1177/41.4.8450192 · Cited by 24
Effects of Exogenous Nerve Growth Factor upon Sympathetic Sprouting into the Hippocampal Formation
Conner, J. M., & Varon, S. S. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1089 · Cited by 22
Self-citationMonitoring Release of Neurotrophic Activity in the Brains of Awake Rats
Humpel, C., Lindqvist, E., Söderström, S., Kylberg, A., Ebendal, T., & Olson, L. (1995) · Science · doi:10.1126/science.7624780 · Cited by 18
Comparative Anatomy of the Hippocampus
Gall, C. M. (1990) · Cerebral cortex · doi:10.1007/978-1-4615-3824-0_3 · Cited by 17
Self-citation
Cited by
Sorted by citations
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129
The induction of pain: an integrative review
Millan, M. J. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00048-3 · Cited by 1,774
Neurotrophins as synaptic modulators
Poo, M.-M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049004 · Cited by 1,775
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579
Binder (2004) · doi:10.1080/08977190410001723308 · Cited by 1,481
Metadata
- Authors
- Conner, J. M., Lauterborn, J. C., Yan, Q., Gall, C. M., & Varon, S.
- Affiliations
- University of California San Diego (US)
- University of California, Irvine (US)
- Amgen (United States) (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1997-04-01
- Volume
- 17
- Issue
- 7
- Pages
- 2295-2313
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6573520
- OpenAlex
- W2117830068
- Cited by
- 1,097
- References
- 57
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 25 · 2023: 23 · 2022: 41 · 2021: 38 · 2020: 32 · 2019: 39 · 2018: 40 · 2017: 42 · 2016: 49 · 2015: 58 · 2014: 44 · 2013: 52 · 2012: 48
- FWCI
- 13.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns016349-16, 5k02mh000974-03, 5r01ns026748-10)
- National Institute of Mental Health (MH00974)
- National Institute of Neurological Disorders and Stroke (NS-26748, NS 16349)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- brain-derived neurotrophic factor, anterograde axonal transport, BDNF mRNA, central nervous system, afferent systems, medial habenula, central amygdala, bed nucleus of the stria terminalis, lateral septum, spinal cord
- MeSH terms
- Animals, Axonal Transport, Brain, Female, Immunohistochemistry, Male, Nerve Fibers, Neurons, Organ Specificity, Reference Values, RNA, Messenger, Spinal Cord, Rats, Sprague-Dawley, In Situ Hybridization, DNA, Complementary, Brain-Derived Neurotrophic Factor, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
