Cited by 1,097Nerve injury and regenerationNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Distribution of Brain-Derived Neurotrophic Factor (BDNF) Protein and mRNA in the Normal Adult Rat CNS: Evidence for Anterograde Axonal Transport

Open access

Conner, James M., Lauterborn, Julie C., Yan, Qiao, Gall, Christine M., Varon, Silvio·1997·The Journal of Neuroscience

DOI 10.1523/jneurosci.17-07-02295.1997PMC PMC6573520

Open this paper in CoChat — free account Open PDF

Abstract

A sensitive immunohistochemical technique was used, along with highly specific affinity-purified antibodies to brain-derived neurotrophic factor (BDNF), to generate a detailed mapping of BDNF immunoreactivity (BDNF-ir) throughout the adult rat CNS. A parallel analysis of sites of BDNF synthesis was performed with in situ hybridization techniques using a cRNA probe to the exon encoding mature rat BDNF protein. These combined data revealed (1) groups of cell bodies containing diffuse BDNF-ir throughout the CNS that were strongly correlated with fields of cells containing BDNF mRNA; (2) varying degrees of BDNF-ir outside of cell bodies, in what appeared to be fibers and/or terminals; and (3) many regions containing extremely heavy BDNF-immunoreactive fiber/terminal labeling that lacked BDNF mRNA (e.g., medial habenula, central nucleus of the amygdala, bed nucleus of stria terminalis, lateral septum, and spinal cord). The latter observation suggested that in these regions BDNF was derived from anterograde axonal transport by afferent systems. In the two cases in which this hypothesis was tested by the elimination of select afferents, BDNF immunostaining was completely eliminated. These data, along with the observation that BDNF-ir was rarely found within dendrites or fibers en passage, suggest that BDNF protein produced in adult CNS neurons is polarized primarily along axonal processes and is preferentially stored in terminals within the innervation target.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.17-07-02295.1997

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,501
Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,015
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8856 · Cited by 1,426
Long-Lasting Neurotrophin-Induced Enhancement of Synaptic Transmission in the Adult Hippocampus
Kang, H., & Schuman, E. M. (1995) · Science · doi:10.1126/science.7886457 · Cited by 1,354
NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression
Maisonpierre, P. C., Belluscio, L., Friedman, B., Alderson, R. F., Wiegand, S. J., Furth, M. E., Lindsay, R. M., & Yancopoulos, G. D. (1990) · Neuron · doi:10.1016/0896-6273(90)90089-x · Cited by 1,250
Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation.
Korsching, S. I., Auburger, G. W. J., Heumann, R., Scott, J., & Thoenen, H. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03791.x · Cited by 938
Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB
Berkemeier, L. R., Winslow, J. W., Kaplan, D. R., Nikolics, K., Goeddel, D. V., & Rosenthal, A. (1991) · Neuron · doi:10.1016/0896-6273(91)90287-a · Cited by 836
Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family
Ernfors, P., Wetmore, C., Olson, L., & Persson, H. (1990) · Neuron · doi:10.1016/0896-6273(90)90090-3 · Cited by 819
Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF
Lohof, A. M., Ip, N. Y., & Poo, M.-M. (1993) · Nature · doi:10.1038/363350a0 · Cited by 755

Show all 57 references

Sorted by citations

Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129
The induction of pain: an integrative review
Millan, M. J. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00048-3 · Cited by 1,774
Neurotrophins as synaptic modulators
Poo, M.-M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049004 · Cited by 1,775
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579
Untitled work
Binder (2004) · doi:10.1080/08977190410001723308 · Cited by 1,481
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity
Kowiański, P., Lietzau, G., Czuba, E., Waśkow, M., Steliga, A., & Moryś, J. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0510-4 · Cited by 1,359
NEUROTROPHINS AND SYNAPTIC PLASTICITY
McAllister, A. K., Katz, L. C., & Lo, D. C. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.295 · Cited by 1,337
Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease
Zuccato, C., Ciammola, A., Rigamonti, D., Leavitt, B. R., Goffredo, D., Conti, L., MacDonald, M. E., Friedlander, R. M., Silani, V., Hayden, M. R., et al. (2001) · Science · doi:10.1126/science.1059581 · Cited by 1,123
BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis
Bramham, C. R., & Messaoudi, E. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.003 · Cited by 1,193
Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer
Colucci-D’Amato, L., Speranza, L., & Volpicelli, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207777 · Cited by 991
Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice
Lee, J., Duan, W., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01085.x · Cited by 975
Anterograde transport of brain-derived neurotrophic factor and its role in the brain
Altar, C. A., Cai, N., Bliven, T., Juhasz, M., Conner, J. M., Acheson, A. L., Lindsay, R. M., & Wiegand, S. J. (1997) · Nature · doi:10.1038/39885 · Cited by 880
Self-citation
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease
Murer, M. G., Yan, Q., & Raisman-Vozari, R. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00014-9 · Cited by 874
Self-citation
Mouse and rat BDNF gene structure and expression revisited
Aid, T., Kazantseva, A., Piirsoo, M., Palm, K., & Timmusk, T. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21139 · Cited by 943
The neurotrophin hypothesis for synaptic plasticity
Schinder, A. F. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01672-6 · Cited by 741
Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats
Scharfman, H., Goodman, J., Macleod, A., Phani, S., Antonelli, C., & Croll, S. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2004.11.016 · Cited by 719
Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters
Pruunsild, P., Kazantseva, A., Aid, T., Palm, K., & Timmusk, T. (2007) · Genomics · doi:10.1016/j.ygeno.2007.05.004 · Cited by 699
Locus coeruleus: a new look at the blue spot
Poe, G. R., Foote, S., Eschenko, O., Johansen, J. P., Bouret, S., Aston-Jones, G., Harley, C. W., Manahan-Vaughan, D., Weinshenker, D., Valentino, R., et al. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0360-9 · Cited by 720
From Acquisition to Consolidation: On the Role of Brain-Derived Neurotrophic Factor Signaling in Hippocampal-Dependent LearningPreprint
Tyler, W. J., Alonso, M., Bramham, C. R., & Pozzo‐Miller, L. D. (2002) · Learning & Memory · doi:10.1101/lm.51202 · Cited by 699
Neurotrophin secretion: current facts and future prospects
Leßmann, V., Gottmann, K., & Malcangio, M. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00019-4 · Cited by 683
Brain-Derived Neurotrophic Factor in Alzheimer’s Disease and Its Pharmaceutical Potential
Gao, L., Zhang, Y., Sterling, K., & Song, W. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00279-0 · Cited by 606
BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization
Guillin, O., Díaz, J., Carroll, P., Griffon, N., Schwartz, J.-C., & Sokoloff, P. (2001) · Nature · doi:10.1038/35075076 · Cited by 573
Role of brain-derived neurotrophic factor in Huntington's disease
Zuccato, C., & Cattaneo, E. F. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.01.003 · Cited by 568
Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety
Gatt, J. M., Nemeroff, C. B., Dobson-Stone, C., Paul, R. H., Bryant, R. A., Schofield, P. R., Gordon, E., Kemp, A. H., & Williams, L. M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.143 · Cited by 525
Regulation of affect by the lateral septum: implications for neuropsychiatry
Sheehan, T. P., Chambers, R. A., & Russell, D. S. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.04.009 · Cited by 514
Nerve Growth Factor Treatment Increases Brain-Derived Neurotrophic Factor Selectively in TrkA-Expressing Dorsal Root Ganglion Cells and in Their Central Terminations within the Spinal Cord
Michael, G. J., Averill, S., Nitkunan, A., Rattray, M., Bennett, D., Yan, Q., & Priestley, J. V. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08476.1997 · Cited by 512
Self-citation
The paraventricular thalamus controls a central amygdala fear circuit
Penzo, M. A., Robert, V., Tucciarone, J., De Bundel, D., Wang, M., Van Aelst, L., Darvas, M., Parada, L. F., Palmiter, R. D., He, M., et al. (2015) · Nature · doi:10.1038/nature13978 · Cited by 506
BDNF as a Promising Therapeutic Agent in Parkinson’s Disease
Palasz, E., Wysocka, A., Gasiorowska, A., Chalimoniuk, M., Niewiadomski, W., & Niewiadomska, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031170 · Cited by 504
Sex differences in neural mechanisms mediating reward and addiction
Becker, J. B., & Chartoff, E. H. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0125-6 · Cited by 478
BDNF and epilepsy: too much of a good thing?
Binder, D. K., Croll, S. D., Gall, C. M., & Scharfman, H. E. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01682-9 · Cited by 454
Self-citation
2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP–dependent metabolic regulation of chromatin structure
Garriga-Canut, M., Schoenike, B. A., Qazi, R., Bergendahl, K., Daley, T. J., Pfender, R. M., Morrison, J. F., Ockuly, J. C., Stafstrom, C. E., Sutula, T. P., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1791 · Cited by 446
Abnormal Cerebellar Development and Foliation in BDNF−/− Mice Reveals a Role for Neurotrophins in CNS Patterning
Schwartz, P. M., Borghesani, P. R., Levy, R. L., Pomeroy, S. L., & Segal, R. A. (1997) · Neuron · doi:10.1016/s0896-6273(00)80938-1 · Cited by 438
BDNF and Hippocampal Synaptic Plasticity
Leal, G., Bramham, C. R., & Duarte, C. B. (2017) · Vitamins and Hormones · doi:10.1016/bs.vh.2016.10.004 · Cited by 425
Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression
Eisch, A. J., Bolaños, C. A., de Wit, J., Simonak, R. D., Pudiak, C. M., Barrot, M., Verhaagen, J., & Nestler, E. J. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.003 · Cited by 420
Regulation of hippocampal synaptic plasticity by BDNF
Leal, G., Afonso, P. M., Salazar, I. L., & Duarte, C. B. (2015) · Brain Research · doi:10.1016/j.brainres.2014.10.019 · Cited by 410
Cellular Mechanisms Regulating Activity-Dependent Release of Native Brain-Derived Neurotrophic Factor from Hippocampal Neurons
Bałkowiec, A., & Katz, D. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10399.2002 · Cited by 411
Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly
Murakami, S., Imbe, H., Morikawa, Y., Kubo, C., & Senba, E. (2005) · Neuroscience Research · doi:10.1016/j.neures.2005.06.008 · Cited by 398
Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse
Graham, D. L., Edwards, S., Bachtell, R. K., Dileone, R., Rios, M., & Self, D. W. (2007) · Nature Neuroscience · doi:10.1038/nn1929 · Cited by 401
Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders
Notaras, M. J., & van den Buuse, M. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0639-2 · Cited by 404
Selective Deletion ofBdnfin the Ventromedial and Dorsomedial Hypothalamus of Adult Mice Results in Hyperphagic Behavior and Obesity
Unger, T. J., Calderon, G. A., Bradley, L., Sena‐Esteves, M., & Rios, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3308-07.2007 · Cited by 385
Brain-derived neurotrophic factor Val66met polymorphism and volume of the hippocampal formation
Szeszko, P. R., Lipsky, R. H., Mentschel, C., Robinson, D. G., Gunduz‐Bruce, H., Sevy, S. M., Ashtari, M., Napolitano, B. A., Bilder, R. M., Kane, J. M., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001656 · Cited by 378
Environmental Enrichment Rescues Protein Deficits in a Mouse Model of Huntington's Disease, Indicating a Possible Disease Mechanism
Spires‐Jones, T. L., Grote, H., Varshney, N. K., Cordery, P. M., van Dellen, A., Blakemore, C. B., & Hannan, A. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1658-03.2004 · Cited by 367
Physiology of BDNF: focus on hypothalamic function
Tapia‐Arancibia, L. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.04.001 · Cited by 378
Ultrastructural localization of estrogen receptor β immunoreactivity in the rat hippocampal formation
Milner, T. A., Ayoola, K. A., Drake, C., Herrick, S. P., Tabori, N., Mcewen, B. S., Warrier, S., & Alves, S. E. (2005) · The Journal of comparative neurology · doi:10.1002/cne.20724 · Cited by 370
BDNF as a pain modulator
Merighi, A., Salio, C., Ghirri, A., Lossi, L., Ferrini, F., Betelli, C., & Bardoni, R. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.04.004 · Cited by 362
Activity-Dependent Transfer of Brain-Derived Neurotrophic Factor to Postsynaptic Neurons
Kohara, K., Kitamura, A., Morishima, M., & Tsumoto, T. (2001) · Science · doi:10.1126/science.1057415 · Cited by 354
Differential Sorting of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Hippocampal Neurons
Mowla, S. J., Pareek, S., Farhadi, H. F., Petrecca, K., Fawcett, J. P., Seidah, N. G., Morris, S. J., Sossin, W. S., & Murphy, R. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02069.1999 · Cited by 350
BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons
Dieni, S., Matsumoto, T., Dekkers, M. P. J., Rauskolb, S., Ionescu, M. S., Deogracias, R., Gundelfinger, E. D., Kojima, M., Nestel, S., Frotscher, M., et al. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201201038 · Cited by 362
Immediate-Early Genes and Synaptic Function
Lanahan, A. A., & Worley, P. F. (1998) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1998.3836 · Cited by 357
Neurobiology of local and intercellular BDNF signaling
Sasi, M., Vignoli, B., Canossa, M., & Blum, R. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1964-4 · Cited by 324
Mechanisms, locations, and kinetics of synaptic BDNF secretion: An update
Leßmann, V., & Brigadski, T. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.06.004 · Cited by 360
proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus
Yang, J., Harte‐Hargrove, L. C., Siao, C.-J., Marinic, T. E., Clarke, R., Ma, Q., Jing, D., LaFrancois, J. J., Bath, K. G., Mark, W. H., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.040 · Cited by 333
Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: Complexity of steroid hormone-growth factor interactions in the adult CNS
Scharfman, H. E., & MacLusky, N. J. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.09.004 · Cited by 342
Activity-Dependent Dendritic Targeting of BDNF and TrkB mRNAs in Hippocampal Neurons
Tongiorgi, E., Righi, M., & Cattaneo, A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-24-09492.1997 · Cited by 328
Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease
Weinshenker, D. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.01.010 · Cited by 339
Postnatal repeated maternal deprivation produces age-dependent changes of brain-derived neurotrophic factor expression in selected rat brain regions
Roceri, M., Cirulli, F., Pessina, C., Peretto, P., Racagni, G., & Riva, M. A. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.12.011 · Cited by 317
Neurotrophin trafficking by anterograde transport
Altar, C. A., & DiStefano, P. S. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01273-9 · Cited by 319
Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex
Croll, S. D., Suri, C., Compton, D. L., Simmons, M. V., Yancopoulos, G. D., Lindsay, R. M., Wiegand, S. J., Rudge, J., & Scharfman, H. E. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00296-1 · Cited by 315
Brain-Derived Neurotrophic Factor Is Released in the Dorsal Horn by Distinctive Patterns of Afferent Fiber Stimulation
Lever, I. J., Bradbury, E. J., Cunningham, J. R., Adelson, D. W., Jones, M. G., McMahon, S. B., Marvizón, J. C. G., & Malcangio, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04469.2001 · Cited by 300
Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases
Mufson, E. J., Kroin, J. S., Sendera, T. J., & Sobreviela, T. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00059-8 · Cited by 296
BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses
Gottmann, K., Mittmann, T., & Leßmann, V. (2009) · Experimental Brain Research · doi:10.1007/s00221-009-1994-z · Cited by 314
Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine
Liu, Q., Lü, L., Zhu, X.-G., Gong, J.-P., Shaham, Y., & Uhl, G. R. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.004 · Cited by 297
Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases
Alexi, T. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00032-5 · Cited by 296
Long-Term Repetitive Transcranial Magnetic Stimulation Increases the Expression of Brain-Derived Neurotrophic Factor and Cholecystokinin mRNA, but not Neuropeptide Tyrosine mRNA in Specific Areas of Rat Brain
Müller, M. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00099-3 · Cited by 292
Role of the brain‐derived neurotrophic factor at glutamatergic synapses
Carvalho, A. L., Caldeira, M. V., Santos, S. D., & Duarte, C. B. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707509 · Cited by 290
Neurotrophic Factors and Receptors in the Immature and Adult Spinal Cord after Mechanical Injury or Kainic Acid
Widenfalk, J., Lundströmer, K., Jubran, M., Brené, S., & Olson, L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03457.2001 · Cited by 286
Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats
Mu, J.-S., Li, W., Yao, Z., & Zhou, X. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01592-9 · Cited by 282
The lighter side of BDNF
Noble, E. E., Billington, C. J., Kotz, C. M., & Wang, C. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00776.2010 · Cited by 284
Specific and common genes implicated across major mental disorders: A review of meta-analysis studies
Gatt, J. M., Burton, K., Williams, L. M., & Schofield, P. R. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.09.014 · Cited by 281
Zinc-Mediated Transactivation of TrkB Potentiates the Hippocampal Mossy Fiber-CA3 Pyramid Synapse
Huang, Y. Z., Pan, E., Xiong, Z., & McNamara, J. O. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.026 · Cited by 275
Hippocampal Excitability Increases during the Estrous Cycle in the Rat: A Potential Role for Brain-Derived Neurotrophic Factor
Scharfman, H., Mercurio, T. C., Goodman, J., Wilson, M., & MacLusky, N. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-37-11641.2003 · Cited by 260
Corticosterone effects on BDNF expression in the hippocampus. Implications for memory formation
Schaaf, M. J. M., De Kloet, E. R., & Vreugdenhil, E. (2000) · Stress · doi:10.3109/10253890009001124 · Cited by 270
Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics.
de Vos, C. M. H., Mason, N. L., & Kuypers, K. P. C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.724606 · Cited by 269
Voluntary exercise protects against stress-induced decreases in brain-derived neurotrophic factor protein expression
Adlard, P. A., & Cotman, C. W. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.039 · Cited by 265
Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper
Grønli, J., Bramham, C., Murison, R., Kanhema, T., Fiske, E., Bjorvatn, B., Ursin, R., & Portas, C. M. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.11.021 · Cited by 260
The exercise-induced expression of BDNF within the hippocampus varies across life-span
Adlard, P. A., Perreau, V. M., & Cotman, C. W. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.05.006 · Cited by 260
Norepinephrine: The redheaded stepchild of Parkinson's disease
Rommelfanger, K. S., & Weinshenker, D. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.01.036 · Cited by 261
Rapid induction of BDNF expression in the hippocampus during immobilization stress challenge in adult rats
Marmigère, F., Givalois, L., Rage, F., Arancibia, S., & Tapia‐Arancibia, L. (2003) · Hippocampus · doi:10.1002/hipo.10109 · Cited by 253
Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment
de Foubert, G., Carney, S. L., Robinson, C. S., Destexhe, E. J., Tomlinson, R., Hicks, C. A., Murray, T. K., Gaillard, J. P., Deville, C., Xhenseval, V., et al. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.054 · Cited by 249
Pre- and postsynaptic twists in BDNF secretion and action in synaptic plasticity.
Edelmann, E., Leßmann, V., & Brigadski, T. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.043 · Cited by 248
BDNF signaling and survival of striatal neurons
Baydyuk, M., & Xu, B. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00254 · Cited by 264
Dynamic plasticity: The role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors
Gray, J. D., Milner, T. A., & McEwen, B. S. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.034 · Cited by 250
Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles
Vilar, M., & Mira, H. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00026 · Cited by 235
Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?
Müller, P., Duderstadt, Y., Lessmann, V., & Müller, N. G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041136 · Cited by 241
Effect of brain‐derived neurotrophic factor haploinsufficiency on stress‐induced remodeling of hippocampal neurons
Magariños, A. M., Li, C. J., Gal Toth, J., Bath, K. G., Jing, D., Lee, F. S., & McEwen, B. S. (2011) · Hippocampus · doi:10.1002/hipo.20744 · Cited by 232
Development and regulation of chloride homeostasis in the central nervous system
Watanabe, M., & Fukuda, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00371 · Cited by 244
Ultrastructural Localization of Full-Length trkB Immunoreactivity in Rat Hippocampus Suggests Multiple Roles in Modulating Activity-Dependent Synaptic Plasticity
Drake, C. T., Milner, T. A., & Patterson, S. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-18-08009.1999 · Cited by 230
Stress during development: Impact on neuroplasticity and relevance to psychopathology
Fumagalli, F., Molteni, R., Racagni, G., & Riva, M. A. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.01.002 · Cited by 226
Brain-derived neurotrophic factor (BDNF) and food intake regulation: A minireview
Lebrun, B., Bariohay, B., Moyse, E., & Jean, A. (2006) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.02.027 · Cited by 219
The Gut Microbiota Reduces Leptin Sensitivity and the Expression of the Obesity-Suppressing Neuropeptides Proglucagon (Gcg) and Brain-Derived Neurotrophic Factor (Bdnf) in the Central Nervous System
Schéle, E., Grahnemo, L., Anesten, F., Hallén, A., Bäckhed, F., & Jansson, J.-O. (2013) · Endocrinology · doi:10.1210/en.2012-2151 · Cited by 209
Beneficial effects of exercise and its molecular mechanisms on depression in rats.
Zheng, H., Liu, Y., Li, W., Yang, B., Chen, D., Wang, X., Jiang, Z., Wang, H., Wang, Z., Cornelisson, G., et al. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.10.007 · Cited by 212
The physiology of regulated BDNF release
Brigadski, T., & Leßmann, V. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03253-2 · Cited by 218
Stress and IL-1β contribute to the development of depressive-like behavior following peripheral nerve injury
Norman, G. J., Karelina, K., Zhang, N., Walton, J. C., Morris, J. S., & DeVries, A. C. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.91 · Cited by 209
Transcranial magnetic stimulation as a therapeutic tool in psychiatry: what do we know about the neurobiological mechanisms?
Post, A., & Keck, M. E. (2001) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(01)00023-1 · Cited by 209
Acute Intrahippocampal Infusion of BDNF Induces Lasting Potentiation of Synaptic Transmission in the Rat Dentate Gyrus
Messaoudi, E., Bårdsen, K., Srebro, B., & Bramham, C. R. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.1.496 · Cited by 208
Spontaneous Limbic Seizures after Intrahippocampal Infusion of Brain-Derived Neurotrophic Factor
Scharfman, H. E., Goodman, J. H., Sollas, A. L., & Croll, S. D. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7869 · Cited by 208
Brain-Derived Neurotrophic Factor: Three Ligands, Many Actions.
Hempstead, B. L. (2015) · Europe PMC (PubMed Central) · Cited by 203
NGF, BDNF, NT3, and NT4
Bothwell, M. A. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-45106-5_1 · Cited by 217
The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise
Adlard, P. A., Perreau, V. M., Engesser‐Cesar, C., & Cotman, C. W. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.03.058 · Cited by 202
Altered expression of BDNF and its high-affinity receptor TrkB in response to complex motor learning and moderate exercise
Klintsova, A. Y., Dickson, E., Yoshida, R., & Greenough, W. T. (2004) · Brain Research · doi:10.1016/j.brainres.2004.09.003 · Cited by 200

Authors: Conner, J. M., Lauterborn, J. C., Yan, Q., Gall, C. M., & Varon, S.
Affiliations: University of California San Diego (US)
University of California, Irvine (US)
Amgen (United States) (US)
ORCID: Conner, James M.
Lauterborn, Julie C.
Gall, Christine M.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 1997-04-01
Volume: 17
Issue: 7
Pages: 2295-2313
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.17-07-02295.1997
PMC: PMC6573520
OpenAlex: W2117830068
Cited by: 1,097
References: 57
Citations by year: 2026: 10 · 2025: 12 · 2024: 25 · 2023: 23 · 2022: 41 · 2021: 38 · 2020: 32 · 2019: 39 · 2018: 40 · 2017: 42 · 2016: 49 · 2015: 58 · 2014: 44 · 2013: 52 · 2012: 48
FWCI: 13.92
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ns016349-16, 5k02mh000974-03, 5r01ns026748-10)
National Institute of Mental Health (MH00974)
National Institute of Neurological Disorders and Stroke (NS-26748, NS 16349)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: brain-derived neurotrophic factor, anterograde axonal transport, BDNF mRNA, central nervous system, afferent systems, medial habenula, central amygdala, bed nucleus of the stria terminalis, lateral septum, spinal cord
MeSH terms: Animals, Axonal Transport, Brain, Female, Immunohistochemistry, Male, Nerve Fibers, Neurons, Organ Specificity, Reference Values, RNA, Messenger, Spinal Cord, Rats, Sprague-Dawley, In Situ Hybridization, DNA, Complementary, Brain-Derived Neurotrophic Factor, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Distribution of Brain-Derived Neurotrophic Factor (BDNF) Protein and mRNA in the Normal Adult Rat CNS: Evidence for Anterograde Axonal Transport

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks