CD200 Ligand–Receptor Interaction Modulates Microglial Activation In Vivo and In Vitro: A Role for IL-4

Down-Regulation of the Macrophage Lineage Through Interaction with OX2 (CD200)

Hoek, R. M., Ruuls, S. R., Murphy, C. A., Wright, G. J., Goddard, R., Zurawski, S. M., Blom, B., Homola, M. E., Streit, W. J., Brown, M. H., et al. (2000) · Science · doi:10.1126/science.290.5497.1768 · Cited by 1,022

Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease

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Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease

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Characterization of the CD200 Receptor Family in Mice and Humans and Their Interactions with CD200

Wright, G. J., Cherwinski, H. M., Foster‐Cuevas, M., Brooke, G. P., Puklavec, M. J., Bigler, M., Song, Y., Jenmalm, M. C., Gorman, D., McClanahan, T., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.6.3034 · Cited by 434

CD200 and membrane protein interactions in the control of myeloid cells

Barclay, A. N., Wright, G. J., Brooke, G. P., & Brown, M. H. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02223-8 · Cited by 422

GM-CSF Production by Autoreactive T Cells Is Required for the Activation of Microglial Cells and the Onset of Experimental Autoimmune Encephalomyelitis1

Ponomarev, E., Shriver, L., Maresz, K., Pedras-Vasconcelos, J., Verthelyi, D., & Dittel, B. (2007) · Journal of Immunology · doi:10.4049/jimmunol.178.1.39 · Cited by 413

Control of glial immune function by neurons

Neumann, H. (2001) · Glia · doi:10.1002/glia.1108 · Cited by 319

The age-related attenuation in long-term potentiation is associated with microglial activation

Griffin, R., Nally, R., Nolan, Y., McCartney, Y., Linden, J., & Lynch, M. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04165.x · Cited by 282

Different reticular elements in rat lymphoid tissue identified by localization of Ia, Thy-1 and MRC OX 2 antigens.

Barclay, A. N. (1981) · PubMed · Cited by 240

Constitutive Retinal CD200 Expression Regulates Resident Microglia and Activation State of Inflammatory Cells during Experimental Autoimmune Uveoretinitis

Broderick, C. A., Hoek, R. M., Forrester, J. V., Liversidge, J., Sedgwick, J. D., & Dick, A. D. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64444-6 · Cited by 230

Glial PAMPering and DAMPening of Adult Hippocampal Neurogenesis

Parkitny, L., & Maletić‐Savatić, M. (2021) · Brain Sciences · doi:10.3390/brainsci11101299 · Cited by 9

CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease

Comella-Bolla, A., Valente, T., Miguez, A., Brito, V., Ginés, S., Solà, C., Straccia, M., & Canals, J. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224901 · Cited by 10

Emerging role of neural stem/progenitor cell secretome in brain inflammatory response modulation

Łukowicz, K., Grygier, B., & Basta‐Kaim, A. (2025) · Pharmacological Reports · doi:10.1007/s43440-025-00733-6 · Cited by 8

Events Occurring in the Axotomized Facial Nucleus

Nakajima, K., & Ishijima, T. (2022) · Cells · doi:10.3390/cells11132068 · Cited by 8

The Dual Role of Microglia in Multiple Sclerosis and its Implications for Diagnostics and Repair

Goulart, M. T., Queiroz, D. T. U., & Ribeiro, F. M. (2025) · Current Neuropharmacology · doi:10.2174/011570159x352356241126044933 · Cited by 8

CD157 and CD200 at the crossroads of endothelial remodeling and immune regulation

Katoh, M., & Katoh, M. (2019) · Stem Cell Investigation · doi:10.21037/sci.2019.04.01 · Cited by 7

A Novel Phospholipid-Based Drug Formulation, VP025, Modulates Age- and LPS-Induced Microglial Activity in the Rat

Martin, D. S. D., Walsh, M., Miller, A., Skerrett, H. E., Byrne, P., Mandel, A., Bolton, A. E., & Lynch, M. A. (2009) · NeuroImmunoModulation · doi:10.1159/000228915 · Cited by 8

Low Serum Levels of Fibroblast Growth Factor 2 in Gunn Rats: A Hyperbilirubinemia Animal Model of Schizophrenic Symptoms

Hayashida, M., Hashioka, S., Hayashida, K., Miura, S., Tsuchie, K., Araki, T., Izuhara, M., Kanayama, M., Otsuki, K., Nagahama, M., et al. (2020) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527319999200729153907 · Cited by 6

High CD200 Expression on T CD4+ and T CD8+ Lymphocytes as a Non-Invasive Marker of Idiopathic Pulmonary Hypertension–Preliminary Study

Tomaszewski, M., Grywalska, E., Topyła, W., Błaszczak, P., Kurzyna, M., Roliński, J., & Kopeć, G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10050950 · Cited by 6

Analysis of the Impact of CD200 on Neurodegenerative Diseases

Miller, A., Brian, F., Downer, E. J., Lyons, A., Henrich‐Noack, P., Nolan, Y. M., & Marina, A. (2011) · InTech eBooks · doi:10.5772/32003 · Cited by 5

The impact of aging on the brain – Risk, resilience and repair

Lynch, M. A., & Johnson, R. W. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.02.005 · Cited by 5

Research Committee Report on Diagnosis and Treatment of Chronic Inflammatory Response Syndrome Caused by Exposure to the Interior Environment of Water-Damaged Buildings

Shoemaker, R. C., Mark, L. V. N., McMahon, S., Thrasher, J. D., & Hhs, C. G. (2010) · Cited by 5

IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity

Avloniti, M., Evangelidou, M., Gomini, M., Loupis, T., Emmanouil, M., Mitropoulou, A., Tselios, T. V., Lassmann, H., Gruart, A., Delgado-Garcia, J. M., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03023-9 · Cited by 5

How neural stem cells promote the repair of brain injury through immunoregulation

Jiang, C. S., Hou, B.-R., Wang, Z.-N., Chen, Y., Wang, D., & Ren, H. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001039 · Cited by 4

Cellular distribution of CD200 receptor in rats and its interaction with cytomegalovirus e127 protein

El‐Mokhtar, M. A., Bauer, A., Madela, J., & Voigt, S. (2018) · Medical Microbiology and Immunology · doi:10.1007/s00430-018-0552-3 · Cited by 4

Aging and the Immune System

Fenn, A. M., Corona, A. W., & Godbout, J. P. (2013) · Wiley eBooks · doi:10.1002/9781118314814.ch16 · Cited by 4

An introduction to innate immunity in the central nervous system

Harry, G. J., Childers, G. M., & McPherson, C. A. (2018) · Advances in neurotoxicology · doi:10.1016/bs.ant.2018.10.002 · Cited by 3

Origin and Development of Microglia

Patro, N., & Patro, I. K. (2022) · Springer eBooks · doi:10.1007/978-981-16-8313-8_7 · Cited by 3

Peripheral CD200R signaling: A critical regulator of post-stroke inflammation in aged mice

Ngwa, C., Misrani, A., Xu, Y., Wang, J., Ritzel, R. M., & Liu, F. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111686 · Cited by 2

Immunity in Parkinson's disease – The role of innate responses

Iyengar, A. S., Dunkley, P. R., & Dickson, P. W. (2025) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2025.578716 · Cited by 4

Uncovering the Path to Neurodegeneration from Playingfield to Battlefield

Baas, F., & Ramagli, V. (2014) · InTech eBooks · doi:10.5772/57186 · Cited by 1

Generating and Co-culturing Murine Primary Microglia and Cortical Neurons

Park, J., Yu, R., & Dong, Y. (2024) · Journal of Visualized Experiments · doi:10.3791/67078 · Cited by 2

Microglial state transitions are constrained by developmental and metabolic checkpoints

Mesaoudi, A. E., & Kim, D. W. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1852176 · Cited by 1

HMC3 revealed: how much do these “Microglia” really tell us?

Buccarello, L., Privitera, A., Partsinevelos, K., Serwa, K., Carota, G., Pietro, L. D., Cardaci, V., Mangione, R., Sibbitts, J., Lazzarino, G., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1778798 · Cited by 2

The CNS Innate Immune System and the Emerging Roles of the Neuroimmune Regulators (NIRegs) in Response to Infection, Neoplasia and Neurodegeneration

W., J., Denizot, M., J., J., & Gasque, P. (2012) · InTech eBooks · doi:10.5772/37824 · Cited by 1

Effect of acupuncture on short-term memory and apoptosis after transient cerebral ischemia in gerbils

Choi, I.-H., & Lim, H.-H. (2018) · 대한한의학회지 · doi:10.13048/jkm.18030 · Cited by 1

CD200 Change Is Involved in Neuronal Death in Gerbil Hippocampal CA1 Field Following Transient Forebrain Ischemia and Postischemic Treatment with Risperidone Displays Neuroprotection without CD200 Change

Lee, T.-K., Shin, M. C., Ahn, J. H., Kim, D. W., Kim, B., Sim, H., Lee, J., Cho, J. H., Park, J. H., Kim, Y., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031116 · Cited by 1

Alzheimer’s Disease

Ikezu, T. (2016) · Springer eBooks · doi:10.1007/978-3-319-44022-4_30 · Cited by 1

Neuroinflammation in Aging

Fenn, A. M., Norden, D. M., & Godbout, J. P. (2015) · Wiley eBooks · doi:10.1002/9781118732748.ch6 · Cited by 1

Myeloid cell-specific ablation of the mineralocorticoid receptor attenuates experimental autoimmune encephalomyelitis

Li, X. (2013) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3713 · Cited by 1

The role of miRNAs in stroke

Breen, C. (2015) · Enlighten: Theses (The University of Glasgow) · Cited by 1

Inflammation in Parkinson’s Disease: Causes and Consequences

Louise, M., Toulouse, A., & Yvonne, M. (2012) · InTech eBooks · doi:10.5772/18184

Ageing and the Immune Response in the CNS

Raj, D. D. A., Eggen, B. J. L., & Boddeke, H. W. G. M. (2014) · Wiley eBooks · doi:10.1002/9781118406557.ch4

An Examination of the Long-lasting Effects of Lipopolysaccharide-induced Sepsis on Cognitive and Affective Behaviour in Mice

Anderson, S. T. (2014) · Maynooth University ePrints and eTheses Archive (Maynooth University)

Aging and Microglial Activation in Neurodegenerative Diseases

Oyarzabal, E. A., Shih, Y. I., & Hong, J. (2016) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-319-33486-8_7

Role of Primed Microglia in the Aging Brain in Prolonged Sickness and Depressive Behavior Concomitant with Peripheral Immune Stimulation

Henry, C. J. (2011) · OhioLink ETD Center (Ohio Library and Information Network)

Elucidating the functions of fibroblast growth factor 9 in multiple sclerosis

McElroy, D. (2018) · Enlighten: Theses (The University of Glasgow)

Linking CD200 in brains and dementia

Walker, D. G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815868-5.00023-2

The Immune Response in Parkinson's Disease

Lira, A. (2014) · uO Research (University of Ottawa) · doi:10.20381/ruor-3524

Molecular aspects of neuroinflammation: Contribution of eicosanoids, cytokines, and chemokines

Farooqui, A. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-88460-0.00009-6

Alzheimer’s Disease

Ikezu, T. (2024) · Springer eBooks · doi:10.1007/978-3-031-68237-7_22

Biomarkers for early detection and monitoring of abnormal brain development in mild fetal growth restriction

Onoda, A., Kitase, Y., Coq, J., Ueda, K., Shimizu, S., Tsuji, M., Hayakawa, M., & Sato, Y. (2025) · iScience · doi:10.1016/j.isci.2025.113237

Identification of Critical Hub Genes and Pathways Regulating Chemotherapy Responses in Triple‐Negative Breast Cancer: An Integrated Analysis

Ashabi, S., Mavadat, E., Moradalizadeh, M., Khoshnevis, A., Farani, M. R., Bakhtiyari, S., & Alipourfard, I. (2025) · Cell Biochemistry and Function · doi:10.1002/cbf.70153

Additional file 5 of IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity

Avloniti, M., Evangelidou, M., Gomini, M., Loupis, T., Emmanouil, M., Mitropoulou, A., Tselios, T., Lassmann, H., Gruart, A., Delgado-García, J. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673507

Additional file 4 of IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity

Avloniti, M., Evangelidou, M., Gomini, M., Loupis, T., Emmanouil, M., Mitropoulou, A., Tselios, T., Lassmann, H., Gruart, A., Delgado-García, J. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673504

Additional file 6 of IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity

Avloniti, M., Evangelidou, M., Gomini, M., Loupis, T., Emmanouil, M., Mitropoulou, A., Tselios, T., Lassmann, H., Gruart, A., Delgado-García, J. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673510

Additional file 8 of IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity

Avloniti, M., Evangelidou, M., Gomini, M., Loupis, T., Emmanouil, M., Mitropoulou, A., Tselios, T., Lassmann, H., Gruart, A., Delgado-García, J. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673516

Additional file 3 of IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity

Avloniti, M., Evangelidou, M., Gomini, M., Loupis, T., Emmanouil, M., Mitropoulou, A., Tselios, T., Lassmann, H., Gruart, A., Delgado-García, J. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673501

Additional file 2 of IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity

Avloniti, M., Evangelidou, M., Gomini, M., Loupis, T., Emmanouil, M., Mitropoulou, A., Tselios, T., Lassmann, H., Gruart, A., Delgado-García, J. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673498

Additional file 9 of IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity

Avloniti, M., Evangelidou, M., Gomini, M., Loupis, T., Emmanouil, M., Mitropoulou, A., Tselios, T., Lassmann, H., Gruart, A., Delgado-García, J. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673519

Additional file 1 of IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity

Avloniti, M., Evangelidou, M., Gomini, M., Loupis, T., Emmanouil, M., Mitropoulou, A., Tselios, T., Lassmann, H., Gruart, A., Delgado-García, J. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673495

Additional file 7 of IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity

Avloniti, M., Evangelidou, M., Gomini, M., Loupis, T., Emmanouil, M., Mitropoulou, A., Tselios, T., Lassmann, H., Gruart, A., Delgado-García, J. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673513

Introduction to microglial aging and its involvement in neurodegenerative diseases

Ben-Azu, B., Gargus, M., Verkhratsky, A., & Tremblay, M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27340-7.00007-3

Primitive macrophages regulate the development of dorsal root ganglia sensory neurons in mouse embryos

Angelim, M. K. S. C. (2017) · theses.fr (ABES) · doi:10.70675/2f402166z8a8bz4e47z93c4z20ae8f982074

Étude des perturbations astrocytaires sous l’influence de l’apolipoprotéine E4 : implications et applications dans la maladie d’Alzheimer

Arnaud, L. (2021) · theses.fr (ABES) · doi:10.70675/11e3cc48zf040z4b8azb1d3zb7f6a6eed96b

Depression and the Immune Responses

Sunzeri, F. (2026) · Springer eBooks · doi:10.1007/978-3-032-14465-2_10

CD47 – SIRPα Axis as a Target for Neuroprotection

Gómez‐López, A. R., Manich, G., Penas, C., Pampalona, J., Villacampa, N., Almolda, B., Viennois, É., Rojas, S., González, B., & Castellano, B. (2026) · Glia · doi:10.1002/glia.70242

Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide

Lyons, A., McQuillan, K., Deighan, B. F., O’Reilly, J.-A., Downer, E. J., Murphy, A. C., Watson, M., Piazza, A., O’Connell, F., Griffin, R., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.05.060 · Cited by 98

The role of N-glycosylation of CD200-CD200R1 interaction in classical microglial activation

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Expression of CD200 in alternative activation of microglia following an excitotoxic lesion in the mouse hippocampus

Yi, M., Zhang, E., Kang, J. W., Shin, Y. N., Byun, J. Y., Oh, S., Seo, J. H., Lee, Y., & Kim, D. W. (2012) · Brain Research · doi:10.1016/j.brainres.2012.08.053 · Cited by 37

P4‐166: CD200Fc fusion protein alleviates beta amyloid‐induced glial‐activation and neurodegeneration in vitro and in vivo

Cowley, T. R., Miller, A., Piazza, A., Downer, E. J., & Lynch, M. A. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.04.733

Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression

Suzumura, A., Sawada, M., Itoh, Y., & Marunouchi, T. (1994) · Journal of Neuroimmunology · doi:10.1016/0165-5728(94)90031-0 · Cited by 93