Down-Regulation of the Macrophage Lineage Through Interaction with OX2 (CD200)
Abstract
OX2 (CD200) is a broadly expressed membrane glycoprotein, shown here to be important for regulation of the macrophage lineage. In mice lacking CD200, macrophage lineage cells, including brain microglia, exhibited an activated phenotype and were more numerous. Upon facial nerve transection, damaged CD200-deficient neurons elicited an accelerated microglial response. Lack of CD200 resulted in a more rapid onset of experimental autoimmune encephalomyelitis (EAE). Outside the brain, disruption of CD200-CD200 receptor interaction precipitated susceptibility to collagen-induced arthritis (CIA) in mice normally resistant to this disease. Thus, in diverse tissues OX2 delivers an inhibitory signal for the macrophage lineage.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CD200-knockout mice have deramified microglia with upregulated levels of CD11b and CD45 at baseline, indicative of an activated phenotype.
“Indeed, despite normal lifespan and no obvious behavioral abnormalities, CD200-knockout mice have deramified microglia with upregulated levels of CD11b and CD45 at baseline, overall indicative of an activated phenotype (Hoek et al, 2000).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Hoek et al, 2000
Cites
Macrophages and microglia in the nervous system
Perry, V. H., & Gordon, S. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90110-5 · Cited by 747 · see citing works
Sedgwick, J. D., Schwender, S., Imrich, H., Dörries, R., Butcher, G. W., & ter Meulen, V. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7438 · Cited by 691 · see citing works
Self-citationBiology of disease. Analysis of autoimmune demyelination: its impact upon multiple sclerosis.
Raine, C. S. (1984) · PubMed · Cited by 425 · see citing works
Wright, G. J., Puklavec, M. J., Willis, A. C., Hoek, R. M., Sedgwick, J. D., Brown, M. H., & Barclay, A. N. (2000) · Immunity · doi:10.1016/s1074-7613(00)00023-6 · Cited by 388 · see citing works
Self-citationGraeber, M. B., Streit, W. J., & Kreutzberg, G. W. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490210104 · Cited by 367 · see citing works
Self-citationTargeted disruption of the MHC class II Aa gene in C57BL/6 mice
Köntgen, F., Süss, G., Stewart, C. L., Steinmetz, M., & Bluethmann, H. (1993) · International Immunology · doi:10.1093/intimm/5.8.957 · Cited by 364 · see citing works
DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming.
Bakker, A. B., Hoek, R., Cerwenka, A., Blom, B., Lucian, L., McNeil, T., Murray, R., Phillips, L., Sedgwick, J., & Lanier, L. (2000) · Immunity · doi:10.1016/s1074-7613(00)00034-0 · Cited by 269 · see citing works
Self-citationMarginal metallophilic cells of the mouse spleen identified by a monoclonal antibody.
Kraal, G., & Janse, M. (1986) · PubMed · Cited by 224 · see citing works
Watson, W. C., & Townes, A. S. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.162.6.1878 · Cited by 202 · see citing works
Riminton, S., Körner, H., Strickland, D. H., Lemckert, F. A., Pollard, J. D., & Sedgwick, J. D. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.9.1517 · Cited by 163 · see citing works
Self-citationCD2 and the nature of protein interactions mediating cell‐cell recognition
Davis, S. J., Ikemizu, S., Wild, M. K., & van der Merwe, P. A. (1998) · Immunological Reviews · doi:10.1111/j.1600-065x.1998.tb01199.x · Cited by 153 · see citing works
McColl, S. R., Staykova, M. A., Wozniak, A., Fordham, S., Bruce, J., & Willenborg, D. O. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.6421 · Cited by 142 · see citing works
Localisation of the MRC OX‐2 Glycoprotein on the Surfaces of Neurones
Webb, M. H., & Barclay, A. N. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb12844.x · Cited by 114 · see citing works
Self-citationGranulocyte-macrophage colony stimulating factor exacerbates collagen induced arthritis in mice
Campbell, I. K., Bendele, A. M., Smith, D. A., & Hamilton, J. A. (1997) · Annals of the Rheumatic Diseases · doi:10.1136/ard.56.6.364 · Cited by 110 · see citing works
Sedgwick, J. D., Schwender, S., Gregersen, R., Dörries, R., & ter Meulen, V. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.4.1145 · Cited by 98 · see citing works
Self-citationA demineralization procedure for immunohistopathological use
Jonsson, R., Tarkowski, A., & Klareskog, L. (1986) · Journal of Immunological Methods · doi:10.1016/0022-1759(86)90058-x · Cited by 91 · see citing works
Lemckert, F. A., Sedgwick, J., & Körner, H. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.4.917 · Cited by 73 · see citing works
Self-citationThe leukocyte/neuron cell surface antigen OX2 binds to a ligand on macrophages
Preston, S., Wright, G. J., Starr, K., Barclay, A. N., & Brown, M. H. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270814 · Cited by 68 · see citing works
Self-citationBates, E. E. M., Dieu‐Nosjean, M., Ravel, O., et al. (1998) · Molecular Immunology · doi:10.1016/s0161-5890(98)00045-5 · Cited by 42 · see citing works
Borriello, F., Tizard, R., Rue, E. E., et al. (1998) · Mammalian Genome · doi:10.1007/s003359900700 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269 · see citing works
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676 · see citing works
Points of control in inflammation
Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738 · see citing works
Microglial <scp>M1/M2</scp> polarization and metabolic states
Orihuela, R., McPherson, C. A., & Harry, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13139 · Cited by 2,070 · see citing works
Microglial physiology: unique stimuli, specialized responses
Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858 · see citing works
Microglia in neurodegenerative disease
Perry, V. H., Nicoll, J. A. R., & Holmes, C. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.17 · Cited by 1,543 · see citing works
Control of microglial neurotoxicity by the fractalkine receptor
Cardona, A. E., Pioro, E. P., Sasse, M. E., Kostenko, V., Cardona, S. M., Dijkstra, I. M., Huang, D., Kidd, G., Dombrowski, S., Dutta, R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1715 · Cited by 1,531 · see citing works
IL-25 Induces IL-4, IL-5, and IL-13 and Th2-Associated Pathologies In Vivo
Fort, M. M., Cheung, J., Yen, D., Li, J., Zurawski, S. M., Lo, S., Menon, S., Clifford, T., Hunte, B., Lesley, R., et al. (2001) · Immunity · doi:10.1016/s1074-7613(01)00243-6 · Cited by 1,203 · see citing works
Self-citationMicroglial priming in neurodegenerative disease
Perry, V. H., & Holmes, C. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.38 · Cited by 1,127 · see citing works
Microglial Activation and Chronic Neurodegeneration
Lull, M. E., & Block, M. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.014 · Cited by 1,047 · see citing works
Systemic infections and inflammation affect chronic neurodegeneration
Perry, V. H., Cunningham, C., & Holmes, C. (2007) · Nature Reviews Immunology · doi:10.1038/nri2015 · Cited by 1,027 · see citing works
Microglia as neuroprotective, immunocompetent cells of the CNS
Streit, W. J. (2002) · Glia · doi:10.1002/glia.10154 · Cited by 919 · see citing works
Self-citationMicroglia in Alzheimer's disease
Sarlus, H., & Heneka, M. T. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90606 · Cited by 911 · see citing works
Neuroinflammation in Parkinson's disease and its potential as therapeutic target
Wang, Q., Liu, Y., & Zhou, J. (2015) · Translational Neurodegeneration · doi:10.1186/s40035-015-0042-0 · Cited by 884 · see citing works
The myeloid cells of the central nervous system parenchyma
Ransohoff, R. M., & Cardona, A. E. (2010) · Nature · doi:10.1038/nature09615 · Cited by 804 · see citing works
Review: microglia of the aged brain: primed to be activated and resistant to regulation
Norden, D. M., & Godbout, J. P. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01306.x · Cited by 792 · see citing works
Neuronal ‘On’ and ‘Off’ signals control microglia
Biber, K., Neumann, H., Inoue, K., & Boddeke, H. W. G. M. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.08.007 · Cited by 787 · see citing works
What is immune privilege (not)?
Galea, I., Bechmann, I., & Perry, V. H. (2007) · Trends in Immunology · doi:10.1016/j.it.2006.11.004 · Cited by 768 · see citing works
Chtanova, T., Tangye, S. G., Newton, R., Frank, N., Hodge, M. R., Rolph, M. S., & Mackay, C. R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.68 · Cited by 722 · see citing works
TREMs in the immune system and beyond
Colonna, M. (2003) · Nature Reviews Immunology · doi:10.1038/nri1106 · Cited by 701 · see citing works
Kim, Y. S., & Joh, T. H. (2006) · Experimental & Molecular Medicine · doi:10.1038/emm.2006.40 · Cited by 655 · see citing works
Frank, M. G., Baratta, M. V., Sprunger, D. B., Watkins, L. R., & Maier, S. F. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.03.005 · Cited by 578 · see citing works
The Indispensable Roles of Microglia and Astrocytes during Brain Development
Reemst, K., Noctor, S. C., Lucassen, P. J., & Hol, E. M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00566 · Cited by 516 · see citing works
What is the blood–brain barrier (not)?
Bechmann, I., Galea, I., & Perry, V. H. (2007) · Trends in Immunology · doi:10.1016/j.it.2006.11.007 · Cited by 520 · see citing works
Microglia activation in retinal degeneration
Langmann, T. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0207114 · Cited by 496 · see citing works
A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia
Hsieh, C. L., Koike, M., Spusta, S. C., Niemi, E. C., Yenari, M., Nakamura, M. C., & Seaman, W. E. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06042.x · Cited by 475 · see citing works
The role of microglia in central nervous system immunity and glioma immunology
Yang, I., Han, S. J., Kaur, G., Crane, C., & Parsa, A. T. (2010) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2009.05.006 · Cited by 410 · see citing works
“Upon activation, microglia upregulate opsonic receptors including complement receptors (CR1, CR3, CR4) and Fc gamma receptors (I, II, III), which enhance phagocytic activity by binding to complement components and immunoglobulin fragments respectively [50, 51].”
BackgroundMicroglia Priming with Aging and Stress
Niraula, A., Sheridan, J. F., & Godbout, J. P. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.185 · Cited by 398 · see citing works
Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned
Gudi, V., Gingele, S., Skripuletz, T., & Stangel, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00073 · Cited by 375 · see citing works
“The receptors CD200R and SIRP-α, suggested to inhibit activation of microglia or keep them in a resting state (Hoek et al., 2000; Kierdorf and Prinz, 2013), were expressed on microglia at any time either in untreated or cuprizone-challenged animals.”
BackgroundDurable antitumor responses to CD47 blockade require adaptive immune stimulation
Sockolosky, J. T., Dougan, M., Ingram, J. R., Ho, C. C. M., Kauke, M. J., Almo, S. C., Ploegh, H. L., & Garcia, K. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604268113 · Cited by 366 · see citing works
Factors regulating microglia activation
Kierdorf, K., & Prinz, M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00044 · Cited by 360 · see citing works
Schmid, C. D., Sautkulis, L. N., Danielson, P. E., Cooper, J., Hasel, K. W., Hilbush, B. S., Sutcliffe, J. G., & Carson, M. J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01243.x · Cited by 351 · see citing works
González, H., Elgueta, D., Montoya, A., & Pacheco, R. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.07.012 · Cited by 352 · see citing works
Immune Regulation in the Aging Retina
Chen, M., Luo, C., Zhao, J., Devarajan, G., & Xu, H. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.10.003 · Cited by 305 · see citing works
mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging
Frank, M. G., Barrientos, R. M., Biedenkapp, J. C., Rudy, J. W., Watkins, L. R., & Maier, S. F. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.013 · Cited by 327 · see citing works
Neuroplastic changes in depression: A role for the immune system
Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319 · see citing works
Control of glial immune function by neurons
Neumann, H. (2001) · Glia · doi:10.1002/glia.1108 · Cited by 319 · see citing works
Microglial phenotypes in Parkinson’s disease and animal models of the disease
Joers, V., Tansey, M. G., Mulas, G., & Carta, A. R. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.006 · Cited by 285 · see citing works
Arcuri, C., Mecca, C., Bianchi, R., Giambanco, I., & Donato, R. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00191 · Cited by 279 · see citing works
Lyons, A., Downer, E. J., Crotty, S., Nolan, Y. M., Mills, K. H. G., & Lynch, M. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1781-07.2007 · Cited by 258 · see citing works
Neumann, H., & Takahashi, K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.032 · Cited by 249 · see citing works
Jurgens, H. A., Amancherla, K., & Johnson, R. W. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6389-11.2012 · Cited by 243 · see citing works
Microglia in the aging brain: relevance to neurodegeneration
Luo, X.-G., Ding, J.-Q., & Chen, S.-D. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-12 · Cited by 236 · see citing works
“Microglia activation is normally controlled under physiological conditions of the CNS through neuron-glia contact, CD200R-CD200 pathway[19], neuronal electrical activity[20], and/or some soluble neurotransmitters [21].”
BackgroundHart, A. D., Wyttenbach, A., Hugh Perry, V., & Teeling, J. L. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.11.006 · Cited by 230 · see citing works
Neural stem cell therapy for subacute and chronic ischemic stroke
Boese, A. C., Le, Q.-S. E., Pham, D., Hamblin, M. H., & Lee, J.-P. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0913-2 · Cited by 205 · see citing works
Microglia in the healthy and degenerating retina: Insights from novel mouse models
Karlstetter, M., Ebert, S., & Langmann, T. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.05.010 · Cited by 197 · see citing works
de Pablos, R. M., Herrera, A. J., Espinosa-Oliva, A. M., Sarmiento, M., Muñoz, M. F., Machado, A., & Venero, J. L. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-34 · Cited by 201 · see citing works
Dysregulated neuronal–microglial cross-talk during aging, stress and inflammation
Jurgens, H. A., & Johnson, R. W. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2010.11.014 · Cited by 179 · see citing works
Glia Crosstalk in Neuroinflammatory Diseases
Bernaus, A., Blanco, S., & Sevilla, A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00209 · Cited by 157 · see citing works
Zhang, S., Wang, X.-J., Tian, L.-P., Pan, J., Lu, G.-Q., Zhang, Y.-J., Ding, J.-Q., & Chen, S.-D. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-154 · Cited by 154 · see citing works
Microglial degeneration in the aging brain - bad news for neurons?
Streit, W. (2008) · Frontiers in Bioscience · doi:10.2741/2937 · Cited by 150 · see citing works
Self-citationBarrientos, R. M., Frank, M. G., Crysdale, N. Y., Chapman, T. R., Ahrendsen, J. T., Day, H. E. W., Campeau, S., Watkins, L. R., Patterson, S. L., & Maier, S. F. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2266-11.2011 · Cited by 148 · see citing works
Human iPSC‐derived microglia: A growing toolset to study the brain's innate immune cells
Hasselmann, J., & Blurton‐Jones, M. (2020) · Glia · doi:10.1002/glia.23781 · Cited by 145 · see citing works
Regulation of microglia development and homeostasis.
Greter, M., & Merad, M. (2013) · Glia · doi:10.1002/glia.22408 · Cited by 141 · see citing works
The brain’s best friend: microglial neurotoxicity revisited
Hellwig, S., Heinrich, A., & Biber, K. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00071 · Cited by 126 · see citing works
Microglia: unique and common features with other tissue macrophages
Prinz, M., Tay, T. L., Wolf, Y., & Jung, S. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1267-1 · Cited by 126 · see citing works
Wang, X.-J., Zhang, S., Yan, Z.-Q., Zhao, Y.-X., Zhou, H.-Y., Wang, Y., Lu, G.-Q., & Zhang, J.-D. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.01.032 · Cited by 108 · see citing works
Lyons, A., McQuillan, K., Deighan, B. F., O’Reilly, J.-A., Downer, E. J., Murphy, A. C., Watson, M., Piazza, A., O’Connell, F., Griffin, R., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.05.060 · Cited by 98 · see citing works
Microglia: dismantling and rebuilding circuits after acute neurological injury
Ziebell, J. M., Adelson, P. D., & Lifshitz, J. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-014-9539-y · Cited by 84 · see citing works
Loss of tau rescues inflammation-mediated neurodegeneration
Maphis, N., Xu, G., Kokiko-Cochran, O. N., Cardona, A. E., Ransohoff, R. M., Lamb, B. T., & Bhaskar, K. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00196 · Cited by 91 · see citing works
Simon, E., Obst, J., & Gomez-Nicola, D. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2018.01.059 · Cited by 83 · see citing works
The Neuroinflammatory Response in ALS: The Roles of Microglia and T Cells
Lewis, C.-A., Manning, J., Rossi, F., & Krieger, C. (2012) · Neurology Research International · doi:10.1155/2012/803701 · Cited by 76 · see citing works
Neuroinflammation in Huntington’s disease: From animal models to clinical therapeutics
Jia, Q., Li, S., Li, X.-J., & Yin, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1088124 · Cited by 70 · see citing works
Wang, L., Liu, Y., Yan, S., Du, T., Fu, X., Gong, X., Zhou, X., Zhang, T., & Wang, X. (2020) · Aging and disease · doi:10.14336/ad.2019.0615 · Cited by 49 · see citing works
Relevance of chronic stress and the two faces of microglia in Parkinson's disease
Herrera, A. J., Espinosa-Oliva, A. M., Carrillo-Jiménez, A., Oliva-Martín, M. J., García-Revilla, J., García-Quintanilla, A., de Pablos, R. M., & Venero, J. L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00312 · Cited by 42 · see citing works
Brain Activation of Monocyte-Lineage Cells: Involvement of Interleukin-6
Shafer, L. L., McNulty, J. A., & Young, M. R. I. (2002) · Neuroimmunomodulation · doi:10.1159/000069973 · Cited by 13 · see citing works
TGFβ in the obese liver mediates conversion of NK cells to a less cytotoxic ILC1-like phenotype
Cuff, A. O., Sillito, F., Dertschnig, S., Hall, A., Luong, T. V., Chakraverty, R., & Male, V. (2019) · doi:10.1101/576538 · Cited by 101 · see citing works
- Authors
- Hoek, R. M., Ruuls, S. R., Murphy, C. A., Wright, G. J., Goddard, R., Zurawski, S. M., Blom, B., Homola, M. E., Streit, W. J., Brown, M. H., Barclay, A. N., & Sedgwick, J. D.
- Affiliations
- DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA.
- University of Oxford (GB)
- University of Florida (US)
- Corresponding author
- Sedgwick, Jonathon D.
- ORCID
- Venue
- Science
- Published
- 2000-12
- Volume
- 290
- Issue
- 5497
- Pages
- 1768-1771
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2159744102
- Cited by
- 1,022
- References
- 20
- Citations by year
- 2026: 21 · 2025: 20 · 2024: 39 · 2023: 41 · 2022: 34 · 2021: 49 · 2020: 45 · 2019: 38 · 2018: 45 · 2017: 37 · 2016: 52 · 2015: 42 · 2014: 66 · 2013: 63 · 2012: 70
- FWCI
- 11.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- CD200, macrophage lineage, microglia, macrophage activation, CD200R, facial nerve transection, experimental autoimmune encephalomyelitis, collagen-induced arthritis, neuroinflammation, immunosuppression
- MeSH terms
- Animals, Antigens, Surface, Arthritis, Experimental, Central Nervous System, Denervation, Encephalomyelitis, Autoimmune, Experimental, Facial Nerve, Joints, Lymph Nodes, Macrophage Activation, Macrophages, Mice, Inbred C57BL, Neurons, Receptors, Immunologic, Spleen, Down-Regulation, Antigens, CD, Microglia, Gene Targeting, Cell Lineage, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
