Cited by 258Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disordersImmune Response and Inflammation

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CD200 Ligand–Receptor Interaction Modulates Microglial Activation In Vivo and In Vitro: A Role for IL-4

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Lyons, Anthony, Downer, Eric J., Crotty, Suzanne, Nolan, Yvonne M., Mills, Kingston H. G., Lynch, Marina A.·2007·The Journal of Neuroscience

DOI 10.1523/jneurosci.1781-07.2007PMC PMC6673084

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Abstract

Deficits in cognitive function are associated with neuroinflammatory changes, typified by activation of glial cells and an alteration of the pro- and anti-inflammatory cytokine balance in the brain. Although there is evidence to suggest that activation of microglia is regulated by interaction with other cell types in the brain, the mechanism(s) involved is poorly understood. Here, we provide evidence that interaction between CD200 and its receptor plays a role in modulating microglial activation under conditions of chronic and acute inflammation of the brain. We report that interleukin-4 (IL-4) plays a central role in modulating expression of CD200 and identify a mechanism by which IL-4 directly controls microglial cell activation. Our findings provide the first demonstration of a role for IL-4 in modulating CD200 expression and suggest a mechanism for regulation of microglial activation in the intact CNS under inflammatory conditions.

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Authors: Lyons, A., Downer, E. J., Crotty, S., Nolan, Y. M., Mills, K. H. G., & Lynch, M. A.
Affiliations: Trinity College Dublin (IE)
Trinity College (CA)
University College Cork (IE)
Corresponding author: Lynch, Marina A.
ORCID: Downer, Eric J.
Nolan, Yvonne M.
Mills, Kingston H. G.
Lynch, Marina A.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2007-08-01
Volume: 27
Issue: 31
Pages: 8309-8313
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.1781-07.2007
PMC: PMC6673084
OpenAlex: W2059844545
Cited by: 258
References: 22
Citations by year: 2026: 5 · 2025: 7 · 2024: 16 · 2023: 6 · 2022: 9 · 2021: 12 · 2020: 15 · 2019: 9 · 2018: 20 · 2017: 14 · 2016: 17 · 2015: 13 · 2014: 19 · 2013: 20 · 2012: 25
FWCI: 7.20
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion, cc-by-nc-sa)
Funders: Science Foundation Ireland
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: CD200, CD200R, microglial activation, IL-4, neuroinflammation, cognitive impairment, glial activation, cytokine balance
MeSH terms: Acute Disease, Animals, Chronic Disease, Inflammation, Ligands, Male, Membrane Glycoproteins, Mice, Inbred C57BL, Antigens, CD, Interleukin-4, Rats, Wistar, Microglia, Mice, Rats

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CD200 Ligand–Receptor Interaction Modulates Microglial Activation In Vivo and In Vitro: A Role for IL-4

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