CD200 Ligand–Receptor Interaction Modulates Microglial Activation In Vivo and In Vitro: A Role for IL-4

Down-Regulation of the Macrophage Lineage Through Interaction with OX2 (CD200)

Hoek, R. M., Ruuls, S. R., Murphy, C. A., Wright, G. J., Goddard, R., Zurawski, S. M., Blom, B., Homola, M. E., Streit, W. J., Brown, M. H., et al. (2000) · Science · doi:10.1126/science.290.5497.1768 · Cited by 1,022

Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease

Lim, G. P., Yang, F., Chu, T., Chen, P., Beech, W. K., Teter, B., Tran, T., Ubeda, O. J., Ashe, K. H., Frautschy, S. A., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-05709.2000 · Cited by 876

Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease

Griffin, W. S. T., Sheng, J. G., Roberts, G. W., & Mrak, R. E. (1995) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199503000-00014 · Cited by 546

Characterization of the CD200 Receptor Family in Mice and Humans and Their Interactions with CD200

Wright, G. J., Cherwinski, H. M., Foster‐Cuevas, M., Brooke, G. P., Puklavec, M. J., Bigler, M., Song, Y., Jenmalm, M. C., Gorman, D., McClanahan, T., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.6.3034 · Cited by 434

CD200 and membrane protein interactions in the control of myeloid cells

Barclay, A. N., Wright, G. J., Brooke, G. P., & Brown, M. H. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02223-8 · Cited by 422

GM-CSF Production by Autoreactive T Cells Is Required for the Activation of Microglial Cells and the Onset of Experimental Autoimmune Encephalomyelitis1

Ponomarev, E., Shriver, L., Maresz, K., Pedras-Vasconcelos, J., Verthelyi, D., & Dittel, B. (2007) · Journal of Immunology · doi:10.4049/jimmunol.178.1.39 · Cited by 413

Control of glial immune function by neurons

Neumann, H. (2001) · Glia · doi:10.1002/glia.1108 · Cited by 319

The age-related attenuation in long-term potentiation is associated with microglial activation

Griffin, R., Nally, R., Nolan, Y., McCartney, Y., Linden, J., & Lynch, M. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04165.x · Cited by 282

Different reticular elements in rat lymphoid tissue identified by localization of Ia, Thy-1 and MRC OX 2 antigens.

Barclay, A. N. (1981) · PubMed · Cited by 240

Constitutive Retinal CD200 Expression Regulates Resident Microglia and Activation State of Inflammatory Cells during Experimental Autoimmune Uveoretinitis

Broderick, C. A., Hoek, R. M., Forrester, J. V., Liversidge, J., Sedgwick, J. D., & Dick, A. D. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64444-6 · Cited by 230

The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease

Varnum, M. M., Kiyota, T., Dixie, K. L. I., Ikezu, S., & Ikezu, T. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.07.027 · Cited by 77

Astrocyte Regulation of CNS Inflammation and Remyelination

Claycomb, K. I., Johnson, K. M., Winokur, P. N., Sacino, A. V., & Crocker, S. J. (2013) · Brain Sciences · doi:10.3390/brainsci3031109 · Cited by 77

CD200 Positive Human Mesenchymal Stem Cells Suppress TNF-Alpha Secretion from CD200 Receptor Positive Macrophage-Like Cells

Pietilä, M., Lehtonen, S. T., Tuovinen, E. A., Lähteenmäki, K., Laitinen, S., Leskelä, H., Nätynki, A., Pesälä, J., Nordström, K. M., & Lehenkari, P. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031671 · Cited by 67

Systemic lipopolysaccharide (LPS)-induced microglial activation results in different temporal reduction of CD200 and CD200 receptor gene expression in the brain

Masocha, W. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.06.022 · Cited by 65

Attenuation of post-myocardial infarction depression in rats byn-3 fatty acids or probiotics starting after the onset of reperfusion

Kim, G., Arseneault-Bréard, J., Monaco, F. F., Beaudoin, A., Bah, T. M., Tompkins, T. A., Godbout, R., & Rousseau, G. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003807 · Cited by 68

Monocytes, microglia, and CD 200‐ CD 200R1 signaling are essential in the transmission of inflammation from the periphery to the central nervous system

Xie, X., Luo, X., Liu, N., Li, X., Lou, F., Zheng, Y., & Ren, Y. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.13972 · Cited by 64

Neuron-Microglia Dialogue and Hippocampal Neurogenesis in the Aged Brain.

Gemma, C., Bachstetter, A. D., & Bickford, P. C. (2010) · Europe PMC (PubMed Central) · Cited by 62

Ischemic brain injury: A consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction

McGUCKIN, C. P., Jurga, M., Miller, A.-M., Sarnowska, A., Wiedner, M., Boyle, N. T., Lynch, M. A., Jabłońska, A., Drela, K., Łukomska, B., et al. (2013) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.02.005 · Cited by 63

Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal

Kang, S. S., Kurti, A., Baker, K. E., Liu, C.-C., Colonna, M., Ulrich, J. D., Holtzman, D. M., Bu, G., & Fryer, J. D. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddx366 · Cited by 62

Microglial Function and Regulation during Development, Homeostasis and Alzheimer’s Disease

Casali, B. T., & Reed-Geaghan, E. G. (2021) · Cells · doi:10.3390/cells10040957 · Cited by 70

Involvement of the CD200 receptor complex in microglia activation in experimental glaucoma

Taylor, S., Calder, C. J., Albon, J., Erichsen, J. T., Boulton, M., & Morgan, J. E. (2011) · Experimental Eye Research · doi:10.1016/j.exer.2011.01.012 · Cited by 60

Age-related changes in the hippocampus (loss of synaptophysin and glial–synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL

Ojo, B., Rezaie, P., Gabbott, P. L. A., Davies, H. A., Colyer, F. M., Cowley, T. R., Lynch, M. A., & Stewart, M. G. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.09.013 · Cited by 61

The impact of neuroimmune changes on development of amyloid pathology; relevance to A lzheimer's disease

Lynch, M. A. (2013) · Immunology · doi:10.1111/imm.12156 · Cited by 64

Immune and behavioral consequences of microglial reactivity in the aged brain

Wynne, A. M., Henry, C. J., & Godbout, J. P. (2009) · Integrative and Comparative Biology · doi:10.1093/icb/icp009 · Cited by 60

The Role of Microglia in Prion Diseases: A Paradigm of Functional Diversity

Obst, J., Simon, E., Mancuso, R., & Gómez‐Nicola, D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00207 · Cited by 61

CD200R1 and CD200 expression are regulated by PPAR‐γ in activated glial cells

Dentesano, G., Serratosa, J., Tusell, J. M., Ramon-Cañellas, P., Valente, T., Saura, J., & Solà, C. (2014) · Glia · doi:10.1002/glia.22656 · Cited by 62

Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP

Cowley, T. R., O’Sullivan, J. B., Blau, C. W., Deighan, B. F., Jones, R. S., Kerskens, C., Richardson, J. C., Virley, D. J., Upton, N., & Lynch, M. A. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.02.002 · Cited by 57

Luteolin inhibits SH-SY5Y cell apoptosis through suppression of the nuclear transcription factor-κB, mitogen-activated protein kinase and protein kinase B pathways in lipopolysaccharide-stimulated cocultured BV2 cells

ZHU, L., Bi, W., Lu, D., Zhang, C., SHU, X., & Lu, D. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1564 · Cited by 57

The prenatal challenge with lipopolysaccharide and polyinosinic:polycytidylic acid disrupts CX3CL1-CX3CR1 and CD200-CD200R signalling in the brains of male rat offspring: a link to schizophrenia-like behaviours

Chamera, K., Kotarska, K., Szuster-Głuszczak, M., Trojan, E., Skórkowska, A., Pomierny, B., Krzyżanowska, W., Bryniarska, N., & Basta‐Kaim, A. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01923-0 · Cited by 57

Amyloid Proteins and Their Role in Multiple Sclerosis. Considerations in the Use of Amyloid-PET Imaging

Matías‐Guiu, J. A., Oreja‐Guevara, C., Cabrera‐Martín, M. N., Moreno‐Ramos, T., Carreras, J. L., & Matías‐Guiu, J. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00053 · Cited by 54

The Neuroprotective Effect of a Specific P2X7 Receptor Antagonist Derives from its Ability to Inhibit Assembly of the NLRP3 Inflammasome in Glial Cells

Murphy, N., Cowley, T. R., Richardson, J. C., Virley, D. J., Upton, N., Walter, D. S., & Lynch, M. A. (2011) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00531.x · Cited by 56

Exercise-Induced Modulation of Neuroinflammation in Models of Alzheimer’s Disease

Kelly, Á. M. (2018) · Brain Plasticity · doi:10.3233/bpl-180074 · Cited by 55

CD200R1 agonist attenuates glial activation, inflammatory reactions, and hypersensitivity immediately after its intrathecal application in a rat neuropathic pain model

Hernangómez, M., Klusáková, I., Joukal, M., Hradilová‐Svíženská, I., Guaza, C., & Dubový, P. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0508-8 · Cited by 54

‘Tagging’ along memories in aging: Synaptic tagging and capture mechanisms in the aged hippocampus

Shetty, M. S., & Sajikumar, S. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.008 · Cited by 54

Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction

Fonken, L. K., Frank, M. G., D’Angelo, H. M., Heinze, J. D., Watkins, L. R., Lowry, C. A., & Maier, S. F. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.07.012 · Cited by 57

Understanding the Neurobiology of Cd200 and the Cd200 Receptor: A Therapeutic Target For Controlling Inflammation In Human Brains?

Walker, D. G., & Lue, L. (2013) · Future Neurology · doi:10.2217/fnl.13.14 · Cited by 52

Glial Uptake of Amyloid Beta Induces NLRP3 Inflammasome Formation via Cathepsin-Dependent Degradation of NLRP10

Murphy, N., Grehan, B., & Lynch, M. A. (2013) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8274-6 · Cited by 51

Dok2 mediates the CD200Fc attenuation of Aβ-induced changes in glia

Lyons, A., Downer, E. J., Costello, D. A., Murphy, N., & Lynch, M. A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-107 · Cited by 50

Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy

Pfeifer, C. W., Walsh, J. T., Santeford, A. C., Lin, J. B., Beatty, W. L., Terao, R., Liu, Y. A., Hase, K., Ruzycki, P. A., & Apte, R. S. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2308214120 · Cited by 48

Downregulation of CD47 and CD200 in patients with focal cortical dysplasia type IIb and tuberous sclerosis complex

Sun, F., Zhang, C., Chen, X., Wei, Y., Li, S., Liu, S., Zang, Z., He, J., Guo, W., & Yang, H. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0546-2 · Cited by 49

Inhibition of CD200R1 expression by C/EBP beta in reactive microglial cells

Dentesano, G., Straccia, M., Ejarque‐Ortiz, A., Tusell, J. M., Serratosa, J., Saura, J., & Solà, C. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-165 · Cited by 47

CD200-, CX3CL1-, and TREM2-mediated neuron-microglia interactions and their involvements in Alzheimer’s disease

Zhang, L., Xu, J., Gao, J., Wu, Y., Yin, M., & Zhao, W. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0084 · Cited by 51

Glial Activation in AβPP/PS1 Mice is Associated with Infiltration of IFNγ-Producing Cells

Kelly, R. J., Minogue, A. M., Lyons, A., Jones, R. S., Browne, T. C., Costello, D. A., Denieffe, S., O'Sullivan, C., Connor, T. J., & Lynch, M. A. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130539 · Cited by 51

Lung pathology due to hRSV infection impairs blood–brain barrier permeability enabling astrocyte infection and a long-lasting inflammation in the CNS

Böhmwald, K., Soto, J. A., Andrade, C. A., Fernández‐Fierro, A., Espinoza, J. A., Ríos, M., Eugenín, E. A., González, P. A., Opazo, M. C., Riedel, C. A., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.09.021 · Cited by 43

Analysis of the Impact of CD200 on Phagocytosis

Lyons, A., Minogue, A. M., Jones, R. S., Fitzpatrick, O. M., Noonan, J., Campbell, V. A., & Lynch, M. A. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0223-6 · Cited by 45

Altered Regulation of CD200 Receptor in Monocyte-Derived Macrophages from Individuals with Parkinson’s Disease

Luo, X., Zhang, J.-J., Zhang, C., Liu, R., Zheng, L., Wang, X., Chen, S., & Ding, J. (2009) · Neurochemical Research · doi:10.1007/s11064-009-0094-6 · Cited by 42

The role of microglia in neuroprogressive disorders: mechanisms and possible neurotherapeutic effects of induced ketosis

Morris, G., Puri, B. K., Maes, M. H. J., OLIVE, L. S., Berk, M., & Carvalho, A. F. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109858 · Cited by 42

Therapeutic Strategies Under Development Targeting Inflammatory Mechanisms in Amyotrophic Lateral Sclerosis

Crisafulli, S. G., Brajkovic, S., Mis, M. S. C., Parente, V., & Corti, S. P. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0532-4 · Cited by 41

Ovariectomy Induces Microglial Cell Activation and Inflammatory Response in Rat Prefrontal Cortices to Accelerate the Chronic Unpredictable Stress‐Mediated Anxiety and Depression

Ge, F., Hao-Ran, Y., Lu, W., Shi, H., Chen, Q., Luo, Y., Liu, L., & Yan, J. (2020) · BioMed Research International · doi:10.1155/2020/3609758 · Cited by 41

CD200 modulates spinal cord injury neuroinflammation and outcome through CD200R1.

Lago, N., Pannunzio, B., Amo-Aparicio, J., López-Vales, R., & Peluffo, H. (2018) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2018.06.002 · Cited by 38

Macrophages make me sick: How macrophage activation states influence sickness behavior

Moon, M. L., McNeil, L. K., & Freund, G. G. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.002 · Cited by 40

Activation of the P 2 X 7 receptor induces migration of glial cells by inducing cathepsin B degradation of tissue inhibitor of metalloproteinase 1

Murphy, N., & Lynch, M. A. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12031 · Cited by 37

Microglia in Neurodegenerative Events—An Initiator or a Significant Other?

Harry, G. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115818 · Cited by 37

Expression of CD200 in alternative activation of microglia following an excitotoxic lesion in the mouse hippocampus

Yi, M., Zhang, E., Kang, J. W., Shin, Y. N., Byun, J. Y., Oh, S., Seo, J. H., Lee, Y., & Kim, D. W. (2012) · Brain Research · doi:10.1016/j.brainres.2012.08.053 · Cited by 36

A synthetic NCAM‐derived mimetic peptide, FGL, exerts anti‐inflammatory properties via IGF‐1 and interferon‐γ modulation

Downer, E. J., Cowley, T. R., Cox, F., Maher, F. O., Berezin, V., Bock, E., & Lynch, M. A. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06076.x · Cited by 36

CD200 Inhibits Inflammatory Response by Promoting KATP Channel Opening in Microglia Cells in Parkinson’s Disease

Ren, Y., Ye, M., Chen, S.-D., & Ding, J.-Q. (2016) · Medical Science Monitor · doi:10.12659/msm.898400 · Cited by 32

The Role of Microglia and Astrocytes in the Pathomechanism of Neuroinflammation in Parkinson’s Disease—Focus on Alpha-Synuclein

Harackiewicz, O., & Grembecka, B. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2311203 · Cited by 39

Epigenetics and Communication Mechanisms in Microglia Activation with a View on Technological Approaches

Petralla, S., Chirico, F. D., Miti, A., Tartagni, O., Massenzio, F., Poeta, E., Virgili, M., Zuccheri, G., & Monti, B. (2021) · Biomolecules · doi:10.3390/biom11020306 · Cited by 37

Role of the Immune System Elements in Pulmonary Arterial Hypertension

Tomaszewski, M., Bębnowska, D., Hrynkiewicz, R., Dworzyński, J., Niedźwiedzka‐Rystwej, P., Kopeć, G., & Grywalska, E. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10163757 · Cited by 33

Maternal Immune Activation Sensitizes Male Offspring Rats to Lipopolysaccharide-Induced Microglial Deficits Involving the Dysfunction of CD200–CD200R and CX3CL1–CX3CR1 Systems

Chamera, K., Szuster-Głuszczak, M., Trojan, E., & Basta-Kaim, A. (2020) · Cells · doi:10.3390/cells9071676 · Cited by 31

CD200 dysfunction in neuron contributes to synaptic deficits and cognitive impairment

Feng, D., Huang, A., Yan, W., & Chen, D. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.06.134 · Cited by 34

SIGIRR modulates the inflammatory response in the brain

Watson, M. B., Costello, D. A., Carney, D. G., McQuillan, K., & Lynch, M. A. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.04.002 · Cited by 30

Chronic IL-10 overproduction disrupts microglia-neuron dialogue similar to aging, resulting in impaired hippocampal neurogenesis and spatial memory

Sanchez-Molina, P., Almolda, B., Giménez‐Llort, L., González, B., & Castellano, B. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.12.026 · Cited by 32

Sneaky Entry of IFNγ Through Arsenic-Induced Leaky Blood–Brain Barrier Reduces CD200 Expression by Microglial pro-Inflammatory Cytokine

Singh, V., Kushwaha, S., Gera, R., Ansari, J. A., Mishra, J., Dewangan, J., Patnaik, S., & Ghosh, D. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1155-0 · Cited by 30

Tackling the physiological barriers for successful mesenchymal stem cell transplantation into the central nervous system

Vocht, N. D., Praet, J., Reekmans, K., Blon, D. L., Hoornaert, C., Daans, J., Berneman, Z. N., der Linden, A. V., & Ponsaerts, P. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt312 · Cited by 29

Neuronal Glial Crosstalk: Specific and Shared Mechanisms in Alzheimer’s Disease

Chavda, V. K., Singh, K., Patel, V., Mishra, M., & Mishra, A. K. (2022) · Brain Sciences · doi:10.3390/brainsci12010075 · Cited by 29

Melatonin decreases brain apoptosis, oxidative stress, and CD200 expression and increased survival rate in mice infected by Venezuelan equine encephalitis virus

Montiel, M., Bonilla, E., Valero, N. J., Mosquera, J., Espina, L. M., Quiroz, Y., & Álvarez‐Mon, M. (2015) · Antiviral chemistry & chemotherapy · doi:10.1177/2040206616660851 · Cited by 29

Postoperative Delirium in Neurosurgical Patients: Recent Insights into the Pathogenesis

Xu, Y., Ma, Q., Du, H., Yang, C., & Lin, G. (2022) · Brain Sciences · doi:10.3390/brainsci12101371 · Cited by 28

CD200-CD200R signaling and diseases: a potential therapeutic target?

Ngwa, C., & Liu, F. (2019) · PubMed Central · Cited by 27

Microglial activation in Alzheimer's disease: The role of flavonoids and microRNAs

Medrano-Jiménez, E., Meza‐Sosa, K. F., Aragon, J. A. U., Secundino, I., Pedraza-Alva, G., & Pérez-Martínez, L. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr1021-531r · Cited by 28

The Neuro-Immune-Regulators (NIREGs) Promote Tissue Resilience; a Vital Component of the Host’s Defense Strategy against Neuroinflammation

Bedoui, Y., Neal, J. W., & Gasque, P. (2018) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9793-6 · Cited by 28

Loss of neuronal CD200 contributed to microglial activation after acute cerebral ischemia in mice.

Yang, Y., Zhang, X.-J., Zhang, C., Chen, R., Li, L., He, J.-N., Xie, Y.-C., & Chen, Y. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.05.004 · Cited by 27

Interleukin-4 Protects Dopaminergic Neurons In vitro but Is Dispensable for MPTP-Induced Neurodegeneration In vivo

Hühner, L., Rilka, J., Gilsbach, R., Zhou, X., Machado, V., & Spittau, B. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00062 · Cited by 25

Spinal Cord Injury Leads to Hippocampal Glial Alterations and Neural Stem Cell Inactivation

Jure, I., Nicola, A. F. D., Encinas, J. M., & Labombarda, F. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00900-8 · Cited by 25

Transcriptional and epigenetic regulation of microglia in maintenance of brain homeostasis and neurodegeneration

Maurya, S. K., Gupta, S., & Mishra, R. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1072046 · Cited by 26

How dependent is synaptic plasticity on microglial phenotype?

Jones, R. S., & Lynch, M. A. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.08.012 · Cited by 25

Diminished brain resilience syndrome: A modern day neurological pathology of increased susceptibility to mild brain trauma, concussion, and downstream neurodegeneration

Seneff, S., & Morley, W. A. (2014) · Surgical Neurology International · doi:10.4103/2152-7806.134731 · Cited by 25

Infiltrating macrophages contribute to age-related neuroinflammation in C57/BL6 mice

Wolfe, H. E., Minogue, A. M., Rooney, S., & Lynch, M. A. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.05.003 · Cited by 24

Immunology primer for neurosurgeons and neurologists part 2: Innate brain immunity

Blaylock, R. L. (2013) · Surgical Neurology International · doi:10.4103/2152-7806.118349 · Cited by 23

The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner

Cox, F., Berezin, V., Bock, E., & Lynch, M. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.030 · Cited by 22

CD200R/Foxp3-mediated signalling regulates microglial activation

Yi, M., Zhang, E., Kim, J.-J., Baek, H., Shin, N., Kim, S., Kim, S. R., Kim, H., Lee, S. J., Park, J. B., et al. (2016) · Scientific Reports · doi:10.1038/srep34901 · Cited by 21

Association study of interleukin 2 (IL2) and IL4 with schizophrenia in a Japanese population

Watanabe, Y., Nunokawa, A., Shibuya, M., Kaneko, N., Nawa, H., & Someya, T. (2008) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-008-0813-z · Cited by 21

Ethanol Induction of Innate Immune Signals Across BV2 Microglia and SH-SY5Y Neuroblastoma Involves Induction of IL-4 and IL-13

Lawrimore, C. J., Coleman, L. G., Zou, J., & Crews, F. T. (2019) · Brain Sciences · doi:10.3390/brainsci9090228 · Cited by 21

Age and sex differences in primary microglia culture: A comparative study

Ngwa, C., Qi, S., Mamun, A. A., Xu, Y., Sharmeen, R., & Liu, F. (2021) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2021.109359 · Cited by 22

Characterization of macrophages from schizophrenia patients

Ormel, P. R., van Mierlo, H. C., Litjens, M., van Strien, M. E., Hol, E. M., Kahn, R. S., & de Witte, L. D. (2017) · Schizophrenia · doi:10.1038/s41537-017-0042-4 · Cited by 22

Neuroinflammatory changes increase the impact of stressors on neuronal function

Piazza, A., & Lynch, M. A. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370303 · Cited by 20

Single-cell RNA sequencing identifies hippocampal microglial dysregulation in diet-induced obesity

Henn, R. E., Guo, K., Elzinga, S. E., Noureldein, M. H., Mendelson, F. E., Hayes, J. M., Rigan, D. M., Savelieff, M. G., Hur, J., & Feldman, E. L. (2023) · iScience · doi:10.1016/j.isci.2023.106164 · Cited by 18

Painful Neuron-Microglia Interactions in the Trigeminal Sensory System

Davies, A. J., Kim, Y. H., & Oh, S. B. (2010) · The Open Pain Journal · doi:10.2174/1876386301003010014 · Cited by 19

The role of N-glycosylation of CD200-CD200R1 interaction in classical microglial activation

Liu, C., Shen, Y., Tang, Y., & Gu, Y. (2018) · Journal of Inflammation · doi:10.1186/s12950-018-0205-8 · Cited by 19

With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions

Drechsler, S., Lynch, M. A., Novella, S., Navarro, H. G., Hecimovic, S. K., Barini, E., Tucci, V., Castro, R. E., Vandenbroucke, R. E., Osuchowski, M. F., et al. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.07.005 · Cited by 20

Parkinsonian neurotoxicants impair the anti-inflammatory response induced by IL4 in glial cells: involvement of the CD200-CD200R1 ligand-receptor pair

Rabaneda‐Lombarte, N., Blasco-Agell, L., Serratosa, J., Ferigle, L., Saura, J., & Solà, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-67649-4 · Cited by 18

Effect of acupuncture on neuroinflammation in animal models of Alzheimer’s disease: A preclinical systematic review and meta-analysis

Wu, Z., Huang, Y., Wang, T.-Y., Deng, C.-Y., Xu, Z.-R., & Tang, C. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1110087 · Cited by 18

Repeated exposure to two stressors in sequence demonstrates that corticosterone and paraventricular nucleus of the hypothalamus interleukin‐1β responses habituate independently

Lovelock, D. F., & Deak, T. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12514 · Cited by 16

Plasticity of microglia in remote regions after focal brain injury

Bisicchia, E., Sasso, V., Molinari, M., & Viscomi, M. T. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.01.011 · Cited by 17

Modelling the Interplay Between Neuron-Glia Cell Dysfunction and Glial Therapy in Autism Spectrum Disorder

Unnisa, A., Greig, N. H., & Kamal, M. A. (2022) · Current Neuropharmacology · doi:10.2174/1570159x21666221221142743 · Cited by 17

Microglia signaling in health and disease – Implications in sex-specific brain development and plasticity

Pramanik, S., Harini Devi, M., Chakrabarty, S., Paylar, B., Pradhan, A., Thaker, M., Ayyadhury, S., Manavalan, A., Olsson, P., Pramanik, G., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105834 · Cited by 18

A Logic Model of Neuronal-Glial Interaction Suggests Altered Homeostatic Regulation in the Perpetuation of Neuroinflammation

Craddock, T. J. A., Michalovicz, L. T., Kelly, K. A., Rice, M. A., Miller, D. B., Klimas, N. G., Morris, M., O'Callaghan, J. P., & Broderick, G. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00336 · Cited by 15

Immunoexcitotoxicity as a Central Mechanism of Chronic Traumatic Encephalopathy – A Unifying Hypothesis

Blaylock, R. L., & Maroon, J. C. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849734745-00045 · Cited by 16

Matrix Metalloproteinase-8 Inhibitor Ameliorates Inflammatory Responses and Behavioral Deficits in LRRK2 G2019S Parkinson's Disease Model Mice

Kim, T., Jeon, J., Park, J., Park, Y., Kim, J., Noh, H., Kim, H.-S., & Seo, H. (2021) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2020.181 · Cited by 14

Does the Interplay Between Aging and Neuroinflammation Modulate Alzheimer’s Disease Clinical Phenotypes? A Clinico-Pathological Perspective

Taipa, R. J. F., Sousa, A. L., Pires, M. M., & Sousa, N. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160121 · Cited by 15

Pharmacological Tools to Activate Microglia and their Possible use to Study Neural Network Patho-physiology

Peña‐Ortega, F. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160928151546 · Cited by 14

Lysosome as the Black Hole for Checkpoint Molecules

Wang, H., Han, X. N., & Xu, J. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-3266-5_14 · Cited by 15

Novel distribution of cluster of differentiation 200 adhesion molecule in glial cells of the peripheral nervous system of rats and its modulation after nerve injury

Chang, C., Lee, Y.-H., Jiang‐Shieh, Y., Chien, H., Pai, M.-H., Chen, H.-M., Fong, T.-H., & Wu, C.-H. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.049 · Cited by 13

Neuron–Microglia Contacts Govern the PGE2 Tolerance through TLR4-Mediated de Novo Protein Synthesis

Kuo, H., Lee, K.-F., Chen, S., Chiu, S.-C., Lee, L., Chen, W.-P., Chen, C., & Chu, C. (2022) · Biomedicines · doi:10.3390/biomedicines10020419 · Cited by 13

A preclinical and phase I clinical study of ex vivo-expanded amyloid beta-specific human regulatory T cells in Alzheimer’s disease

Yang, H., Byun, M. S., Ha, N.-Y., Yang, J., Park, S., Park, J. E., Yi, D., Chang, Y., Jung, W. S., Kim, J. Y., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117721 · Cited by 14

CD200Fc Improves Neurological Function by Protecting the Blood–brain Barrier after Intracerebral Hemorrhage

Le, C., Hao, X., Li, J., Zhong, J., Lin, H., Zhou, Y., Travis, Z. D., Tong, L., & Gao, F. (2019) · Cell Transplantation · doi:10.1177/0963689719857655 · Cited by 13

Microglial modulation as a mechanism behind the promotion of central nervous system well‐being by physical exercise

Jensen, S. K., & Yong, V. W. (2014) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12093 · Cited by 14

Dynamic Intercellular Networks in the CNS: Mechanisms of Crosstalk from Homeostasis to Neurodegeneration

Zheng, Y., Huang, R., & Pan, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178155 · Cited by 11

Temporal-logic analysis of microglial phenotypic conversion with exposure to amyloid-β

Anastasio, T. J. (2014) · Molecular BioSystems · doi:10.1039/c4mb00457d · Cited by 11

Ageing-related changes in the regulation of microglia and their interaction with neurons

Rommy von Bernhardi, M., & Eugenín, J. L. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110241 · Cited by 10

Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide

Lyons, A., McQuillan, K., Deighan, B. F., O’Reilly, J.-A., Downer, E. J., Murphy, A. C., Watson, M., Piazza, A., O’Connell, F., Griffin, R., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.05.060 · Cited by 98

The role of N-glycosylation of CD200-CD200R1 interaction in classical microglial activation

Liu, C., Shen, Y., Tang, Y., & Gu, Y. (2018) · Journal of Inflammation · doi:10.1186/s12950-018-0205-8 · Cited by 19

Expression of CD200 in alternative activation of microglia following an excitotoxic lesion in the mouse hippocampus

Yi, M., Zhang, E., Kang, J. W., Shin, Y. N., Byun, J. Y., Oh, S., Seo, J. H., Lee, Y., & Kim, D. W. (2012) · Brain Research · doi:10.1016/j.brainres.2012.08.053 · Cited by 37

P4‐166: CD200Fc fusion protein alleviates beta amyloid‐induced glial‐activation and neurodegeneration in vitro and in vivo

Cowley, T. R., Miller, A., Piazza, A., Downer, E. J., & Lynch, M. A. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.04.733

Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression

Suzumura, A., Sawada, M., Itoh, Y., & Marunouchi, T. (1994) · Journal of Neuroimmunology · doi:10.1016/0165-5728(94)90031-0 · Cited by 93