The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Mitochondrial Susceptibility to Oxidative Stress Exacerbates Cerebral Infarction That Follows Permanent Focal Cerebral Ischemia in Mutant Mice with Manganese Superoxide Dismutase Deficiency
Open accessAbstract
Mitochondrial injury has been implicated in ischemic neuronal injury. Mitochondria, producing adenosine triphosphate by virtue of electron flow, have been shown to be both the sites of superoxide anion (O 2−) production and the target of free radical attacks. We evaluated these mechanisms in an in vivo cerebral ischemia model, using mutant mice with a heterozygous knock-out gene (Sod2−/+) encoding mitochondrial manganese superoxide dismutase (Mn-SOD).Sod2−/+ mice demonstrated a prominent increase in O 2−production under normal physiological conditions and in ischemia, as evidenced by specific oxidation of a fluorescent probe, hydroethidine, reflecting decreased activity of Mn-SOD. A mitochondrial viability assay that used rhodamine 123, which is accumulated by transmembrane potential of viable mitochondria, demonstrated accelerated development of mitochondrial injury. This rapid progress of ischemic injury resulted in exacerbation of infarct size and hemisphere enlargement, causing advanced neurological deficits but without altering DNA fragmentation induction. The present study suggests that O 2−overproduced in a mitochondrial compartment, when uncoupled from antioxidant defenses, induces impairment of mitochondrial function and causes exacerbation of cerebral infarction after ischemia.
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Cites
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Cited by
Nitric Oxide and Peroxynitrite in Health and Disease
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Pathobiology of ischaemic stroke: an integrated view
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Ischemic Cell Death in Brain Neurons
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Oxidative Stress and Vascular Disease
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Metadata
- Authors
- Murakami, K., Kondo, T., Kawase, M., Li, Y., Sato, S., Chen, S. F., & Chan, P. H.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1998-01-01
- Volume
- 18
- Issue
- 1
- Pages
- 205-213
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1635047156
- Cited by
- 469
- References
- 23
- FWCI
- 10.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Mitochondrial Susceptibility to Oxidative Stress Exacerbates Cerebral Infarction That Follows Permanent Focal Cerebral Ischemia in Mutant Mice with Manganese Superoxide Dismutase Deficiency. https://app.cochat.ai/papers/10.1523/jneurosci.18-01-00205.1998
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- Murakami, K., Kondo, T., Kawase, M., Li, Y., Sato, S., Chen, S. F., & Chan, P. H. (1998). Mitochondrial Susceptibility to Oxidative Stress Exacerbates Cerebral Infarction That Follows Permanent Focal Cerebral Ischemia in Mutant Mice with Manganese Superoxide Dismutase Deficiency. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.18-01-00205.1998
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
