Cited by 223Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

The persistence of behavioral sensitization to cocaine parallels enhanced inhibition of nucleus accumbens neurons

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Henry, DJ, White, FJ·1995·The Journal of Neuroscience

Abstract

The mesoaccumbens dopamine system is intricately involved in the locomotor stimulation produced by cocaine and sensitization of this effect following repeated cocaine administration. The mechanisms responsible for the expression of sensitized locomotion appear to involve alterations in both presynaptic (increased dopamine release) and postsynaptic (increased responsiveness of dopamine D1 receptors) aspects of dopamine neurotransmission within the nucleus accumbens. The present experiments used behavioral and single-cell electrophysiological techniques to determine the persistence of sensitization and of enhanced postsynaptic responses to cocaine within the nucleus accumbens following various periods of withdrawal from repeated cocaine treatment (10 mg/kg i.p., twice daily, 14 d). Behavioral sensitization to the locomotor stimulant effects of cocaine was evident after 1 d, 1 week, and 1 month, but not 2 months of withdrawal. A similar time course was observed for the enhanced efficacy of cocaine-induced inhibition of nucleus accumbens neurons, whether cocaine was administered systemically or locally by microiontophoresis. Nucleus accumbens neurons also exhibited sensitized inhibitory responses to iontophoretically applied GABA after 1 d of withdrawal, but not later times. These findings suggest that cocaine sensitization is relatively persistent, but not necessarily permanent, and support the hypothesis that expression of behavioral sensitization to cocaine involves actions within the NAc, particularly those mediated by dopamine D1 receptors.

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Crossref · 10.1523/jneurosci.15-09-06287.1995

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  • Chronic cocaine exposure is associated with increased phasic D1R signaling involved in reward prediction, sensitized reward responses, and dampening further reinforcing effects of drugs of abuse.

    “Chronic exposure to cocaine is associated with an increase in phasic D1R signaling, and these increases are involved in reward prediction, sensitized responses to reward, and in dampening further reinforcing effects of drugs of abuse (Ljungberg et al 1992; Henry and White 1995; Self et al 1996; Anderson et al 2008; Bertran-Gonzalez et al 2008; Zweifel et al 2009).”

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Research works printed but not linked: 2

  1. Kleven MS, Perry BD, Woolverton WL, Seiden LS (1990) Effects of havior produced by chronic amphetamine administration: a review repeated injections of cocaine on D, and D, dopamine receptors in and evaluation of animal models of amphetamine psychosis. Brain rat brain. Brain Res 532:265-270. Res Rev 11:157-198.
  2. Segal DS, Kuczenski R (1987b) Behavioral and neurochemical char- Maisonneuve IM, Kreek M-J (1994) Acute tolerance to the dopamine acteristics of stimulant-induced augmentation. Psychopharmacol Bull response induced by a binge pattern of cocaine administration in male 231417424. rats: an in vivo microdialysis study. J Pharmacol Exp Ther 268:916- Segal DS, Kuczenski R (1992a) In vivo microdialysis reveals a dimin- 921. ished amphetamine-induced dopamine response corresponding to be- Mattingly BA, Hart TC, Lim K, Perkins C (1994) Selective antagonism havioral sensitization produced by repeated amphetamine pretreat- of dopamine D, and D, receptors does not block the development of ment. Brain Res 57 1:330-337. behavioral sensitization to cocaine. Psychopharmacology 1 14:239- Segal DS, Kuczenski R (1992b) Repeated cocaine administration in- 242. duces behavioral sensitization and corresponding decreased extracel- The Journal of Neuroscience, September 1995, 15(9) 6299 lular dopamine responses in caudate and accumbens. Brain Res 577: 351-355.

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Authors
Henry, D., & White, F.
Affiliations
University of Washington (US)
Venue
The Journal of Neuroscience
Published
1995-09-01
Volume
15
Issue
9
Pages
6287-6299
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W1653336699
Cited by
223
References
23
Citations by year
2026: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 4
FWCI
3.60
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k02da000207-04)
  • U.S. Public Health Service
  • National Institute on Drug Abuse (DA-04093, DA00207)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
cocaine, behavioral sensitization, nucleus accumbens, dopamine D1 receptor, cocaine withdrawal, locomotor stimulation, postsynaptic inhibition, GABA, microiontophoresis, single-cell electrophysiology
MeSH terms
Animals, Behavior, Animal, Cocaine, Electrophysiology, Male, Neural Inhibition, Neurons, Nucleus Accumbens, Time Factors, Rats, Sprague-Dawley, Rats

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