The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems
Open accessAbstract
The novel neuropeptides called hypocretins (orexins) have recently been identified as being localized exclusively in cell bodies in a subregion of the tuberal part of the hypothalamus. The structure of the hypocretins, their accumulation in vesicles of axon terminals, and their excitatory effect on cultured hypothalamic neurons suggest that the hypocretins function in intercellular communication. To characterize these peptides further and to help understand what physiological functions they may serve, we undertook an immunohistochemical study to examine the distribution of preprohypocretin-immunoreactive neurons and fibers in the rat brain. Preprohypocretin-positive neurons were found in the perifornical nucleus and in the dorsal and lateral hypothalamic areas. These cells were distinct from those that express melanin-concentrating hormone. Although they represent a restricted group of cells, their projections were widely distributed in the brain. We observed labeled fibers throughout the hypothalamus. The densest extrahypothalamic projection was found in the locus coeruleus. Fibers were also seen in the septal nuclei, the bed nucleus of the stria terminalis, the paraventricular and reuniens nuclei of the thalamus, the zona incerta, the subthalamic nucleus, the central gray, the substantia nigra, the raphe nuclei, the parabrachial area, the medullary reticular formation, and the nucleus of the solitary tract. Less prominent projections were found in cortical regions, central and anterior amygdaloid nuclei, and the olfactory bulb. These results suggest that hypocretins are likely to have a role in physiological functions in addition to food intake such as regulation of blood pressure, the neuroendocrine system, body temperature, and the sleep-waking cycle.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Recent data suggest that the lateral hypothalamic area contains hyporcretin/orexin (de Lecea et al., 1998, Sakurai et al., 1998) neurons (Peyron et al., 1998), which appear to play a critical role in arousal (Siegel, 2004; Saper et al., 2005) and probably reward (Harris et al., 2005; Harris and Aston-Jones, 2006).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Peyron et al., 1998
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
Estimation of nuclear population from microtome sections
Abercrombie, M. (1946) · The Anatomical Record · doi:10.1002/ar.1090940210 · Cited by 4,363
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878
Self-citationFunctional organization of central pathways regulating the cardiovascular system
Dampney, R. A. L. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.2.323 · Cited by 1,648
A role for melanin-concentrating hormone in the central regulation of feeding behaviour
Qu, D., Ludwig, D. S., Gammeltoft, S., Piper, M., Pelleymounter, M. A., Cullen, M. J., Mathes, W. F., Przypek, J., Kanarek, R. B., & Maratos–Flier, E. (1996) · Nature · doi:10.1038/380243a0 · Cited by 1,320
Direct hypothalamo-autonomic connections
Saper, C. B., Loewy, A. D., Swanson, L. W., & Cowan, W. M. (1976) · Brain Research · doi:10.1016/0006-8993(76)90738-1 · Cited by 1,199
Bittencourt, J. C., Presse, F., Arias, C. M., Peto, C. A., Vaughan, J. M., Nahon, J., Vale, W., & Sawchenko, P. E. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903190204 · Cited by 1,075
Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus
Håkansson, M., Brown, H., Ghilardi, N., Skoda, R. C., & Meister, B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00559.1998 · Cited by 741
Neuroreptide Y: Stimulation of feeding and drinking by injection into the paraventricular nucleus
Stanley, B. G., & LEIBOWITZ, S. F. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90032-8 · Cited by 665
Research works printed but not linked: 8
- Jones BE (1994) Basic mechanisms of sleep-waking states. in Principles and practice of sleep medicine, 2nd Edition, eds Kryger MH Roth T Dement WC (Saunders, Philadelphia), pp 145–162.
- Peyron, 1997, Distribution of immunoreactive neurons and fibers for a hypothalamic neuropeptide precursor related to secretin., Soc Neurosci Abstr, 23, 2032
- 10.1210/en.138.1.351 · DOI
- Simerly RB (1995) Anatomical substrates of hypothalamic integration. in The rat nervous system, 2nd Edition, ed Paxinos G (Academic), pp 353–376.
- Sutcliffe, 1997, Two novel hypothalamic peptides related to secretin derived from a single neuropeptide precursor., Soc Neurosci Abstr, 23, 2032
- Swanson LW (1987) The hypothalamus. in Handbook of chemical neuroanatomy, Vol 5, Integrated systems of the CNS, eds Björklund A Hökfelt T Swanson LW (Elsevier, Amsterdam), pp 1–124.
- Vanni-Mercier, 1984, “Waking state specific” neurons in the caudal hypothalamus of the cat., C R Acad Sci Paris, 298, 195
- Vertes RP (1990) Brainstem mechanisms of slow wave sleep and REM sleep. in Brainstem mechanisms of behavior, eds Klemm WR Vertes RP (Wiley, New York), pp 535–581.
Cited by
Sorted by citations
Items 801–900 of 1,018
Morganstern, I., Chang, G., Barson, J. R., Ye, Z., Karatayev, O., & Leibowitz, S. F. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01161.x · Cited by 79
Gentile, T. A., Simmons, S. J., Barker, D. J., Shaw, J. K., España, R. A., & Muschamp, J. W. (2017) · Addiction Biology · doi:10.1111/adb.12507 · Cited by 77
Antiallodynic Effects of Intrathecal Orexins in a Rat Model of Postoperative Pain
Cheng, J., Chou, R. C.-C., Hwang, L.-L., & Chiou, L. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.056663 · Cited by 78
Calipari, E. S., & España, R. A. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00054 · Cited by 79
Hypocretins in the Control of Sleep and Wakefulness
Bonnavion, P., & de Lecea, L. (2010) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-010-0101-y · Cited by 82
Orexin neurons project to diverse sympathetic outflow systems
Geerling, J. C., Mettenleiter, T. C., & Loewy, A. D. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.07.008 · Cited by 78
The Deakin/Graeff hypothesis: Focus on serotonergic inhibition of panic
Paul, E. D., Johnson, P. L., Shekhar, A., & Lowry, C. A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.010 · Cited by 80
Saper, C. B. (2013) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000427215.07715.73 · Cited by 81
Repeated orexin 1 receptor antagonism effects on cocaine seeking in rats
Zhou, L., Smith, R. J., Do, P. H., Aston‐Jones, G., & See, R. E. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.07.044 · Cited by 78
Brain orexin promotes obesity resistance
Kotz, C. M., Nixon, J. P., Butterick, T. A., Perez‐Leighton, C. E., Teske, J. A., & Billington, C. J. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06585.x · Cited by 79
Martin‐Fardon, R., & Boutrel, B. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00075 · Cited by 79
Neural Pathways Underlying Lactate-Induced Panic
Johnson, P. L., Truitt, W. A., Fitz, S. D., Lowry, C. A., & Shekhar, A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301621 · Cited by 78
Glucose hypometabolism of hypothalamus and thalamus in narcolepsy
Joo, E. Y., Tae, W., Kim, J. H., Kim, B. T., & Hong, S. B. (2004) · Annals of Neurology · doi:10.1002/ana.20212 · Cited by 78
Nattie, E., & Li, A. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01261.2009 · Cited by 79
Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain
Terao, A., Apte-Deshpande, A. D., Morairty, S. R., Freund, Y. R., & Kilduff, T. S. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00953-9 · Cited by 77
Self-citationJohnson, A. W. (2017) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2017.06.012 · Cited by 79
Selective orexin receptor antagonists
Lebold, T. P., Bonaventure, P., & Shireman, B. T. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.06.057 · Cited by 78
Roch, C., Bergamini, G., Steiner, M. A., & Clozel, M. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05954-0 · Cited by 83
The Effects of Light and the Circadian System on Rhythmic Brain Function
von Gall, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052778 · Cited by 82
Christensen, J., Li, C. N., & Mychasiuk, R. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221082786 · Cited by 78
Barateau, L., Pizza, F., Plazzi, G., & Dauvilliers, Y. A. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13631 · Cited by 88
The brain orexin system and almorexant in fear-conditioned startle reactions in the rat
Steiner, M. A., Lecourt, H., & Jenck, F. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2736-7 · Cited by 80
Role of orexin in the central regulation of glucose and energy homeostasis [Review]
Tsuneki, H., Wada, T., & Sasaoka, T. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0030 · Cited by 79
Orexin neuronal changes in the locus coeruleus of the aging rhesus macaque
Downs, J. L., Dunn, M. R., Borók, E., Shanabrough, M., Horváth, T. L., Kohama, S. G., & Urbanski, H. F. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.05.025 · Cited by 77
Furutani, N., Hondo, M., Kageyama, H., Tsujino, N., Mieda, M., Yanagisawa, M., Shioda, S., & Sakurai, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062391 · Cited by 81
Hypocretin/orexin and narcolepsy: new basic and clinical insights
Nishino, S., Okuro, M., Kotorii, N., Anegawa, E., Ishimaru, Y., Matsumura, M., & Kanbayashi, T. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.02012.x · Cited by 77
Henny, P., Brischoux, F., Mainville, L., Stroh, T., & Jones, B. E. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.003 · Cited by 77
Growing Up with Type 1 Narcolepsy: Its Anthropometric and Endocrine Features
Ponziani, V., Gennari, M., Pizza, F., Balsamo, A., Bernardi, F., & Plazzi, G. (2016) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6352 · Cited by 77
Sexually Dimorphic Changes of Hypocretin (Orexin) in Depression
Lu, J., Zhao, J., Balesar, R., Fronczek, R., Zhu, Q.-B., Wu, X.-Y., Hu, S.-H., Bao, A.-M., & Swaab, D. F. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.03.043 · Cited by 77
Lateral hypothalamic circuits for sleep–wake control
Yamashita, T., & Yamanaka, A. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.03.020 · Cited by 80
Okumura, T., Takeuchi, S., Motomura, W., Yamada, H., Egashira, S., Asahi, S., Kanatani, A., Ihara, M., & Kohgo, Y. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4235 · Cited by 76
McGranaghan, P. A., & Piggins, H. D. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02463-5 · Cited by 77
The hypocretin/orexin system in health and disease
Nishino, S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00349-4 · Cited by 77
Pillai, J. A., & Leverenz, J. B. (2017) · CHEST Journal · doi:10.1016/j.chest.2017.01.002 · Cited by 85
Update on the pharmacologic management of narcolepsy: mechanisms of action and clinical implications
Thorpy, M. J., & Bogan, R. (2019) · Sleep Medicine · doi:10.1016/j.sleep.2019.09.001 · Cited by 81
Heterogeneity in the Paraventricular Thalamus: The Traffic Light of Motivated Behaviors
McGinty, J. F., & Otis, J. M. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.590528 · Cited by 76
Rossi, M. A., Basiri, M. L., Liu, Y., Hashikawa, Y., Hashikawa, K., Fenno, L. E., Kim, Y. S., Ramakrishnan, C., Deisseroth, K. A., & Stuber, G. D. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.020 · Cited by 73
Ciriello, J., McMurray, J. C., Babic, T., & de Oliveira, C. V. R. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.016 · Cited by 75
Convergent actions of orexin/hypocretin and CRF on dopamine neurons: Emerging players in addiction
Borgland, S. L., Ungless, M. A., & Bonci, A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.10.068 · Cited by 80
Sawai, N., Ueta, Y., Nakazato, M., & Ozawa, H. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.10.061 · Cited by 75
Gaykema, R. P. A., & Goehler, L. E. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.03.005 · Cited by 80
Cardioacceleratory responses to hypocretin-1 injections into rostral ventromedial medulla
Ciriello, J., Li, Z., & de Oliveira, C. V. R. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.008 · Cited by 75
Region-Specific Dissociation between Cortical Noradrenaline Levels and the Sleep/Wake Cycle
Bellesi, M., Tononi, G., Cirelli, C., & Serra, P. A. (2015) · SLEEP · doi:10.5665/sleep.5336 · Cited by 80
Orexin/hypocretin treatment restores hippocampal-dependent memory in orexin-deficient mice
Mavanji, V., Butterick, T. A., Duffy, C. M., Nixon, J. P., Billington, C. J., & Kotz, C. M. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.10.014 · Cited by 77
Ida, T., Nakahara, K., Kuroiwa, T., Fukui, K., Nakazato, M., Murakami, T., & Murakami, N. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01498-1 · Cited by 76
Matzeu, A., Zamora-Martinez, E. R., & Martin‐Fardon, R. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00117 · Cited by 84
Kim, T.-K., Kim, J., Park, J. Y., Lee, J. E., Choi, J., Kim, H., Lee, E. H., Kim, S.-W., Lee, J.-K., Kang, H., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.04.004 · Cited by 76
The use of the reinstatement model to study relapse to palatable food seeking during dieting
Calu, D. J., Chen, Y., Kawa, A. B., Nair, S. G., & Shaham, Y. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.030 · Cited by 74
Tao, R., Ma, Z., McKenna, J. T., Thakkar, M. M., Winston, S. H., Strecker, R. E., & McCarley, R. W. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.05.027 · Cited by 75
Samson, W. K., Bagley, S. L., Ferguson, A. V., & White, M. M. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00496.2006 · Cited by 75
The other side of the orexins: endocrine and metabolic actions
Taylor, M. M., & Samson, W. K. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00359.2002 · Cited by 75
Hypocretin/orexin suppresses corticotroph responsiveness in vitro
Samson, W. K., & Taylor, M. M. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.4.r1140 · Cited by 74
Neural Control of the Upper Airway: Respiratory and State‐Dependent Mechanisms
Kubin, L. K. (2016) · Comprehensive physiology · doi:10.1002/cphy.c160002 · Cited by 90
Escape From Oblivion: Neural Mechanisms of Emergence From General Anesthesia
Kelz, M. B., García, P. S., Mashour, G. A., & Solt, K. (2019) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004006 · Cited by 75
Lowry, C. A., Evans, A. K., Gasser, P. J., Hale, M. W., Staub, D. R., & Shekhar, A. (2008) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-8561-3_2 · Cited by 76
Neural integration of satiation and food reward: Role of GLP-1 and orexin pathways
Williams, D. L. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.03.013 · Cited by 74
Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic–pituitary axes)
López, M., Tena‐Sempere, M., & Diéguez, C. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.07.001 · Cited by 74
The effect of age on prepro-orexin gene expression and contents of orexin A and B in the rat brain
Porkka‐Heiskanen, T., Alanko, L., Kalinchuk, A. V., Heiskanen, S., & Stenberg, D. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00043-5 · Cited by 73
Memory Enhancement with Event-Related Stimulation of the Rostral Intralaminar Thalamic Nuclei
Mair, R. G., & Hembrook‐Short, J. R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3301-08.2008 · Cited by 74
Neurophysiological Mechanisms of Sleep and Wakefulness: A Question of Balance
Sinton, C. M., & McCarley, R. W. (2004) · Seminars in Neurology · doi:10.1055/s-2004-835067 · Cited by 73
Brown, R. E., Winston, S. H., Basheer, R., Thakkar, M. M., & McCarley, R. W. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.045 · Cited by 73
Summers, C. H., Yaeger, J. D. W., Staton, C. D., Arendt, D. H., & Summers, T. R. (2018) · Brain Research · doi:10.1016/j.brainres.2018.12.036 · Cited by 76
Role of Homer Proteins in the Maintenance of Sleep-Wake States
Naidoo, N. N., Ferber, M. F., Galante, R. J., McShane, B. B., Hu, J. H., Zimmerman, J. E., Maislin, G., Cater, J., Wyner, A. J., Worley, P. F., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035174 · Cited by 75
Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice
Liu, M., Thankachan, S., Kaur, S., Begum, S., Blanco‐Centurion, C., Sakurai, T., Yanagisawa, M., Neve, R. L., & Shiromani, P. J. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06446.x · Cited by 72
Srinivasan, S., Simms, J. A., Nielsen, C. K., Lieske, S. P., Bito‐Onon, J. J., Yi, H. Y., Hopf, F. W., Bonci, A., & Bartlett, S. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044726 · Cited by 74
Mechanisms of Sleep-Wake Cycle Modulation
Murillo‐Rodríguez, E., Arias-Carrión, Ó., Sanguino-Rodriguez, K., Gonzalez-Arias, M., & Haro, R. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709788921654 · Cited by 74
Sundvik, M., Kudo, H., Toivonen, P., Rozov, S. V., Chen, Y., & Panula, P. (2011) · The FASEB Journal · doi:10.1096/fj.11-188268 · Cited by 73
A Quartet Neural System Model Orchestrating Sleep and Wakefulness Mechanisms
Tamakawa, Y., Karashima, A., Koyama, Y., Katayama, N., & Nakao, M. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00575.2005 · Cited by 73
Reduced Orexin System Function Contributes to Resilience to Repeated Social Stress
Grafe, L. A., Eacret, D., Dobkin, J., & Bhatnagar, S. (2018) · eNeuro · doi:10.1523/eneuro.0273-17.2018 · Cited by 73
Bayer, L., Mairet‐Coello, G., Risold, P., & Griffond, B. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00320-2 · Cited by 72
Patel, K. V., Aspesi, A. V., & Evoy, K. E. (2015) · Annals of Pharmacotherapy · doi:10.1177/1060028015570467 · Cited by 72
Dopaminergic and non-dopaminergic value systems in conditioning and outcome-specific revaluation
Dranias, M. R., Grossberg, S., & Bullock, D. H. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.013 · Cited by 75
Electroencephalogram paroxysmal theta characterizes cataplexy in mice and children
Vassalli, A., Dellepiane, J. M., Emmenegger, Y., Jimenez, S., Vandi, S., Plazzi, G., Franken, P., & Tafti, M. (2013) · Brain · doi:10.1093/brain/awt069 · Cited by 72
Delayed Orexin Signaling Consolidates Wakefulness and Sleep: Physiology and Modeling
Behn, C. D., Kopell, N., Brown, E. N., Mochizuki, T., & Scammell, T. E. (2008) · Journal of Neurophysiology · doi:10.1152/jn.01243.2007 · Cited by 70
Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdala
Arendt, D. H., Hassell, J. E., Li, H., Achua, J. K., Guarnieri, D. J., Dileone, R., Ronan, P. J., & Summers, C. H. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.10.010 · Cited by 73
Noseda, R., Borsook, D., & Burstein, R. (2017) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13083 · Cited by 74
Orexin-A Exerts Neuroprotective Effects via OX1R in Parkinson’s Disease
Liu, M., Xue, Y., Liu, C., Liu, Y.-H., Diao, H., Wang, Y., Pan, Y.-P., & Chen, L. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00835 · Cited by 72
Vanini, G., Torterolo, P., McGregor, R., Chase, M. H., & Morales, F. R. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.051 · Cited by 72
Willie, J. T., Lim, M. M., Bennett, R. E., Azarion, A. A., Schwetye, K. E., & Brody, D. L. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2012.2404 · Cited by 79
Basic Sleep Mechanisms: An Integrative Review
Murillo‐Rodríguez, E., Arias-Carrión, Ó., Zavala-Garcia, A., Sarro-Ramírez, A., & Huitrón‐Reséndiz, S. (2012) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/187152412800229107 · Cited by 71
Hypocretin/Orexin Receptor Pharmacology and Sleep Phases
Sun, Y., Tisdale, R. K., & Kilduff, T. S. (2021) · Monographs in clinical neuroscience/Frontiers of neurology and neuroscience/Monographs in neural sciences · doi:10.1159/000514963 · Cited by 72
Self-citationSleep timing and the circadian clock in mammals: Past, present and the road ahead
Sanchez, R. E. A., Kalume, F. K., & de la Iglesia, H. O. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.05.034 · Cited by 73
The orexin story, sleep and sleep disturbances
Pizza, F., Barateau, L., Dauvilliers, Y. A., & Plazzi, G. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13665 · Cited by 75
Architectural Organization of the African Elephant Diencephalon and Brainstem
Maseko, B. C., Patzke, N., Fuxé, K., & Manger, P. R. (2013) · Brain Behavior and Evolution · doi:10.1159/000352004 · Cited by 71
Biomedical Application of Orexin/Hypocretin Receptor Ligands in Neuroscience
Boss, C., Roch, C., & Jenck, F. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm801296d · Cited by 72
Jöhren, O., Brüggemann, N., Dendorfer, A., & Dominiak, P. (2003) · Endocrinology · doi:10.1210/en.2002-0030 · Cited by 72
Cai, X., Lister, C. A., Buckingham, R. E., Pickavance, L. C., Wilding, J. P. H., Arch, J. R. S., Wilson, S., & Williams, G. H. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00041-3 · Cited by 72
Petrovich, G. D., Hobin, M., & Reppucci, C. J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.036 · Cited by 73
Hutcheson, D. M., Quarta, D., Halbout, B., Rigal, A., Valerio, E., & Heidbreder, C. A. (2011) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328343d761 · Cited by 71
Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism
Dugovic, C., Shelton, J. E., Yun, S., Bonaventure, P., Shireman, B. T., & Lovenberg, T. W. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00028 · Cited by 73
Orexin Receptor Antagonists: A New Concept In CNS Disorders?
Gatfield, J., Roch, C., Jenck, F., & Boss, C. (2010) · ChemMedChem · doi:10.1002/cmdc.201000132 · Cited by 72
Narcolepsy–cataplexy and schizophrenia in adolescents
Huang, Y., Guilleminault, C., Chen, C., Lai, P., & Hwang, F.-M. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2013.09.018 · Cited by 71
Baker, P. M., Oh, S., Kidder, K. S., & Mizumori, S. J. Y. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00295 · Cited by 76
Staton, C. D., Yaeger, J. D. W., Khalid, D., Haroun, F., Fernandez, B. S., Fernandez, J. S., Summers, B., Summers, T. R., Sathyanesan, M., Newton, S. S., et al. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.09.016 · Cited by 74
Meffre, J., Sicre, M., Diarra, M., Marchessaux, F., Paleressompoulle, D., & Ambroggi, F. (2019) · Current Biology · doi:10.1016/j.cub.2019.07.069 · Cited by 76
Can we Develop Neurally Acting Drugs for the Treatment of Migraine?
Goadsby, P. J. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1822 · Cited by 71
Mondal, M. S., Nakazato, M., Date, Y., Murakami, N., Hanada, R., Sakata, T., & Matsukura, S. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00624-2 · Cited by 70
Hypothalamic Regulation of Sleep
Salín-Pascual, R. J. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00318-9 · Cited by 71
Tobacco dependence, the insular cortex and the hypocretin connection
Kenny, P. J. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.08.015 · Cited by 69
Zisapel, N. (2012) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2012.690735 · Cited by 71
Metadata
- Authors
- Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S.
- Affiliations
- Stanford University (US)
- Scripps Research Institute (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1998-12-01
- Volume
- 18
- Issue
- 23
- Pages
- 9996-10015
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6793310
- OpenAlex
- W1627229807
- Cited by
- 3,466
- References
- 49
- Citations by year
- 2026: 48 · 2025: 88 · 2024: 102 · 2023: 123 · 2022: 128 · 2021: 122 · 2020: 144 · 2019: 111 · 2018: 146 · 2017: 145 · 2016: 157 · 2015: 156 · 2014: 183 · 2013: 169 · 2012: 182
- FWCI
- 36.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns033396-03, 5p01ag011084-05)
- National Institute on Aging (AG-11084)
- National Institute of General Medical Sciences (GM-32355, R01GM032355)
- National Institute of Neurological Disorders and Stroke (R01NS034887, NS33396)
- Army Research Office
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- orexin, hypothalamic neurons, neuronal projections, melanin-concentrating hormone, locus coeruleus, septal nuclei, bed nucleus of the stria terminalis, thalamic nuclei, raphe nuclei, parabrachial area, medullary reticular formation, nucleus tractus solitarius, sleep-wake cycle, blood pressure regulation, neuroendocrine regulation, thermoregulation
- MeSH terms
- Orexins, Animals, Antibody Specificity, Blood Pressure, Brain Chemistry, Carrier Proteins, Dendrites, Eating, Male, Microscopy, Electron, Nerve Fibers, Neurons, Afferent, Neurons, Efferent, Neuropeptides, Rats, Wistar, Neurotransmitter Agents, Intracellular Signaling Peptides and Proteins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
