Cited by 69Sleep and Wakefulness ResearchSmoking Behavior and CessationNeurotransmitter Receptor Influence on Behavior

Tobacco dependence, the insular cortex and the hypocretin connection

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Kenny, Paul J.·2011·Pharmacology Biochemistry and Behavior

Abstract

Tobacco use is a major cause of disease and premature death in the United States. Nicotine is considered the key component of tobacco responsible for addiction in human smokers. Accumulating evidence supports an important role for the hypocretin (orexin) neuropeptide system in regulating the reinforcing properties of most major drugs of abuse, including nicotine. Here, data showing that nicotine activates hypocretin-producing neurons in the lateral hypothalamus, and that disruption of hypocretin transmission decreases nicotine self-administration behavior in rats will be reviewed. Recent findings suggesting that plasma hypocretin levels may be related to the magnitude of cigarette craving in abstinent smokers will be discussed. Finally, the data suggesting that hypocretin transmission in the insular cortex may play an important role in regulating nicotine self-administration behavior in rats will be reviewed. This latter finding may provide mechanistic insight into the apparent disruption of tobacco addiction reported in human smokers with stroke-associated damage to the insular cortex.

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Crossref · 10.1016/j.pbb.2010.08.015

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  • Chronic nicotine exposure likely causes global alterations in brain neurotransmission because nAChR activation affects release of virtually every major neurotransmitter.

    “As nAChR activation affects the release of virtually every major neurotransmitter [106, 117, 118], chronic nicotine exposure is likely to cause global alterations in brain neurotransmission.”

    From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [117]

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Authors
Kenny, P. J.
Affiliations
Scripps Research Institute (US)
Corresponding author
Kenny, Paul J.
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2011-02
Volume
97
Issue
4
Pages
700-707
ISSN
0091-3057 (ISSN-L)
OpenAlex
W2010147037
Cited by
69
References
146
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 20 · 2019: 6 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 4 · 2013: 8 · 2012: 7
FWCI
0.46
Type
journal article
Language
en
Open access
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Drug Abuse (R01DA030929, DA020686, R01DA020686, R01DA023915, R37DA020686)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
tobacco dependence, nicotine dependence, orexin, insula, lateral hypothalamus, nicotine self-administration, cigarette craving, stroke, nicotine reinforcement
MeSH terms
Orexins, Animals, Humans, Neuropeptides, Tobacco Use Disorder, Intracellular Signaling Peptides and Proteins, Rats

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