The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Neural Circuitry of Stress-Induced Insomnia in Rats
Open accessAbstract
Sleep architecture is often disturbed after a stressful event; nevertheless, little is known about the brain circuitry responsible for the sleep perturbations induced by stress. We exposed rats to a psychological stressor (cage exchange) that initially causes an acute stress response, but several hours later generates a pattern of sleep disturbances similar to that observed in stress-induced insomnia in humans: increased sleep latency, decreased non-REM (nREM) and REM sleep, increased fragmentation, and high-frequency EEG activity during nREM sleep. We examined the pattern of Fos expression to identify the brain circuitry activated, and found increased Fos in the cerebral cortex, limbic system, and parts of the arousal and autonomic systems. Surprisingly, there was simultaneous activation of the sleep-promoting areas, most likely driven by ongoing circadian and homeostatic pressure. The activity in the cerebral cortex and arousal system while sleeping generates a novel intermediate state characterized by EEG high-frequency activity, distinctive of waking, during nREM sleep. Inactivation of discrete limbic and arousal regions allowed the recovery of specific sleep components and altered the Fos pattern, suggesting a hierarchical organization of limbic areas that in turn activate the arousal system and subsequently the cerebral cortex, generating the high-frequency activity. This high-frequency activity during nREM was eliminated in the stressed rats after inactivating parts of the arousal system. These results suggest that shutting down the residual activity of the limbic-arousal system might be a better approach to treat stress-induced insomnia, rather than potentiation of the sleep system, which remains fully active.
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Citations
Cites
Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior
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“…Dalley et al., 2004), as well as in the cingulate cortex; in the lateral septum and the hippocampus; and in the CeA and the lateral division (dorsal and posterior subnuclei) of the BST, two areas involved in fear, anxiety, and emotional processing (Davis and Shi, 1999; Phelps and LeDoux, 2005).”
BackgroundNarcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
Self-citationThe role of corticotropin-releasing factor in depression and anxiety disorders
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Psychophysiological insomnia: the behavioural model and a neurocognitive perspective
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“Our results fit well with the conceptual models of primary insomnia as a disorder of hyperarousal (both physiologic and cognitive) (Morin, 1993; Bonnet and Arand, 1997; Perlis et al., 1997; Richardson and Roth, 2001; Nofzinger et al., 2004) or a disorder of sleep engagement caused by the inability to inhibit wakefulne…”
BackgroundResultFunctional Neuroimaging Evidence for Hyperarousal in Insomnia
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“The pattern of Fos in our rats is also similar to the results of positron emission tomographic (PET) studies in primary insomniacs (Nofzinger et al., 2004).”
BackgroundResultInfluentialFos Expression in Orexin Neurons Varies with Behavioral State
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“…disorder of hyperarousal (both physiologic and cognitive) (Morin, 1993; Bonnet and Arand, 1997; Perlis et al., 1997; Richardson and Roth, 2001; Nofzinger et al., 2004) or a disorder of sleep engagement caused by the inability to inhibit wakefulness rather than the inability to sleep (Espie, 2002).”
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“CeA–BST lesions totally restore Fos expression to control levels as if the rats were not exposed to stress.”
BackgroundInfluential
Cited by
The hyperarousal model of insomnia: A review of the concept and its evidence
Riemann, D., Spiegelhalder, K., Feige, B., Voderholzer, U., Berger, M., Perlis, M., & Nissen, C. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.04.002 · Cited by 1,789
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
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Self-citationHyperarousal and insomnia: state of the science
Bonnet, M. H., & Arand, D. L. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.05.002 · Cited by 914
Insomnia with objective short sleep duration: The most biologically severe phenotype of the disorder
Vgontzas, A. N., Fernandez-Mendoza, J., Liao, D., & Bixler, E. O. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.09.005 · Cited by 776
Metadata
- Authors
- Cano, G., Mochizuki, T., & Saper, C. B.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-10-01
- Volume
- 28
- Issue
- 40
- Pages
- 10167-10184
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2059226449
- Cited by
- 242
- References
- 15
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
