The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Differential Excitability and Modulation of Striatal Medium Spiny Neuron Dendrites
Open accessAbstract
The loss of striatal dopamine (DA) in Parkinson's disease (PD) models triggers a cell-type-specific reduction in the density of dendritic spines in D 2 receptor-expressing striatopallidal medium spiny neurons (D 2 MSNs). How the intrinsic properties of MSN dendrites, where the vast majority of DA receptors are found, contribute to this adaptation is not clear. To address this question, two-photon laser scanning microscopy (2PLSM) was performed in patch-clamped mouse MSNs identified in striatal slices by expression of green fluorescent protein (eGFP) controlled by DA receptor promoters. These studies revealed that single backpropagating action potentials (bAPs) produced more reliable elevations in cytosolic Ca 2+concentration at distal dendritic locations in D 2 MSNs than at similar locations in D 1 receptor-expressing striatonigral MSNs (D 1 MSNs). In both cell types, the dendritic Ca 2+entry elicited by bAPs was enhanced by pharmacological blockade of Kv4, but not Kv1 K+channels. Local application of DA depressed dendritic bAP-evoked Ca 2+transients, whereas application of ACh increased these Ca 2+transients in D 2 MSNs, but not in D 1 MSNs. After DA depletion, bAP-evoked Ca 2+transients were enhanced in distal dendrites and spines in D 2 MSNs. Together, these results suggest that normally D 2 MSN dendrites are more excitable than those of D 1 MSNs and that DA depletion exaggerates this asymmetry, potentially contributing to adaptations in PD models.
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Cites
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
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Self-citationDay, M., Wang, Z., Ding, J., An, X., Ingham, C. A., Shering, A. F., Wokosin, D., Ilijic, E., Sun, Z., Sampson, A. R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1632 · Cited by 745 · cited 5×
“Adaptations in MSN connectivity and dendritic architecture in PD models are dependent on the loss of DA and the consequent rise in ACh signaling through broadly expressed M1 muscarinic receptors (Day et al., 2006; Shen et al., 2007).”
BackgroundMethodInfluentialSelf-citationDendritic Ih normalizes temporal summation in hippocampal CA1 neurons
Magee, J. C. (1999) · Nature Neuroscience · doi:10.1038/9158 · Cited by 617
Propagation of action potentials in dendrites depends on dendritic morphology
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Hernández-López, S., Tkatch, T., Perez-Garci, E., Galarraga, E., Bargas, J., Hamm, H., & Surmeier, D. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-08987.2000 · Cited by 443
Self-citationStriatal Fos expression is indicative of dopamine D1/D2 synergism and receptor supersensitivity.
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Cited by
Surmeier, D. J., Ding, J., Day, M., Wang, Z., & Shen, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.008 · Cited by 1,203
Self-citationDopaminergic modulation of synaptic transmission in cortex and striatum
Tritsch, N. X., & Sabatini, B. L. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.023 · Cited by 756
MicroRNA-128 governs neuronal excitability and motor behavior in mice
Tan, C. L., Plotkin, J. L., Venø, M. T., von Schimmelmann, M., Feinberg, P., Mann, S., Handler, A., Kjems, J., Surmeier, D. J., O’Carroll, D., et al. (2013) · Science · doi:10.1126/science.1244193 · Cited by 301
Self-citationFieblinger, T., Graves, S. M., Sebel, L. E., Alcacer, C., Plotkin, J. L., Gertler, T. S., Chan, C. S., Heiman, M., Greengard, P., Cenci, M. A., et al. (2014) · Nature Communications · doi:10.1038/ncomms6316 · Cited by 295
Self-citationRetinal Dopamine Mediates Multiple Dimensions of Light-Adapted Vision
Jackson, C. R., Ruan, G.-X., Aseem, F., Abey, J., Gamble, K., Stanwood, G., Palmiter, R. D., Iuvone, P. M., & McMahon, D. G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0711-12.2012 · Cited by 277
Metadata
- Authors
- Day, M., Wokosin, D., Plotkin, J. L., Tian, X., & Surmeier, D. J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-11-05
- Volume
- 28
- Issue
- 45
- Pages
- 11603-11614
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2049856923
- Cited by
- 243
- References
- 7
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Day, M., Wokosin, D., Plotkin, J. L., Tian, X., & Surmeier, D. J. (2008). Differential Excitability and Modulation of Striatal Medium Spiny Neuron Dendrites. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.1840-08.2008
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