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Cited by 268

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Caspase-8 and Caspase-3 Are Expressed by Different Populations of Cortical Neurons Undergoing Delayed Cell Death after Focal Stroke in the Rat

Open access
Velier, James J., Ellison, Julie A., Kikly, Kristine K., Spera, Patricia A., Barone, Frank C., Feuerstein, Giora Z.·1999·The Journal of Neuroscience
DOI 10.1523/jneurosci.19-14-05932.1999
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Abstract

A number of studies have provided evidence that neuronal cell loss after stroke involves programmed cell death or apoptosis. In particular, recent biochemical and immunohistochemical studies have demonstrated the expression and activation of intracellular proteases, notably caspase-3, which act as both initiators and executors of the apoptotic process. To further elucidate the involvement of caspases in neuronal cell death induced by focal stroke we developed a panel of antibodies and investigated the spatial and temporal pattern of both caspase-8 and caspase-3 expression. Our efforts focused on caspase-8 because its “apical” position within the enzymatic cascade of caspases makes it a potentially important therapeutic target. Constitutive expression of procaspase-8 was detectable in most cortical neurons, and proteolytic processing yielding the active form of caspase-8 was found as early as 6 hr after focal stroke induced in rats by permanent middle cerebral artery occlusion. This active form of caspase-8 was predominantly seen in the large pyramidal neurons of lamina V. Active caspase-3 was evident only in neurons located within lamina II/III starting at 24 hr after injury and in microglia throughout the core infarct at all times examined. Terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling, gel electrophoresis of DNA, and neuronal cell quantitation indicated that there was an early nonapoptotic loss of cortical neurons followed by a progressive elimination of neurons with features of apoptosis. These data indicate that the pattern of caspase expression occurring during delayed neuronal cell death after focal stroke will vary depending on the neuronal phenotype.

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Crossref · 10.1523/jneurosci.19-14-05932.1999

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Metadata

Authors
Velier, J. J., Ellison, J. A., Kikly, K. K., Spera, P. A., Barone, F. C., & Feuerstein, G. Z.
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
1999-07-15
Volume
19
Issue
14
Pages
5932-5941
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.19-14-05932.1999
OpenAlex
W1557242726
Cited by
268
References
47
FWCI
10.00
Type
journal article
Language
en
Open access
hybrid

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