The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Methylphenidate Enhances Working Memory by Modulating Discrete Frontal and Parietal Lobe Regions in the Human Brain
Open accessAbstract
The indirect catecholamine agonist methylphenidate (Ritalin) is the drug treatment of choice in attention deficit/hyperactivity disorder (AD/HD), one of the most common behavioral disorders of childhood (DSM-IV), although symptoms may persist into adulthood. Methylphenidate can enhance cognitive performance in adults and children diagnosed with AD/HD (Kempton et al., 1999; Riordan et al., 1999) and also in normal human volunteers on tasks sensitive to frontal lobe damage, including aspects of spatial working memory (SWM) performance (Elliott et al., 1997). The present study investigated changes in regional cerebral blood flow (rCBF) induced by methylphenidate during performance of a self-ordered SWM task to define the neuroanatomical loci of the beneficial effect of the drug. The results show that the methylphenidate-induced improvements in working memory performance occur with task-related reductions in rCBF in the dorsolateral prefrontal cortex and posterior parietal cortex. The beneficial effects of methylphenidate on working memory were greatest in the subjects with lower baseline working memory capacity. This is to our knowledge the first demonstration of a localization of a drug-induced improvement in SWM performance in humans and has relevance for understanding the treatment of AD/HD.
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“Indeed, imaging studies have shown that methylphenidate enhances the efficiency of PFC activity both in healthy college students (Mehta et al., 2000) and in subjects with ADHD (Bush et al., 2008).”
From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Mehta et al., 2000
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“Research additionally shows that ADHD is associated with decreased activity in frontal brain areas and increased activity in posterior (parietal and occipital) brain areas (Durston, 2003), and that MPH affects not only frontal but also posterior areas (Mehta et al., 2000).”
From Implementation Intentions Facilitate Response Inhibition in Children with ADHD (2008) · cites this paper as Mehta et al., 2000
In the citing paper
“Based on accumulating evidence that effects of methylphenidate and related drugs on cognition are baseline performance-dependent (Kimberg et al., 1997; Mattay et al., 2000; Mehta et al., 2000; Gibbs and D’Esposito, 2005; Tipper et al., 2005; Finke et al., 2010), changes in sustained attention following methylphenidate were assessed as a function of baseline A’ scores, independent of group.”
From A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment (2013) · cites this paper as Mehta et al., 2000
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“The effects of methylphenidate and related stimulant drugs in healthy individuals have been shown to be baseline-dependent; i.e. those subjects with relatively low performance levels exhibit greater benefit after the drug (Naylor et al., 1985; Rogers et al., 1999; Mehta et al., 2000; Turner et al., 2003; Clatworthy et al., 2009).”
From A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment (2013) · cites this paper as Mehta et al., 2000
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Cites
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
The use of analogue scales in rating subjective feelings
BOND, A., & LADER, M. (1974) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1974.tb02285.x · Cited by 1,972
Vaidya, C. J., Austin, G., Kirkorian, G., Ridlehuber, H. W., Desmond, J. E., Glover, G. H., & Gabrieli, J. D. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14494 · Cited by 845
Neuroimaging analyses of human working memory
Smith, E. E., & Jonides, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.12061 · Cited by 806
Owen, A. M., Evans, A. C., & Petrides, M. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.1.31 · Cited by 756
Self-citationPetrides, M., Alivisatos, B., Evans, A. C., & Meyer, E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.3.873 · Cited by 660
Architecture of the Prefrontal Cortex and the Central Executive
Goldman, P. S. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb38132.x · Cited by 654
Arnsten, A. F. T., & Goldman-Rakic, P. S. (1985) · Science · doi:10.1126/science.2999977 · Cited by 549
Catecholamine regulation of the prefrontal cortex
Arnsten, A. F. T. (1997) · Journal of Psychopharmacology · doi:10.1177/026988119701100208 · Cited by 493
Effects of putative neurotransmitters on neuronal activity in monkey auditory cortex
Foote, S. L., Freedman, R., & Oliver, A. P. (1975) · Brain Research · doi:10.1016/0006-8993(75)90699-x · Cited by 458
Research works printed but not linked: 2
- Baddeley AD (1986) Working memory. Oxford: Clarendon.
- Cochran WG, Cox GM (1957) Experimental designs. New York: Wiley.
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EFEITOS DO TÉDIO NO SISTEMA IMUNE HUMANO E SUAS POSSÍVEIS INTERVENÇÕES FARMACOLÓGICAS
Oliveira, M. E. A., Santos, L. A., Souza, H. G. C. D., Pereira, É. J., Neto, A. J., Figueiredo, F. J. B., Pinheiro, T. D. A., Pinheiro, T. D. A., de Souza, R. R., Vasconcelos, V. D. O., et al. (2026) · Revista de Geopolítica · doi:10.56238/revgeov17n2-048
Grandjean, A. (2020) · theses.fr (ABES) · doi:10.70675/09142f43z5b6fz462bz83c7za94811509c36
Lauer, J., Poppke, J., Nickl‐Jockschat, T., Dieterich, D. C., Fendt, M., & Afzal, S. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02476-1
“…baseline performance the greatest cognitive bene fi t with GNE-5729, a pattern that parallels baseline-dependent pro-cognitive effects observed in humans with ADHD treated with methylphenidate [39 – 41] and similarly with other neuromodulators such as amphetamine [42] or memantine [43] in rodents.”
Quint, P., Schmidt, P.-M., Mackert, S., Aslan, B., Guth, M., von der Emde, L., Lechtenboehmer, R., Faßbender, K., Baumert, P. M., Stoffel‐Wagner, B., et al. (2026) · Human Brain Mapping · doi:10.1002/hbm.70598
Dwivedi, A., Gulabani, P., Rathod, H. K., Uzair, K. H. A. N., Palal, D., Sowani, M., Tiwari, S., Bonissoni, M., Bonissoni, S., Jadav, V., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9939090/v1
Li, L., Bo, T., Lopez, E. M., Gonzalez, M. R., Fernández‐del‐Olmo, M., Gurevich, T., Desojo, L. V., & Fogelson, N. (2026) · Clinical Neurophysiology Practice · doi:10.1016/j.cnp.2026.09.001
“In subjects with ADHD, MPD has also been shown to increase the suppression of the default mode network, thus improving its interaction with the prefrontal cortex (Peterson et al., 2009).”
InfluentialNeuropharmacology of language: ERP evidence for catecholaminergic modulation of syntactic processing
Tan, Y., Lewis, A., Schmits, I. C., Verkes, R. J., Cools, R., & Peter Hagoort, A. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2606806123
“Catecholamines have also been linked to cost–benefit evaluation of cognitive effort (33–36).”
InfluentialCognitive impairment: quantification and possibilities for pharmacological treatment
Housden, C. R. (2013) · Apollo (University of Cambridge) · doi:10.17863/cam.16550
Metadata
- Authors
- Mehta, M. A., Owen, A. M., Sahakian, B. J., Mavaddat, N., Pickard, J. D., & Robbins, T. W.
- Affiliations
- University of Cambridge (GB)
- MRC Cognition and Brain Sciences Unit (GB)
- Addenbrooke's Hospital (GB)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-03-15
- Volume
- 20
- Issue
- 6
- Pages
- RC65-RC65
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6772505
- OpenAlex
- W2170595219
- Cited by
- 608
- References
- 31
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 16 · 2023: 8 · 2022: 9 · 2021: 14 · 2020: 26 · 2019: 21 · 2018: 13 · 2017: 15 · 2016: 27 · 2015: 29 · 2014: 26 · 2013: 34 · 2012: 42
- FWCI
- 11.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust
- Medical Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- methylphenidate, working memory, spatial working memory, attention deficit hyperactivity disorder, regional cerebral blood flow, dorsolateral prefrontal cortex, posterior parietal cortex, catecholamine agonists, working memory capacity
- MeSH terms
- Adult, Central Nervous System Stimulants, Cerebrovascular Circulation, Frontal Lobe, Humans, Functional Laterality, Male, Memory, Short-Term, Methylphenidate, Parietal Lobe, Tomography, Emission-Computed, Adrenergic Uptake Inhibitors, Dopamine Uptake Inhibitors
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