The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Vertical Shifts in Self-Administration Dose–Response Functions Predict a Drug-Vulnerable Phenotype Predisposed to Addiction
Open accessAbstract
The role of individual differences in the etiology of addiction is a very controversial issue. Neuroendocrine phenotypes that are able to predispose an individual to the development of drug intake have been identified previously. However, such information has been gathered by comparing individuals who differ in their sensitivity to low doses of the drug. Consequently, it remains unclear whether a phenotype predicting a higher sensitivity to low drug doses would be relevant in environmental conditions, such as the ones encountered by humans in which high drug doses are available. In this report, we studied dose–response, dose–intake, and ratio–intake functions for intravenous cocaine self-administration in the laboratory rat. We show that individual differences in drug self-administration originate from vertical shift in the dose–response function. Thus, no matter the dose, drug intake is very high in some “vulnerable” subjects and very low in other “resistant” ones. Vulnerable subjects, the upward shifted ones, would then have a higher chance to develop drug abuse also when high drug doses are available. In conclusion, these results provide a solid foundation for the existence of a drug-vulnerable phenotype relevant for the etiology of addiction.
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Cites
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Self-citationThe role of stress in drug self-administration
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Cited by
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
Evidence for Addiction-like Behavior in the Rat
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Self-citationAdult neurogenesis: from precursors to network and physiology
Abrous, D. N., Koehl, M., & Le Moal, M. (2005) · Physiological Reviews · doi:10.1152/physrev.00055.2003 · Cited by 971
Self-citationSocial dominance in monkeys: dopamine D2 receptors and cocaine self-administration
Morgan, D., Grant, K. A., Gage, H. D., Mach, R. H., Kaplan, J. R., Prioleau, O., Nader, S. H., Buchheimer, N., Ehrenkaufer, R. L., & Nader, M. A. (2002) · Nature Neuroscience · doi:10.1038/nn798 · Cited by 674
PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys
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Metadata
- Authors
- Piazza, P. V., Deroche-Gamonent, V., Rouge-Pont, F., & Le Moal, M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-06-01
- Volume
- 20
- Issue
- 11
- Pages
- 4226-4232
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2124427850
- Cited by
- 355
- References
- 40
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Piazza, P. V., Deroche-Gamonent, V., Rouge-Pont, F., & Le Moal, M. (2000). Vertical Shifts in Self-Administration Dose–Response Functions Predict a Drug-Vulnerable Phenotype Predisposed to Addiction. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.20-11-04226.2000
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
