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Cited by 606

The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.

Lens Injury Stimulates Axon Regeneration in the Mature Rat Optic Nerve

Open access
Leon, Steven, Yin, Yuqin, Nguyen, Jennifer, Irwin, Nina, Benowitz, Larry I.·2000·The Journal of Neuroscience
DOI 10.1523/jneurosci.20-12-04615.2000
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Abstract

In mature mammals, retinal ganglion cells (RGCs) are unable to regenerate their axons after optic nerve injury, and they soon undergo apoptotic cell death. However, a small puncture wound to the lens enhances RGC survival and enables these cells to regenerate their axons into the normally inhibitory environment of the optic nerve. Even when the optic nerve is intact, lens injury stimulates macrophage infiltration into the eye, Müller cell activation, and increased GAP-43 expression in ganglion cells across the entire retina. In contrast, axotomy, either alone or combined with intraocular injections that do not infringe on the lens, causes only a minimal change in GAP-43 expression in RGCs and a minimal activation of the other cell types. Combining nerve injury with lens puncture leads to an eightfold increase in RGC survival and a 100-fold increase in the number of axons regenerating beyond the crush site. Macrophage activation appears to play a key role, because intraocular injections of Zymosan, a yeast cell wall preparation, stimulated monocytes in the absence of lens injury and induced RGCs to regenerate their axons into the distal optic nerve.

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Citations

Cites

Show all 71 references

Research works printed but not linked: 11

  1. Caroni, 1988, Central nervous system regeneration: oligodendrocytes and myelin as non-permissive substrates for neurite growth., Prog Brain Res, 78, 363, 10.1016/S0079-6123(08)60305-2 · doi:10.1016/s0079-6123(08)60305-2
  2. 10.1016/S0165-3806(97)00081-3 · doi:10.1016/s0165-3806(97)00081-3
  3. 10.1016/S0006-8993(99)01202-0 · doi:10.1016/s0006-8993(99)01202-0
  4. 10.1002/(SICI)1098-1136(199811)24:3<329::AID-GLIA7>3.0.CO;2-X · doi:10.1002/(sici)1098-1136(199811)24:3<329::aid-glia7>3.0.co;2-x
  5. 10.1016/0306-4522(94)90552-5 · doi:10.1016/0306-4522(94)90552-5
  6. 10.1523/JNEUROSCI.08-12-04445.1988 · doi:10.1523/jneurosci.08-12-04445.1988
  7. Osusky, 1996, Vitreous body affects activation and maturation of monocytes into macrophages., Graefes Arch Clin Exp Ophthalmol, 234, 637, 10.1007/BF00185298 · doi:10.1007/bf00185298
  8. 10.1016/0306-4522(94)90565-7 · doi:10.1016/0306-4522(94)90565-7
  9. Stewart, 1989, Carbohydrates as recognition molecules in macrophage activities., J Clin Lab Immunol, 28, 103
  10. Wodarczyk, 1997, Differential regulation of fast axonally transported proteins during the early response of rat retinal ganglion cells to axotomy., J Neurochem, 68, 1114, 10.1046/j.1471-4159.1997.68031114.x · doi:10.1046/j.1471-4159.1997.68031114.x
  11. Wouters, 1998, Up-regulation of fast-axonally transported proteins in retinal ganglion cells of adult rats with optic-peroneal nerve grafts., Mol Brain Res, 53, 53, 10.1016/S0169-328X(97)00274-X · doi:10.1016/s0169-328x(97)00274-x

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Metadata

Authors
Leon, S., Yin, Y., Nguyen, J., Irwin, N., & Benowitz, L. I.
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2000-06-15
Volume
20
Issue
12
Pages
4615-4626
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.20-12-04615.2000
OpenAlex
W1675594938
Cited by
606
References
71
FWCI
5.52
Type
journal article
Language
en
Open access
hybrid
Licence
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)

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CoChat. (2026). Citation check: Lens Injury Stimulates Axon Regeneration in the Mature Rat Optic Nerve. https://app.cochat.ai/papers/10.1523/jneurosci.20-12-04615.2000
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Leon, S., Yin, Y., Nguyen, J., Irwin, N., & Benowitz, L. I. (2000). Lens Injury Stimulates Axon Regeneration in the Mature Rat Optic Nerve. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.20-12-04615.2000

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.