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Cited by 215

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Impairment of Long-term Potentiation and Associative Memory in Mice That Overexpress Extracellular Superoxide Dismutase

Open access
Thiels, Edda, Urban, Nathan N., Gonzalez-Burgos, Guillermo R., Kanterewicz, Beatriz I., Barrionuevo, German, Chu, Charleen T., Oury, Tim D., Klann, Eric·2000·The Journal of Neuroscience
DOI 10.1523/jneurosci.20-20-07631.2000
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Abstract

Reactive oxygen species, including superoxide, generally are considered neurotoxic molecules whose effects can be alleviated by antioxidants. Different from this view, we show that scavenging of superoxide with an antioxidant enzyme is associated with deficits in hippocampal long-term potentiation (LTP), a putative neural substrate of memory, and hippocampal-mediated memory function. Using transgenic mice that overexpress extracellular superoxide dismutase (EC-SOD), a superoxide scavenger, we found that LTP was impaired in hippocampal area CA1 despite normal LTP in area CA3. The LTP impairment in area CA1 could be reversed by inhibition of EC-SOD. In addition, we found that EC-SOD transgenic mice exhibited impaired long-term memory of fear conditioning to contextual cues despite exhibiting normal short-term memory of the conditioning experience. These findings strongly suggest that superoxide, rather than being considered exclusively a neurotoxic molecule, should also be considered a signaling molecule necessary for normal neuronal function.

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Crossref · 10.1523/jneurosci.20-20-07631.2000

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Metadata

Authors
Thiels, E., Urban, N. N., Gonzalez-Burgos, G. R., Kanterewicz, B. I., Barrionuevo, G., Chu, C. T., Oury, T. D., & Klann, E.
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2000-10-15
Volume
20
Issue
20
Pages
7631-7639
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.20-20-07631.2000
OpenAlex
W1784600579
Cited by
215
References
10
FWCI
2.82
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Impairment of Long-term Potentiation and Associative Memory in Mice That Overexpress Extracellular Superoxide Dismutase. https://app.cochat.ai/papers/10.1523/jneurosci.20-20-07631.2000
The paper
Thiels, E., Urban, N. N., Gonzalez-Burgos, G. R., Kanterewicz, B. I., Barrionuevo, G., Chu, C. T., Oury, T. D., & Klann, E. (2000). Impairment of Long-term Potentiation and Associative Memory in Mice That Overexpress Extracellular Superoxide Dismutase. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.20-20-07631.2000

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.