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The molecular and cellular biology of enhanced cognition

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Lee, Yong-Seok, Silva, Alcino J.·2009·Nature Reviews Neuroscience
DOI 10.1038/nrn2572PMC PMC2664745
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Abstract

Most molecular and cellular studies of cognitive function have focused on either normal or pathological states, but recent research with transgenic mice has started to address the mechanisms of enhanced cognition. These results point to key synaptic and nuclear signalling events that can be manipulated to facilitate the induction or increase the stability of synaptic plasticity, and therefore enhance the acquisition or retention of information. Here, we review these surprising findings and explore their implications to both mechanisms of learning and memory and to ongoing efforts to develop treatments for cognitive disorders. These findings represent the beginning of a fundamental new approach in the study of enhanced cognition.

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Cited by

Sorted by citations

Authors
Lee, Y.-S., & Silva, A. J.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Silva, Alcino J.
ORCID
Venue
Nature Reviews Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2009-02
Volume
10
Issue
2
Pages
126-140
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
DOI
10.1038/nrn2572
PMC
PMC2664745
OpenAlex
W2106095767
Cited by
361
References
11
Citations by year
2026: 1 · 2025: 17 · 2024: 16 · 2023: 17 · 2022: 21 · 2021: 15 · 2020: 11 · 2019: 15 · 2018: 12 · 2017: 21 · 2016: 29 · 2015: 30 · 2014: 22 · 2013: 26 · 2012: 38
FWCI
3.04
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (RF1AG013622, AG 13622, U01AG013622, R37AG013622, R01AG013622)
  • National Institute of Mental Health (P50MH077972, MH077972)
  • National Institute of Neurological Disorders and Stroke (NS38480, R01NS038480)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
transgenic mice, NMDA receptor, CREB, long-term potentiation, synaptic plasticity, learning and memory, synaptic signalling, nuclear signalling, cognitive disorders, cognitive enhancement therapy
MeSH terms
Animals, Calcium, Cognition, Humans, Mice, Transgenic, Molecular Biology, Neuronal Plasticity, Neurons, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Mice

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