The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic13C Nuclear Magnetic Resonance Spectroscopy
Open accessAbstract
To determine whether plasma lactate can be a significant fuel for human brain energy metabolism, infusions of [3-13 C]lactate and 1 H-13 C polarization transfer spectroscopy were used to detect the entry and utilization of lactate. During the 2 h infusion study,13 C incorporation in the amino acid pools of glutamate and glutamine were measured with a 5 min time resolution. With a plasma concentration ([Lac]P) being in the 0.8–2.8 mmol/L range, the tissue lactate concentration ([Lac]B) was assessed as well as the fractional contribution of lactate to brain energy metabolism (CMRlac). From the measured relationship between unidirectional lactate influx (Vin) and plasma and brain lactate concentrations, lactate transport constants were calculated using a reversible Michaelis–Menten model. The results show that (1) in the physiological range, plasma lactate unidirectional transport (Vin) and concentration in tissue increase close to linearly with the lactate concentration in plasma; (2) the maximum potential contribution of plasma lactate to brain metabolism is 10% under basal plasma lactate conditions of ∼1.0 mmol/L and as much as 60% at supraphysiological plasma lactate concentrations when the transporters are saturated; (3) the half-saturation constant KT is 5.1 ± 2.7 mmol/L and VMAX is 0.40 ± 0.13 μmol · g−1· min−1(68% confidence interval); and (4) the majority of plasma lactate is metabolized in neurons similar to glucose.
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Cites
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Self-citationCEREBRAL BLOOD FLOW, BLOOD VOLUME AND OXYGEN UTILIZATION: NORMAL VALUES AND EFFECT OF AGE
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Quantitation of Hepatic Glycogenolysis And Gluconeogenesis in Fasting Humans With 13 C NMR
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Self-citationBlood lactate is an important energy source for the human brain.
van Hall, G., Stømstad, M., Rasmussen, P., Jans, Ø., Zaar, M., Gam, C., Quistorff, B., Secher, N. H., & Nielsen, H. B. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.35 · Cited by 522
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“However, lactate can cross the blood– brain barrier through monocarboxylate transporters (MCTs) (Oldendorf, 1973; Simpson et al., 2007), and recent studies have provided evidence that lactate can become a significant fuel source when elevated in the blood (Smith et al.”
BackgroundDetermination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13 C NMR
Shen, J., Petersen, K. F., Behar, K. L., Brown, P., Nixon, T. W., Mason, G. F., Petroff, O. A. C., Shulman, G. I., Shulman, R. G., & Rothman, D. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8235 · Cited by 462
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Cited by
Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation
Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Lactate in the brain: from metabolic end-product to signalling molecule
Magistretti, P. J., & Allaman, I. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.19 · Cited by 1,298
A Cellular Perspective on Brain Energy Metabolism and Functional Imaging
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Comprehensive review on lactate metabolism in human health
Adeva-Andany, M., López-Ojén, M., Funcasta-Calderón, R., Ameneiros-Rodríguez, E., Donapetry-García, C., Vila-Altesor, M., & Rodríguez-Seijas, J. (2014) · Mitochondrion · doi:10.1016/j.mito.2014.05.007 · Cited by 615
Metadata
- Authors
- Boumezbeur, F., Petersen, K. F., Cline, G. W., Mason, G. F., Behar, K. L., Shulman, G. I., & Rothman, D. L.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-10-20
- Volume
- 30
- Issue
- 42
- Pages
- 13983-13991
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2162210848
- Cited by
- 359
- References
- 60
- FWCI
- 15.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic13C Nuclear Magnetic Resonance Spectroscopy. https://app.cochat.ai/papers/10.1523/jneurosci.2040-10.2010
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- Boumezbeur, F., Petersen, K. F., Cline, G. W., Mason, G. F., Behar, K. L., Shulman, G. I., & Rothman, D. L. (2010). The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic13C Nuclear Magnetic Resonance Spectroscopy. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.2040-10.2010
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
