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Cholinergic Modulation of Locomotion and Striatal Dopamine Release Is Mediated by 6 4* Nicotinic Acetylcholine Receptors
Open accessAbstract
Dopamine (DA) release in striatum is governed by firing rates of midbrain DA neurons, striatal cholinergic tone, and nicotinic ACh receptors (nAChRs) on DA presynaptic terminals. DA neurons selectively express alpha6* nAChRs, which show high ACh and nicotine sensitivity. To help identify nAChR subtypes that control DA transmission, we studied transgenic mice expressing hypersensitive alpha6(L9'S)* receptors. alpha6(L9'S) mice are hyperactive, travel greater distance, exhibit increased ambulatory behaviors such as walking, turning, and rearing, and show decreased pausing, hanging, drinking, and grooming. These effects were mediated by alpha6alpha4* pentamers, as alpha6(L9'S) mice lacking alpha4 subunits displayed essentially normal behavior. In alpha6(L9'S) mice, receptor numbers are normal, but loss of alpha4 subunits leads to fewer and less sensitive alpha6* receptors. Gain-of-function nicotine-stimulated DA release from striatal synaptosomes requires alpha4 subunits, implicating alpha6alpha4beta2* nAChRs in alpha6(L9'S) mouse behaviors. In brain slices, we applied electrochemical measurements to study control of DA release by alpha6(L9'S) nAChRs. Burst stimulation of DA fibers elicited increased DA release relative to single action potentials selectively in alpha6(L9'S), but not WT or alpha4KO/alpha6(L9'S), mice. Thus, increased nAChR activity, like decreased activity, leads to enhanced extracellular DA release during phasic firing. Bursts may directly enhance DA release from alpha6(L9'S) presynaptic terminals, as there was no difference in striatal DA receptor numbers or DA transporter levels or function in vitro. These results implicate alpha6alpha4beta2* nAChRs in cholinergic control of DA transmission, and strongly suggest that these receptors are candidate drug targets for disorders involving the DA system.
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“Similarly, expression of a hypersensitive α6 subunit in a bacterial artificial chromosome (BAC) transgenic mouse line potentiates nicotine-induced burst firing in DA neurons, and potentiates nicotine place preference at low doses of nicotine (Drenan et al. 2008a(Drenan et al. , 2010)).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Drenan et al. 2010
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Cites
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
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Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning
Tsai, H.-C., Zhang, F., Adamantidis, A., Stuber, G. D., Bonci, A., de Lecea, L., & Deisseroth, K. (2009) · Science · doi:10.1126/science.1168878 · Cited by 1,266
Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system
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Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation
Coe, J. W., Brooks, P. R., Vetelino, M. G., Wirtz, M. C., Arnold, E. P., Huang, J., Sands, S. B., Davis, T. I., Lebel, L. A., Fox, C. B., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050069n · Cited by 930
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Nicotine amplifies reward-related dopamine signals in striatum
Rice, M. E., & Cragg, S. J. (2004) · Nature Neuroscience · doi:10.1038/nn1244 · Cited by 594
Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum
Zhou, F.-M., Liang, Y., & Dani, J. A. (2001) · Nature Neuroscience · doi:10.1038/nn769 · Cited by 585
Cited by
Sorted by citations
Nicotinic acetylcholine receptors: From basic science to therapeutics
Hurst, R. S., Rollema, H., & Bertrand, D. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.08.012 · Cited by 543
Reward, addiction, withdrawal to nicotine
De Biasi, M., & Dani, J. A. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113734 · Cited by 366
“In the midbrain, nAChRs comprising the β2 nAChR subunit in combination with α4 and/or α6 subunits are essential for nicotine-induced reinforcement and the DA signal (Drenan et al. 2010, Mameli-Engvall et al. 2006, Picciotto et al. 1998, Pons et al. 2008, Tapper et al. 2004).”
BackgroundDopamine Signaling in Dorsal Versus Ventral Striatum: The Dynamic Role of Cholinergic Interneurons
Threlfell, S., & Cragg, S. J. (2011) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2011.00011 · Cited by 200
α6β2* and α4β2* Nicotinic Acetylcholine Receptors As Drug Targets for Parkinson’s Disease
Quik, M., & Wonnacott, S. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003269 · Cited by 201
Molecular Mechanisms Underlying Behaviors Related to Nicotine AddictionPreprint
Picciotto, M. R., & Kenny, P. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012112 · Cited by 186
Metadata
- Authors
- Drenan, R. M., Grady, S. R., Steele, A. D., McKinney, S., Patzlaff, N. E., McIntosh, J. M., Marks, M. J., Miwa, J. M., & Lester, H. A.
- Affiliations
- California Institute of Technology (US)
- University of Colorado Boulder (US)
- University of Utah (US)
- Corresponding author
- Lester, H. A.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-07-21
- Volume
- 30
- Issue
- 29
- Pages
- 9877-9889
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3390922
- OpenAlex
- W2010309382
- Cited by
- 127
- References
- 61
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 10 · 2019: 8 · 2018: 9 · 2017: 7 · 2016: 2 · 2015: 8 · 2014: 19 · 2013: 14 · 2012: 13
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion, cc-by-nc-sa)
- Funders
- Ellison Medical Foundation
- Gordon and Betty Moore Foundation
- Tobacco-Related Disease Research Program
- California Institute of Technology
- National Institutes of Health (5t32ns007251-22, AG033954, MH53631, GM 48677)
- National Institute on Aging (R01AG033954, AG033954)
- National Institute of Mental Health (MH53631, R01MH053631, R29MH053631)
- National Institute on Drug Abuse (DA-19375, U19DA019375, DA 015663, DA 03194, DA17279, R01DA017279, P30DA015663, F32DA021492, R01DA003194, R01DA012242, DA12242, DA021492)
- National Institute of General Medical Sciences (P01GM048677, GM48677)
- National Institute of Neurological Disorders and Stroke (T32 NS-007251, NS007251)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nicotinic acetylcholine receptors, alpha4 subunit, striatal dopamine release, locomotion, burst firing, presynaptic terminals, dopaminergic neurons
- MeSH terms
- Animals, Corpus Striatum, Dopamine, Ganglionic Stimulants, Hyperkinesis, Locomotion, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Nicotine, Receptors, Dopamine, Receptors, Nicotinic, Synaptosomes, Mice, Knockout, Dopamine Plasma Membrane Transport Proteins, Mice
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