Lester, Henry A.

Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization

Tapper, A. R., McKinney, S. L., Nashmi, R., Schwarz, J., Deshpande, P., Labarca, C., Whiteaker, P., Marks, M. J., Collins, A. C., & Lester, H. A. (2004) · Science

Nicotinic Acetylcholine Receptors StudySmoking Behavior and Cessation

Cited by 686

Nicotine binding to brain receptors requires a strong cation–π interaction

Xiu, X., Puskar, N. L., Shanata, J. A. P., Lester, H. A., & Dougherty, D. A. (2009) · Nature

Nicotinic Acetylcholine Receptors StudyReceptor Mechanisms and Signaling

Cited by 363

Cation−π Interactions in Ligand Recognition by Serotonergic (5-HT3A) and Nicotinic Acetylcholine Receptors: The Anomalous Binding Properties of Nicotine

Beene, D. L., Brandt, G. S., Zhong, W., Zacharias, N. M., Lester, H. A., & Dougherty, D. A. (2002) · Biochemistry

Nicotinic Acetylcholine Receptors StudyReceptor Mechanisms and Signaling

Cited by 300

Chronic Nicotine Cell Specifically Upregulates Functional α4* Nicotinic Receptors: Basis for Both Tolerance in Midbrain and Enhanced Long-Term Potentiation in Perforant Path

Nashmi, R., Xiao, C., Deshpande, P., McKinney, S., Grady, S. R., Whiteaker, P., Huang, Q., McClure-Begley, T., Lindstrom, J. M., Labarca, C., et al. (2007) · The Journal of Neuroscience

Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology Research

Cited by 274

A Proposal for a Coordinated Effort for the Determination of Brainwide Neuroanatomical Connectivity in Model Organisms at a Mesoscopic Scale

Bohland, J. W., Wu, C., Barbas, H., Bokil, H., Bota, M., Breiter, H. C., Cline, H. T., Doyle, J. C., Freed, P. J., Greenspan, R. J., et al. (2009) · PLoS Computational Biology

Functional Brain Connectivity StudiesAdvanced Neuroimaging Techniques and Applications

Cited by 261

Persistent Amyloidosis following Suppression of Aβ Production in a Transgenic Model of Alzheimer Disease

Jankowsky, J. L., Slunt, H. H., Gonzales, V., Savonenko, A. V., Wen, J. C., Jenkins, N. A., Copeland, N. G., Younkin, L. H., Lester, H. A., Younkin, S. G., et al. (2005) · PLoS Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 237

Multiplexed, High Density Electrophysiology with Nanofabricated Neural Probes

Du, J., Blanche, T. J., Harrison, R. R., Lester, H. A., & Masmanidis, S. C. (2011) · PLoS ONE

Neuroscience and Neural EngineeringAnalog and Mixed-Signal Circuit Design

Cited by 231

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses

Miwa, J. M., Freedman, R., & Lester, H. A. (2011) · Neuron

Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology Research

Cited by 205

In vivo activation of midbrain dopamine neurons via sensitized, high-affinity α6 nicotinic acetylcholine receptors

Drenan, R. M., Grady, S. R., Whiteaker, P., McClure-Begley, T., McKinney, S., Miwa, J. M., Bupp, S., Heintz, N., McIntosh, J. M., Bencherif, M., et al. (2008) · Neuron

Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology Research

Cited by 197

Assembly of α4β2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons

Nashmi, R., Dickinson, M. E., McKinney, S., Jareb, M., Labarca, C., Fraser, S. E., & Lester, H. A. (2003) · The Journal of Neuroscience

Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology Research

Cited by 188

Numerical reconstruction of the quantal event at nicotinic synapses

Wathey, J. C., Nass, M. M., & Lester, H. A. (1979) · Biophysical Journal

Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology Research

Cited by 181

Point mutant mice with hypersensitive α4 nicotinic receptors show dopaminergic deficits and increased anxiety

Labarca, C., Schwarz, J., Deshpande, P., Schwarz, S., Nowak, M. W., Fonck, C., Nashmi, R., Kofuji, P., Dang, H., Shi, W., et al. (2001) · Proceedings of the National Academy of Sciences

Nicotinic Acetylcholine Receptors StudyParkinson's Disease Mechanisms and Treatments

Cited by 177

Nicotine up-regulates α4β2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning

Srinivasan, R., Pantoja, R., Moss, F. J., Mackey, E. D. W., Son, C. D., Miwa, J., & Lester, H. A. (2011) · Journal of General Physiology

Nicotinic Acetylcholine Receptors StudySmoking Behavior and Cessation

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Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery

Lester, H. A., Xiao, C., Srinivasan, R., Son, C. D., Miwa, J., Pantoja, R., Banghart, M. R., Dougherty, D. A., Goate, A. M., & Wang, J. C. (2009) · The AAPS Journal

Nicotinic Acetylcholine Receptors StudyReceptor Mechanisms and Signaling

Cited by 163

The Prototoxin lynx1 Acts on Nicotinic Acetylcholine Receptors to Balance Neuronal Activity and Survival In Vivo

Miwa, J. M., Stevens, T. R., King, S. L., Caldarone, B. J., Ibanez-Tallon, I., Xiao, C., Fitzsimonds, R. M., Pavlides, C., Lester, H. A., Picciotto, M. R., et al. (2006) · Neuron

Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology Research

Cited by 154

Differential Expression and Function of Nicotinic Acetylcholine Receptors in Subdivisions of Medial Habenula

Shih, P.-Y., Engle, S. E., Oh, G., Deshpande, P., Puskar, N. L., Lester, H. A., & Drenan, R. M. (2014) · The Journal of Neuroscience

Nicotinic Acetylcholine Receptors StudySmoking Behavior and Cessation

Cited by 136

Cholinergic Modulation of Locomotion and Striatal Dopamine Release Is Mediated by 6 4* Nicotinic Acetylcholine Receptors

Drenan, R. M., Grady, S. R., Steele, A. D., McKinney, S., Patzlaff, N. E., McIntosh, J. M., Marks, M. J., Miwa, J. M., & Lester, H. A. (2010) · Journal of Neuroscience

Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology Research

Cited by 127

Rodent Aβ Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice

Jankowsky, J. L., Younkin, L. H., Gonzales, V., Fadale, D. J., Slunt, H. H., Lester, H. A., Younkin, S. G., & Borchelt, D. R. (2007) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 122

Using Physical Chemistry To Differentiate Nicotinic from Cholinergic Agonists at the Nicotinic Acetylcholine Receptor

Cashin, A. L., Petersson, E. J., Lester, H. A., & Dougherty, D. A. (2005) · Journal of the American Chemical Society

Nicotinic Acetylcholine Receptors StudyReceptor Mechanisms and Signaling

Cited by 120

Subcellular trafficking, pentameric assembly, and subunit stoichiometry of neuronal nicotinic acetylcholine receptors containing fluorescently labeled α6 and β3 subunits

Drenan, R. M., Nashmi, R., Imoukhuede, P., Just, H., McKinney, S., & Lester, H. A. (2008) · Molecular Pharmacology

Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology Research

Cited by 100

Structural differences determine the relative selectivity of nicotinic compounds for native α4β2*-, α6β2*-, α3β4*- and α7-nicotine acetylcholine receptors

Grady, S. R., Drenan, R. M., Breining, S. R., Yohannes, D., Wageman, C. R., Fedorov, N. B., McKinney, S., Whiteaker, P., Bencherif, M., Lester, H. A., et al. (2010) · Neuropharmacology

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Five ADNFLE Mutations Reduce the Ca2+ Dependence of the Mammalian α4β2 Acetylcholine Response

Rodrigues‐Pinguet, N., Jia, L., Li, M., Figl, A., Klaassen, A., Truong, A., Lester, H. A., & Cohen, B. N. (2003) · The Journal of Physiology

Nicotinic Acetylcholine Receptors StudyIon channel regulation and function

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Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors

Henderson, B. J., Srinivasan, R., Nichols, W. A., Dilworth, C. N., Gutierrez, D. F., Mackey, E. D. W., McKinney, S., Drenan, R. M., Richards, C. I., & Lester, H. A. (2014) · Journal of General Physiology

Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology Research

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Nicotine normalizes intracellular subunit stoichiometry of nicotinic receptors carrying mutations linked to autosomal dominant nocturnal frontal lobe epilepsy

Son, C. D., Moss, F. J., Cohen, B. N., & Lester, H. A. (2009) · Molecular Pharmacology

Nicotinic Acetylcholine Receptors StudyIon channel regulation and function

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