The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Amyloid β42Activates a G-Protein-Coupled Chemoattractant Receptor, FPR-Like-1
Open accessAbstract
Amyloid beta (Abeta) is a major contributor to the pathogenesis of Alzheimer's disease (AD). Although Abeta has been reported to be directly neurotoxic, it also causes indirect neuronal damage by activating mononuclear phagocytes (microglia) that accumulate in and around senile plaques. In this study, we show that the 42 amino acid form of beta amyloid peptide, Abeta(42), is a chemotactic agonist for a seven-transmembrane, G-protein-coupled receptor named FPR-Like-1 (FPRL1), which is expressed on human mononuclear phagocytes. Moreover, FPRL1 is expressed at high levels by inflammatory cells infiltrating senile plaques in brain tissues from AD patients. Thus, FPRL1 may mediate inflammation seen in AD and is a potential target for developing therapeutic agents.
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“whereas the formylpeptide receptor-like-1 (FPRL1) plays a role in the endocytosis and aggregation of A in mononuclear phagocytes.19”
From Lipoprotein Receptor-Related Protein-1 Mediates Amyloid-β-Mediated Cell Death of Cerebrovascular Cells (2007) · cites this paper as [19]
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Self-citationTranslating cell biology into therapeutic advances in Alzheimer's disease
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Cited by
Pathways towards and Away from Alzheimer’s Disease
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Role of the Immune system in chronic pain
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The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide
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Annexin A1 and glucocorticoids as effectors of the resolution of inflammation
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Alzheimer's Disease: From Pathology to Therapeutic Approaches
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Metadata
- Authors
- Le, Y., Gong, W., Tiffany, H. L., Tumanov, A., Nedospasov, S., Shen, W., Dunlop, N. M., Gao, J.-L., Murphy, P. M., Oppenheim, J. J., & Wang, J. M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-01-15
- Volume
- 21
- Issue
- 2
- Pages
- RC123-RC123
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1577244262
- Cited by
- 270
- References
- 38
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Amyloid β42Activates a G-Protein-Coupled Chemoattractant Receptor, FPR-Like-1. https://app.cochat.ai/papers/10.1523/jneurosci.21-02-j0003.2001
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- Le, Y., Gong, W., Tiffany, H. L., Tumanov, A., Nedospasov, S., Shen, W., Dunlop, N. M., Gao, J.-L., Murphy, P. M., Oppenheim, J. J., & Wang, J. M. (2001). Amyloid β42Activates a G-Protein-Coupled Chemoattractant Receptor, FPR-Like-1. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.21-02-j0003.2001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
