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Cited by 428

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Amyloid-β peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease

Open access
Du Yan, Shi, Zhu, Huaijie, Fu, Jin, Yan, Shi Fang, Roher, Alex, Tourtellotte, Wallace W., Rajavashisth, Tripathi, Chen, Xi, Godman, Gabriel C., Stern, David, Schmidt, Ann Marie·1997·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.94.10.5296
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Abstract

In Alzheimer disease (AD), neurons are thought to be subjected to the deleterious cytotoxic effects of activated microglia. We demonstrate that binding of amyloid-beta peptide (Aβ) to neuronal Receptor for Advanced Glycation Endproduct (RAGE), a cell surface receptor for Aβ, induces macrophage-colony stimulating factor (M-CSF) by an oxidant sensitive, nuclear factor κB-dependent pathway. AD brain shows increased neuronal expression of M-CSF in proximity to Aβ deposits, and in cerebrospinal fluid from AD patients there was ≈5-fold increased M-CSF antigen ( P < 0.01), compared with age-matched controls. M-CSF released by Aβ-stimulated neurons interacts with its cognate receptor, c-fms, on microglia, thereby triggering chemotaxis, cell proliferation, increased expression of the macrophage scavenger receptor and apolipoprotein E, and enhanced survival of microglia exposed to Aβ, consistent with pathologic findings in AD. These data delineate an inflammatory pathway triggered by engagement of Aβ on neuronal RAGE. We suggest that M-CSF, thus generated, contributes to the pathogenesis of AD, and that M-CSF in cerebrospinal fluid might provide a means for monitoring neuronal perturbation at an early stage in AD.

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Show all 16 references

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Metadata

Authors
Du Yan, S., Zhu, H., Fu, J., Yan, S. F., Roher, A., Tourtellotte, W. W., Rajavashisth, T., Chen, X., Godman, G. C., Stern, D., & Schmidt, A. M.
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1997-05-13
Volume
94
Issue
10
Pages
5296-5301
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.94.10.5296
OpenAlex
W2117690477
Cited by
428
References
16
FWCI
12.06
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Amyloid-β peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease. https://app.cochat.ai/papers/10.1073/pnas.94.10.5296
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Du Yan, S., Zhu, H., Fu, J., Yan, S. F., Roher, A., Tourtellotte, W. W., Rajavashisth, T., Chen, X., Godman, G. C., Stern, D., & Schmidt, A. M. (1997). Amyloid-β peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.10.5296

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.