Cited by 455Memory and Neural MechanismsMemory Processes and InfluencesNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Hippocampal Inactivation Disrupts Contextual Retrieval of Fear Memory after Extinction

Open access

Corcoran, Kevin A., Maren, Stephen·2001·The Journal of Neuroscience

DOI 10.1523/jneurosci.21-05-01720.2001PMC PMC6762930

Open this paper in CoChat — free account Open PDF

Abstract

Recent studies implicate the hippocampus in contextual memory retrieval. The present experiments explore this possibility by examining the impact of reversible inactivation of the dorsal hippocampus (DH) on the context-specific expression of extinction. In experiment 1, rats were conditioned to fear a tone conditional stimulus (CS) and subsequently extinguished either in the same context as conditioning or in a novel context. A third group of rats underwent fear conditioning but did not receive extinction. After extinction, conditional fear to the tone CS was assessed in the conditioning context by measuring freezing. Rats extinguished in the conditioning context exhibited low levels of freezing, whereas those extinguished in a different context and those that received no extinction showed high levels of freezing. This indicates that the expression of extinction is context-specific. In experiment 2, the context-specific expression of extinction was disrupted by infusion of muscimol, a GABA(A) receptor agonist, into the DH. Rats that received muscimol infusions into the DH showed little freezing to the tone CS, regardless of whether the CS had been extinguished in the testing context or another context. In experiment 3, intrahippocampal muscimol infusions did not disrupt the expression of conditional freezing to the tone CS in rats that did not receive extinction. Thus, muscimol infusion into the DH produced a selective impairment in the context-specific expression of extinction. These results extend findings from other behavioral paradigms and provide additional support for a role for the hippocampus in contextual memory retrieval.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.21-05-01720.2001

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Encoding specificity and retrieval processes in episodic memory.
Tulving, E., & Thomson, D. M. (1973) · Psychological Review · doi:10.1037/h0020071 · Cited by 4,540
The neuroanatomical and neurochemical basis of conditioned fear
Fendt, M., & Fanselow, M. S. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00016-0 · Cited by 1,092
Memory deficits for implicit contextual information in amnesic subjects with hippocampal damage
Chun, M. M., & Phelps, E. A. (1999) · Nature Neuroscience · doi:10.1038/12222 · Cited by 554

Show all 0 references

Sorted by citations

Items 201–300 of 398

Understanding the dynamic and destiny of memories
Alvares, L. D. O., & Monte, F. H. D. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.03.009 · Cited by 51
“acquisition and retrieval of extinction for both context-dependent fear-associated memories (Bernier et al., 2017; Corcoran et al., 2005; Corcoran and Maren, 2001; Hobin et al., 2006) and reward-associated memories (Bossert and Stern, 2014; Busse and Schwarting, 2016;”
Background
The prelimbic cortex is critical for context-dependent fear expression
Kim, E. J., Kim, N., Kim, H. T., & Choi, J.-S. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00073 · Cited by 37
Roles of hippocampal GABAA and muscarinic receptors in consolidation of context memory and context–shock association in contextual fear conditioning: A double dissociation study
Chang, S., & Liang, K. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.04.004 · Cited by 37
Lesions of the entorhinal cortex or fornix disrupt the context-dependence of fear extinction in rats
Ji, J., & Maren, S. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.07.011 · Cited by 35
“performance of freezing response is not affected [10].”
Self-citation
Network model of fear extinction and renewal functional pathways.
Bruchey, A. K., Shumake, J., & Gonzalez-Lima, F. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.014 · Cited by 37
“Additionally, greater hippocampal activation was observed in the renewal as compared to extinction group, lending further support to the importance of hippocampus in fear renewal (Corcoran and Maren, 2001, Corcoran and Maren, 2004, Corcoran et al., 2005, Ji and Maren, 2005).”
BackgroundResult
Pharmacological enhancement of drug cue extinction learning: translational challenges
Kantak, K. M., & Dhonnchadha, B. Á. N. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05899.x · Cited by 35
Chronic stress, cyclic 17β-estradiol, and daily handling influences on fear conditioning in the female rat
Hoffman, A. N., Armstrong, C. E., Hanna, J. J., & Conrad, C. D. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.08.010 · Cited by 35
Review of EEG Affective Recognition with a Neuroscience Perspective
Lim, R. Y., Lew, W.-C. L., & Ang, K. K. (2024) · Brain Sciences · doi:10.3390/brainsci14040364 · Cited by 38
“…wherein the hippocampus is found to be involved in both the encoding and retrieval of a contextual fear conditioning episode via genetic manipulations and optogenetics [231,232] and that the mPFC plays a crucial role in the maturation, storage, and recall of remote (long-term) fear memory [63].”
Background
Phytocannabinoids modulate emotional memory processing through interactions with the ventral hippocampus and mesolimbic dopamine system: implications for neuropsychiatric pathology
Hudson, R., Rushlow, W. J., & Laviolette, S. R. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4766-7 · Cited by 40
“The hippocampus encodes and consolidates information related to aversive stimuli during fear conditioning (Corcoran and Maren 2001), and can contribute to impairments in identifying safe contexts (Bremner et al. 1993).”
Background
Heightened fear in response to a safety cue and extinguished fear cue in a rat model of maternal immune activation
Sangha, S., Greba, Q., Robinson, P., Ballendine, S., & Howland, J. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00168 · Cited by 33
“…changes in tasks such as prepulse inhibition, latent inhibition, working memory, set shifting, and reversal learning (Meyer et al., 2009; Brown and Derkits, 2010; Brown and Patterson, 2011; Howland et al., 2012; Piontkewitz et al., 2012; Zhang et al., 2012; Dickerson and Bilkey, 2013; Meyer, 2014).”
BackgroundInfluential
Hippocampal activation during contextual fear inhibition related to resilience in the early aftermath of trauma
van Rooij, S. J. H., Ravi, M., Ely, T. D., Michopoulos, V., Winters, S., Shin, J., Marin, M., Milad, M. R., ROTHBAUM, B. O., Ressler, K. J., et al. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113282 · Cited by 38
Issues in the extinction of specific stimulus-outcome associations in Pavlovian conditioning
Delamater, A. R. (2012) · Behavioural Processes · doi:10.1016/j.beproc.2012.03.006 · Cited by 30
Toxicological and pharmacological profile of Amanita muscaria (L.) Lam. – a new rising opportunity for biomedicine
Voynova, M., Shkondrov, A., Kondeva-Burdina, M., & Krasteva, I. (2020) · doi:10.3897/pharmacia.67.e56112 · Cited by 31
“5 mg of muscimol per hemisphere) (Corcoran and Maren 2001) and working memory (at a dose of 0.”
BackgroundMethodInfluential
Opposing effects of d-cycloserine on fear despite a common extinction duration: Interactions between brain regions and behavior
Bolkan, S. S., & Lattal, K. M. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.12.009 · Cited by 28
The Neurobiology of Panic: A Chronic Stress Disorder
Goddard, A. W. (2017) · Chronic Stress · doi:10.1177/2470547017736038 · Cited by 39
Involvement of Dopamine D1/D5 and D2 Receptors in Context-Dependent Extinction Learning and Memory Reinstatement
André, M., & Manahan-Vaughan, D. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00372 · Cited by 30
“Although the hippocampus is believed to be involved in both context-dependent aversive (Corcoran and Maren, 2001), and appetitive, extinction learning (André et al., 2015a,b), these processes are likely to be mediated by different cellular mechanisms: context-dependent fear memory triggers robust…”
Background
Baclofen administration alters fear extinction and GABAergic protein levels
Heaney, C. F., Bolton, M., Murtishaw, A., Sabbagh, J. J., Magcalas, C. M., & Kinney, J. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.09.005 · Cited by 30
Pathway specific activation of ventral hippocampal cells projecting to the prelimbic cortex diminishes fear renewal
Vasquez, J. H., Leong, K.-C., Gagliardi, C. M., Harland, B., Apicella, A., & Muzzio, I. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.03.003 · Cited by 29
Intra-hippocampal administration of ZIP alleviates depressive and anxiety-like responses in an animal model of posttraumatic stress disorder
Ji, L.-L., Tong, L., Xu, B.-K., Fu, C.-H., Shu, W., Peng, J.-B., & Wang, Z. (2014) · Behavioral and Brain Functions · doi:10.1186/1744-9081-10-28 · Cited by 31
Oxytocin and Fear Memory Extinction: Possible Implications for the Therapy of Fear Disorders?
Baldi, E., Costa, A., Rani, B., Passani, M. B., Blandina, P., Romano, A., & Provensi, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810000 · Cited by 35
Mushroom Body Extrinsic Neurons in the Honeybee Brain Encode Cues and Contexts Differently
Hussaini, S. A., & Menzel, R. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1331-12.2013 · Cited by 28
“It appears that contextdependent learning requires an intact hippocampus (Chen et al., 1996; Logue et al., 1997; Holland and Bouton, 1999; Anagnostaras et al., 2001; Corcoran and Maren, 2001), whereas cued learning does not require the hippocampus (Gould et al.”
Background
Role of the basolateral amygdala and NMDA receptors in higher-order conditioned fear
Parkes, S. L., & Westbrook, R. F. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.025 · Cited by 40
“Specifi cally, the hippocampus is thought to process contextual information during fear conditioning, extinction, and renewal (Wilson et al. , 1995 ; Frohardt et al. , 2000 ; Corcoran and Maren , 2001, 2004 ; Ji and Maren , 2005 ; Bouton et al. , 2006 ; Hobin et al. , 2006 ).”
Background
Galanin peptide levels in hippocampus and cortex of galanin-overexpressing transgenic mice evaluated for cognitive performance.
Wrenn, C. C., Marriott, L. K., Kinney, J. W., Holmes, A., Wenk, G., & Crawley, J. N. (2002) · Neuropeptides · doi:10.1016/s0143-4179(02)00111-7 · Cited by 28
Fear conditioning: Insights into learning, memory and extinction and its relevance to clinical disorders
Trent, S., Abdullah, M. H., Parwana, K., Valdivieso, M. A., Hassan, Z., & Müller, C. P. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111310 · Cited by 33
“This phenomenon also demonstrates that cued learning does not occur in isolation from contextual learning, although paradigms can be arranged to tease apart these components (LeDoux, 2000; Maren, 2001).”
Influential
Neuronal Ensembles Organize Activity to Generate Contextual Memory
Marks, W. D., Yokose, J., 北村, 貴., & Ogawa, S. K. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.805132 · Cited by 27
Enhanced Histone Acetylation in the Infralimbic Prefrontal Cortex is Associated with Fear Extinction
Siddiqui, S. A., Singh, S. P., Ranjan, V., Ugale, R. R., Saha, S., & Prakash, A. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0464-6 · Cited by 34
Extra-cellular signal-regulated kinase 1/2 (ERK1/2) activated in the hippocampal CA1 neurons is critical for retrieval of auditory trace fear memory
Huang, C.-H., Chiang, Y.-W., Liang, K., Thompson, R. F., & Liu, I. Y. (2010) · Brain Research · doi:10.1016/j.brainres.2010.02.033 · Cited by 28
Disruption of medial septum and diagonal bands of Broca cholinergic projections to the ventral hippocampus disrupt auditory fear memory
Staib, J. M., Valle, R. R. D., & Knox, D. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.05.009 · Cited by 26
ABA and ABC renewal of conditioned magazine approach are not impaired by dorsal hippocampus inactivation or lesions
Campese, V. D., & Delamater, A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.03.044 · Cited by 25
“While this literature points to the amygdala ([14]; for a review see [15]) and ventromedial prefrontal cortex [16] as being involved in extinction, Maren and colleagues [17,26,18] have also found that the dorsal hippocampus (DH) is especially important in the contextual control of extinction.”
Background
Evidence of a role for multiple memory systems in behavioral extinction.
Gabriele, A., & Packard, M. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.12.004 · Cited by 25
The role of the GABA(A) agonist muscimol on memory performance: reward contingencies determine the nature of the deficit.
Ramirez, D. R., Buzzetti, R. A., & Savage, L. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.06.005 · Cited by 25
The transition from memory retrieval to extinction
Cammarota, M., Barros, D. M., Vianna, M. R. M. R., Bevilaqua, L. R., Coitinho, A. S., Szapiro, G., Izquierdo, L. A., Medina, J. H., & Izquierdo, I. (2004) · Anais da Academia Brasileira de Ciências · doi:10.1590/s0001-37652004000300011 · Cited by 28
“Retrieval has been traditionally considered to depend on the hippocampus (Eldridge et al. 2000, Corcoran and Maren 2001, *Member of Academia Brasileira de Ciências Correspondence to: Dr. Iván Izquierdo E-mail: izquier@terra.com.br Anderson et al. 2004).”
Background
5-HT mechanisms of median raphe nucleus in the conditioned freezing caused by light/foot-shock association.
Avanzi, V., Silva, R. C. B., Macedo, C. E., & Brandão, M. L. (2003) · Physiology and Behavior · doi:10.1016/s0031-9384(03)00029-5 · Cited by 25
Posttraining but not pretraining lesions of the hippocampus interfere with feature‐negative discrimination of fear‐potentiated startle
Heldt, S. A., Coover, G. D., & Falls, W. (2002) · Hippocampus · doi:10.1002/hipo.10033 · Cited by 25
“However, Corcoran and Maren (2001) have recently demonstrated that reversible lesions of the dorsal hippocampus after training by infusion of muscimol, a GABAa receptor agonist, severely reduces the expression of fear outside the extinction context.”
Brain mechanisms controlling Pavlovian fear conditioning.
Yau, J. O.-Y., & McNally, G. P. (2018) · Journal of Experimental Psychology Animal Learning and Cognition · doi:10.1037/xan0000181 · Cited by 35
Neural correlates of fear appeal in advertising: An fMRI analysis
Mostafa, M. M. (2018) · Journal of Marketing Communications · doi:10.1080/13527266.2018.1497680 · Cited by 29
“For example, the hippocampus was implicated in emotional cue acquisition and retrieval (Corcoran and Maren 2001; Kalisch et al. 2006) and in contingency encoding (Cacciaglia et al. 2014).”
Background
Neural measures associated with configural threat acquisition
Stout, D. M., Glenn, D. E., Acheson, D. T., Spadoni, A. D., Risbrough, V. B., & Simmons, A. N. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.03.012 · Cited by 26
Extinction Generates Outcome-Specific Conditioned Inhibition.
Laurent, V., Chieng, B., & Balleine, B. (2016) · Current Biology · doi:10.1016/j.cub.2016.09.021 · Cited by 23
Early adversity disrupts the adult use of aversive prediction errors to reduce fear in uncertainty
Wright, K. M., DiLeo, A., & McDannald, M. A. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00227 · Cited by 23
Dorsal Hippocampal Administration of Triiodothyronine Enhances Long‐Term Memory for Trace Cued and Delay Contextual Fear Conditioning in Rats
Sui, L., Wang, F., Liu, F., Wang, J., & Li, B. (2006) · Journal of neuroendocrinology · doi:10.1111/j.1365-2826.2006.01480.x · Cited by 23
Hippocampal Context Processing during Acquisition of a Predictive Learning Task Is Associated with Renewal in Extinction Recall
Lissek, S., Glaubitz, B., Schmidt-Wilcke, T., & Tegenthoff, M. (2016) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00928 · Cited by 22
SiRNA-mediated serotonin transporter knockdown in the dorsal raphe nucleus rescues single prolonged stress-induced hippocampal autophagy in rats
Wu, Z., Zheng, C., Zhu, Z., Wu, F., Ni, G.-L., & Liang, Y. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.11.056 · Cited by 37
“Specifically,muscimol inactivation of the dorsal hippocampus reduces the rate of extinction and prevents the context dependency of extinction [50,53].”
Background
Contextual learning and context effects during infancy: 30 years of controversial research revisited.
Revillo, D. A., Cotella, E., Paglini, M. G., & Arias, C. (2015) · Physiology and Behavior · doi:10.1016/j.physbeh.2015.02.012 · Cited by 22
The dual-route hypothesis: evaluating a neurocomputational model of fear conditioning in rats
Lowe, R. J., Humphries, M. D., & Ziemke, T. (2009) · Connection Science · doi:10.1080/09540090802414085 · Cited by 21
“Aside from mono-modal sensory cortical structures, the regulatory interplay between the amygdala and orbitofrontal (OFC) cortex has been demonstrated to account for, above all, time-delayed stimulus conditioning and devaluation conditioning (see Cardinal, Parkinson, Hall and Everitt 2002; Balleine, Kilcross and Dickin…”
BackgroundMethod
Temporary inactivation of dorsal hippocampus attenuates explicitly nonspatial, unimodal, contextual fear conditioning.
Parsons, T., & Otto, T. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.03.007 · Cited by 22
“…to be critically involved in the acquisition or retrieval of contextual fear memory and context-specific fear expression without affecting contextual discrimination or performance of the freezing response (Corcoran & Maren, 2001; Holt & Maren, 1999; Matus-Amat, Higgins, Barrientos, & Rudy, 2004).”
The Dorsal Subiculum Mediates the Acquisition of Conditioned Reinstatement of Cocaine-Seeking
Martin-Fardon, R., Ciccocioppo, R., Aujla, H., & Weiss, F. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301589 · Cited by 22
“…of the association between cocaine and the drugrelated context is consistent with literature showing that the hippocampus is a critical substrate for contextual memory (eg Corcoran and Maren, 2001; Holland and Bouton, 1999; Ji and Maren, 2007; Nadel et al, 1985; Phillips and LeDoux, 1992, 1994).”
Result
CDKL5 Deficiency Augments Inhibitory Input into the Dentate Gyrus That Can Be Reversed by Deep Brain Stimulation
Hao, S., Wang, Q., Tang, B., Wu, Z.-Y., Yang, T.-T., & Tang, J.-R. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1010-21.2021 · Cited by 21
“Freezing, defined as an absence of all movement except for respiration (Maren et al., 1994), was scored only if the animal was immobile for at least 1 s (Corcoran and Maren, 2001).”
Background
Using c-Jun to identify fear extinction learning-specific patterns of neural activity that are affected by single prolonged stress
Knox, D., Stanfield, B. R., Staib, J. M., David, N. P., DePietro, T., Chamness, M., Schneider, E. K., Keller, S. M., & Lawless, C. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.037 · Cited by 26
“Differences in contextual features between extinction training and testing can prime fear memory retrieval during extinction testing [2,18,58,59].”
Background
Memory retrieval and its lasting consequences
Izquierdo, I., Vianna, M. R. M. R., Izquierdo, L. A., Barros, D. M., Szapiro, G., Coitinho, A. S., Muller, L., Cammarota, M., Bevilaqua, L. R., & Medina, J. H. (2002) · Neurotoxicity Research · doi:10.1080/10298420290031441 · Cited by 27
“, 2000) and extinction (Corcoran and Maren, 2001) are processed by the hippocampus.”
Influential
A systems-neuroscience model of phasic dopamine.
Mollick, J., Hazy, T. E., Krueger, K. A., Nair, A., Mackie, P., Herd, S. A., & O’Reilly, R. C. (2020) · Psychological Review · doi:10.1037/rev0000199 · Cited by 23
“Further, inactivating hippocampus with muscimol before extinction also produced a lack of either ABC or AAB renewal (Corcoran & Maren, 2001, 2004; Corcoran et al., 2005).”
Activation of medial orbitofrontal cortex abolishes fear extinction and interferes with fear expression in rats
Hsieh, H.-T., & Chang, C. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107170 · Cited by 20
Neural circuits involved in the renewal of extinguished fear
Chen, W., Wang, Y., Wang, X., & Li, H. (2017) · IUBMB Life · doi:10.1002/iub.1636 · Cited by 22
“These findings suggest a role for the dorsal hippocampus in the context-dependent renewal of extinguished fear memories (30).”
BackgroundMethod
Nicotine-Derived Compounds as Therapeutic Tools Against Post-Traumatic Stress Disorder
Barreto, G. E., Yarkov, A., Ávila-Rodriguez, M., Aliev, G., & Echeverrı́a, V. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150710145250 · Cited by 23
“In fact, lesions of the hippocampus greatly affect the contextdependence of extinction in rodents [32, 33].”
Background
Stress and risk avoidance by exploring rats: implications for stress management in fear-related behaviours.
Nemati, F., Kolb, B., & Metz, G. (2013) · Behavioural Processes · doi:10.1016/j.beproc.2012.12.005 · Cited by 20
Genes and neurons: molecular insights to fear and anxiety
Stoppel, C. M., Albrecht, A., Pape, H., & Stork, O. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00229.x · Cited by 21
“Moreover, fear memory extinction is context-specific, and inactiva- tion of the dorsal hippocampus disrupts (cued) fear mem- ory extinction in a context-specific manner (Corcoran & Maren 2001).”
Background
Involvement of D1‐ and D2‐like dopamine receptors in the dentate gyrus in the acquisition, expression, and extinction of the morphine‐induced conditioned place preference in rats
Katebi, N., Farahimanesh, S., Fatahi, Z., Zarrabian, S., & Haghparast, A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.07.018 · Cited by 19
“The HIP is involved in contextual representation and reports indicate that alteration in the context between extinction and testing affects the conditioning fear [50,51].”
NMDA receptors in the avian amygdala and the premotor arcopallium mediate distinct aspects of appetitive extinction learning
Gao, M., Lengersdorf, D., Stüttgen, M. C., & Güntürkün, O. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.01.026 · Cited by 18
A Key Role for Nectin-1 in the Ventral Hippocampus in Contextual Fear Memory
Fantin, M., van der Kooij, M. A., Grosse, J., Krummenacher, C., & Sandi, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056897 · Cited by 19
“Importantly, while the amygdala is also involved in unimodal conditioning, such as auditory cue-shock associations, the role of the hippocampus has been associated with multimodal context-shock associations [15,16,17].”
Background
The role of the ventromedial prefrontal cortex and context in regulating fear learning and extinction.
Gonzalez, S. T., & Fanselow, M. S. (2020) · Psychology & Neuroscience · doi:10.1037/pne0000207 · Cited by 27
“Pre-training and post-training DH lesions, as well as pharmacological DH inactivation, have been shown to impair the context-specificity of fear extinction by reducing renewal (Corcoran & Maren, 2001; Ji & Maren, 2005).”
Background
Characterizing the neural circuitry associated with configural threat learning
Stout, D. M., Glenn, D. E., Acheson, D. T., Simmons, A. N., & Risbrough, V. B. (2019) · Brain Research · doi:10.1016/j.brainres.2019.06.003 · Cited by 22
“Consistent with this, disrupting hippocampal activity via lesion and optogenetic manipulations is associated with reduced configural threat learning and contextual memory retrieval (Anagnostaras et al., 2001; Corcoran and Maren, 2001; Kheirbek et al., 2013).”
Background
Effects of Vivo Morpholino Knockdown of Lateral Hypothalamus Orexin/Hypocretin on Renewal of Alcohol Seeking
Prasad, A. A., & McNally, G. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110385 · Cited by 17
Early-life exposure to fibroblast growth factor-2 facilitates context-dependent long-term memory in developing rats.
Graham, B. M., & Richardson, R. (2010) · Behavioral Neuroscience · doi:10.1037/a0019582 · Cited by 18
CA1‐specific deletion of NMDA receptors induces abnormal renewal of a learned fear response
Hirsch, S., Regmi, N., Birnbaum, S. G., & Greene, R. (2015) · Hippocampus · doi:10.1002/hipo.22457 · Cited by 17
“In other words, the dorsal hippocampus is required for contextual gating; the cued fear response is supressed in both a context in which it was extinguished as well as a novel context (Corcoran and Maren, 2001; Ji and Maren, 2005; Ji and Maren, 2008).”
BackgroundInfluential
Extinction learning is slower, weaker and less context specific after alcohol
Bisby, J., King, J., Sulpizio, V., Dégeilh, F., Curran, H., & Burgess, N. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.07.014 · Cited by 17
“At retrieval, context dictates whether an extinction memory successfully competes with the fear memory (Alvarez, Johnson, & Grillon, 2007; Bouton & King, 1983; Corcoran & Maren, 2001).”
C-fos activation patterns in rat prefrontal cortex during acquisition of a cued classical conditioning task.
Nordquist, R., Pennartz, C., Uylings, H., Joosten, R., Jonker, A., Groenewegen, H., & Voorn, P. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.014 · Cited by 17
Fear Conditioning and Extinction
Graham, B. M., & Milad, M. R. (2016) · Innovations in cognitive neuroscience · doi:10.1007/978-1-4614-3846-5_8 · Cited by 2
Brain Region-Dependent Effects of Neuropeptide Y on Conditioned Social Fear and Anxiety-Like Behavior in Male Mice
Kornhuber, J., & Zoicas, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073695 · Cited by 16
“The septum and the hippocampus are key components of the behavioral inhibition system regulating emotional behavior and cognitive functions, especially learning and memory, and the septohippocampal circuits are important for fear-related behaviors [42,43].”
Background
Input associativity underlies fear memory renewal
Li, W., Wu, Y., Gu, X., Fan, H.-R., Wang, Q., Zhu, J., Yi, X., Wang, Q., Jiang, Q., Li, Y., et al. (2021) · National Science Review · doi:10.1093/nsr/nwab004 · Cited by 17
“It has long been considered that this contextual control of extinguished fear memory critically depends on the hippocampus, as pharmacological inhibition of either the dorsal [30] or ventral [32] areas of this structure leads to a context-independent expression of extinction andprevents fear renewal.”
Dorsal hippocampus plays a causal role in context-induced reinstatement of alcohol-seeking in rats.
Felipe, J., Palombo, P., Bianchi, P., Zaniboni, C. R., Anesio, A., Yokoyama, T., Engi, S. A., Carneiro-de-Oliveira, P. E., Planeta, C. D. S., Leão, R. M., et al. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112978 · Cited by 16
Decreased plasma adiponectin among male firefighters with symptoms of post-traumatic stress disorder
Na, K.-S., Kim, E. K., & Park, J. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.06.015 · Cited by 16
The GABAergic system in prefrontal cortex and hippocampus modulates context-related extinction learning and renewal in humans
Lissek, S., Golisch, A., Glaubitz, B., & Tegenthoff, M. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9662-y · Cited by 16
“…particular brain regions showed that local hippocampal GABA A agonism in rats disrupted contextual fear extinction learning (Corcoran et al. 2005; Corcoran and Maren 2001), a result that closely corresponds to our finding of reduced hippocampal activation associated with impaired extinction…”
Influential
Tumor Necrosis Factor-α Suppresses Sustained Potassium Currents in Rat Small Diameter Sensory Neurons
Liu, B.-G., Dobretsov, M., Stimers, J., & Zhang, J.-M. (2008) · The Open Pain Journal · doi:10.2174/1876386300902010001 · Cited by 16
“Traditionally, retrieval has been related to the hippocampus [64-66].”
Background
Closed-loop brain stimulation augments fear extinction in male rats
Sierra, R. O., Pedraza, L. K., Barcsai, L., Pejin, A., Li, Q., Kozák, G., Takeuchi, Y., Nagy, A. J., Lörincz, M. L., Devinsky, O., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39546-7 · Cited by 16
“Furthermore, inactivation of the hippocampus has been found to enhance extinction to the CS+ and promote low fear expression in environments different from the extinction context 18,19 .”
Background
Decreased level of histone acetylation in the infralimbic prefrontal cortex following immediate extinction may result in deficit of extinction memory
Singh, S. P., Siddiqui, S. A., Tripathy, S., Kumar, S., Saha, S., Ugale, R. R., Modi, D. R., & Prakash, A. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.06.004 · Cited by 14
Kappa opioid receptors mediate where fear is expressed following extinction training.Preprint
Cole, S., Richardson, R., & McNally, G. (2011) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.2049511 · Cited by 15
“There is some evidence that the hippocampus is important for renewal of fear because lesions or temporary inactivation of the dorsal hippocampus (DH) prevent renewal (Corcoran and Maren 2001, 2004; Ji and Maren 2005).”
Background
Cued Fear Conditioning in Carioca High- and Low-Conditioned Freezing Rats
Macêdo-Souza, C., Maisonnette, S. S., Filgueiras, C. C., Landeira-Fernández, J., & Krahe, T. E. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00285 · Cited by 18
Efficacy and mechanisms of non-invasive brain stimulation to enhance exposure therapy: A review
Nuñez, M. C., Zinbarg, R. E., & Mittal, V. A. (2019) · Clinical Psychology Review · doi:10.1016/j.cpr.2019.04.001 · Cited by 15
Intact renewal after extinction of conditioned suppression with lesions of either the retrosplenial cortex or dorsal hippocampus
Todd, T. P., Jiang, M. Y., DeAngeli, N. E., & Bucci, D. J. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.11.033 · Cited by 14
Region-specific roles of the prelimbic cortex, the dorsal CA1, the ventral DG and ventral CA1 of the hippocampus in the fear return evoked by a sub-conditioning procedure in rats.
Fu, J., Xing, X., Han, M., Xu, N., Piao, C.-J., Zhang, Y., & Zheng, X.-G. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.12.006 · Cited by 14
Increased hippocampal volume and gene expression following cognitive behavioral therapy in PTSD
Moustafa, A. A. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00747 · Cited by 13
“Further, many animal and human studies show that the hippocampus is involved in contextual fear responses (Anagnostaras et al., 1999; Corcoran and Maren, 2001; Ji and Maren, 2007; Acheson et al., 2012), such that hippocampal damage leads to increased fear response regardless of the context. fMRI…”
Background
Context Processing in Aging: Older Mice Are Impaired in Renewal of Extinguished Fear
Sanders, M. J. (2011) · Experimental Aging Research · doi:10.1080/0361073x.2011.619874 · Cited by 14
“After a 3-min exposure period, they were exposed to a single tone of 8-min duration (modeled after Corcoran & Maren, 2001).”
BackgroundMethodInfluential
A principal component network analysis of prefrontal-limbic functional magnetic resonance imaging time series in schizophrenia patients and healthy controls
Rǎdulescu, A., & Mujica-Parodi, L. R. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2009.04.017 · Cited by 13
“Conversely, however, studies such as that of Corcoran and Maren (2001) have opened the possibility that hippocampal projections to the B might be important for contextual contributions in fear extinction.”
Result
Renewal and spontaneous recovery, but not latent inhibition, are mediated by gamma-aminobutyric acid in appetitive conditioning.
Delamater, A. R., Campese, V. D., & Westbrook, R. F. (2009) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/a0013293 · Cited by 15
Extract of Ginkgo biloba EGb 761 facilitates fear conditioning measured by fear-potentiated startle.
Yang, Y.-L., Su, Y., Ng, M.-C., Chang, C.-L., & Lu, K.-T. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.04.003 · Cited by 14
Docosahexaenoic Acid Helps to Lessen Extinction Memory in Rats
Hashimoto, M., Hossain, S., Katakura, M., al Mamun, A., & Shido, O. (2018) · Molecules · doi:10.3390/molecules23020451 · Cited by 13
“Memory consolidation and extinction of conditioned fear may be dependent on NMDAR activities in the hippocampus [55,56].”
Background
Off-target potential of AMN082 on sleep EEG and related physiological variables: Evidence from mGluR7 (−/−) mice
Ahnaou, A., Raeyemaekers, L., Huysmans, H., & Drinkenburg, W. H. I. M. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.035 · Cited by 16
Schizophrenia--a parameters' game?
Rǎdulescu, A. R. (2007) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2008.05.009 · Cited by 13
“Conversely however, some studies ( Corcoran and Maren, 2001 ) have opened the possibility that hippocampal projections to the B might be important for contextual contributions in fear extinction.”
Possible Modulation of the Amygdala on Metaplasticity Deficits in the Hippocampal CA1 Field in Early Postnatally Stressed Rats
Hiraide, S., Saito, Y., Matsumoto, M., Yanagawa, Y., Ishikawa, S., Kubo, Y., Inoue, S., Yoshioka, M., & Togashi, H. (2012) · Journal of Pharmacological Sciences · doi:10.1254/jphs.12023fp · Cited by 13
Retrieval from Memory
Urcelay, G., & Miller, R. R. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21004-3 · Cited by 13
Parsing neural circuits of fear learning and extinction across basic and clinical neuroscience: Towards better translation
Namkung, H., Thomas, K. L., Hall, J., & Sawa, A. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.12.025 · Cited by 17
High-dose corticosterone after fear conditioning selectively suppresses fear renewal by reducing anxiety-like response.
Wang, H., Xing, X., Liang, J., Bai, Y.-J., Lui, Z., & Zheng, X.-G. (2014) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2014.06.003 · Cited by 12
“Lastly, after extinction, the hippocampus, which serves as a key structure of glucocorticoid action in the brain, is critical for fear renewal (Corcoran and Maren, 2001, 2004; Ji and Maren, 2005, 2007).”
Dorsal hippocampus inactivation impairs spontaneous recovery of Pavlovian magazine approach responding in rats
Campese, V. D., & Delamater, A. R. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.014 · Cited by 10
Context and the renewal of conditioned taste aversion: the role of rat dorsal hippocampus examined by electrolytic lesion
Fujiwara, H., Sawa, K., Takahashi, M., Lauwereyns, J., Tsukada, M., & Aihara, T. (2012) · Cognitive Neurodynamics · doi:10.1007/s11571-012-9208-y · Cited by 12
Renewal of an extinguished instrumental response: neural correlates and the role of D1 dopamine receptors.
Hamlin, A., Blatchford, K., & McNally, G. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.07.035 · Cited by 12
“Bouton, 2004; Corcoran and Maren, 2001, 2004; Frohardt et al., 2000).”
Early postnatal stress and neural circuit underlying emotional regulation.
Matsumoto, M., Yoshioka, M., & Togashi, H. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)85007-1 · Cited by 12
“Several studies, however, have provided evidence that hippocampus-dependent extinction is involved in contextual encoding processes (Corcoran and Maren, 2001, 2004; Ji and Maren, 2005) and is mediated by protein synthesis-independent mechanisms (Fischer et al., 2004; Lattal and Abel, 2001).”
Background
Development of Comorbid Depression after Social Fear Conditioning in Mice and Its Effects on Brain Sphingolipid Metabolism
Zoicas, I., Mühle, C., Schumacher, F., Kleuser, B., & Kornhuber, J. (2023) · Cells · doi:10.3390/cells12101355 · Cited by 11
“Besides modulating emotional behavior and cognitive functions, the hippocampus regulates fear-related behaviors together with the prefrontal cortex, lateral septum and amygdala [54,55] and processes contextual information, i.”
Background
Fear response failed to return in AAB extinction paradigm accompanied with increased NR2B and GluR1 per845 in hippocampal CA1
Xue, L., Li, Z. D., Chen, Z. X., Wang, X. G., Shi, Y., & Zhao, H. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.12.014 · Cited by 11
“…memory (Kim and Fanselow, 1992; Phillips and LeDoux, 1992), numerous studies have implicated it in the contextual modulation of fear extinction (Corcoran and Maren, 2001, 2004; Corcoran et al., 2005), moreover, different subfields of the hippocampus had different contributions in extinction.”
MethodInfluential
Ventral Hippocampal Kappa Opioid Receptors Mediate the Renewal of Fear following Extinction in the Rat
Cole, S., Richardson, R., & McNally, G. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058701 · Cited by 12
“In light of the prior studies demonstrating involvement of the DH in the renewal of fear [5,23], it might seem surprising that here infusion of norBNI into the DH had no significant effect.”
BackgroundInfluential
The Basolateral Amygdala: The Core of a Network for Threat Conditioning, Extinction, and Second-Order Threat Conditioning
Sepahvand, T., Power, K. D., Qin, T., & Yuan, Q. (2023) · Biology · doi:10.3390/biology12101274 · Cited by 17
“The role of hippocampus, which is reciprocally connected to the BLA [131], has been shown to play a role in threat extinction and renewal [132].”
Update on neurobiological mechanisms of fear: illuminating the direction of mechanism exploration and treatment development of trauma and fear-related disorders
Li, Y., Zhi, W., Qi, B., Wang, L., & Hu, X. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1216524 · Cited by 16
“For example, inactivating the HPC using pharmacological techniques impairs the renewal of extinguished memory (Corcoran and Maren, 2001; Ji and Maren, 2008).”
Method

Authors: Corcoran, K. A., & Maren, S.
Affiliations: University of Michigan (US)
ORCID: Maren, Stephen
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2001-03-01
Volume: 21
Issue: 5
Pages: 1720-1726
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.21-05-01720.2001
PMC: PMC6762930
OpenAlex: W1525373779
Cited by: 455
References: 0
Citations by year: 2026: 6 · 2025: 6 · 2024: 14 · 2023: 15 · 2022: 6 · 2021: 19 · 2020: 18 · 2019: 17 · 2018: 17 · 2017: 21 · 2016: 21 · 2015: 20 · 2014: 26 · 2013: 30 · 2012: 25
FWCI: 8.22
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Deep Blue (University of Michigan) (submittedVersion)
Funders: National Institutes of Health (5r29mh057865-03)
National Institute of Mental Health (MH57865)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: hippocampus, dorsal hippocampus, fear memory, fear extinction, muscimol, GABAA receptor, fear conditioning, freezing behavior, hippocampal inactivation
MeSH terms: Acoustic Stimulation, Animals, Behavior, Animal, Conditioning, Classical, Cues, Electroshock, Extinction, Psychological, Fear, Hippocampus, Infusions, Parenteral, Male, Memory, Microinjections, Muscimol, GABA Agonists, Rats, Long-Evans, Rats, GABA-A Receptor Agonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hippocampal Inactivation Disrupts Contextual Retrieval of Fear Memory after Extinction

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks