The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Hippocampal Inactivation Disrupts Contextual Retrieval of Fear Memory after Extinction
Open accessAbstract
Recent studies implicate the hippocampus in contextual memory retrieval. The present experiments explore this possibility by examining the impact of reversible inactivation of the dorsal hippocampus (DH) on the context-specific expression of extinction. In experiment 1, rats were conditioned to fear a tone conditional stimulus (CS) and subsequently extinguished either in the same context as conditioning or in a novel context. A third group of rats underwent fear conditioning but did not receive extinction. After extinction, conditional fear to the tone CS was assessed in the conditioning context by measuring freezing. Rats extinguished in the conditioning context exhibited low levels of freezing, whereas those extinguished in a different context and those that received no extinction showed high levels of freezing. This indicates that the expression of extinction is context-specific. In experiment 2, the context-specific expression of extinction was disrupted by infusion of muscimol, a GABA(A) receptor agonist, into the DH. Rats that received muscimol infusions into the DH showed little freezing to the tone CS, regardless of whether the CS had been extinguished in the testing context or another context. In experiment 3, intrahippocampal muscimol infusions did not disrupt the expression of conditional freezing to the tone CS in rats that did not receive extinction. Thus, muscimol infusion into the DH produced a selective impairment in the context-specific expression of extinction. These results extend findings from other behavioral paradigms and provide additional support for a role for the hippocampus in contextual memory retrieval.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Reversible inactivation of the dorsal hippocampus, through either pharmacologic or chemogenetic means, interferes with context-specific information of a threat memory [40, 41].”
From Prefrontal cortex, amygdala, and threat processing: implications for PTSD (2022) · cites this paper as [40]
In the citing paper
“Also consistent with animal models (e.g., [40]), research suggests that the hippocampus is involved in contextual modulation of extinction and works in concert with the PFC during contextual extinction learning.”
From Prefrontal cortex, amygdala, and threat processing: implications for PTSD (2022) · cites this paper as [40]
Citations
Cites
Encoding specificity and retrieval processes in episodic memory.
Tulving, E., & Thomson, D. M. (1973) · Psychological Review · doi:10.1037/h0020071 · Cited by 4,540
The neuroanatomical and neurochemical basis of conditioned fear
Fendt, M., & Fanselow, M. S. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00016-0 · Cited by 1,092
Memory deficits for implicit contextual information in amnesic subjects with hippocampal damage
Chun, M. M., & Phelps, E. A. (1999) · Nature Neuroscience · doi:10.1038/12222 · Cited by 554
Cited by
Sorted by citations
Items 301–398 of 398
Duan, Q., Huang, F., Li, S.-J., Chen, K., Gong, L., Qi, J., Yang, Z.-H., Yang, T., Li, F., & Li, C.-Q. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108255 · Cited by 10
Posterior parietal cortex mediates fear renewal in a novel context
Joo, B., Koo, J. W., & Lee, S. (2020) · Molecular Brain · doi:10.1186/s13041-020-0556-y · Cited by 14
Bender, C. L., Giachero, M., Mutis, R. C., Molina, V. A., & Calfa, G. D. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.09.002 · Cited by 12
Mohammadkhani, R., Darbandi, N., Vafaei, A. A., Ahmadalipour, A., & Rashidy‐Pour, A. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.12.011 · Cited by 9
“…and that both hippocampal lesions and the administration of specific GR agonists such as RU 28362 into the hippocampus disrupt the retrieval of contextual and/or spatial information (Corcoran & Maren, 2001; Moser & Moser, 1998; Roozendaal, Griffith, Buranday, Dominique, & McGaugh, 2003).”
BackgroundMineralocorticoid receptors in the ventral hippocampus are involved in extinction memory in rats
Xing, X., Wang, H., Liang, J., Bai, Y., Liu, Z., & Zheng, X. (2014) · PsyCh Journal · doi:10.1002/pchj.58 · Cited by 9
Neuroanatomical Structures Underlying the Extinction of Drug-Seeking Behavior
Cleva, R. M., & Gass, J. T. (2013) · The Open Addiction Journal · doi:10.2174/18749410010030200063 · Cited by 6
“In this study, control animals maintained a preference for the cocaine-paired chamber until their sixth extinction session whereas DCS treated animals extinguished a cocaine CPP after only three extinction sessions and maintained a neutral preference in extinction tests 3 and 14 days later [81].”
MethodNeural and Molecular Mechanisms of Fear Memory
Schafe, G. E., & LeDoux, J. E. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00045-0 · Cited by 11
Ma, Y., Jiao, F., Batsikadze, G., Yavari, F., & Nitsche, M. A. (2024) · Brain Stimulation · doi:10.1016/j.brs.2024.07.004 · Cited by 9
Musical experience prior to traumatic exposure as a resilience factor: a conceptual analysis
Fraile, E., Gagnepain, P., Eustache, F., Groussard, M., & Platel, H. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1220489 · Cited by 15
“In this case, impairment of the hippocampus, a key structure for memory, may be manifested by intrusions and/or disturbances in the encoding of contextual aspects of the traumatic event (Corcoran and Maren, 2001; Brewin et al., 2010).”
BackgroundGuo, X., Liu, X., Wang, J., Lu, S., Yu, M., Zhang, Y., Sun, B., Huang, B., Lu, X., Li, X., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02496-1 · Cited by 9
Nucleus reuniens inactivation does not impair consolidation or reconsolidation of fear extinctionPreprint
Vasudevan, K., Ramanathan, K. R., Vierkant, V., & Maren, S. (2022) · Learning & Memory · doi:10.1101/lm.053611.122 · Cited by 11
“This work has revealed a critical role for neural activity in the hippocampus (HPC) (Corcoran and Maren 2001; Corcoran et al. 2005; Tronson et al. 2009; Marek et al. 2018; Lacagnina et al. 2019), amygdala (Falls et al. 1992; Sotres-Bayon et al. 2007; Laurent et al. 2008; Zimmerman and Maren 2010;…”
Self-citationExtinction of Contextual Fear with Timed Exposure to Enriched Environment: A Differential Effect
Hegde, P., O'Mara, S., & Laxmi, T. (2017) · Annals of Neurosciences · doi:10.1159/000475898 · Cited by 9
Park, K., Song, B., Kim, J., Hong, I., Song, S., Lee, J., Park, S., Kim, J., An, B., Lee, H. W., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100108 · Cited by 11
“The dorsal hippocampus plays a critical role in ABC renewal [15,16], but not ABA renewal [4,17].”
BackgroundKnox, D., Fitzpatrick, C. J., George, S. A., Abelson, J., & Liberzon, I. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.03.002 · Cited by 9
Hippocampal ensembles regulate circuit-induced relapse of extinguished fear
Hassell, J. E., Pérez, A. D. A., Vasudevan, K., Ressler, R. L., Garcia, G. M., Parr, M., Vierkant, V., Bayer, H., & Maren, S. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03064-3 · Cited by 10
“Consistent with this, previous work shows that pharmacological inactivation of the HPC reduces the renewal of fear to an extinguished CS when tested outside the extinction context [31, 33 – 35].”
Self-citationAdkins, J. M., Lynch, J. F., Gray, M., & Jasnow, A. M. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05831-w · Cited by 9
“Additionally, given the role of the dorsal CA1 region of the hippocampus and the basolateral amygdala in fear extinction, renewal, and generalization, we targeted those two regions (Corcoran et al. 2005; Corcoran and Maren 2001; Corcoran and Maren 2004; Lynch III et al. 2017; Maren et al. 1996; Ortiz et al. 2019; Shab…”
BackgroundMethodFear renewal requires nitric oxide signaling in the lateral amygdala.
Song, S., Lee, J., Park, S., & Choi, S. (2019) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2019.12.038 · Cited by 8
Fear renewal activates cyclic adenosine monophosphate signaling in the dentate gyrus
Shi, Y.-W., Fan, B.-F., Xue, L., Wang, X.-G., & Ou, X.-L. (2019) · Brain and Behavior · doi:10.1002/brb3.1280 · Cited by 8
“Rats were anesthetized with sodium pentobarbital (65 mg/kg, i.p.) (Corcoran & Maren, 2001; Hobin, Ji, & Maren, 2006) and were sub‐ sequently secured in a stereotaxic apparatus (RWD Life Science, Shenzhen, China).”
MethodRelationships between GAT1 and PTSD, Depression, and Substance Use Disorder
Bountress, K. E., Wei, W., Sheerin, C. M., Chung, D., Amstadter, A. B., Mandel, H., & Wang, Z. (2017) · Brain Sciences · doi:10.3390/brainsci7010006 · Cited by 14
“These findings are consistent with research suggesting that GAT1 may impact anxious behaviors [12,13] and fear extinction [9] in rats.”
BackgroundResultInfluentialLaBar, K. S., & LeDoux, J. E. (2006) · CRC Press eBooks · doi:10.1201/9781420004205.ch7 · Cited by 10
Enhancing cognition: The power of neuroplasticity
Mukhtar, I., & Iftikhar, K. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102882 · Cited by 7
Knox, D., & Parikh, V. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105569 · Cited by 8
Wang, Q., Tang, B., Hao, S., Wu, Z., Yang, T., & Tang, J. (2023) · Brain stimulation · doi:10.1016/j.brs.2023.09.002 · Cited by 7
“Freezing, defined as an absence of any movement except for respiration [34], was scored only if the animal was immobile for at least 1 s [35].”
Collins, B., Biddle, M., Wood, D. R., Boyapati, S., Barth, M., Jeun, C., & Knox, D. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114579 · Cited by 7
Hippocampal Arc protein expression and conditioned fear
Hudgins, C. D., & Otto, T. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.04.004 · Cited by 8
Russo, A. S., Lee, J., & Parsons, R. G. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05195-2 · Cited by 7
O’Connor, R. M., McCafferty, C. P., Bravo, J. A., Singewald, N., Holmes, A., & Cryan, J. F. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5031-4 · Cited by 9
Integration of contextual cues into memory depends on “prefrontal” N-methyl-D-aspartate receptors
Starosta, S., Bartetzko, I., Stüttgen, M. C., & Güntürkün, O. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.05.012 · Cited by 8
“For example, Maren and Hobin (2007) reported that context-dependent neuronal activity in the amygdala was mediated by the hippocampus and inactivation of the hippocampus led to an impairment in context-specific memory retrieval (Corcoran & Maren, 2001).”
Tano, M. C., Molina, V. A., & Pedreira, M. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12328 · Cited by 7
“Therefore, it is generally accepted that the activation of the GABAA receptors during acquisition seems to impair extinction memory formation (Kamano, 1972; Goldman, 1977; Corcoran & Maren, 2001; Hart et al., 2009).”
BackgroundZarrindast, M., Mashayekhi, M., Rezayof, A., & Ahmadi, S. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.11.004 · Cited by 7
“One-trial inhibitory avoidance (IA) task is a much used conditioned fear paradigm that affects some molecular systems required for IA memory located in the hippocampus (Cammarota et al., 2008; Corcoran & Maren, 2001; Izquierdo et al., 2008).”
BackgroundFunctional Neuroimaging in Post-Traumatic Stress Disorder
Liberzon, I., & Garfinkel, S. N. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-329-9_14 · Cited by 19
Rabinak, C. A., Zimmerman, J. M., Chang, C.-H., & Orsini, C. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2130-08.2008 · Cited by 7
“The expression of extinction is also context dependent, and hippocampal modulation of either the prefrontal cortex or amygdala may mediate this phenomenon (Corcoran and Maren, 2001; Maren and Quirk, 2004).”
BackgroundMaren, S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21090-0 · Cited by 5
Self-citationKim, E. J., Park, S., Schuessler, B. P., Boo, H., Cho, J., & Kim, J. J. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116081 · Cited by 10
“36–41 fMRI studies in humans and single-unit recordings in animals performing probabilistic/delay-discounting tasks link decision-making to mPFC and dHPC activity.”
Golisch, A., Heba, S., Glaubitz, B., Tegenthoff, M., & Lissek, S. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00034 · Cited by 6
“, 2013) as well as during fear extinction respectively recall (Corcoran and Maren, 2001; Corcoran et al., 2005; Kalisch et al., 2006; Milad et al., 2007).”
BackgroundExtinction of relapsed fear does not require the basolateral amygdala
Lingawi, N. W., Westbrook, R. F., & Laurent, V. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.01.005 · Cited by 7
“…this brain region to subsequently control the retrieval of extinction via its projections to the IL (Corcoran, Desmond, Frey, & Maren, 2005; Corcoran & Maren, 2001; Duvarci & Pare, 2014; Ji & Maren, 2007, but see Campese & Delamater, 2013; Frohardt, Guarraci, & Bouton, 2000; Todd, Jian,…”
Philpot, R. M. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1528-y · Cited by 6
Pharmacological Studies of the Molecular Basis of Memory Extinction
Vianna, M. R. M. R., Cammarota, M., Coitinho, A. S., Medina, J. H., & Izquierdo, I. (2003) · Current Neuropharmacology · doi:10.2174/1570159033360539 · Cited by 6
Unambiguous representation of overlapping serial events in the rat hippocampal formation.
Furusawa, A., Hori, E., Umeno, K., Tabuchi, E., Ono, T., & Nishijo, H. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.09.002 · Cited by 6
Zuniga, A., Han, J., Miller-Crews, I., Agee, L. A., Hofmann, H. A., & Drew, M. R. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01897-0 · Cited by 13
“Disruption of hippocampal activity both interferes with extinction learning [4 – 6] and can alter generalization of the extinction memory to other contexts [7 – 9].”
Sepahvand, T., Nazari, N., Qin, T., Rajani, V., & Yuan, Q. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2309986120 · Cited by 7
“Further research suggests that anatomically distinct populations in the BLA facilitate threat learning or extinction via unique circuitry (17) and that neuronal responses are extinction context - dependent (18), a role for which the hippocampus is critical (19, 20).”
BackgroundThe effectiveness of extinction training in male rats: temporal considerations and brain mechanisms.
Correia, P., Demeter, K., Varga, J., Urbán, E., Török, B., Balázsfi, D., Bakos, N., Haller, J., & Zelena, D. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114285 · Cited by 5
“The medial prefrontal cortex (mPFC) [22,24,42], amygdala [21,32, 34] and hippocampus (HC) [12,4] are all heavily involved in the extinction of conditioned fear and may undergo structural and functional changes [31,52,55].”
BackgroundMemory reconsolidation and extinction of fear conditioning induced different Arc/Arg3.1 expression
Zhu, L., Zhu, L., Huang, Y., Shi, W., & Yu, B. (2018) · Neuroreport · doi:10.1097/wnr.0000000000001069 · Cited by 6
Shih, C.-W., & Chang, C.-H. (2023) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2023.107800 · Cited by 4
The dorsal hippocampus’ role in context-based timing in rodents
Corte, B. J. D., Farley, S. J., Heslin, K. A., Parker, K., & Freeman, J. (2022) · bioRxiv · doi:10.1101/2022.01.10.475732 · Cited by 4
Neuroimaging in PTSD-Related Psychotherapies
Pagani, M., & Cavallo, M. (2014) · Springer eBooks · doi:10.1007/978-3-642-40384-2_15 · Cited by 6
Principles of extinction learning of nonaversive experience
Uengoer, M., Lissek, S., Tegenthoff, M., Manahan‐Vaughan, D., & Lachnit, H. (2020) · e-Neuroforum · doi:10.1515/nf-2020-0013 · Cited by 5
Reduced renewal of conditioned suppression following lesions of the dorsal hippocampus in male rats
Tavakkoli, A., Fournier, D. I., Bucci, D. J., & Todd, T. P. (2020) · Behavioral Neuroscience · doi:10.1037/bne0000379 · Cited by 4
“Indeed, even in studies of conditioned freezing a role for the hippocampus in ABA renewal is not clear, with some negative (e.g., Corcoran & Maren, 2001) and some positive results (e.g., Ji & Maren, 2005).”
BackgroundResultNeural Basis of Fear Conditioning
Bush, D. E. A., Schafe, G. E., & LeDoux, J. E. (2009) · Wiley eBooks · doi:10.1002/9780470478509.neubb002039 · Cited by 4
Carnicella, S., de Vasconcelos, A. P., Pain, L., Majchrzak, M., & Oberling, P. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.03.005 · Cited by 4
Neurobiology of traumatic stress disorders and their impact on physical health
Ford, J. D., Grasso, D. J., Elhai, J. D., & Courtois, C. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801288-8.00005-4 · Cited by 6
The hippocampus as a generative model
Nalluru, S., Glitz, L., Przygodda, X., Mancini, V., & Barron, H. C. (2026) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2025.0247 · Cited by 1
“A mature and intact hippocampus appears necessary to infer new latent causes in response to rapid extinction, as both adult rats with hippocampal lesions and young rats with an intact hippocampus display a lack of renewal behaviour following fear conditioning with rapid extinction [51–53].”
Buehler, S. K., Lowther, M., Lukow, P. B., Kirk, P., Pike, A., Yamamori, Y., Chavanne, A., Gormley, S., Goble, T., Tuominen, E. W., et al. (2024) · Communications Psychology · doi:10.1038/s44271-024-00128-y · Cited by 3
“Animal work, which has since been replicated in humans 79 , has also experimentally demonstrated disrupted context-dependent retrieval of threat-related memories when the hippocampus was inactivated via GABA receptor agonism 80 .”
Zuniga, A., Han, J., Miller-Crews, I., Agee, L., Hofmann, H. A., & Drew, M. R. (2024) · bioRxiv · doi:10.1101/2023.12.31.573787 · Cited by 3
“Disruption of hippocampal activity both interferes with extinction learning [4–6] and can alter generalization of the extinction memory to other contexts [7–9].”
BackgroundPre-extinction activation of hippocampal AMPK prevents fear renewal in mice.
Wang, C.-M., Zhang, Y.-F., Lin, Z.-Q., Cai, Y.-F., Fu, X.-Y., & Lin, Z.-H. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105099 · Cited by 3
Fernández, R. S., Moyano, M. D., Radloff, M., Campos, J., Tano, M. C., Allegri, R., Pedreira, M. E., & Forcato, C. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.03.014 · Cited by 3
“Furthermore, it has been shown that GABAergic transmission is responsible for the inhibition of the original memory expression (Corcoran & Maren, 2001; Harris & Westbrook, 1998).”
BackgroundThe Role of Mitogen-Activated Protein Kinase in Treatment Strategies for Fear and Drug Addiction
Mary, R., Andrew, J., & Hyun, J. (2012) · InTech eBooks · doi:10.5772/36756 · Cited by 2
“…into this neural circuitry, to account for the context www.intechopen.com The Role of Mitogen-Activated Protein Kinase in Treatment Strategies for Fear and Drug Addiction 345 effects on extinction (Bouton et al., 2006; Corcoran & Maren, 2001; Myers & Davis, 2007; Sotres-Bayon et al., 2006).”
BackgroundDelayed impairment of response extinction after single seizures induced by picrotoxin.
Arkhipov, V. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00271-6 · Cited by 3
Maeng, L. Y., & Milad, M. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802114-9.00003-2 · Cited by 2
Urcelay, G., & Miller, R. R. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00075-9 · Cited by 3
Effects of ayahuasca on fear and anxiety: cross-talk between 5HT1A and 5HT2A receptors
Guerra, L. T. L., SANTOS, R. G. D., & Hallak, J. E. C. (2024) · Psychedelics. · doi:10.61373/pp024i.0037 · Cited by 3
McDonald, R. J., Kopp, J., Zelinski, E., Sutherland, R. J., Lehmann, H., Sparks, F. T., & Hong, N. S. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2311205 · Cited by 2
“The hippocampus and related circuits have been implicated in certain forms of context, spatial, and relational [7–9] learning and memory functions.”
Qin, T., Xia, Y., Nazari, N., Sepahvand, T., & Yuan, Q. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1355140 · Cited by 3
“…is achieved through a coordination of circuitry which includes inhibitory neurons of the amygdala, hippocampus and infralimbic prefrontal cortex (Corcoran and Maren, 2001; Herry and Mons, 2004; Burgos-Robles et al., 2007; Mueller et al., 2008; Sotres-Bayon et al., 2009; Lacagnina et al., 2019).”
BackgroundThalamic nucleus reuniens coordinates prefrontal-hippocampal synchrony to suppress extinguished fear
Totty, M. S., Ramanathan, K. R., Jin, J., Peters, S. E., & Maren, S. (2022) · bioRxiv · doi:10.1101/2022.11.11.516165 · Cited by 2
Self-citationEarly pharmacological interventions for acute traumatic stress symptoms: a network meta-analysis
Bertolini, F., Robertson, L., Ostuzzi, G., Meader, N., Bisson, J. I., Churchill, R. C., & Barbui, C. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013613 · Cited by 2
Schafe, G. E. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-415804-7.00013-7 · Cited by 4
The Neural Substrates of Fear Extinction
Lueken, U., & Maslowski, N. I. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3342-2_5 · Cited by 3
Maren, S. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00129-7 · Cited by 2
Self-citationThe Search for Neurophysiological Mechanisms of Configural Learning
Chernyshev, B., Ushakov, V. L., & Poznyak, L. A. (2024) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-024-01723-6 · Cited by 1
Patterns of Brain Activity During the Configural and Elemental Associative Learning in Mice
Ivashkina, O. I., Toropova, K. A., Roshchina, M. A., Ivanova, A., & Anokhin, K. V. (2024) · International Conference Neurotechnologies and Neurointerfaces (CNN) · doi:10.1109/cnn63506.2024.10705833 · Cited by 1
“Numerous pharmacological and optogenetic studies have confirmed that hippocampal lesions or inactivation impair both configural learning and the corresponding memory retrieval [22, 34-37].”
BackgroundPedraza, L. K., Sierra, R. O., Barcsai, L., Li, Q., Pejin, A., Gellért, L., Lörincz, M. L., & Berényi, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.30.591894 · Cited by 1
Neurobiology of Posttraumatic Stress Disorder
Carletto, S., Panero, M., Cavallo, M., & Pagani, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-57231-0_11 · Cited by 3
Bertolini, F., Robertson, L., Ostuzzi, G., Meader, N., Bisson, J. I., Churchill, R. C., & Barbui, C. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013443 · Cited by 1
Potential Mechanisms Underlying the Facilitation of Fear Memory Extinction by Cotinine
Echeverrı́a, V., & Iarkov, A. (2013) · Journal of Advances in Medicine and Medical Research · doi:10.9734/bjmmr/2014/5219 · Cited by 1
“In addition, local hippocampal lesions diminish the context-dependence of extinction in rodents [18,19].”
BackgroundRebello, T. J. (2012) · doi:10.7916/d8bv7pq3 · Cited by 1
“to context (Phillips and LeDoux 1992; Chen et al., 1996; Corcoran and Maren, 2001; Bast et al., 2001; Anagnostaras et al., 2001; Bast et al., 2003).”
Fear conditioning- and extinction-induced neuronal plasticity in the mouse amygdala
Ciocchi, S. (2009) · edoc (University of Basel) · doi:10.5451/unibas-004840917 · Cited by 1
“2000), processes contextual information during fear conditioning, extinction and renewal (Corcoran and Maren 2001; Corcoran, Desmond et al. 2005; Bouton, Westbrook et al. 2006).”
BackgroundInfluentialHammerman, E., Penna, S. R., Gonzalez, S. E., Patel, S., Roebuck, C., Lock, E., Desmond, C., Fukunaga, Y., Maloy, G. C., & Cazares, V. A. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02577-x
Neuromodulation to Augment Cognitive-behaviour Therapy for Obsessive-compulsive Disorder
Reddy, S., Kumar, A., Venkatasubramanian, G., & Arumugham, S. S. (2026) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-026-00322-8
“The hippocampus contributes contextual regulation, specifying when extinction memories are expressed and mediating fear renewal under context shifts [60, 63].”
Predicting individual differences of fear and cognitive learning and extinction
Gomes, C. A., Bach, D. R., Razi, A., Batsikadze, G., Elsenbruch, S., Engler, H., Ernst, T., Fellner, M.-C., Fraenz, C., Genç, E., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71830-0 · Cited by 1
“Indeed, fear renewal increases connectivity between HIP andPFC 35 , inactivation of eitherofthese twocomponents reduces fear renewal 62,63 , and both PFC and HIP activity during extinction is positively correlated with renewal in predictive learning 21 – 23 .”
Foo, M., Himawan, K. K., & Susanto, E. (2025) · Mental Health Review Journal · doi:10.1108/mhrj-01-2024-0003
Brown, A., Martins, M., Richard, I., & Chaudhri, N. (2022) · bioRxiv · doi:10.3758/s13420-023-00583-3
“Other aversive conditioning tasks, such as Pavlovian fear conditioning and conditioned suppression, allow assessment of only passive coping behaviours such as freezing (e.g., Bouton & Bolles, 1979; Bouton & King, 1983; Corcoran & Maren, 2001; Hobin et al., 2003).”
Closed-loop brain stimulation to reduce pathologic fearPreprint
Sierra, R. O., Pedraza, L., Barcsai, L., Pejin, A., Kozák, G., Takeuchi, Y., Lőrincz, M., Devinsky, O., Buzsáki, G., & Berényi, A. (2022) · bioRxiv · doi:10.1101/2022.07.24.501314
DaSilva, J. K., Lei, Y., Morrison, A., & Tejani-butt, S. (2022) · Medicinal Chemistry Research · doi:10.1007/s00044-022-02865-3
Xing, X., Fu, J., Wang, H., & Zheng, X.-G. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147398
Battaglia, S. (2020) · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna) · doi:10.6092/unibo/amsdottorato/9085
“(Corcoran and Maren, 2001; 2004; Hobin et al, 2006).”
The neural circuitry of fear conditioning : a theoretical account
Angelhuber, M. (2016) · doi:10.5451/unibas-007077296
Chamizo, A. M. (2012) · InTech eBooks · doi:10.5772/47761
“The hippocampus seems to be involved in memory processes and contextual learning [136], mainly in the paradigm of fear conditioning and in spatial tasks, such as the Morris water-maze [137-139].”
Neuroimaging and posttraumatic stress disorder
Garfinkel, S., & Liberzon, I. (2009) · CRC Press eBooks · doi:10.3109/9781841847207-6
Kim, E.-J., 김, 남., 권, 정., Kim, H.-T., & Choi, J.-S. (2007) · 한국심리학회지: 인지 및 생물 · doi:10.22172/cogbio.2007.19.4.006
Role of the endogenous opioid system in addiction to alcohol and cocaine
Burattini, C. (2007) · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna) · doi:10.6092/unibo/amsdottorato/444
“Several studies have tested the dependence of conditioned responding on the training environment using similar attributes to form distinct contexts (Frankland et al., 1998, Corcoran and Maren, 2001, Burwell et al., 2004).”
BackgroundSenn, V. (2009) · edoc (University of Basel) · doi:10.5451/unibas-004970335
“Inactivation of the HC in mice leads to a severe deficit in spatial and contextual learning (Corcoran and Maren, 2001).”
BackgroundParsons, T. (2008) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t3wh2qcq
“The role of dorsal hippocampus in contextual fear conditioning has been examined using both temporary inactivation (Corcoran & Maren, 2001; Holt & Maren, 1999) and multiple means of producing permanent damage (Maren 1999; Maren & Fanselow, 1997; Otto & Poon, 2006).”
BackgroundMethodEffects of the number and spacing of conditioning sessions on spontaneous recovery from extinction
Papachristos, E. B. (2008) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t3h70g56 · Cited by 1
“…curves reveals that, like acquisition curves, they too are gradual (Amsel, 1962; Bouton & Garcia-Gutierrez, 2006; Cain, Blouin, & Barad, 2003; Corcoran & Maren, 2001; Kamprath & Wotjak, 2004; Lewis, 1956; Milad & Quirk, 2002; Moody, Sunsay, & Bouton, 2006; Quirk, Garcia, & Gonzalez-Lima,…”
Neural mechanisms underlying extinction of emotional memory
Yamada, K., & Ichitani, Y. (2008) · Japanese Journal of Physiological Psychology and Psychophysiology · doi:10.5674/jjppp1983.26.27
Chapter 3.4 Spatio-temporal context and object recognition memory in rodents
Good, M. A. (2008) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(08)00217-8
Herry, C., & Garcia, R. (2004) · Kluwer Academic Publishers eBooks · doi:10.1007/1-4020-7949-4_6
“Behaviorally, we know that if CS–US pairings and repeated CS-alone presentations take place in the same context, further presentations of the CS in a different environment preferentially activate the expression of traumatic memory (Frohardt et al., 2000; Corcoran and Maren, 2001 ).”
BackgroundInfluential
Metadata
- Authors
- Corcoran, K. A., & Maren, S.
- Affiliations
- University of Michigan (US)
- ORCID
- Maren, Stephen
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-03-01
- Volume
- 21
- Issue
- 5
- Pages
- 1720-1726
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6762930
- OpenAlex
- W1525373779
- Cited by
- 455
- References
- 0
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 14 · 2023: 15 · 2022: 6 · 2021: 19 · 2020: 18 · 2019: 17 · 2018: 17 · 2017: 21 · 2016: 21 · 2015: 20 · 2014: 26 · 2013: 30 · 2012: 25
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institutes of Health (5r29mh057865-03)
- National Institute of Mental Health (MH57865)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampus, dorsal hippocampus, fear memory, fear extinction, muscimol, GABAA receptor, fear conditioning, freezing behavior, hippocampal inactivation
- MeSH terms
- Acoustic Stimulation, Animals, Behavior, Animal, Conditioning, Classical, Cues, Electroshock, Extinction, Psychological, Fear, Hippocampus, Infusions, Parenteral, Male, Memory, Microinjections, Muscimol, GABA Agonists, Rats, Long-Evans, Rats, GABA-A Receptor Agonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
