The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Functional interaction between opioid and cannabinoid receptors in drug self-administration.
Open accessAbstract
The present study was designed to explore the relationship between the cannabinoid and opioid receptors in animal models of opioid-induced reinforcement. The acute administration of SR141716A, a selective central cannabinoid CB1 receptor antagonist, blocked heroin self-administration in rats, as well as morphine-induced place preference and morphine self-administration in mice. Morphine-dependent animals injected with SR141716A exhibited a partial opiate-like withdrawal syndrome that had limited consequences on operant responses for food and induced place aversion. These effects were associated with morphine-induced changes in the expression of CB1 receptor mRNA in specific nuclei of the reward circuit, including dorsal caudate putamen, nucleus accumbens, and septum. Additionally, the opioid antagonist naloxone precipitated a mild cannabinoid-like withdrawal syndrome in cannabinoid-dependent rats and blocked cannabinoid self-administration in mice. Neither SR141716A nor naloxone produced any intrinsic effect on these behavioral models. The present results show the existence of a cross-interaction between opioid and cannabinoid systems in behavioral responses related to addiction and open new strategies for the treatment of opiate dependence.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Evidence from pre-clinical studies demonstrates that antagonists of opioid receptors were able to reduce discriminative stimulus and reinforcing effects produced by the activation of CB1 receptors 71, 72.”
From Psychosocial and pharmacological interventions for the treatment of cannabis use disorder (2018) · cites this paper as [71]
Citations
Cites
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Ledent, C. A., Valverde, O., Cossu, G., Petitet, F., Aubert, J.-F., Beslot, F., Böhme, G. A., Impérato, A., Pedrazzini, T., Roques, B. P., et al. (1999) · Science · doi:10.1126/science.283.5400.401 · Cited by 3,628
Self-citationMechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913
Determination and characterization of a cannabinoid receptor in rat brain
Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443 · cited 2×
“It is composed by the cannabinoid CB1 receptor (Devane et al., 1988; Matsuda et al., 1993), several endogenous lipid transmitters, including anandamide (Devane et al.”
BackgroundHerkenham, M., Lynn, A., Johnson, M., Melvin, L., de Costa, B., & Rice, K. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00563.1991 · Cited by 2,159
Naltrexone in the Treatment of Alcohol Dependence
Volpicelli, J. R. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820110040006 · Cited by 1,828
SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
Rinaldi, M. L., Barth, F., Héaulme, M., Shire, D. J., Calandra, B., Congy, C., Martinez, S., Maruani, J., Neliat, G., Caput, D., et al. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00773-x · Cited by 1,762
Matthes, H. W. D., Maldonado, R., Simonin, F., Valverde, O., Slowe, S., Kitchen, I., Befort, K., Dierich, A., Le Meur, M., Dollé, P., et al. (1996) · Nature · doi:10.1038/383819a0 · Cited by 1,722
Self-citationA second endogenous cannabinoid that modulates long-term potentiation
Stella, N., Schweitzer, P., & Piomelli, D. (1997) · Nature · doi:10.1038/42015 · Cited by 1,496
Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications
Mansour, A., Fox, C. A., Akil, H., & Watson, S. J. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93946-u · Cited by 1,297
Molecular and Cellular Basis of Addiction
Nestler, E. J., & Aghajanian, G. K. (1997) · Science · doi:10.1126/science.278.5335.58 · Cited by 1,295
Endogenous Opioids: Biology and Function
Akil, H., Watson, S. J., Young, E. A., Lewis, M. E., Khachaturian, H., & Walker, J. M. (1984) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.07.030184.001255 · Cited by 1,224
Tanda, G., Pontieri, F. E., & Chiara, G. D. (1997) · Science · doi:10.1126/science.276.5321.2048 · Cited by 1,085
Koob, G. F., Sanna, P. P., & Bloom, F. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80557-7 · Cited by 1,026
Self-citationDopamine activation of endogenous cannabinoid signaling in dorsal striatum
Giuffrida, A., Parsons, L. H., Kerr, T. M., de Fonseca, F. R., Navarro, M. A., & Piomelli, D. (1999) · Nature Neuroscience · doi:10.1038/7268 · Cited by 782
Self-citationLocalization of cannabinoid receptor mRNA in rat brain
Matsuda, L. A., Bonner, T. I., & Lolait, S. J. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903270406 · Cited by 631
Opioids: first lessons from knockout mice
Kieffer, B. L. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(98)01279-6 · Cited by 501
Activation of Corticotropin-Releasing Factor in the Limbic System During Cannabinoid Withdrawal
Rodrı́guez de Fonseca, F., Carrera, M. R. A., Navarro, M., Koob, G. F., & Weiss, F. (1997) · Science · doi:10.1126/science.276.5321.2050 · Cited by 499
Self-citationPharmacology of Cannabinoid Receptors
Howlett, A. C. (1995) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.003135 · Cited by 493
Cloning and pharmacological characterization of a rat μ opioid receptor
Thompson, R. C., Mansour, A., Akil, H., & Watson, S. J. (1993) · Neuron · doi:10.1016/0896-6273(93)90120-g · Cited by 451
Absence of opiate rewarding effects in mice lacking dopamine D2 receptors
Maldonado, R. J., Saiardi, A., Valverde, O., Samad, T. A., Roques, B. P., & Borrelli, E. (1997) · Nature · doi:10.1038/41567 · Cited by 436
Self-citationCANNABINOID RECEPTORS AND THEIR ENDOGENOUS AGONISTS
Felder, C. C., & Glass, M. (1998) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.38.1.179 · Cited by 400
Pharmacological and biochemical interactions between opioids and cannabinoids
Manzanares, J., Corchero, J., Romero, J., Fernández‐Ruíz, J., Ramos, J. A., & Fuentes, J. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01339-5 · Cited by 391
Tanda, G., Munzar, P., & Goldberg, S. R. (2000) · Nature Neuroscience · doi:10.1038/80577 · Cited by 347
Chen, J., Paredes, W. M., Li, J., Smith, D. M., Lowinson, J. H., & Gardner, E. L. (1990) · Psychopharmacology · doi:10.1007/bf02245916 · Cited by 329
Sim, L. J., Hampson, R. E., Deadwyler, S. A., & Childers, S. R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-24-08057.1996 · Cited by 314
Chaperon, F., Soubrié, P., Puech, A. J., & Thiébot, M.-H. (1998) · Psychopharmacology · doi:10.1007/s002130050518 · Cited by 292
Gellert, V. F., & Holtzman, S. G. (1978) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)31261-9 · Cited by 265
Sim, L., De, S., Si, D., & Childers, S. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02684.1996 · Cited by 263
Cannabinoid Transmission and Reward-Related Events
Gardner, E. L., & Vorel, S. R. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0219 · Cited by 253
Martín, M., Ledent, C. A., Parmentier, M., Maldonado, R. J., & Valverde, O. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00287.x · Cited by 237
Self-citationIncreased motivation for beer in rats following administration of a cannabinoid CB1 receptor agonist
Gallate, J. E., Saharov, T., Mallet, P. E., & McGregor, I. S. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00170-3 · Cited by 235
Colombo, G., Agabio, R., Fà, M., Guano, L., Loche, A., Reali, R., & Gessa, G. L. (1998) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a008368 · Cited by 226
Heinrichs, S. C., Menzaghi, F., Schulteis, G., Koob, G. F., & Stinus, L. (1995) · Behavioural Pharmacology · doi:10.1097/00008877-199501000-00011 · Cited by 226
Self-citationDelfs, J. M., Kong, H., Mestek, A., Chen, Y., Yu, L., Reisine, T., & Chesselet, M. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903450104 · Cited by 213
Welch, S. P., & Stevens, D. L. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10720-9 · Cited by 208
Self-administration of the cannabinoid receptor agonist WIN 55,212-2 in drug-naive mice
Martellotta, M. C., Cossu, G., Fattore, L., Gessa, G. L., & Fratta, W. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00052-9 · Cited by 205
Self-citationHutcheson, D. M., Tzavara, E. T., Smadja, C., Valjent, E., Roques, B. P., Hanoune, J., & Maldonado, R. J. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702228 · Cited by 194
Self-citationMesolimbic dopaminergic decline after cannabinoid withdrawal
Diana, M., Melis, M., Muntoni, A. L., & Gessa, G. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.10269 · Cited by 192
Cannabinoid receptor gene (CNR1): association with IV drug use
Comings, D. E., Muhleman, D. R., Gade, R., Johnson, P., Verde, R., Saucier, G., & MacMurray, J. P. (1997) · Molecular Psychiatry · doi:10.1038/sj.mp.4000247 · Cited by 175
Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats.
Diana, M., Pistis, M., Muntoni, A. L., & Gessa, G. L. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24484-6 · Cited by 170
CB1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats
Navarro, M., Chowen, J., Carrera, M. R. A., del Arco, I., Villanúa, M. A., Martin, Y., Roberts, A. J., Koob, G. F., & de Fonseca, F. R. (1998) · NeuroReport · doi:10.1097/00001756-199810260-00012 · Cited by 152
Self-citationMorphine-Dependent Rats: Blockade of Precipitated Abstinence by Tetrahydrocannabinol
Hine, B., Friedman, E., Torrelio, M., & Gershon, S. (1975) · Science · doi:10.1126/science.1167428 · Cited by 125
Mascia, M. S., Obinu, M. C., Ledent, C. A., Parmentier, M., Böhme, G. A., Impérato, A., & Fratta, W. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00656-1 · Cited by 125
Self-citationVela, G., Ruiz-gayo, M., & Fuentes, J. A. (1995) · Neuropharmacology · doi:10.1016/0028-3908(95)00032-2 · Cited by 118
Valverde, O., Ledent, C. A., Beslot, F., Parmentier, M., & Roques, B. P. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00929.x · Cited by 112
Self-citationde Fonseca, F. R., Roberts, A. J., Bilbao, A., Koob, G. F., & Navarro, M. (1999) · PubMed · Cited by 103
Self-citationGenetic analysis of drug addiction: the role of cAMP response element binding protein
Blendy, J. A., & Maldonado, R. J. (1998) · Journal of Molecular Medicine · doi:10.1007/s001090050197 · Cited by 100
Self-citationde Fonseca, F. R., Rubio, P., Martı́n-Calderón, J. L., Caine, S. B., Koob, G. F., & Navarro, M. A. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)00708-f · Cited by 95
Self-citationBasavarajappa, B. S., & Hungund, B. L. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01072-5 · Cited by 90
Pugh, G., Mason, D. J., Combs, V., & Welch, S. P. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36640-6 · Cited by 81
Modulation of rat brain cannabinoid receptors after chronic morphine treatment
Rubino, T., Tizzoni, L., Viganò, D., Massi, P., & Parolaro, D. (1997) · Neuroreport · doi:10.1097/00001756-199710200-00007 · Cited by 77
Cannabinoid modulation of drug reward and the implications of marijuana legalization
Covey, D. P., Wenzel, J. M., & Cheer, J. F. (2014) · Brain Research · doi:10.1016/j.brainres.2014.11.034 · Cited by 75
Preferential inhibition of inducible nitric oxide synthase by ebselen
Hattori, R., Inoue, R., Sase, K., Eizawa, H., Kosuga, K., Aoyama, T., Masayasu, H., Kawai, C., Sasayama, S., & Yui, Y. (1994) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(94)90179-1 · Cited by 62
Rubino, T., Massi, P., Viganò, D., Fuzio, D., & Parolaro, D. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00547-6 · Cited by 61
Molecular Mechanisms of Opiate Receptor Coupling to G Proteins and Effector Systemsa
Reisine, T., Law, S. F., Blake, A. D., & Tallent, M. K. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb15121.x · Cited by 55
Heroin self-administration in dependent Wistar rats: increased sensitivity to naloxone
Carrera, M. R. A., Schulteis, G., & Koob, G. F. (1999) · Psychopharmacology · doi:10.1007/s002130050983 · Cited by 45
Self-citationMartin, T. J., Kim, S. A., Cannon, D. G., Sizemore, G. M., Bian, D., Porreca, F., & Smith, J. E. (2000) · PubMed · Cited by 28
δ-9-Tetrahydrocannabinol regulates substance P and enkephalin mRNAs levels in the caudate-putamen
Mailleux, P., & Vanderhaeghen, J. (1994) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(94)90234-8 · Cited by 22
Busiguina, Argente, J., García‐Segura, L. M., & Chowen, J. A. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00416.x · Cited by 19
Self-citationMason, D. J., Lowe, J. A., III, & Welch, S. P. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00542-7 · Cited by 19
Martin, T. J., Kim, S. A., Cannon, D. G., Sizemore, G. M., Bian, D., Porreca, F., & Smith, J. E. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39161-x · Cited by 17
Research works printed but not linked: 1
- Caine SB Lintz R Koob GF (1993) Intravenous drug self-administration techniques in animals. in Behavioral neuroscience: a practical approach, ed Sahgal A (Oxford UP, Oxford), pp 117–143.
Cited by
Sorted by citations
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077
Tzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336
Pierce, R. C., & Kumaresan, V. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.016 · Cited by 913
Involvement of the endocannabinoid system in drug addiction
Maldonado, R. J., Valverde, O., & Berrendero, F. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.01.008 · Cited by 601
Self-citationTHE ENDOCANNABINOID SYSTEM: PHYSIOLOGY AND PHARMACOLOGY
de Fonseca, F. R., del Arco, I., Bermúdez‐Silva, F. J., Bilbao, A., Cippitelli, A., & Navarro, M. (2004) · Alcohol and Alcoholism · doi:10.1093/alcalc/agh110 · Cited by 419
Self-citation
Metadata
- Authors
- Navarro, M., Carrera, M. R. A., Fratta, W., Valverde, O., Cossu, G., Fattore, L., Chowen, J. A., Gómez, R., del Arco, I., Villanúa, M. A., Maldonado, R., Koob, G. F., & de Fonseca, F. R.
- Affiliations
- Scripps Research Institute (US)
- University of Cagliari (IT)
- Universitat Pompeu Fabra (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Universidad Complutense de Madrid (ES)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-07-15
- Volume
- 21
- Issue
- 14
- Pages
- 5344-5350
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6762870
- OpenAlex
- W1699530412
- Cited by
- 378
- References
- 63
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 7 · 2023: 5 · 2022: 13 · 2021: 7 · 2020: 10 · 2019: 5 · 2018: 14 · 2017: 14 · 2016: 11 · 2015: 12 · 2014: 18 · 2013: 18 · 2012: 14
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Funders
- Sanofi
- Comunidad de Madrid
- Universidad Complutense de Madrid
- Consiglio Nazionale delle Ricerche
- National Institutes of Health
- Plan Nacional sobre Drogas
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 26741, P01DK026741)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- opioid-cannabinoid interaction, CB1 receptor, SR141716A, naloxone, heroin self-administration, morphine self-administration, place preference, opioid withdrawal, cannabinoid withdrawal, reward systems, nucleus accumbens, caudate-putamen, septum, addiction, opioid use disorder
- MeSH terms
- Rimonabant, Animals, Avoidance Learning, Cannabinoids, Caudate Nucleus, Conditioning, Operant, Heroin, Disease Models, Animal, Heroin Dependence, Male, Morphine, Morphine Dependence, Naloxone, Narcotic Antagonists, Nucleus Accumbens, Piperidines, Putamen, Pyrazoles, Receptors, Drug, Receptors, Opioid, RNA, Messenger, Self Administration, Rats, Wistar, Septum of Brain, Receptors, Cannabinoid, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
