Localization of cannabinoid receptor mRNA in rat brain
Abstract
Cannabinoid receptor mRNA was localized in adult rat brain by 35S-tailed oligonucleotide probes and in situ hybridization histochemistry. Labelling is described as uniform or non-uniform depending on the relative intensities of individual cells expressing cannabinoid receptor mRNA within a given region or nucleus. Uniform labelling was found in the hypothalamus, thalamus, basal ganglia, cerebellum and brainstem. Non-uniform labelling that resulted from the presence of cells displaying two easily distinguishable intensities of hybridization signals was observed in several regions and nuclei in the forebrain (cerebral cortex, hippocampus, amygdala, certain olfactory structures). Olfactory-associated structures, basal ganglia, hippocampus, and cerebellar cortex displayed the heaviest amounts of labelling. Many regions that displayed cannabinoid receptor mRNA could reasonably be identified as sources for cannabinoid receptors on the basis of well documented hodologic data. Other sites that were also clearly labelled could not be assigned as logical sources of cannabinoid receptors. The localization of cannabinoid receptor mRNA indicates that sensory, motor, cognitive, limbic, and autonomic systems should all be influenced by the activation of this receptor by either exogenous cannabimimetics, including marijuana, or the yet unknown endogenous "cannabinoid" ligand.
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CB1 receptors are localized to the central nervous system and periphery and are found in sites associated with pain processing, including the periaqueductal gray, rostral ventromedial medulla, thalamus, dorsal root ganglia, amygdala, and cortex.
“CB1 receptors are localized to the central nervous system (CNS) and the periphery. CB1 receptors are found in sites associated with pain processing, including the periaqueductal gray (PAG),8 rostral ventromedial medulla (RVM),8 thalamus,9 dorsal root ganglia (DRG),10 amygdala,8 and cortex8.”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [9]
Cites
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011 · see citing works
Handbook of Chemical Neuroanatomy
Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,159 · see citing works
Determination and characterization of a cannabinoid receptor in rat brain
Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443 · see citing works
Cannabinoid receptor localization in brain.
Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321 · see citing works
Herkenham, M., Lynn, A., Johnson, M., Melvin, L., de Costa, B., & Rice, K. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00563.1991 · Cited by 2,159 · see citing works
Cerebellar Cortex: Cytology and Organization
Palay, S. L., & Chan‐Palay, V. (1974) · Medical Entomology and Zoology · Cited by 1,679 · see citing works
Palay, S. L., & Chan‐Palay, V. (1974) · Springer eBooks · doi:10.1007/978-3-642-65581-4 · Cited by 1,527 · see citing works
Kelley, A. E., Domesick, V. B., & Nauta, W. J. H. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90067-7 · Cited by 888 · see citing works
Jones, E. G., & Leavitt, R. Y. (1974) · The Journal of Comparative Neurology · doi:10.1002/cne.901540402 · Cited by 882 · see citing works
Efferent connections of the habenular nuclei in the rat
Herkenham, M. A., & Nauta, W. J. H. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901870103 · Cited by 855 · see citing works
Beckstead, R. M. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901840104 · Cited by 792 · see citing works
de Olmos, J. S., Hardy, H., & Heimer, L. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901810202 · Cited by 712 · see citing works
Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells.
Mackie, K., & Hille, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.3825 · Cited by 693 · see citing works
Mailleux, P., & Vanderhaeghen, J. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90409-u · Cited by 663 · see citing works
Ribak, C. E., Vaughn, J. E., & Saito, K. (1978) · Brain Research · doi:10.1016/0006-8993(78)90463-8 · Cited by 628 · see citing works
Neuronal localization of cannabinoid receptors in the basal ganglia of the rat
Herkenham, M. A., Lynn, A. B., de Costa, B. R., & Richfield, E. K. (1991) · Brain Research · doi:10.1016/0006-8993(91)90970-7 · Cited by 515 · see citing works
Hollister, L. E. (1987) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(87)90030-4 · Cited by 499 · see citing works
Cholecystokinin innervation of the ventral striatum: A morphological and radioimmunological study
Záborszky, L., Alheid, G. F., Beinfeld, M. C., Eiden, L. E., Heimer, L., & Palkovits, M. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90302-1 · Cited by 489 · see citing works
Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs.
Howlett, A. C., Qualy, J. M., & Khachatrian, L. (1986) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10219-8 · Cited by 470 · see citing works
Dewey, W. L. (1987) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(87)90061-4 · Cited by 377 · see citing works
Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms
Limbird, L. E. (1988) · The FASEB Journal · doi:10.1096/fasebj.2.11.2840317 · Cited by 344 · see citing works
Cortico-striate interrelations in the albino rat.
Webster, K. E. (1961) · PubMed · Cited by 328 · see citing works
The cannabinoid receptor: biochemical, anatomical and behavioral characterization
Howlett, A. C., Bidaut‐Russell, M., Devane, W. A., Melvin, L. S., Johnson, M. R., & Herkenham, M. A. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90124-s · Cited by 312 · see citing works
Neuronal localisation of neuropeptide Y gene expression in rat brain
MORRIS, B. J. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902900305 · Cited by 292 · see citing works
Veening, J. G., Cornelissen, F. M., & Lieven, P. A. J. M. (1980) · Neuroscience · doi:10.1016/0306-4522(80)90198-0 · Cited by 289 · see citing works
The Olfactory Cortex and the Ventral Striatum
Heimer, L. (1978) · Springer eBooks · doi:10.1007/978-1-4757-0716-8_7 · Cited by 283 · see citing works
Caulfield, M. P., & Brown, D. A. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14321.x · Cited by 280 · see citing works
GABAergic cells in the dentate gyrus appear to be local circuit and projection neurons
Seress, L., & Ribak, C. E. (1983) · Experimental Brain Research · doi:10.1007/bf00239181 · Cited by 266 · see citing works
Structure of the granular layer of the rat dentate gyrus. A light microscopic and Golgi study.
Seress, L., & Pokorny, J. (1981) · PubMed · Cited by 246 · see citing works
Selective dendritic transport of RNA in hippocampal neurons in culture
Davis, L. A., Banker, G. A., & Steward, O. (1987) · Nature · doi:10.1038/330477a0 · Cited by 216 · see citing works
Cannabinoid Receptors and Modulation of Cyclic AMP Accumulation in the Rat Brain
Bidaut‐Russell, M., Devane, W. A., & Howlett, A. C. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb08815.x · Cited by 208 · see citing works
The thalamostriatal projection in the cat
Beckstead, R. M. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902230302 · Cited by 206 · see citing works
Central chemosensitivity: A respiratory drive
Schlaefke, M. E. (1981) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bfb0034080 · Cited by 199 · see citing works
Price, J. L., & Powell, T. P. S. (1970) · PubMed · Cited by 190 · see citing works
Single subthalamic nucleus neurons project to both the globus pallidus and substantia nigra in rat
van der Kooy, D., & Hattori, T. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901920409 · Cited by 189 · see citing works
Fukuda, Y., & Loeschcke, H. H. (1977) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00580780 · Cited by 185 · see citing works
Young, W. S., Alheid, G., & Heimer, L. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-06-01626.1984 · Cited by 179 · see citing works
Cannabis: Effects on memory and the cholinergic limbic system.
Miller, L. L., & Branconnier, R. J. (1983) · Psychological Bulletin · doi:10.1037/0033-2909.93.3.441 · Cited by 136 · see citing works
Switzer, R. C., Hill, J., & Heimer, L. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90005-7 · Cited by 131 · see citing works
Cell configurations in the olfactory tubercle of the rat
Millhouse, O. E., & Heimer, L. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902280409 · Cited by 129 · see citing works
Hammond, C., & Yelnik, J. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90009-x · Cited by 124 · see citing works
Neuronal localization of cannabinoid receptors and second messengers in mutant mouse cerebellum
Herkenham, M. A., Groen, B. G. S., Lynn, A. B., Costa, B., & Richfield, E. K. (1991) · Brain Research · doi:10.1016/0006-8993(91)90096-e · Cited by 111 · see citing works
Cloning and expression of a novel rat GABA A receptor
Lolait, S. J., O’Carroll, A., Kusano, K., Jm, M., Brownstein, M., & Mahan, L. C. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)80271-6 · Cited by 107 · see citing works
Fallon, J. H. (1983) · Brain Research Bulletin · doi:10.1016/0361-9230(83)90210-1 · Cited by 85 · see citing works
Scott Young, III, Warden, M. K., & Mezey, É. (2008) · Neuroendocrinology · doi:10.1159/000124858 · Cited by 68 · see citing works
Topography and synaptology of mamillary body projections to the mesencephalon and pons in the rat
Allen, G. V., & Hopkins, D. A. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903010206 · Cited by 66 · see citing works
Behavioral role of the mammillary efferent system
Field, T. D., Rosenstock, J., King, E. C., & Greene, E. G. (1978) · Brain Research Bulletin · doi:10.1016/0361-9230(78)90074-6 · Cited by 56 · see citing works
Ablations of the mammillary nuclei in monkeys: Effects on postoperative memory
Holmes, E. J., Jacobson, S., Stein, B. M., & Butters, N. (1983) · Experimental Neurology · doi:10.1016/0014-4886(83)90160-7 · Cited by 53 · see citing works
Campbell, K. A., Foster, T. C., Hampson, R. E., & Deadwyler, S. A. (1986) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23359-6 · Cited by 30 · see citing works
The role of the habenula in the respiratory response of the rabbit to warmth or to restraint
Cragg, B. G. (1961) · Experimental Neurology · doi:10.1016/0014-4886(61)90035-8 · Cited by 22 · see citing works
Identification of projecting neurons in rat neostriatal slices
Misgeld, U., Frotscher, M., & Wagner, A. (1984) · Brain Research · doi:10.1016/0006-8993(84)90721-2 · Cited by 19 · see citing works
DELTA-9-TETRAHYDROCANNABINOL: SITE OF ACTION FOR AUTONOMIC EFFECTS
Hosko, M. J., Schmeling, W. T., & Hardman, H. F. (1984) · Elsevier eBooks · doi:10.1016/b978-0-12-044620-9.50048-8 · Cited by 6 · see citing works
Flagged first, then by citations
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Sorted by citations
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Howlett, A. C., Barth, F., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., Felder, C. C., Herkenham, M., Mackie, K., Martin, B. R., et al. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.161 · Cited by 2,819 · see citing works
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
Tsou, K., Brown, S., Sañudo-Peña, M. C., Mackie, K., & Walker, J. M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00436-3 · Cited by 1,586 · see citing works
Role of Endogenous Cannabinoids in Synaptic Signaling
Freund, T. F., Katona, I., & Piomelli, D. (2003) · Physiological Reviews · doi:10.1152/physrev.00004.2003 · Cited by 1,567 · see citing works
Endocannabinoid-Mediated Control of Synaptic Transmission
Kano, M., Ohno‐Shosaku, T., Hashimotodani, Y., Uchigashima, M., & Watanabe, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00019.2008 · Cited by 1,529 · see citing works
Endocannabinoid Signaling in the Brain
Wilson, R. I., & Nicoll, R. A. (2002) · Science · doi:10.1126/science.1063545 · Cited by 1,260 · see citing works
Katona, I., Sperlágh, B., Sı́k, A., Käfalvi, A., Vizi, E. S., Mackie, K., & Freund, T. F. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04544.1999 · Cited by 1,218 · see citing works
CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity
Marsicano, G., Goodenough, S., Monory, K., Hermann, H., Eder, M., Cannich, A., Azad, S. C., Cascio, M. G., Gutiérrez, S. O., van der Stelt, M., et al. (2003) · Science · doi:10.1126/science.1088208 · Cited by 1,208 · see citing works
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
Zimmer, A., Zimmer, A. M., Hohmann, A. G., Herkenham, M. A., & Bonner, T. I. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5780 · Cited by 1,065 · see citing works
Marsicano, G., & Lutz, B. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00847.x · Cited by 937 · see citing works
Kreitzer, A. C., & Regehr, W. G. (2001) · Neuron · doi:10.1016/s0896-6273(01)00246-x · Cited by 873 · see citing works
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance
Pagotto, U., Marsicano, G., Cota, D., Lutz, B., & Pasquali, R. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0009 · Cited by 856 · see citing works
Ohno‐Shosaku, T., Maejima, T., & Kano, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00247-1 · Cited by 846 · see citing works
Functional Role of High-Affinity Anandamide Transport, as Revealed by Selective Inhibition
Beltramo, M., Stella, N., Calignano, A., Lin, S. Y., Makriyannis, A., & Piomelli, D. (1997) · Science · doi:10.1126/science.277.5329.1094 · Cited by 813 · see citing works
The effects of cannabinoids on the brain
Ameri, A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00087-2 · Cited by 805 · see citing works
Distribution of cannabinoid receptors in the central and peripheral nervous system
Mackie, K. (2005) · Handbook of Experimental Pharmacology · doi:10.1007/3-540-26573-2_10 · Cited by 744 · see citing works
The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus
Monory, K., Massa, F., Egertová, M., Eder, M., Blaudzun, H., Westenbroek, R., Kelsch, W., Jacob, W., Marsch, R., Ekker, M., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.006 · Cited by 706 · see citing works
Katona, I., Rancz, E. A., Acsády, L., Ledent, C., Mackie, K., Hájos, N., & Freund, T. F. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09506.2001 · Cited by 668 · see citing works
Cannabinoid Receptors: Where They are and What They do
Mackie, K. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01671.x · Cited by 638 · see citing works
Mackie, K., Lai, Y. Y., Westenbroek, R. E., & Mitchell, R. A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06552.1995 · Cited by 626 · see citing works
CB2: a cannabinoid receptor with an identity crisis
Atwood, B. K., & Mackie, K. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00729.x · Cited by 633 · see citing works
Shen, M., Piser, T. M., Seybold, V. S., & Thayer, S. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04322.1996 · Cited by 605 · see citing works
Maejima, T., Hashimoto, K., Yoshida, T., Aiba, A., & Kano, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00375-0 · Cited by 556 · see citing works
Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons
Twitchell, W., Brown, S., & Mackie, K. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.1.43 · Cited by 544 · see citing works
Han, J., Kesner, P., Metna-Laurent, M., Duan, T., Xu, L., Georges, F., Koehl, M., Abrous, D. N., Mendizabal-Zubiaga, J., Grandes, P., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.037 · Cited by 514 · see citing works
Cristino, L., PETROCELLIS, L. D., Pryce, G., Baker, D., Guglielmotti, V., & Marzo, V. D. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.074 · Cited by 489 · see citing works
Giuffrida, A., Leweke, F. M., Gerth, C. W., Schreiber, D., Koethe, D., Faulhaber, J., Klosterkötter, J., & Piomelli, D. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300558 · Cited by 481 · see citing works
Felder, C. C., Briley, E. M., Axelrod, J., Simpson, J. T., Mackie, K., & Devane, W. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7656 · Cited by 478 · see citing works
Melis, M., Pistis, M., Perra, S., Muntoni, A. L., Pillolla, G., & Gessa, G. L. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4503-03.2004 · Cited by 478 · see citing works
Bouaboula, M., Perachon, S., Milligan, L., Canat, X., Rinaldi, M. L., Portier, M., Barth, F., Calandra, B., Pecceu, F., Lupker, J. H., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.35.22330 · Cited by 461 · see citing works
Svíženská, I. H., Dubový, P., & Šulcová, A. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.05.010 · Cited by 459 · see citing works
Sim, L. J., Selley, D. E., & Childers, S. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7242 · Cited by 455 · see citing works
Central neurocircuitry associated with emesis
Hornby, P. J. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00849-x · Cited by 431 · see citing works
Molina‐Holgado, E., Vela, J. M., Arévalo‐Martín, Á., Almazán, G., Molina‐Holgado, F., Borrell, J. I., & Guaza, C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09742.2002 · Cited by 420 · see citing works
The neurobiology and evolution of cannabinoid signalling
Elphick, M. R., & Egertová, M. (2001) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0787 · Cited by 416 · see citing works
THE ENDOCANNABINOID SYSTEM: PHYSIOLOGY AND PHARMACOLOGY
de Fonseca, F. R., del Arco, I., Bermúdez‐Silva, F. J., Bilbao, A., Cippitelli, A., & Navarro, M. (2004) · Alcohol and Alcoholism · doi:10.1093/alcalc/agh110 · Cited by 409 · see citing works
Cadas, H., di Tomaso, E., & Piomelli, D. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-04-01226.1997 · Cited by 394 · see citing works
Striatal dopamine neurotransmission: Regulation of release and uptake
Sulzer, D., Cragg, S. J., & Rice, M. E. (2016) · Basal Ganglia · doi:10.1016/j.baga.2016.02.001 · Cited by 382 · see citing works
Functional interaction between opioid and cannabinoid receptors in drug self-administration.
Navarro, M., Carrera, M. R. A., Fratta, W., Valverde, O., Cossu, G., Fattore, L., Chowen, J. A., Gómez, R., del Arco, I., Villanúa, M. A., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05344.2001 · Cited by 378 · see citing works
Uchigashima, M., Narushima, M., Fukaya, M., Katona, I., Kano, M., & Watanabe, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0448-07.2007 · Cited by 375 · see citing works
Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra
French, E. D., Dillon, K. A., & Wu, X. (1997) · Neuroreport · doi:10.1097/00001756-199702100-00014 · Cited by 374 · see citing works
Michaela, E., & Elphick, M. R. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000626)422:2 · Cited by 364 · see citing works
Rodriguez, J. J., Mackie, K., & Pickel, V. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-03-00823.2001 · Cited by 363 · see citing works
Cerebellar Depolarization-Induced Suppression of Inhibition Is Mediated by Endogenous Cannabinoids
Kreitzer, A. C., & Regehr, W. G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-j0005.2001 · Cited by 353 · see citing works
Egertová, M., Cravatt, B. F., & Elphick, M. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00145-3 · Cited by 347 · see citing works
Tsou, K., Mackie, K., Sañudo-Peña, M. C., & Walker, J. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00086-x · Cited by 343 · see citing works
Anandamide Amidohydrolase Activity in Rat Brain Microsomes
Desarnaud, F., Cadas, H., & Piomelli, D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.11.6030 · Cited by 336 · see citing works
Bodor, Á. L., Katona, I., Nyíri, G., Mackie, K., Ledent, C., Hájos, N., & Freund, T. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0442-05.2005 · Cited by 325 · see citing works
Egertová, M., Giang, D. K., Cravatt, B. F., & Elphick, M. R. (1998) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1998.0543 · Cited by 333 · see citing works
An Amino-terminal Variant of the Central Cannabinoid Receptor Resulting from Alternative Splicing
Shire, D. J., Carillon, C., Kaghad, M., Calandra, B., Rinaldi, M. L., Fur, G. L., Caput, D., & Ferrara, P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.8.3726 · Cited by 330 · see citing works
Gubellini, P., Picconi, B., Bari, M., Battista, N., Calabresi, P., Centonze, D., Bernardi, G., Finazzi‐Agrò, A., & Maccarrone, M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-16-06900.2002 · Cited by 321 · see citing works
Olfaction Under Metabolic Influences
Palouzier‐Paulignan, B., Lacroix, M. C., Aimé, P., Baly, C., Caillol, M., Congar, P., Julliard, A., Tucker, K. R., & Fadool, D. A. (2012) · Chemical Senses · doi:10.1093/chemse/bjs059 · Cited by 318 · see citing works
Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside
Rahn, E. J., & Hohmann, A. G. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.08.002 · Cited by 305 · see citing works
Hohmann, A. G., & Herkenham, M. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00524-7 · Cited by 301 · see citing works
Ohno‐Shosaku, T., Tsubokawa, H., Mizushima, I., Yoneda, N., Zimmer, A., & Kano, M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-10-03864.2002 · Cited by 301 · see citing works
Cannabis and psychosis/schizophrenia: human studies
D’Souza, D. C., Sewell, R. A., & Ranganathan, M. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-009-0024-2 · Cited by 292 · see citing works
Auclair, N., Otani, S., Soubrié, P., & Crépel, F. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.6.3287 · Cited by 293 · see citing works
van der Stelt, M., & Marzo, V. D. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.101 · Cited by 286 · see citing works
Marijuana and cannabinoid regulation of brain reward circuits
Lupica, C. R., Riegel, A. C., & Hoffman, A. F. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705931 · Cited by 289 · see citing works
Westlake, T. M., Howlett, A., Bonner, T., Matsuda, L., & Herkenham, M. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90511-8 · Cited by 290 · see citing works
Szabó, B., Siemes, S., & Wallmichrath, I. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02041.x · Cited by 277 · see citing works
Zavitsanou, K., Garrick, T. M., & Huang, X. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.11.005 · Cited by 264 · see citing works
Expression of the CB1 and CB2 receptor messenger RNAs during embryonic development in the rat
Buckley, N. E., Hansson, S. R., Harta, G., & Mezey, É. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00348-5 · Cited by 265 · see citing works
Eggan, S. M., & Lewis, D. A. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhj136 · Cited by 261 · see citing works
Effects of Cannabinoids on Neurotransmission
Szabó, B., & Schlicker, E. (2005) · Springer eBooks · doi:10.1007/3-540-26573-2_11 · Cited by 256 · see citing works
Lupica, C. R., & Riegel, A. C. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.03.016 · Cited by 256 · see citing works
Gerfen, C. R., & Wilson, C. J. (1996) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(96)80004-2 · Cited by 253 · see citing works
Cannabinoid Transmission and Reward-Related Events
Gardner, E. L., & Vorel, S. R. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0219 · Cited by 247 · see citing works
Crestani, C. C., Alves, F. H. F., Gomes, F. V., Resstel, L. B. M., Corrêa, F. M. D. A., & Herman, J. P. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311020002 · Cited by 245 · see citing works
Zhang, P. J., Ishiguro, H., Ohtsuki, T., Hess, J., Carillo, F., Walther, D. M., Onaivi, E. S., Arinami, T., & Uhl, G. R. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001560 · Cited by 247 · see citing works
GABAergic interneurons are the targets of cannabinoid actions in the human hippocampus
Katona, I., Sperlágh, B., Maglóczky, Z., Sántha, E., Köfalvi, A., Czirják, S., Mackie, K., Vizi, E. S., & Freund, T. F. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00286-4 · Cited by 242 · see citing works
Pickel, V. M., Chan, J., Kash, T. L., Rodrı́guez, J.-J., & Mackie, K. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.015 · Cited by 243 · see citing works
Köfalvi, A., Rodrigues, R. J., Ledent, C. A., Mackie, K., Vizi, E. S., Cunha, R. A., & Sperlágh, B. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4232-04.2005 · Cited by 242 · see citing works
Vaughan, C. W., Connor, M. A., Bagley, E. E., & Christie, M. J. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)23200-4 · Cited by 241 · see citing works
Leweke, F. M., Giuffrida, A., Koethe, D., Schreiber, D., Nolden, B. M., Kranaster, L., Neatby, M. A., Schneider, M., Gerth, C. W., Hellmich, M., et al. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.04.025 · Cited by 240 · see citing works
Genetic Dissection of Behavioural and Autonomic Effects of Δ9-Tetrahydrocannabinol in Mice
Monory, K., Blaudzun, H., Massa, F., Kaiser, N., Lemberger, T., Schütz, G., Wotjak, C. T., Lutz, B., & Marsicano, G. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050269 · Cited by 241 · see citing works
Reversal of Dopamine D2Receptor Responses by an Anandamide Transport Inhibitor
Beltramo, M., de Fonseca, F. R., Navarro, M. A., Calignano, A., Gorriti, M. Á., Grammatikopoulos, G., Sadile, A. G., Giuffrida, A., & Piomelli, D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03401.2000 · Cited by 232 · see citing works
Crawley, J. N., Corwin, R. L., Robinson, J. K., Felder, C. C., Devane, W. A., & Axelrod, J. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90230-q · Cited by 231 · see citing works
Panikashvili, D., Shein, N. A., Mechoulam, R., Trembovler, V., Kohen, R., Alexandrovich, A. G., & Shohami, E. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.11.004 · Cited by 229 · see citing works
Levenes, C., Daniel, H., Soubrié, P., & Crépel, F. (1998) · Journal of Physiology · doi:10.1111/j.1469-7793.1998.867bj.x · Cited by 246 · see citing works
Riegel, A. C., & Lupica, C. R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3695-04.2004 · Cited by 227 · see citing works
Kruman, I. I., Guo, Q., & Mattson, M. P. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980201)51:3 · Cited by 377 · see citing works
A field guide to the anterior olfactory nucleus (cortex)
Brunjes, P. C., Illig, K. R., & Meyer, E. A. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.08.005 · Cited by 224 · see citing works
Retrograde signaling by endocannabinoids
Kreitzer, A. C. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00328-8 · Cited by 220 · see citing works
Lack of CB1 Cannabinoid Receptor Impairs Cocaine Self-Administration
Sòria, G., Mendizábal, V. E., Touriño, C., Robledo, P., Ledent, C. A., Parmentier, M., Maldonado, R. J., & Valverde, O. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300707 · Cited by 214 · see citing works
Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor
Shire, D. J., Calandra, B., Rinaldi, M. L., Oustric, D., Pessègue, B., Bonnin, O., Fur, G. L., Caput, D., & Ferrara, P. (1996) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(96)00047-4 · Cited by 208 · see citing works
Ongali, B., Ase, A. R., H�bert, C., Amdiss, F., & Reader, T. A. (2000) · Synapse · doi:10.1002/(sici)1098-2396(200007)37:1 · Cited by 21 · see citing works
Diana, M. A., Lévénès, C., Mackie, K., & Marty, A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00200.2002 · Cited by 199 · see citing works
Solinas, M., Panlilio, L. V., Antoniou, K., Pappas, L., & Goldberg, S. R. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.047928 · Cited by 194 · see citing works
Subcellular localization of type 1 cannabinoid receptors in the rat basal ganglia
Mátyás, F., Yanovsky, Y., Mackie, K., Kelsch, W., Misgeld, U., & Freund, T. F. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.09.005 · Cited by 191 · see citing works
Hypersensitization of the Orexin 1 Receptor by the CB1 Receptor
Hilairet, S., Bouaboula, M., Carrière, D., Fur, G. L., & Casellas, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212369200 · Cited by 188 · see citing works
Julian, M. D., Martin, A. B., Cuéllar, B., de Fonseca, F. R., Navarro, M. A., Moratalla, R., & García‐Segura, L. M. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00070-8 · Cited by 189 · see citing works
BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout mice
Aso, E., Ozaita, A., Valdizán, E. M., Ledent, C. A., Pazos, Á., Maldonado, R. J., & Valverde, O. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05149.x · Cited by 189 · see citing works
Heng, L., Beverley, J. A., Steiner, H., & Tseng, K. Y. (2010) · Synapse · doi:10.1002/syn.20844 · Cited by 180 · see citing works
Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors
Serrano, A., & Parsons, L. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.06.005 · Cited by 180 · see citing works
Yoshida, T., Hashimoto, K., Zimmer, A., Maejima, T., Araishi, K., & Kano, M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01690.2002 · Cited by 180 · see citing works
Ohno‐Shosaku, T., Shosaku, J., Tsubokawa, H., & Kano, M. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01929.x · Cited by 179 · see citing works
Distribution of the Endocannabinoid System in the Central Nervous System
Hu, S. S., & Mackie, K. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-20825-1_3 · Cited by 177 · see citing works
Cannabinoid Receptor Modulation of Synapses Received by Cerebellar Purkinje Cells
Takahashi, K. A., & Linden, D. J. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.3.1167 · Cited by 177 · see citing works
Agonist-Induced Internalization and Trafficking of Cannabinoid CB1Receptors in Hippocampal Neurons
Coutts, A. A., Anavi‐Goffer, S., Ross, R. A., MacEwan, D. J., Mackie, K., Pertwee, R. G., & Irving, A. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02425.2001 · Cited by 176 · see citing works
Functional CB1 Receptors Are Broadly Expressed in Neocortical GABAergic and Glutamatergic Neurons
Hill‐Yardin, E. L., Gallopin, T., Férézou, I., Cauli, B., Rossier, J., Schweitzer, P., & Lambolez, B. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00603.2006 · Cited by 176 · see citing works
- Authors
- Matsuda, L. A., Bonner, T. I., & Lolait, S. J.
- Affiliations
- National Institute of Mental Health (US)
- Corresponding author
- Matsuda, Lisa A.
- ORCID
- Lolait, Stephen J.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 1993-01-22
- Volume
- 327
- Issue
- 4
- Pages
- 535-550
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W2025390026
- Cited by
- 631
- References
- 52
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 8 · 2022: 10 · 2021: 15 · 2020: 20 · 2019: 11 · 2018: 21 · 2017: 19 · 2016: 16 · 2015: 20 · 2014: 14 · 2013: 25 · 2012: 22
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- cannabinoid receptors, mRNA localization, rat brain, hypothalamus, thalamus, basal ganglia, cerebellum, brainstem, cerebral cortex, hippocampus, amygdala, endocannabinoids, cannabis
- MeSH terms
- Animals, Brain Chemistry, Male, Mesencephalon, Receptors, Drug, Rhombencephalon, RNA, Messenger, Prosencephalon, Rats, Sprague-Dawley, Receptors, Cannabinoid, Rats
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