The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Repetitive Transcranial Magnetic Stimulation of the Human Prefrontal Cortex Induces Dopamine Release in the Caudate Nucleus
Open accessAbstract
Dopamine is implicated in movement, learning, and motivation, and in illnesses such as Parkinson's disease, schizophrenia, and drug addiction. Little is known about the control of dopamine release in humans, but research in experimental animals suggests that the prefrontal cortex plays an important role in regulating the release of dopamine in subcortical structures. Here we used [(11)C]raclopride and positron emission tomography to measure changes in extracellular dopamine concentration in vivo after repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex in healthy human subjects. Repetitive TMS of the left dorsolateral prefrontal cortex caused a reduction in [(11)C]raclopride binding in the left dorsal caudate nucleus compared with rTMS of the left occipital cortex. There were no changes in binding in the putamen, nucleus accumbens, or right caudate. This shows that rTMS of the prefrontal cortex induces the release of endogenous dopamine in the ipsilateral caudate nucleus. This finding has implications for the therapeutic and research use of rTMS in neurological and psychiatric disorders.
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“In the early 2000s, two influential studies demonstrated a causal relationship between the application of transcranial magnetic stimulation (TMS) on the prefrontal cortex and dopamine binding in the caudate nucleus, leading to an increase in extracellular dopamine and glutamate in the ventral striatum by TMS”
From A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder (2024) · cites this paper as [106]
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“Another study by the same group, using the same tracer, demonstrated that rTMS of the left dlPFC induced dopamine release specifically in the head of the ipsilateral caudate nucleus, but not the NAcc, putamen or contralateral caudate nucleus (Strafella et al., 2001).”
From Cortico-striatal-thalamic loop circuits of the salience network: A central pathway in psychiatric disease and treatment (2016) · cites this paper as Strafella et al., 2001
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Citations
Cites
Talairach, J., Tournoux, P., & Rayport, M. (1988) · Thieme eBooks · Cited by 5,058
Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space
Collins, D. L., Neelin, P., Peters, T. M., & Evans, A. C. (1994) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199403000-00005 · Cited by 3,431 · cited 3×
“A high-resolution magnetic resonance image (MRI) of the subject’s brain was acquired and transformed into standardized stereotaxic space (Collins et al., 1994).”
MethodDepression of motor cortex excitability by low-frequency transcranial magnetic stimulation
Chen, R., Classen, J., Gerloff, C., Celnik, P., Wassermann, E. M., Hallett, M., & Cohen, L. G. (1997) · Neurology · doi:10.1212/wnl.48.5.1398 · Cited by 2,128 · cited 1×
“…of direct stimulation of the corticostriatal axons (Rothwell, 1997), indirect trans-synaptic activation of corticostriatal neurons caused by a reduction in GABA-mediated intracortical inhibition (Chen et al., 1997; Nakamura et al., 1997; Rothwell, 1997; Pascual-Leone et al., 1998), or both.”
BackgroundSimplified Reference Tissue Model for PET Receptor Studies
Lammertsma, A. A., & Hume, S. P. (1996) · NeuroImage · doi:10.1006/nimg.1996.0066 · Cited by 2,025
Uneven Pattern of Dopamine Loss in the Striatum of Patients with Idiopathic Parkinson's Disease
Kish, S. J., Shannak, K. S., & Hornykiewicz, O. (1988) · New England Journal of Medicine · doi:10.1056/nejm198804073181402 · Cited by 1,945
Grace, A. A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90196-u · Cited by 1,831
MRI-PET Registration with Automated Algorithm
Woods, R. P., Mazziotta, J. C., & Cherry, A. S. R. (1993) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199307000-00004 · Cited by 1,636
Evidence for striatal dopamine release during a video game
Koepp, M. J., Gunn, R. N., Lawrence, A. D., Cunningham, V. J., Dagher, A., Jones, T., Brooks, D. J., Bench, C. J., & Grasby, P. M. (1998) · Nature · doi:10.1038/30498 · Cited by 1,279
Self-citationParametric Imaging of Ligand-Receptor Binding in PET Using a Simplified Reference Region Model
Gunn, R. N., Lammertsma, A. A., Hume, S. P., & Cunningham, V. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0303 · Cited by 1,085
Longitudinal topography and interdigitation of corticostriatal projections in the rhesus monkey
Selemon, L. D., & Goldman-Rakic, P. S. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-03-00776.1985 · Cited by 1,074
Research works printed but not linked: 2
- Breier A, Su TP, Saunders R, Carson RE, Kolachana BS, De Bartolomeis A, Weinberger DR, Weisenfeld N, Malhotra AK, Eckelman WC, Pickar D (1998) Effects of NMDA antagonism on striatal dopamine release in healthy subjects: application of a novel PET approach. Syn- apse 29:142-147.
- Endres CJ, Kolachana BS, Saunders RC, Su T, Weinberger D, Breier A, Eckelman WC, Carson RE (1997) Kinetic modelling of [ 11 C]raclo- pride: combined PET-microdialysis studies. J Cereb Blood Flow Metab 9:932-942.
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Ros, T. (2010) · Goldsmiths (University of London) · doi:10.13140/rg.2.1.2055.7521
Kičić, D., Bikmullina, R., Lioumis, P., Nurminen, J., Kaakkola, S., Mäkelä, J. P., & Pekkonen, E. (2007) · International Congress Series · doi:10.1016/j.ics.2007.03.007
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Kreuzer, P. M., Wendler, L., Schönfeldt‐Lecuona, C., Eichhammer, P., Lefaucheur, J. P., Langguth, B., & Höppner, J. (2015) · Nervenheilkunde · doi:10.1055/s-0038-1627656
Knoch, D., Brugger, P., & Regard, M. (2016)
Effects of Transcranial Magnetic Stimulation on Patients with Prolonged Consciousness Disturbance
Takayama, K., KAWAI, N., Kawanishi, M., MASADA, T., Jinnai, T., Matsumoto, Y., Tamiya, T., & Nagao, S. (2004) · Japanese Journal of Neurosurgery · doi:10.7887/jcns.13.32
Nuclear medicine in neuromodulation
Rodman, A. M., & Dougherty, D. D. (2015) · Wiley eBooks · doi:10.1002/9781118801086.ch5 · Cited by 1
Biomarkers and Neurodegenerative Diseases: Promising Inroads Toward a Distant Goal
(2014) · CRC Press eBooks · doi:10.1201/b17644-23
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Stone, S. S. D., Mukhida, K., & Lozano, A. M. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-5316-3.00086-1
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Sako, W., Uluğ, A. M., & Eidelberg, D. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405195-9.00012-3
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Lefaucheur, J. (2015) · doi:10.1002/9781118801086.ch7
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Tremblay, C. (2015) · Corpus Université Laval (Université Laval)
Estimulación magnética transcraneal
Tormos, J. M., Estébañez, C. R., Valero‐Cabré, A., Giménez, J. C., & Pascual‐Leone, Á. (2008) · Elsevier eBooks · doi:10.1016/b978-84-458-1776-6.50010-1
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Unturbe, C. M., & García, E. R. (2008) · Elsevier eBooks · doi:10.1016/b978-84-458-1776-6.50011-3
Khodaie, B., Ravandi, H. H., Azma, K., & Saba, V. (2014) · The Neuroscience Journal of Shefaye Khatam · doi:10.18869/acadpub.shefa.2.3.27
晴成, 高. (2012) · 日本生物学的精神医学会誌 = Japanese journal of biological psychiatry · doi:10.11249/jsbpjjpp.23.2_137
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Barr, M. S. (2011) · TSpace (University of Toronto)
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McLoughlin, D. M., & Mogg, A. (2012) · doi:10.1093/med/9780199696758.003.0162
Mansouroyeh, N., Rostami, R., & Aliloo, M. M. (2016) · DOAJ (DOAJ: Directory of Open Access Journals)
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Parent, K. L. (2017) · UA Campus Repository (The University of Arizona)
Dutra, T. G., Foerster, Á., Baltar, A., da Costa, M. L. G., & Monte-Silva, K. K. (2017) · Summa Psicológica · doi:10.18774/448x.2017.14.339
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Myczkowski, M. L. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2018.tde-02082018-100807
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Riddle, J. (2018) · eScholarship (California Digital Library)
Chernenko, M. (2019) · Ukrains kyi Visnyk Psykhonevrolohii · doi:10.36927/2079-0325-v27-is4-2019-16
Hyde, M. (2019) · uO Research (University of Ottawa) · doi:10.20381/ruor-24171
Effects of Cortical Stimulation on Cortical Functional Connectivity: Imaging Studies
Angstmann, S., & Siebner, H. R. (2012) · Springer eBooks · doi:10.1007/978-3-642-32767-4_4 · Cited by 1
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Singh, A. (2021) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-8452
THESE POUR LE DOCTORAT EN MEDECINE
Demas, A. (2015)
Neuroplasticity induction using transcranial magnetic stimulation
Chernenko, M. (2019) · Psychiatry Neurology and Medical Psychology · doi:10.26565/2312-5675-2019-12-07
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Radolovic, D. (2021) · PNEI REVIEW · doi:10.3280/pnei2021-001004
신혜원, & 손영호 (2011)
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Repetitive Transcranial Magnetic Stimulation and Stroke Rehabilitation
Kepplinger, B. (2018) · Neurodegeneration and Neurorehabilitation · doi:10.31579/2692-9422/001
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Why product standardization fails.
Freed, D. H. (1993) · PubMed
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Emerging non-invasive neuroplastic-targeting therapies for substance use disorder treatment
George, P. S., & Kinnevey, C. (2022) · Osteopathic Family Physician · doi:10.33181/13064
(2010) · Biological Psychiatry · doi:10.1002/9780470689394.refs
Bauer, R. M., Leritz, E. C., & Bowers, D. (2003) · Wiley eBooks · doi:10.1002/0471264385.wei0212
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Murgaš, M., Unterholzner, J., Stöhrmann, P., Philippe, C., Godbersen, G. M., Nics, L., Reed, M. B., Vraka, C., Vanicek, T., Wadsak, W., et al. (2022) · medRxiv · doi:10.1101/2022.02.18.22271165
Ghazi, N., & Hamid Soltanian-zadeh, A. (2021) · International Conference on Signal Processing and Intelligent Systems (ICSPIS) · doi:10.1109/icspis54653.2021.9729348
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Transkranielle Magnetstimulation
Hajak, G., Langguth, B., Zowe, M., & Eichhammer, P. (2004) · Steinkopff eBooks · doi:10.1007/978-3-7985-1957-2_44
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Doma, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-57231-0_34
Flöel, A., Hummel, F. C., & Gerloff, C. P. (2007) · Springer eBooks · doi:10.1007/978-3-540-71905-2_56
Ragland, J. D. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733469590.793552378
Bradberry, C. W. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7264-3_30
Clinical Application of Transcranical Stimulation(<Special Issue> The Brain and Medical Instruments)
Kanno, M., & 眞野, 行. (2003) · JAPANES JOURNAL OF MEDICAL INSTRUMENTATION · doi:10.4286/ikakikaigaku.73.7_353
Somatic Treatments and Neuromodulation in Psychiatry
Fitzgerald, P. B., & Arns, M. (2023) · Springer eBooks · doi:10.1007/978-3-030-42825-9_144-1
Hung, K.-C., Cheng, C.-M., Liang, S.-C., Sun, C., Chen, C.-M., Cheng, Y., & Chiu, H. (2023) · doi:10.2196/preprints.53381
Zatorre, R. J. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780197558287.002.0004
Zatorre, R. J. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780197558287.003.0010
Zatorre, R. J. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780197558287.002.0003
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Zatorre, R. J. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780197558287.003.0002
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(2009) · PubMed · Cited by 19
Metadata
- Authors
- Strafella, A. P., Paus, T., Barrett, J., & Dagher, A.
- Affiliations
- Montreal Neurological Institute and Hospital (CA)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-08-01
- Volume
- 21
- Issue
- 15
- Pages
- RC157-RC157
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6762641
- OpenAlex
- W2118266586
- Cited by
- 1,058
- References
- 39
- Citations by year
- 2026: 29 · 2025: 38 · 2024: 44 · 2023: 53 · 2022: 49 · 2021: 57 · 2020: 55 · 2019: 52 · 2018: 51 · 2017: 51 · 2016: 45 · 2015: 54 · 2014: 48 · 2013: 45 · 2012: 35
- FWCI
- 19.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- repetitive transcranial magnetic stimulation, dopamine release, caudate nucleus, dorsolateral prefrontal cortex, dopamine transporter binding, extracellular dopamine, putamen, nucleus accumbens
- MeSH terms
- Adult, Autonomic Nervous System, Behavior, Carbon Isotopes, Caudate Nucleus, Dopamine, Electric Stimulation, Electromagnetic Fields, Female, Humans, Male, Nucleus Accumbens, Occipital Lobe, Putamen, Receptors, Dopamine, Reference Values, Tomography, Emission-Computed, Prefrontal Cortex, Dopamine Antagonists, Raclopride, Transcranial Magnetic Stimulation
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