Microglial Receptor for Advanced Glycation End Product-Dependent Signal Pathway Drives β-Amyloid-Induced Synaptic Depression and Long-Term Depression Impairment in Entorhinal Cortex

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., & Selkoe, D. J. (2002) · Nature · doi:10.1038/416535a · Cited by 4,291

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685

Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins

Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., Leisten, J. C., Motiwala, A., Pierce, S., Satoh, Y., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251194298 · Cited by 2,558

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012

RAGE Mediates a Novel Proinflammatory Axis

Hofmann, M. A., Drury, S., Fu, C., Qu, W., Taguchi, A., Lu, Y., Avila, C., Kambham, N., Bierhaus, A., Nawroth, P., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80801-6 · Cited by 1,864

High-Level Neuronal Expression of Aβ1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856

Regulation of NMDA receptor trafficking by amyloid-β

Snyder, E. M., Nong, Y., Almeida, C. G., Paul, S., Moran, T., Choi, E. Y., Nairn, A. C., Salter, M. W., Lombroso, P. J., Gouras, G. K., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1503 · Cited by 1,561 · cited 7×

RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

Deane, R., Du Yan, S., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., et al. (2003) · Nature Medicine · doi:10.1038/nm890 · Cited by 1,426

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

Lustbader, J. W., Cirilli, M., Lin, C., Xu, H. W., Takuma, K., Wang, N., Caspersen, C., Chen, X., Pollak, S., Chaney, M., et al. (2004) · Science · doi:10.1126/science.1091230 · Cited by 1,303

The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses

Schmidt, A. M., Yan, S. D., Yan, S. F., & Stern, D. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14002 · Cited by 1,256

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G.-Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., & Mucke, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3228 · Cited by 1,123

AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss

Hsieh, H., Boehm, J., Sato, C., Iwatsubo, T., Tomita, T., Sisodia, S., & Malinow, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.035 · Cited by 1,042

The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses

Schmidt, A. M., Yan, S. D., Yan, S. F., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200114002 · Cited by 1,039

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

Li, S., Hong, S., Shepardson, N. E., Walsh, D. M., Shankar, G. M., & Selkoe, D. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.012 · Cited by 972

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

Chapman, P. F., White, G. L., Jones, M. W., Cooper-Blacketer, D., Marshall, V. J., Irizarry, M., Younkin, L., Good, M. A., Bliss, T. V. P., Hyman, B. T., et al. (1999) · Nature Neuroscience · doi:10.1038/6374 · Cited by 946

Functional organization of the extrinsic and intrinsic circuitry of the parahippocampal region

Witter, M. P., Groenewegen, H. J., Lopes, F. H. D. S., & Lohman, A. H. M. (1989) · Progress in Neurobiology · doi:10.1016/0301-0082(89)90009-9 · Cited by 918

Staging of Alzheimer-Related Cortical Destruction

Braak, H., Braak, E., & Bohl, J. (2008) · European Neurology · doi:10.1159/000116984 · Cited by 836 · cited 2×

Ras and Rap control AMPA receptor trafficking during synaptic plasticity

Zhu, J. J., Qin, Y., Zhao, M., Van Aelst, L., & Malinow, R. (2002) · Cell · doi:10.1016/s0092-8674(02)00897-8 · Cited by 769

Early Aβ accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

Ingelsson, M., Fukumoto, H., Newell, K. L., Growdon, J. H., Hedley–Whyte, E. T., Frosch, M. P., Albert, M. S., Hyman, B. T., & Irizarry, M. C. (2004) · Neurology · doi:10.1212/01.wnl.0000115115.98960.37 · Cited by 666

RAGE Drives the Development of Glomerulosclerosis and Implicates Podocyte Activation in the Pathogenesis of Diabetic Nephropathy

Wendt, T., Tanji, N., Guo, J., Kislinger, T., Qu, W., Lu, Y., Bucciarelli, L. G., Rong, L., Moser, B., Markowitz, G. S., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63909-0 · Cited by 599

Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections

Braak, H., & Braak, E. (1991) · Brain Pathology · doi:10.1111/j.1750-3639.1991.tb00661.x · Cited by 598

Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling

Vitolo, O. V., Sant'Angelo, A., Costanzo, V., Battaglia, F., Arancio, O., & Shelanski, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172504199 · Cited by 534

Soluble oligomers of β amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus

Wang, H.-W., Pasternak, J. F., Kuo, H., Ristic, H., Lambert, M. P., Chromy, B., Viola, K. L., Klein, W. L., Stine, W. B., Krafft, G. A., et al. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03058-x · Cited by 527

β-Amyloid Induces Neuronal Apoptosis Via a Mechanism that Involves the c-Jun N-Terminal Kinase Pathway and the Induction of Fas Ligand

MORISHIMA, Y., Gotoh, Y., Zieg, J., Barrett, T., Takano, H., Flavell, R. A., Davis, R. J., Shirasaki, Y., & Greenberg, M. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07551.2001 · Cited by 486

Involvement of Microglial Receptor for Advanced Glycation Endproducts (RAGE) in Alzheimer's Disease: Identification of a Cellular Activation Mechanism

Lue, L.-F., Walker, D. G., Brachova, L., Beach, T. G., Rogers, J., Schmidt, A. M., Stern, D. M., & Yan, S. D. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7732 · Cited by 439

Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5

Wang, Q., Walsh, D. M., Rowan, M. J., Selkoe, D. J., & Anwyl, R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1633-03.2004 · Cited by 437

Amyloid-β peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease

Yan, S. D., Zhu, H., Fu, J., Yan, S. F., Roher, A. E., Tourtellotte, W. W., Rajavashisth, T. B., Chen, X., Godman, G. C., Stern, D. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5296 · Cited by 429

Actions of TNF‐α on glutamatergic synaptic transmission in the central nervous system

Pickering, M., Cumiskey, D., & O'Connor, J. J. (2005) · Experimental Physiology · doi:10.1113/expphysiol.2005.030734 · Cited by 421

The LTP Program: a data acquisition program for on-line analysis of long-term potentiation and other synaptic events

Anderson, W. W., & Collingridge, G. L. (2001) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(01)00374-0 · Cited by 420

PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model

Sasahara, M., Fries, J. W. U., Raines, E. W., Gown, A. M., Westrum, L. E., Frosch, M. P., Bonthron, D. T., Ross, R., & Collins, T. (1991) · Cell · doi:10.1016/0092-8674(91)90223-l · Cited by 411

Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide

Yan, S. D., Yan, S. F., Chen, X., Fu, J., Chen, M., Kuppusamy, P., Smith, M. A., Perry, G., Godman, G. C., Nawroth, P., et al. (1995) · Nature Medicine · doi:10.1038/nm0795-693 · Cited by 406

Progressive age‐related development of Alzheimer‐like pathology in APP/PS1 mice

Trinchese, F., Liu, S., Battaglia, F., Walter, S., Mathews, P. M., & Arancio, O. (2004) · Annals of Neurology · doi:10.1002/ana.20101 · Cited by 384

Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro.

Simmons, L. K., May, P. C., Tomaselli, K. J., Rydel, R. E., Fuson, K. S., Brigham, E. F., Wright, S., Lieberburg, I. M., Becker, G. W., & Brems, D. N. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10007-2 · Cited by 371

Central role of RAGE-dependent neointimal expansion in arterial restenosis

Sakaguchi, T., Yan, S. F., Yan, S. D., Belov, D., Rong, L., Sousa, M. M., Andrassy, M., Marso, S. P., Duda, S., Arnold, B., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17115 · Cited by 371

RAGE‐dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease

Fang, F., Lue, L.-F., Yan, S., Xu, H., Luddy, J. S., Chen, D., Walker, D. G., Stern, D. M., Yan, S., Schmidt, A. M., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-139634 · Cited by 335

RAGE potentiates Aβ‐induced perturbation of neuronal function in transgenic mice

Arancio, O., Zhang, H. P., Chen, X., Lin, C., Trinchese, F., Puzzo, D., Liu, S., Hegde, A. N., Yan, S. F., Stern, A., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600415 · Cited by 333

Central role of RAGE-dependent neointimal expansion in arterial restenosis

Sakaguchi, T., Yan, S. F., Yan, S. D., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317115 · Cited by 313

The Pyridinyl Imidazole Inhibitor SB203580 Blocks Phosphoinositide-dependent Protein Kinase Activity, Protein Kinase B Phosphorylation, and Retinoblastoma Hyperphosphorylation in Interleukin-2-stimulated T Cells Independently of p38 Mitogen-activated Protein Kinase

Lali, F. V., Hunt, A. E., Turner, S. J., & Foxwell, B. M. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.7395 · Cited by 304

Certain Inhibitors of Synthetic Amyloid β-Peptide (Aβ) Fibrillogenesis Block Oligomerization of Natural Aβ and Thereby Rescue Long-Term Potentiation

Walsh, D. M., Townsend, M., Podlisny, M. B., Shankar, G. M., Fadeeva, J. V., El‐Agnaf, O. M. A., Hartley, D. M., & Selkoe, D. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4391-04.2005 · Cited by 295

RAGE-mediated signaling contributes to intraneuronal transport of amyloid-β and neuronal dysfunction

Takuma, K., Fang, F., Zhang, W., Yan, S., Fukuzaki, E., Du, H., Sosunov, A., McKhann, G., Funatsu, Y., Nakamichi, N., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905686106 · Cited by 290

S100B/RAGE-dependent activation of microglia via NF-κB and AP-1

Bianchi, R., Giambanco, I., & Donato, R. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.017 · Cited by 280

ABAD enhances Aβ‐induced cell stress via mitochondrial dysfunction

Takuma, K., Yao, J., Huang, J., Xu, H., Chen, X., Luddy, J. S., Trillat, A., Stern, D. M., Arancio, O., & Yan, S. S. (2005) · The FASEB Journal · doi:10.1096/fj.04-2582fje · Cited by 254

AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice

Chang, E. H., Savage, M. J., Flood, D. G., Thomas, J. M., Levy, R. B., Mahadomrongkul, V., Shirao, T., Aoki, C., & Huerta, P. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507313103 · Cited by 225

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation

Troy, C. M., Rabacchi, S. A., Xu, Z., Maroney, A. C., Connors, T. J., Shelanski, M. L., & Greene, L. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.t01-1-00218.x · Cited by 223

Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3–CA1 synapses

Bolshakov, V. Y., Carboni, L., Cobb, M. H., Siegelbaum, S. A., & Belardetti, F. (2000) · Nature Neuroscience · doi:10.1038/80624 · Cited by 217

RAGE: A Potential Target for Aβ-Mediated Cellular Perturbation in Alzheimers Disease

Yan, S. F., Chen, X., Walker, D. G., Schmidt, A. M., Arancio, O., & Lue, L. (2007) · Current Molecular Medicine · doi:10.2174/156652407783220741 · Cited by 207

Receptor for Advanced Glycation End Product-Dependent Activation of p38 Mitogen-Activated Protein Kinase Contributes to Amyloid-β-Mediated Cortical Synaptic Dysfunction

Origlia, N., Righi, M., Capsoni, S., Cattaneo, A., Fang, F., Stern, D. M., Chen, J. X., Schmidt, A. M., Arancio, O., Yan, S. D., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0204-08.2008 · Cited by 206

Use-Dependent Effects of Amyloidogenic Fragments of β-Amyloid Precursor Protein on Synaptic Plasticity in Rat HippocampusIn Vivo

Kim, J., Anwyl, R., Suh, Y., Djamgoz, M. B. A., & Rowan, M. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01327.2001 · Cited by 186

Activation of p38 Plays a Pivotal Role in the Inhibitory Effect of Lipopolysaccharide and Interleukin-1β on Long Term Potentiation in Rat Dentate Gyrus

Kelly, A. M., Vereker, E., Nolan, Y. M., Brady, M., Barry, C. E., Loscher, C. E., Mills, K. H. G., & Lynch, M. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301938200 · Cited by 182

Alzheimer Amyloid β-Peptide Inhibits the Late Phase of Long-Term Potentiation through Calcineurin-Dependent Mechanisms in the Hippocampal Dentate Gyrus

Chen, Q.-S., Wei, W., Shimahara, T., & Xie, C.-W. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2001.4034 · Cited by 176

JNK activation is associated with intracellular β-amyloid accumulation

Shoji, M., Iwakami, N., Takeuchi, S., Waragai, M., Suzuki, M., Kanazawa, I., Lippa, C. F., Ono, S., & Okazawa, H. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00245-x · Cited by 167

Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration

Pei, J.-J., Braak, E., Braak, H., Grundke-Iqbal, I., Iqbal, K., Winblad, B., & Cowburn, R. F. (2001) · Journal of Alzheimer's Disease · doi:10.3233/jad-2001-3107 · Cited by 165

Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis

Wei, W. (2002) · Brain · doi:10.1093/brain/awf205 · Cited by 155

Amyloid β Prevents Activation of Calcium/Calmodulin-Dependent Protein Kinase II and AMPA Receptor Phosphorylation During Hippocampal Long-Term Potentiation

Zhao, D., Watson, J. B., & Xie, C.-W. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00485.2004 · Cited by 152

The p38 mitogen-activated protein kinase inhibitor SB203580 antagonizes the inhibitory effects of interleukin-1β on long-term potentiation in the rat dentate gyrus in vitro

Coogan, A. N., O'Neill, L. A. J., & O'Connor, J. J. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00100-1 · Cited by 129

Preventing Activation of Receptor for Advanced Glycation Endproducts in Alzheimers Disease

Lue, L.-F., Yan, S. D., Stern, D. F., & Walker, D. G. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007054038210 · Cited by 126

An investigation into signal transduction mechanisms involved in insulin‐induced long‐term depression in the CA1 region of the hippocampus

Huang, C., Lee, C., & Hsu, K. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2003.02307.x · Cited by 120

Activation of the c-Jun N-terminal Kinase Signaling Cascade Mediates the Effect of Amyloid-β on Long Term Potentiation and Cell Death in Hippocampus

Minogue, A. M., Schmid, A. W., Fogarty, M. P., Moore, A. C., Campbell, V. A., Herron, C. E., & Lynch, M. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302530200 · Cited by 117

Group I Metabotropic Glutamate Receptor (mGluR)-Dependent Long-Term Depression Mediated via p38 Mitogen-Activated Protein Kinase Is Inhibited by Previous High-Frequency Stimulation and Activation of mGluRs and Protein Kinase C in the Rat Dentate GyrusIn Vitro

Rush, A. M., Wu, J., Rowan, M. J., & Anwyl, R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-06121.2002 · Cited by 116

Functional Neuroanatomy of the Medial Temporal Lobe Memory System

SUZUKI, W., & AMARAL, D. (2004) · Cortex · doi:10.1016/s0010-9452(08)70958-4 · Cited by 111

Oxygen Deprivation Triggers Upregulation of Early Growth Response-1 by the Receptor for Advanced Glycation End Products

Chang, J. S., Wendt, T., Qu, W., Kong, L., Zou, Y. S., Schmidt, A. M., & Yan, S. (2008) · Circulation Research · doi:10.1161/circresaha.107.165308 · Cited by 110

A role for c-jun n-terminal kinase in the inhibition of long-term potentiation by interleukin-1β and long-term depression in the rat dentate gyrus in vitro

Curran, B. P., Murray, H. J., & O'Connor, J. J. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00941-7 · Cited by 107

NMDA receptor regulation by amyloid-β does not account for its inhibition of LTP in rat hippocampus

Raymond, C. R., Ireland, D. R., & Abraham, W. C. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02269-8 · Cited by 94

Non‐fibrillar β‐amyloid abates spike‐timing‐dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors

Shemer, I., Holmgren, C. D., Min, R., Fülöp, L., Zilberter, M. Y., Sousa, K. M., Farkas, T., Härtig, W., Penke, B., Burnashev, N., et al. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04733.x · Cited by 86

Intracellular Accumulation of Detergent‐Soluble Amyloidogenic Aβ Fragment of Alzheimer's Disease Precursor Protein in the Hippocampus of Aged Transgenic Mice

Li, Q., Maynard, C. J., Cappai, R., McLean, C., Cherny, R. A., Lynch, T., Culvenor, J. G., Trevaskis, J., Tanner, J. E., Bailey, K. A., et al. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0722479.x · Cited by 73

Amyloid β‐peptide Aβ1–42 but not Aβ1–40 attenuates synaptic AMPA receptor function

Parameshwaran, K., Sims‐Robinson, C., Kanju, P. M., Vaithianathan, T., Shonesy, B. C., Dhanasekaran, M., Bahr, B. A., & Suppiramaniam, V. D. (2007) · Synapse · doi:10.1002/syn.20386 · Cited by 71

JNK1 contributes to metabotropic glutamate receptor‐dependent long‐term depression and short‐term synaptic plasticity in the mice area hippocampal CA1

Li, X., Li, C., Yu, S., Chen, J., Sabapathy, K., & Ruan, D. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05300.x · Cited by 70

Surface Plasmon Resonance and Nuclear Magnetic Resonance Studies of ABAD−Aβ Interaction

Yan, Y., Liu, Y., Sorci, M., Belfort, G., Lustbader, J. W., Yan, S. S., & Wang, C. (2007) · Biochemistry · doi:10.1021/bi061314n · Cited by 67

Age associated changes of AGE-receptor expression: RAGE upregulation is associated with human heart dysfunction

Simm, A., Caßelmann, C. A., Schubert, A., Hofmann, S., Reimann, A., & Silber, R. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.12.006 · Cited by 66

A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons

Fogarty, M. P., Downer, E. J., & Campbell, V. A. (2003) · Biochemical Journal · doi:10.1042/bj20021660 · Cited by 66

β‐Amyloid Induces Oxidative DNA Damage and Cell Death through Activation of c‐Jun N Terminal Kinase

Jang, J.-H., & Surh, Y. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04639.x · Cited by 54

Aβ-Dependent Inhibition of LTP in Different Intracortical Circuits of the Visual Cortex: The Role of RAGE

Origlia, N., Capsoni, S., Cattaneo, A., Fang, F., Arancio, O., Yan, S. D., & Domenici, L. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1045 · Cited by 53

Acute cholinergic rescue of synaptic plasticity in the neurodegenerating cortex of anti‐nerve‐growth‐factor mice

Pesavento, E., Capsoni, S., Domenici, L., & Cattaneo, A. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01937.x · Cited by 52

β-Amyloid Peptides Impair PKC-Dependent Functions of Metabotropic Glutamate Receptors in Prefrontal Cortical Neurons

Tyszkiewicz, J. P., & Yan, Z. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00939.2004 · Cited by 51

Patterns of synaptic activity in forward and feedback pathways within rat visual cortex

Domenici, L., Harding, G. W., & Burkhalter, A. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.74.6.2649 · Cited by 50

Interleukin‐1β abrogates long‐term depression of hippocampal CA1 synaptic transmission

Ikegaya, Y., Delcroix, I., Iwakura, Y., Matsuki, N., & Nishiyama, N. (2002) · Synapse · doi:10.1002/syn.10154 · Cited by 49

Anisomycin activates p38 MAP kinase to induce LTD in mouse primary visual cortex

Xiong, W., Kojić, L., Zhang, L., Prasad, S. S., Douglas, R., Wang, Y., & Cynader, M. S. (2006) · Brain Research · doi:10.1016/j.brainres.2006.02.015 · Cited by 44

P38 Activation Mediates Amyloid-β Cytotoxicity

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Cellular signalling of the receptor for advanced glycation end products (RAGE)

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The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

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Receptor for Advanced Glycation End Product-Dependent Activation of p38 Mitogen-Activated Protein Kinase Contributes to Amyloid-β-Mediated Cortical Synaptic Dysfunction

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(2008) Receptor for Advanced Glycation End Product-Dependent Activation of p38 Mitogen-Activated Protein Kinase Contributes to Amyloid-ß-Mediated Cortical Synaptic Dysfunction

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RAGE Inhibition in Microglia Prevents Ischemia-Dependent Synaptic Dysfunction in an Amyloid-Enriched Environment

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Entorhinal Cortex dysfunction can be rescued by inhibition of microglial RAGE in an Alzheimer’s disease mouse model

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