The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Forebrain Glucocorticoid Receptors Modulate Anxiety-Associated Locomotor Activation and Adrenal Responsiveness
Open accessAbstract
Stress potently modulates anxiety- and depression-related behaviors. In response to stressors, the hypothalamic-pituitary-adrenal (HPA) axis is activated, resulting in the release of glucocorticoids from the adrenal cortex. These hormones act peripherally to restore homeostasis but also feed back to the CNS to control the intensity and duration of the stress response. Glucocorticoids act in limbic areas of the CNS to mediate the psychological and behavioral effects of stress. In this study, we investigate the effect of forebrain-specific disruption of the glucocorticoid receptor (GR) on stress- and anxiety-related behaviors. We demonstrate that mice with disruption of forebrain GR show alterations in stress-induced locomotor activation in a number of anxiety-related behavioral paradigms. These changes are associated with alterations in stress-induced HPA axis activation and, importantly, are not attenuated by chronic treatment with the tricyclic antidepressant imipramine. These data demonstrate the importance of forebrain GR in regulation of physiological and behavioral stress reactivity and suggest that distinct pathways regulate despair- and anxiety-related behaviors.
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Cites
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
Ehlert, U., Gaab, J., & Heinrichs, M. (2001) · Biological Psychology · doi:10.1016/s0301-0511(01)00092-8 · Cited by 510
Boyle, M. P., Brewer, J. A., Funatsu, M., Wozniak, D. F., Tsien, J. Z., Izumi, Y., & Muglia, L. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406458102 · Cited by 378 · cited 20×
“The similar activity between control and FBGRKO mice in this open-field measure is consistent with our previous analysis of general locomotor activity under basal conditions using beam breaks in a photocell apparatus (Schaefer et al., 2000; Boyle et al., 2005).”
BackgroundMethodResultInfluentialBELZER, K., & SCHNEIER, F. R. (2004) · Journal of Psychiatric Practice · doi:10.1097/00131746-200409000-00003 · Cited by 235 · cited 1×
“Discussion Altered regulation of anxiety-like behaviors in FBGRKO mice after stress Depression shows a high rate of comorbidity with anxiety disorders (Belzer and Schneier, 2004; Gorwood, 2004).”
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Cited by
Regulation of the Hypothalamic‐Pituitary‐Adrenocortical Stress Response
Herman, J. P., McKlveen, J. M., Ghosal, S., Kopp, B., Wulsin, A., Makinson, R., Scheimann, J., & Myers, B. (2016) · Comprehensive Physiology · doi:10.1002/cphy.c150015 · Cited by 1,819
Labonte, B., Yerko, V., Gross, J., Mechawar, N., Meaney, M. J., Szyf, M., & Turecki, G. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.034 · Cited by 345
Singh, M. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00925 · Cited by 337
Metabolic disturbances connecting obesity and depression
Hryhorczuk, C., Sharma, S., & Fulton, S. E. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00177 · Cited by 322
Glucocorticoid-Related Molecular Signaling Pathways Regulating Hippocampal Neurogenesis
Anacker, C., Cattaneo, A., Luoni, A., Musaelyan, K., Zunszain, P. A., Milanesi, E., Rybka, J., Berry, A., Cirulli, F., Thuret, S., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.253 · Cited by 317
Metadata
- Authors
- Boyle, M. P., Kolber, B. J., Vogt, S. K., Wozniak, D. F., & Muglia, L. J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-02-15
- Volume
- 26
- Issue
- 7
- Pages
- 1971-1978
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1967290761
- Cited by
- 171
- References
- 4
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Boyle, M. P., Kolber, B. J., Vogt, S. K., Wozniak, D. F., & Muglia, L. J. (2006). Forebrain Glucocorticoid Receptors Modulate Anxiety-Associated Locomotor Activation and Adrenal Responsiveness. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.2173-05.2006
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
