The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Intracisternal Interleukin-1 Receptor Antagonist Prevents Postoperative Cognitive Decline and Neuroinflammatory Response in Aged Rats
Open accessAbstract
To investigate the role of the pro-inflammatory cytokine interleukin-1β (IL-1β) in postoperative cognitive dysfunction (POCD) in aged rats, we used laparotomy to mimic human abdominal surgery in adult (3 months) and aged (24 months) F344/BN rats. We demonstrated that memory consolidation of the hippocampal-dependent contextual fear-conditioning task is significantly impaired in aged but not young rats 4 d after surgery. Hippocampal-independent auditory-cued fear memory was not disrupted by laparotomy in either age group. The hippocampal-dependent memory impairment was paralleled by elevations of IL-1β in the hippocampus of aged animals 1 and 4 d after surgery. These findings support our substantial line of previous research showing that aged animals are more vulnerable to cognitive decline after a peripheral immune challenge. In addition, we demonstrated that a single intracisternal administration of interleukin-1 receptor antagonist (IL-1RA; 112 μg) at the time of surgery was sufficient to block both the behavioral deficit and the neuroinflammatory response. Injecting the same dose of IL-1RA peripherally failed to have a protective effect. These data provide strong support for the specific role of central, not peripheral, IL-1β in POCD. Furthermore, the long-lasting presence of IL-1RA in the brain (4 d) compared with in the blood (<24 h) underscores the value of intracisternal administration of IL-1RA for therapeutic purposes.
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“Moreover, intracisternal IL-1 receptor antagonist attenuated the laparotomy-induced hippocampal IL-1β and reversed memory deficits, further highlighting the exaggerated neuroinflammatory response to a peripheral challenge (Barrientos et al, 2012).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Barrientos et al, 2012
In the citing paper
“In rodent models, aged but not young adult rats displayed memory impairments and elevated hippocampal IL-1β levels 4 days after laparotomy (Barrientos et al, 2012).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Barrientos et al, 2012
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Metadata
- Authors
- Barrientos, R. M., Hein, A. M., Frank, M. G., Watkins, L. R., & Maier, S. F.
- Affiliations
- University of Colorado Boulder (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-10-17
- Volume
- 32
- Issue
- 42
- Pages
- 14641-14648
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3492959
- OpenAlex
- W2010036720
- Cited by
- 235
- References
- 32
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 17 · 2023: 17 · 2022: 23 · 2021: 25 · 2020: 23 · 2019: 19 · 2018: 17 · 2017: 16 · 2016: 21 · 2015: 13 · 2014: 15 · 2013: 13 · 2012: 1
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Institute on Aging (R01AG028271)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Keywords
- IL-1β, interleukin-1 receptor antagonist, postoperative cognitive dysfunction, neuroinflammation, aging, hippocampal-dependent memory, contextual fear conditioning, abdominal surgery, intracisternal administration, inflammatory cytokines, neuroprotection
- MeSH terms
- Aging, Animals, Cisterna Magna, Cognition Disorders, Humans, Injections, Intraventricular, Male, Postoperative Complications, Rats, Inbred BN, Rats, Inbred F344, Receptors, Interleukin-1, Inflammation Mediators, Rats, Interleukin-1beta, Interleukin 1 Receptor Antagonist Protein
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