Cited by 236Anesthesia and Neurotoxicity ResearchNeuroinflammation and Neurodegeneration MechanismsIntensive Care Unit Cognitive Disorders

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Intracisternal Interleukin-1 Receptor Antagonist Prevents Postoperative Cognitive Decline and Neuroinflammatory Response in Aged Rats

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Barrientos, Ruth M., Hein, Amy M., Frank, Matthew G., Watkins, Linda R., Maier, Steven F.·2012·The Journal of Neuroscience

DOI 10.1523/jneurosci.2173-12.2012PMC PMC3492959

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Abstract

To investigate the role of the pro-inflammatory cytokine interleukin-1β (IL-1β) in postoperative cognitive dysfunction (POCD) in aged rats, we used laparotomy to mimic human abdominal surgery in adult (3 months) and aged (24 months) F344/BN rats. We demonstrated that memory consolidation of the hippocampal-dependent contextual fear-conditioning task is significantly impaired in aged but not young rats 4 d after surgery. Hippocampal-independent auditory-cued fear memory was not disrupted by laparotomy in either age group. The hippocampal-dependent memory impairment was paralleled by elevations of IL-1β in the hippocampus of aged animals 1 and 4 d after surgery. These findings support our substantial line of previous research showing that aged animals are more vulnerable to cognitive decline after a peripheral immune challenge. In addition, we demonstrated that a single intracisternal administration of interleukin-1 receptor antagonist (IL-1RA; 112 μg) at the time of surgery was sufficient to block both the behavioral deficit and the neuroinflammatory response. Injecting the same dose of IL-1RA peripherally failed to have a protective effect. These data provide strong support for the specific role of central, not peripheral, IL-1β in POCD. Furthermore, the long-lasting presence of IL-1RA in the brain (4 d) compared with in the blood (<24 h) underscores the value of intracisternal administration of IL-1RA for therapeutic purposes.

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RETRACTED: Postoperative cognitive deficits and neuroinflammation in the hippocampus triggered by surgical trauma are exacerbated in aged rats
Cao, X., Ma, H., Wang, J.-K., Liu, F., Wu, B.-Y., Tian, A., Wang, L., & Tan, W. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.027 · Cited by 168
Retracted
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study
Møller, J. T., Cluitmans, P. P., Rasmussen, L., Houx, P. J., Rasmussen, H., Canet, J., Rabbitt, P., Jolles, J., Larsen, K., Hanning, C. D., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07382-0 · Cited by 2,407
Predictors of Cognitive Dysfunction after Major Noncardiac Surgery
Monk, T. G., Weldon, B. C., Garvan, C. W., Dede, D. E., van der Aa, M. T., Heilman, K. M., & GRAVENSTEIN, J. S. (2008) · Anesthesiology · doi:10.1097/01.anes.0000296071.19434.1e · Cited by 1,532
Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system
Godbout, J. P., Chen, J., Abraham, J., Richwine, A. F., Berg, B. M., Kelley, K. W., & Johnson, R. W. (2005) · The FASEB Journal · doi:10.1096/fj.05-3776fje · Cited by 813
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Cunningham, C., Wilcockson, D. C., Campion, S., Lunnon, K., & Perry, V. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2614-05.2005 · Cited by 768
Role of interleukin‐1β in postoperative cognitive dysfunction
Cibelli, M., Fidalgo, A. R., Terrando, N., Ma, D., Monaco, C. G., Feldmann, M., Takata, M., Lever, I. J., Nanchahal, J., Fanselow, M. S., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22082 · Cited by 745
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Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients
Rasmussen, L. S., Johnson, T., Kuipers, H. M., Kristensen, D., Siersma, V., Vila, P., Jolles, J., Papaioannou, A. A., Abildstrøm, H., Silverstein, J. H., et al. (2003) · Acta Anaesthesiologica Scandinavica · doi:10.1034/j.1399-6576.2003.00057.x · Cited by 558
The assessment of postoperative cognitive function
Rasmussen, L. S., Larsen, K., Houx, P. J., Skovgaard, L. T., Hanning, C. D., Møller, J., & the ISPOCD group (2001) · Acta Anaesthesiologica Scandinavica · doi:10.1034/j.1399-6576.2001.045003275.x · Cited by 548

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Authors: Barrientos, R. M., Hein, A. M., Frank, M. G., Watkins, L. R., & Maier, S. F.
Affiliations: University of Colorado Boulder (US)
ORCID: Barrientos, Ruth M.
Frank, Matthew G.
Watkins, Linda R.
Maier, Steven F.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2012-10-17
Volume: 32
Issue: 42
Pages: 14641-14648
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.2173-12.2012
PMC: PMC3492959
OpenAlex: W2010036720
Cited by: 235
References: 32
Citations by year: 2026: 6 · 2025: 9 · 2024: 17 · 2023: 17 · 2022: 23 · 2021: 25 · 2020: 23 · 2019: 19 · 2018: 17 · 2017: 16 · 2016: 21 · 2015: 13 · 2014: 15 · 2013: 13 · 2012: 1
FWCI: 4.53
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 182 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
Funders: National Institute on Aging (R01AG028271)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Keywords: IL-1β, interleukin-1 receptor antagonist, postoperative cognitive dysfunction, neuroinflammation, aging, hippocampal-dependent memory, contextual fear conditioning, abdominal surgery, intracisternal administration, inflammatory cytokines, neuroprotection
MeSH terms: Aging, Animals, Cisterna Magna, Cognition Disorders, Humans, Injections, Intraventricular, Male, Postoperative Complications, Rats, Inbred BN, Rats, Inbred F344, Receptors, Interleukin-1, Inflammation Mediators, Rats, Interleukin-1beta, Interleukin 1 Receptor Antagonist Protein

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Intracisternal Interleukin-1 Receptor Antagonist Prevents Postoperative Cognitive Decline and Neuroinflammatory Response in Aged Rats

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