Intracisternal Interleukin-1 Receptor Antagonist Prevents Postoperative Cognitive Decline and Neuroinflammatory Response in Aged Rats

Modality-Specific Retrograde Amnesia of Fear

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Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study

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Predictors of Cognitive Dysfunction after Major Noncardiac Surgery

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Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system

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Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration

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Role of interleukin‐1β in postoperative cognitive dysfunction

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Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

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Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients

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The assessment of postoperative cognitive function

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Adrenal-dependent diurnal modulation of conditioned fear extinction learning

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Electroacupuncture alleviates surgery-induced cognitive dysfunction by increasing α7-nAChR expression and inhibiting inflammatory pathway in aged rats

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Inhibiting tumor necrosis factor-α signaling attenuates postoperative cognitive dysfunction in aged rats

Ma, Y., Cheng, Q., Wang, E., Li, L., & ZHANG, X. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3744 · Cited by 35

Long-term administration of melatonin attenuates neuroinflammation in the aged mouse brain

Permpoonputtana, K., Tangweerasing, P., Mukda, S., Boontem, P., Nopparat, C., & Govitrapong, P. (2018) · EXCLI journal · doi:10.17179/excli2017-654 · Cited by 35

Repeated propofol exposure-induced neuronal damage and cognitive impairment in aged rats by activation of NF-κB pathway and NLRP3 inflammasome

Liu, P.-F., Gao, T., Li, T., Yang, Y., Xu, Y., Xu, Z., & Mi, W. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135461 · Cited by 35

Microglia and modifiable life factors: Potential contributions to cognitive resilience in aging

Duggan, M. R., & Parikh, V. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113207 · Cited by 38

Selective TLR4 Antagonism Prevents and Reverses Morphine-Induced Persistent Postoperative Cognitive Dysfunction, Dysregulation of Synaptic Elements, and Impaired BDNF Signaling in Aged Male Rats

Muscat, S. M., Deems, N. P., Butler, M. J., Scaria, E. A., Bettes, M. N., Cleary, S. P., Bockbrader, R. H., Maier, S. F., & Barrientos, R. M. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1151-22.2022 · Cited by 35

Microglia-targeted inhibition of miR-17 via mannose-coated lipid nanoparticles improves pathology and behavior in a mouse model of Alzheimer’s disease

Badr, A., Daily, K. P., Eltobgy, M. M., Estfanous, S. Z. K., Tan, M. H., Kuo, J. C., Whitham, O. D., Carafice, C., Gupta, G., Amer, H. M., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.05.006 · Cited by 37

Insulin resistance plays a potential role in postoperative cognitive dysfunction in patients following cardiac valve surgery

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Dorsal raphe neuroinflammation promotes dramatic behavioral stress dysregulation

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Downregulation of Nrf2 in the Hippocampus Contributes to Postoperative Cognitive Dysfunction in Aged Rats by Sensitizing Oxidative Stress and Neuroinflammation

Li, L., Meng, F., & Li, D. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/7272456 · Cited by 33

Short-term high-fat diet consumption impairs synaptic plasticity in the aged hippocampus via IL-1 signaling

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Sex differences in microglia function in aged rats underlie vulnerability to cognitive decline

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Melatonin and Rapamycin Attenuate Isoflurane-Induced Cognitive Impairment Through Inhibition of Neuroinflammation by Suppressing the mTOR Signaling in the Hippocampus of Aged Mice

Yuan, H., Wu, G., Zhai, X., Lu, B., Meng, B., & Chen, J. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00314 · Cited by 33

Green light exposure elicits anti-inflammation, endogenous opioid release and dampens synaptic potentiation to relieve post-surgical pain.

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Inhibiting RIPK1 Limits Neuroinflammation and Alleviates Postoperative Cognitive Impairments in D-Galactose-Induced Aged Mice

Duan, S., Wang, X., Chen, G., Quan, C., Qu, S., & Tong, J. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00138 · Cited by 32

Acute pre-operative ibuprofen improves cognition in a rat model for postoperative cognitive dysfunction

Oberman, K., Hovens, I. B., de Haan, J. J., Salles, J. F., van Leeuwen, B. L., & Schoemaker, R. G. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02206-y · Cited by 32

JNK inhibition alleviates delayed neurocognitive recovery after surgery by limiting microglia pyroptosis

He, J., Liu, T., Li, Y., Mi, X., Han, D., Yang, N., Chen, L., Li, Y., Hong, J., Kuang, C., et al. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107962 · Cited by 33

The NF-κB pathway: Key players in neurocognitive functions and related disorders

Yang, D., Su, J., Chen, Y., & Chen, G. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.177038 · Cited by 31

Inhibition of adult hippocampal neurogenesis induced by postoperative CD8 + T-cell infiltration is associated with cognitive decline later following surgery in adult mice

Li, X., Wang, H., Zhang, Q., Sun, X., Zhang, M., & Wang, G. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02910-x · Cited by 32

Chronic Trigeminal Nerve Stimulation Protects Against Seizures, Cognitive Impairments, Hippocampal Apoptosis, and Inflammatory Responses in Epileptic Rats

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NLRP3 inflammasomes are involved in the progression of postoperative cognitive dysfunction: from mechanism to treatment

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Hydrogen sulfide attenuates postoperative cognitive dysfunction through promoting the pathway of Warburg effect-synaptic plasticity in hippocampus

Chen, S.-M., Li, M., Xie, J., Li, S., Xiang, S.-S., Liu, H., Chen, Z., Zhang, P., Kuang, X., & Tang, X. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115286 · Cited by 30

Galectin‐1 ameliorates perioperative neurocognitive disorders in aged mice

Shen, Z., Xu, H., Song, W. L., Hu, C., Guo, M., Li, J., & Li, J. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13645 · Cited by 31

Dietary DHA prevents cognitive impairment and inflammatory gene expression in aged male rats fed a diet enriched with refined carbohydrates

Butler, M. J., Deems, N. P., Muscat, S. M., Butt, C. M., Belury, M. A., & Barrientos, R. M. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.08.214 · Cited by 34

Translational Selenium Nanotherapeutics Counter-Acts Multiple Risk Factors to Improve Surgery-Induced Cognitive Impairment

Liang, X., Liu, T., Li, L., Li, J., Li, S., Zeng, K., Song, C., Chen, T., & Zou, Y. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.135984 · Cited by 30

Thinking outside the brain for cognitive improvement: Is peripheral immunomodulation on the way?

Zheng, X., Zhang, X., An, K., Ran, C., Wang, G., & Hao, H. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.06.020 · Cited by 29

Inflammatory markers in postoperative cognitive dysfunction for patients undergoing total hip arthroplasty: a meta-analysis

Fu, C., Lin, J., Gong, G., Zhong, W., Chen, H., & Luo, X. (2021) · Aging Clinical and Experimental Research · doi:10.1007/s40520-021-01919-7 · Cited by 29

IL-33/ST2 mediating systemic inflammation and neuroinflammation through NF-kB participated in the neurocognitive impairment in obstructive sleep apnea

Dandan-Zong, Shen, C., Liu, X., Liu, T., Ou, Y., & Ouyang, R. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109604 · Cited by 29

Lifestyle modifications with anti-neuroinflammatory benefits in the aging population

Muscat, S. M., & Barrientos, R. M. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111144 · Cited by 30

Hyperbaric oxygen preconditioning improves postoperative cognitive dysfunction by reducing oxidant stress and inflammation

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The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [11C]PBR28 binding and exploration of its link to post-operative delirium

Katsumi, Y., Racine, A. M., Torrado-Carvajal, Á., Loggia, M. L., Hooker, J. M., Greve, D. N., Hightower, B. G., Catana, C., Cavallari, M., Arnold, S. E., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102346 · Cited by 26

The Perfect Cytokine Storm: How Peripheral Immune Challenges Impact Brain Plasticity & Memory Function in Aging

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Past to Future: What Animal Models Have Taught Us About Alzheimer’s Disease

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Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone

Kwilasz, A. J., Todd, L. S., Duran-Malle, J. C., Schrama, A. E. W., Mitten, E. H., Larson, T. A., Clements, M. A., Harris, K. M., Litwiler, S. T., Wang, X., et al. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112896 · Cited by 28

Memory enhancing effect of Nigella Sativa hydro-alcoholic extract on lipopolysaccharide-induced memory impairment in rats

Norouzi, F., Hosseini, M., Abareshi, A., Beheshti, F., Khazaei, M., Shafei, M. N., Soukhtanloo, M., Gholamnezhad, Z., & Anaeigoudari, A. (2018) · Drug and Chemical Toxicology · doi:10.1080/01480545.2018.1447578 · Cited by 25

Assessment of neuroinflammation in the aging hippocampus using large-molecule microdialysis: Sex differences and role of purinergic receptors

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Effects of andrographolide on postoperative cognitive dysfunction and the association with NF‑κB/MAPK pathway

Ding, Y., Shi, C., Chen, L., Ma, P., Li, K., Jin, J., Zhang, Q., & Li, A. (2017) · Oncology Letters · doi:10.3892/ol.2017.7088 · Cited by 25

Carnosine ameliorates postoperative cognitive dysfunction of aged rats by limiting astrocytes pyroptosis

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Dexmedetomidine inhibits the lipopolysaccharide‐stimulated inflammatory response in microglia through the pathway involving TLR4 and NF‐κB

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Dexmedetomidine ameliorates postoperative cognitive dysfunction by inhibiting Toll‐like receptor 4 signaling in aged mice

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Microglia participate in postoperative cognitive dysfunction by mediating the loss of inhibitory synapse through the complement pathway

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Isoflurane in the presence or absence of surgery increases hippocampal cytokines associated with memory deficits and responses to brain injury in rats

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Transcranial Photobiomodulation Therapy Ameliorates Perioperative Neurocognitive Disorder Through Modulation of Mitochondrial Function in Aged Mice

Zhang, X., Wu, W., Luo, Y., & Wang, Z. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.12.033 · Cited by 23

Characterization of circRNA-Associated-ceRNA Networks Involved in the Pathogenesis of Postoperative Cognitive Dysfunction in Aging Mice

Zhang, M., Lin, J.-R., Yang, S., Zou, J., Yao, X., Feng, C., & Cao, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.727805 · Cited by 22

Effect of parecoxib in the treatment of postoperative cognitive dysfunction

Huang, S. M., Hu, H., Cai, Y.-H., & Hua, F. (2019) · Medicine · doi:10.1097/md.0000000000013812 · Cited by 22

Young adult and aged female rats are vulnerable to amygdala-dependent, but not hippocampus-dependent, memory impairment following short-term high-fat diet

Muscat, S. M., Butler, M. J., Mackey-Alfonso, S. E., & Barrientos, R. M. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.03.001 · Cited by 23

Association study of MiRSNPs with schizophrenia, tardive dyskinesia and cognition

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Post-operative cognitive dysfunction is exacerbated by high-fat diet via TLR4 and prevented by dietary DHA supplementation

Muscat, S. M., Butler, M. J., Bettes, M. N., DeMarsh, J. W., Scaria, E. A., Deems, N. P., & Barrientos, R. M. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.12.028 · Cited by 20

Hyperbaric oxygen preconditioning attenuates postoperative cognitive impairment in aged rats

Sun, L., Xie, K., Zhang, C., Song, R., & Zhang, H. (2014) · Neuroreport · doi:10.1097/wnr.0000000000000181 · Cited by 20

Overexpression of phosphodiesterase-4 subtypes involved in surgery-induced neuroinflammation and cognitive dysfunction in mice

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Ulinastatin attenuates isoflurane-induced cognitive dysfunction in aged rats by inhibiting neuroinflammation and β-amyloid peptide expression in the brain

Guo, M., Zhu, X., Xu, H., Li, J., Yang, S., Zuo, Z., & Lin, D. (2019) · Neurological Research · doi:10.1080/01616412.2019.1642564 · Cited by 19

Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats dependent on NLRP3 activation

Bonfante, S., Netto, M. B., de Oliveira, A. N., Mathias, K., Machado, R. S., Joaquim, L. D. S., Cidreira, T., da Silva, M. G., Daros, G. C., Danielski, L. G., et al. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01425-5 · Cited by 19

Neutrophil gelatinase-associated lipocalin and microglial activity are associated with distinct postoperative behavioral changes in rats

Gouweleeuw, L., Hovens, I. B., van Leeuwen, B. L., & Schoemaker, R. G. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.11.023 · Cited by 19

Activation of AMP-activated protein kinase (AMPK) aggravated postoperative cognitive dysfunction and pathogenesis in aged rats

Cao, M., Fang, J., Wang, X., Wang, Y., Duan, K., Ye, F., Ouyang, W., & Tong, J. (2018) · Brain Research · doi:10.1016/j.brainres.2018.01.027 · Cited by 19

Brain interleukins and Alzheimer’s disease

Abdelhamed, H. G., Hassan, A. A., Sakraan, A., Al-Deeb, R. T., Mousa, D. M., Ezz, H. S. A., Noor, N. A., Khadrawy, Y. A., & Radwan, N. M. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01538-5 · Cited by 20

Lidocaine attenuates CFA‑induced inflammatory pain in rats by regulating the MAPK/ERK/NF‑κB signaling pathway

Zhang, S., Li, Y., & Tu, Y. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.9643 · Cited by 18

Can the dietary fat type facilitate memory impairments in adulthood? A comparative study between Mediterranean and Western-based diet in rats

Haygert, P. F., Roversi, K., Milanesi, L. H., Maurer, L. H., Camponogara, C., Duarte, T., Barcelos, R. C. S., Emanuelli, T., Oliveira, S. M., Duarte, M. M. M. F., et al. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.05.015 · Cited by 18

Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats

Zhang, Z., Guo, L., Yang, F., Peng, S., Wang, D., Lai, X., Su, B., & Xie, H. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00744 · Cited by 17

Chronic unpredictable stress exacerbates surgery-induced sickness behavior and neuroinflammatory responses via glucocorticoids secretion in adult rats

Wang, N., Ma, H., Li, Z., Gao, Y., Cao, X., Jiang, Y., Zhou, Y., & Liu, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183077 · Cited by 18

Endotoxin tolerance induced by lipopolysaccharide preconditioning protects against surgery‑induced cognitive impairment in aging mice

Zhang, Z., Ji, M., Liao, Y., Yang, J., & Gao, J. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8370 · Cited by 17

Effects of Memantine in a Mouse Model of Postoperative Cognitive Dysfunction

Almahozi, A., Radhi, M. A., Alzayer, S., & Kamal, A. (2019) · Behavioral Sciences · doi:10.3390/bs9030024 · Cited by 17

Tanshinone IIA mitigates postoperative cognitive dysfunction in aged rats by inhibiting hippocampal inflammation and ferroptosis: Role of Nrf2/SLC7A11/GPX4 axis activation

Yang, Y., Wang, B., Jiang, Y., & Fu, W. (2025) · NeuroToxicology · doi:10.1016/j.neuro.2025.02.003 · Cited by 16

The Post-Anaesthesia N-acetylcysteine Cognitive Evaluation (PANACEA) trial: study protocol for a randomised controlled trial

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Permethrin exposure affects neurobehavior and cellular characterization in rats' brain

Omotoso, G. O., Oloyede, O., Lawal, S., Gbadamosi, I., Mutholib, N. Y., Abdulsalam, F. A., Bature, A., Babalola, A., Ayeni, B., & Amedu, N. O. (2020) · Environmental Analysis Health and Toxicology · doi:10.5620/eaht.2020022 · Cited by 16

High‑fat treatment prevents postoperative cognitive dysfunction in a hyperlipidemia model by protecting the blood‑brain barrier via Mfsd2a‑related signaling

Zhang, X., Liu, Y., CHAI, M., Yang, H., Wang, G., Han, M., & Li, D. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10675 · Cited by 15

High-Pressure Pneumoperitoneum Aggravates Surgery-Induced Neuroinflammation and Cognitive Dysfunction in Aged Mice

Lu, B., Yuan, H., Zhai, X., Li, X., Qin, J., Chen, J., & Meng, B. (2020) · Mediators of Inflammation · doi:10.1155/2020/6983193 · Cited by 15

CD8+ T cells contribute to diet-induced memory deficits in aged male rats

Butler, M. J., Sengupta, S., Muscat, S. M., Amici, S. A., Biltz, R. G., Deems, N. P., Dravid, P., Mackey-Alfonso, S. E., Ijaz, H., Bettes, M. N., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.02.003 · Cited by 18

The effects of L-arginine on spatial memory and synaptic plasticity impairments induced by lipopolysaccharide

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Aging-Related Neural Disruption Might Predispose to Postoperative Cognitive Impairment Following Surgical Trauma

Ji, M., He, X., Shen, J.-C., & Yang, J. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201590 · Cited by 15

From Bench to Bedside: New Frontiers in Understanding and Treating Postoperative Delirium

Monge, K. M., Shapiro, A. L. B., Coughlan, C. M., Mungo, B., Schulick, R. D., Pratap, A., Kovacs, E. J., & Idrovo, J. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14238418 · Cited by 19

α7 Nicotinic Acetylcholine Receptor May Be a Pharmacological Target for Perioperative Neurocognitive Disorders

Wei, P., Lyu, W., Xu, L., Feng, H., Zhou, H., & Li, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.907713 · Cited by 14

Maresin1 ameliorates postoperative cognitive dysfunction in aged rats by potentially regulating the NF-κB pathway to inhibit astrocyte activation

Li, X., Gao, Y., Han, X., Tang, S., Li, N., Liu, X., & Ni, X. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112168 · Cited by 15

Crucial involvement of catecholamine neurotransmission in postoperative nausea and vomiting: Whole‐transcriptome profiling in the rat nucleus of the solitary tract

Sugino, S., Konno, D., Abe, J., Kawasawa, Y. I., Kido, K., Suzuki, J., Endo, Y., & Yamauchi, M. (2021) · Genes Brain & Behavior · doi:10.1111/gbb.12759 · Cited by 14

Dexmedetomidine Mitigates Microglial Activation Associated with Postoperative Cognitive Dysfunction by Modulating the MicroRNA-103a-3p/VAMP1 Axis

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Dexmedetomidine attenuates hippocampal neuroinflammation in postoperative neurocognitive disorders by inhibiting microRNA-329-3p and activating the CREB1/IL1RA axis

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Surgery-induced cognitive dysfunction is alleviated through triggering receptor expressed on myeloid cells 2

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