State changes rapidly modulate cortical neuronal responsiveness
Open accessAbstract
The responsiveness of cortical neurons is strongly and rapidly influenced by changes in the level of local network activity. In rodent somatosensory cortex, increases in network activity increase neuronal responsiveness to the intracellular injection of brief conductance stimuli but paradoxically decrease responsiveness to brief whisker deflections. However, whisker stimulation frequently evokes long-lasting changes in the level of local circuit activity. The ability of stimuli to successfully evoke prolonged increases in circuit activity is associated with both an increase in the amount of conductance evoked by a whisker stimulus and an increase in action potential responsiveness to whisker stimulation. In addition, brief whisker stimuli presented during periods of high network activity evoke postsynaptic potentials containing a greater proportion of inhibition, consistent with an increased efficiency in the activation of inhibitory mechanisms during the Up state. In contrast, during prolonged and variable whisker stimulation, increased network activity is associated with an increase in overall responsiveness, dynamic range, output gain, and correlation between action potential response and speed of whisker movement. We conclude that stimulus-evoked or spontaneous alterations in cortical state can influence neuronal responsiveness in a complex manner, resulting in large changes in which, and how, sensory stimuli are represented.
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In states with prominent low frequencies in cortical network activity, sensory stimuli may trigger responses that are inappropriately weak or strong and do not optimally represent the spatiotemporal features of the stimulus.
“In contrast, in states with prominent low frequencies in cortical network activity, sensory stimuli may trigger responses that are either inappropriately weak or strong, and which do not optimally represent the spatiotemporal features of the stimulus”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Hasenstaub et al., 2007
The ability of somatosensory cortex to accurately represent complex whisker deflections is facilitated by cortical activation.
“However, the ability of somatosensory cortex to accurately represent complex whisker deflections is facilitated by cortical activation”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Hasenstaub et al., 2007
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Cites
On the Theory of the Brownian Motion
Uhlenbeck, G. E., & Ornstein, L. S. (1930) · Physical Review · doi:10.1103/physrev.36.823 · Cited by 4,618 · see citing works
Hartigan, J. A., & Hartigan, P. M. (1985) · The Annals of Statistics · doi:10.1214/aos/1176346577 · Cited by 1,996 · see citing works
Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex
McCormick, D. A., Connors, B. W., Lighthall, J. W., & Prince, D. A. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.54.4.782 · Cited by 1,935 · see citing works
Self-citationSteriade, M., Nunez, A., & Amzica, F. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03252.1993 · Cited by 1,903 · see citing works
Cellular and network mechanisms of rhythmic recurrent activity in neocortex
Sanchez-Vives, M. V., & McCormick, D. A. (2000) · Nature Neuroscience · doi:10.1038/79848 · Cited by 1,539 · see citing works
Self-citationNatural waking and sleep states: a view from inside neocortical neurons
Steriade, M., Timofeev, I., & Grenier, F. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.5.1969 · Cited by 1,296 · see citing works
Turning on and off recurrent balanced cortical activity
Shu, Y., Hasenstaub, A., & McCormick, D. A. (2003) · Nature · doi:10.1038/nature01616 · Cited by 1,054 · see citing works
Self-citationHaider, B., Duque, A., Hasenstaub, A. R., & McCormick, D. A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5297-05.2006 · Cited by 962 · see citing works
Self-citationOn the theory of brownian motion
Mazur, P. (1959) · Physica · doi:10.1016/s0031-8914(59)91931-7 · Cited by 933 · see citing works
Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex
Petersen, C. C. H., Hahn, T. T. G., Mehta, M. R., Grinvald, A., & Sakmann, B. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2235811100 · Cited by 673 · see citing works
Visual input evokes transient and strong shunting inhibition in visual cortical neurons
Graham, L. J., Monier, C., & Frégnac, Y. (1998) · Nature · doi:10.1038/30735 · Cited by 669 · see citing works
Hasenstaub, A. R., Shu, Y., Haider, B., Kraushaar, U., Duque, A., & McCormick, D. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.016 · Cited by 654 · see citing works
Self-citationSynaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex
Cruikshank, S. J., Lewis, T. J., & Connors, B. W. (2007) · Nature Neuroscience · doi:10.1038/nn1861 · Cited by 558 · see citing works
Correlating whisker behavior with membrane potential in barrel cortex of awake mice
Crochet, S., & Petersen, C. (2006) · Nature Neuroscience · doi:10.1038/nn1690 · Cited by 556 · see citing works
Differential regulation of neocortical synapses by neuromodulators and activity
Gil, Z., Connors, B. W., & Amitai, Y. (1997) · Neuron · doi:10.1016/s0896-6273(00)80380-3 · Cited by 553 · see citing works
Compte, A., Sanchez-Vives, M. V., McCormick, D. A., & Wang, X. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00845.2002 · Cited by 536 · see citing works
Self-citationCowan, R. L., & Wilson, C. J. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.71.1.17 · Cited by 535 · see citing works
Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors.
McCormick, D. A., & von Krosigk, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.2774 · Cited by 500 · see citing works
Self-citationde Boer, E., & Kuyper, P. (1968) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.1968.4502561 · Cited by 471 · see citing works
Paré, D., Shink, É., Gaudreau, H., Alain Destexhe, A., & Lang, E. J. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.3.1450 · Cited by 453 · see citing works
Nowak, L. G., Azouz, R., Sanchez-Vives, M. V., Gray, C. M., & McCormick, D. A. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00580.2002 · Cited by 443 · see citing works
Self-citationStafstrom, C. E., Schwindt, P. C., Chubb, M. C., & Crill, W. E. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.53.1.153 · Cited by 414 · see citing works
Cellular Mechanisms Contributing to Response Variability of Cortical NeuronsIn Vivo
Azouz, R., & Gray, C. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02209.1999 · Cited by 408 · see citing works
Spatiotemporal convergence and divergence in the rat S1 “Barrel” cortex
Armstrong-James, M., & Fox, K. (1987) · The Journal of comparative neurology · doi:10.1002/cne.902630209 · Cited by 389 · see citing works
Porter, J. T., Johnson, C. K., & Agmon, A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02699.2001 · Cited by 344 · see citing works
Temporal encoding in nervous systems: A rigorous definition
Theunissen, F. E., & Miller, J. P. (1995) · Journal of Computational Neuroscience · doi:10.1007/bf00961885 · Cited by 338 · see citing works
Arieli, A., Shoham, D., Hildesheim, R., & Grinvald, A. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.5.2072 · Cited by 337 · see citing works
Barrages of Synaptic Activity Control the Gain and Sensitivity of Cortical Neurons
Shu, Y., Hasenstaub, A., Badoual, M., Bal, T., & McCormick, D. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-32-10388.2003 · Cited by 298 · see citing works
Self-citationThe dynamic clamp: artificial conductances in biological neurons
Sharp, A. A., O'Neil, M. B., Abbott, L. F., & Marder, E. E. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90004-6 · Cited by 293 · see citing works
Neuronal Encoding of Texture in the Whisker Sensory Pathway
Arabzadeh, E., Zorzin, E., & Diamond, M. E. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030017 · Cited by 276 · see citing works
Fellous, J.-M., Rudolph, M., Destexhe, A., & Sejnowski, T. J. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.027 · Cited by 273 · see citing works
What Stops Synchronized Thalamocortical Oscillations?
Bal, T., & McCormick, D. A. (1996) · Neuron · doi:10.1016/s0896-6273(00)80161-0 · Cited by 250 · see citing works
Self-citationCircuit dynamics and coding strategies in rodent somatosensory cortex
Pinto, D. J., Brumberg, J. C., & Simons, D. J. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.3.1158 · Cited by 239 · see citing works
Timofeev, I., Contreras, D., & Steriade, M. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021489 · Cited by 231 · see citing works
Haptic Object Localization in the Vibrissal System: Behavior and Performance
Knutsen, P., Pietr, M., & Ahissar, E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1516-06.2006 · Cited by 228 · see citing works
Shu, Y., Duque, A., Yu, Y., Haider, B., & McCormick, D. A. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00922.2006 · Cited by 221 · see citing works
Self-citationHartmann, M. J., Johnson, N. J., Towal, R. B., & Assad, C. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-16-06510.2003 · Cited by 220 · see citing works
Persistent Cortical Activity: Mechanisms of Generation and Effects on Neuronal Excitability
McCormick, D. A. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg104 · Cited by 199 · see citing works
Self-citationBurst and Tonic Response Modes in Thalamic Neurons During Sleep and Wakefulness
Weyand, T. G., Boudreaux, M., & Guido, W. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.3.1107 · Cited by 199 · see citing works
Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin
Cahalan, M. D., & Almers, W. (1979) · Biophysical Journal · doi:10.1016/s0006-3495(79)85201-7 · Cited by 192 · see citing works
Castro‐Alamancos, M. A., & Oldford, E. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.016857 · Cited by 185 · see citing works
Vibrissa resonance as a transduction mechanism for tactile encoding
Neimark, M. A., Andermann, M. L., Hopfield, J. J., & Moore, C. I. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-16-06499.2003 · Cited by 179 · see citing works
Effect of Subthreshold Up and Down States on the Whisker-Evoked Response in Somatosensory Cortex
Sachdev, R. N. S., Ebner, F. F., & Wilson, C. J. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00347.2004 · Cited by 168 · see citing works
Self-citationMetherate, R., & Ashe, J. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-12-05312.1993 · Cited by 166 · see citing works
Shoykhet, M., Doherty, D., & Simons, D. (2000) · Somatosensory & motor research · doi:10.1080/08990220050020580 · Cited by 165 · see citing works
Dorval, A. D., Christini, D. J., & White, J. A. (2001) · Annals of Biomedical Engineering · doi:10.1114/1.1408929 · Cited by 164 · see citing works
Nathan, T., Jensen, M. S., & Lambert, J. D. C. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90865-7 · Cited by 158 · see citing works
Short-Term Dynamics of Thalamocortical and Intracortical Synapses Onto Layer 6 Neurons in Neocortex
Beierlein, M., & Connors, B. W. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.4.1924 · Cited by 152 · see citing works
Receptive-field construction in cortical inhibitory interneurons
Swadlow, H. A., & Gusev, A. G. (2002) · Nature Neuroscience · doi:10.1038/nn847 · Cited by 148 · see citing works
Whisker Vibration Information Carried by Rat Barrel Cortex Neurons
Arabzadeh, E., Panzeri, S., & Diamond, M. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1389-04.2004 · Cited by 145 · see citing works
Ringach, D. L., Hawken, M. J., & Shapley, R. M. (2002) · Journal of Vision · doi:10.1167/2.1.2 · Cited by 138 · see citing works
Adaptive filtering of vibrissa input in motor cortex of rat.
Kleinfeld, D., Sachdev, R. N., Merchant, L. M., Jarvis, M., & Ebner, F. (2002) · Neuron · doi:10.1016/s0896-6273(02)00732-8 · Cited by 117 · see citing works
Self-citationPerkins, K. L., & Wong, R. K. S. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.2.911 · Cited by 115 · see citing works
Texture Signals in Whisker Vibrations
Hipp, J. F., Arabzadeh, E., Zorzin, E., Conradt, J., Kayser, C., Diamond, M. E., & Peter König, B. (2005) · Journal of Neurophysiology · doi:10.1152/jn.01104.2005 · Cited by 106 · see citing works
Divergent Movement of Adjacent Whiskers
Sachdev, R. N. S., Sato, T. G., & Ebner, F. F. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00539.2001 · Cited by 97 · see citing works
Self-citationSodium inactivation mechanism modulates QX-314 block of sodium channels in squid axons
Yeh, J. Z. (1978) · Biophysical Journal · doi:10.1016/s0006-3495(78)85403-4 · Cited by 97 · see citing works
Impact of Cortical Network Activity on Short-term Synaptic Depression
Reig, R., Gallego, R., Nowak, L. G., & Sanchez-Vives, M. V. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj014 · Cited by 90 · see citing works
Precise Temporal Responses in Whisker Trigeminal Neurons
Jones, L. M., Lee, S., Trageser, J. C., Simons, D. J., & Keller, A. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00031.2004 · Cited by 80 · see citing works
Texture discrimination and unit recordings in the rat whisker/barrel system
Prigg, T., Goldreich, D., Carvell, G., & Simons, D. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00917-4 · Cited by 74 · see citing works
Temporal organization of multi-whisker contact in rats
Sachdev, R. N. S. (2001) · Somatosensory & Motor Research · doi:10.1080/135578501012006192 · Cited by 62 · see citing works
Self-citationSelective Amplification of Neocortical Neuronal Output by Fast Prepotentials InVivo
Crochet, S. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh071 · Cited by 54 · see citing works
Analysis of LFP Phase Predicts Sensory Response of Barrel Cortex
Haslinger, R., Ulbert, I., Moore, C. I., Brown, E. N., & Devor, A. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01288.2005 · Cited by 48 · see citing works
Stimulus Frequency Processing in Awake Rat Barrel Cortex
Melzer, P., Sachdev, R. N. S., Jenkinson, N., & Ebner, F. F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2620-06.2006 · Cited by 33 · see citing works
Self-citationRelief of Synaptic Depression Produces Long-Term Enhancement in Thalamocortical Networks
Hirata, A., & Castro‐Alamancos, M. A. (2005) · Journal of Neurophysiology · doi:10.1152/jn.01145.2005 · Cited by 25 · see citing works
Spatio-temporal cross-correlation analysis of catfish retinal neurons
Powers, R. L., & Arnett, D. W. (1981) · Biological Cybernetics · doi:10.1007/bf00340319 · Cited by 15 · see citing works
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“However, the ability of somatosensory cortex to accurately represent complex whisker deflections is facilitated by cortical activation (Hasenstaub et al., 2007; Zagha et al., 2013), suggesting that the enhanced responses to punctate stimuli during low frequency oscillatory states may be unique to…”
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- Authors
- Hasenstaub, A., Sachdev, R. N. S., & McCormick, D. A.
- Affiliations
- Yale University (US)
- Salk Institute for Biological Studies (US)
- Corresponding author
- McCormick, David A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-09-05
- Volume
- 27
- Issue
- 36
- Pages
- 9607-9622
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6672966
- OpenAlex
- W2004550838
- Cited by
- 196
- References
- 65
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 11 · 2018: 7 · 2017: 14 · 2016: 14 · 2015: 13 · 2014: 13 · 2013: 16 · 2012: 12
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- cortical state, up states, somatosensory cortex, whisker stimulation, network activity, conductance change, postsynaptic inhibition, dynamic range, sensory representation, rodent cortex
- MeSH terms
- Action Potentials, Animals, Biological Clocks, Male, Nerve Net, Neurons, Physical Stimulation, Somatosensory Cortex, Time Factors, Vibrissae, Rats, Sprague-Dawley, Patch-Clamp Techniques, Rats
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