Motor cortex feedback influences sensory processing by modulating network state
Open accessAbstract
Long-range corticocortical communication may have important roles in context-dependent sensory processing, yet we know very little about how these pathways influence their target regions. We studied the influence of primary motor cortex activity on primary somatosensory cortex in the mouse whisker system. We show that primary motor and somatosensory cortices undergo coherent, context-dependent changes in network state. Moreover, we show that motor cortex activity can drive changes in somatosensory cortex network state. A series of experiments demonstrate the involvement of the direct corticocortical feedback pathway, providing temporally precise and spatially targeted modulation of network dynamics. Cortically mediated changes in network state significantly impact sensory coding, with activated states increasing the reliability of responses to complex stimuli. By influencing network state, corticocortical communication from motor cortex may ensure that during active exploration the relevant sensory region is primed for enhanced sensory discrimination.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Motor processes themselves may also regulate low-frequency synchronization in sensory cortex, or states associated with constricting and dilating pupils are distinct even at the same pupil diameter.
“This suggests that motor processes themselves may also regulate low-frequency synchronization in sensory cortex (Schneider et al., 2014; Zagha et al., 2013) or that states associated with constricting and dilating pupils are distinct, even at the same pupil diameter”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Zagha et al., 2013
The ability of somatosensory cortex to accurately represent complex whisker deflections is facilitated by cortical activation.
“However, the ability of somatosensory cortex to accurately represent complex whisker deflections is facilitated by cortical activation”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Zagha et al., 2013
Recent studies have identified thalamocortical, corticocortical and corticothalamic pathways that can control cortical state and sensory responsiveness with high temporal and spatial specificity.
“In addition to the modulation of cortical neuronal excitability by ascending noradrenergic and cholinergic systems, recent studies have identified thalamocortical, corticocortical and corticothalamic pathways that can control cortical state and sensory responsiveness with high temporal and spatial specificity, owing to their activation of ionotropic and metabotropic glutamate receptors (Nelson et”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Zagha et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Distributed hierarchical processing in the primate cerebral cortex
Felleman, D. J., & Van Essen, D. C. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.1 · Cited by 7,783 · see citing works
Buzsáki, G. (2006) · doi:10.1093/acprof:oso/9780195301069.001.0001 · Cited by 4,873 · see citing works
Brain stem reticular formation and activation of the EEG
Moruzzi, G., & Magoun, H. W. (1949) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(49)90219-9 · Cited by 4,307 · see citing works
Über das Elektrenkephalogramm des Menschen
Berger, H. (1929) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf01797193 · Cited by 4,266 · see citing works
Thalamocortical oscillations in the sleeping and aroused brain
Steriade, M., McCormick, D. A., & Sejnowski, T. J. (1993) · Science · doi:10.1126/science.8235588 · Cited by 3,564 · see citing works
Self-citationDynamic predictions: Oscillations and synchrony in top–down processing
Engel, A. K., Fries, P., & Singer, W. (2001) · Nature Reviews Neuroscience · doi:10.1038/35094565 · Cited by 3,454 · see citing works
Preface: Cerebral Cortex Has Come of Age
Goldman, P. S., & RAKIC, P. T. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.1-a · Cited by 3,412 · see citing works
Modulation of Oscillatory Neuronal Synchronization by Selective Visual Attention
Fries, P., Reynolds, J. H., Rorie, A. E., & Desimone, R. (2001) · Science · doi:10.1126/science.1055465 · Cited by 2,786 · see citing works
Selective Attention Gates Visual Processing in the Extrastriate Cortex
Moran, J., & Desimone, R. (1985) · Science · doi:10.1126/science.4023713 · Cited by 2,433 · see citing works
The distinct modes of vision offered by feedforward and recurrent processing
Lamme, V. A. F., & Roelfsema, P. R. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01657-x · Cited by 2,338 · see citing works
Selective Attention Gates Visual Processing in the Extrastriate Cortex
Moran, J., & Desimone, R. (2003) · The MIT Press eBooks · doi:10.7551/mitpress/2834.003.0024 · Cited by 2,164 · see citing works
Steriade, M., Nunez, A., & Amzica, F. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03252.1993 · Cited by 1,903 · see citing works
Dynamics of ongoing activity: explanation of the large variability in evoked cortical responses
Arieli, A., Sterkin, A., Grinvald, A., & Aertsen, A. (1996) · Science · doi:10.1126/science.273.5283.1868 · Cited by 1,660 · see citing works
Modulation of visual responses by behavioral state in mouse visual cortex
Niell, C. M., & Stryker, M. P. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.033 · Cited by 1,483 · see citing works
Top-down modulation: bridging selective attention and working memory
Gazzaley, A., & Nobre, A. C. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.11.014 · Cited by 1,404 · see citing works
Attentional modulation of visual processing
Reynolds, J. H., & Chelazzi, L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131039 · Cited by 1,158 · see citing works
The subcellular organization of neocortical excitatory connections
Petreanu, L., Mao, T., Sternson, S. M., & Svoboda, K. (2009) · Nature · doi:10.1038/nature07709 · Cited by 1,047 · see citing works
Nucleus basalis and thalamic control of neocortical activity in the freely moving rat
Buzsáki, G., Bickford, R. G., Ponomareff, G., Thal, L. J., Mandel, R. J., & Gage, F. H. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-11-04007.1988 · Cited by 1,039 · see citing works
Harris, K. D., & Thiele, A. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3084 · Cited by 871 · see citing works
Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice
Poulet, J. F. A., & Petersen, C. C. H. (2008) · Nature · doi:10.1038/nature07150 · Cited by 796 · see citing works
Anticipatory activity of motor cortex neurons in relation to direction of an intended movement.
Tanji, J., & Evarts, E. (1976) · Journal of Neurophysiology · doi:10.1152/jn.1976.39.5.1062 · Cited by 740 · see citing works
Spatiotemporal Dynamics of Cortical Sensorimotor Integration in Behaving Mice
Férézou, I., Haiss, F., Gentet, L. J., Aronoff, R., Weber, B., & Petersen, C. C. H. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.007 · Cited by 692 · see citing works
Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex
Petersen, C. C. H., Hahn, T. T. G., Mehta, M. R., Grinvald, A., & Sakmann, B. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2235811100 · Cited by 673 · see citing works
Neuromodulation of Brain States
Lee, S., & Dan, Y. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.012 · Cited by 666 · see citing works
Metherate, R., Cox, C. L., & Ashe, J. H. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-12-04701.1992 · Cited by 575 · see citing works
Basal forebrain activation enhances cortical coding of natural scenes
Goard, M. J., & Dan, Y. (2009) · Nature Neuroscience · doi:10.1038/nn.2402 · Cited by 558 · see citing works
Correlating whisker behavior with membrane potential in barrel cortex of awake mice
Crochet, S., & Petersen, C. (2006) · Nature Neuroscience · doi:10.1038/nn1690 · Cited by 556 · see citing works
Multiple dynamic representations in the motor cortex during sensorimotor learning
Huber, D., Gutnisky, D. A., Peron, S., O’Connor, D. H., Wiegert, J. S., Tian, L., Oertner, T. G., Looger, L. L., & Svoboda, K. (2012) · Nature · doi:10.1038/nature11039 · Cited by 540 · see citing works
Jones, B. E. (2003) · Frontiers in bioscience · doi:10.2741/1074 · Cited by 532 · see citing works
Margrie, T. W., Brecht, M., & Sakmann, B. J. (2002) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-002-0831-z · Cited by 525 · see citing works
Cortical Preparatory Activity: Representation of Movement or First Cog in a Dynamical Machine?
Churchland, M. M., Cunningham, J. P., Kaufman, M. T., Ryu, S. I., & Shenoy, K. V. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.015 · Cited by 506 · see citing works
Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors.
McCormick, D. A., & von Krosigk, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.2774 · Cited by 500 · see citing works
Self-citationRapid Neocortical Dynamics: Cellular and Network Mechanisms
Haider, B., & McCormick, D. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.008 · Cited by 441 · see citing works
Self-citationEffects and Mechanisms of Wakefulness on Local Cortical Networks
Constantinople, C. M., & Bruno, R. M. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.040 · Cited by 387 · see citing works
Active sensation: Insights from the rodent vibrissa sensorimotor system
Kleinfeld, D., Ahissar, E., & Diamond, M. E. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.06.009 · Cited by 374 · see citing works
Activity in motor-sensory projections reveals distributed coding in somatosensation
Petreanu, L., Gutnisky, D. A., Huber, D., Xu, N.-L., O’Connor, D. H., Tian, L., Looger, L., & Svoboda, K. (2012) · Nature · doi:10.1038/nature11321 · Cited by 347 · see citing works
Behavioral Modulation of Tactile Responses in the Rat Somatosensory System
Fanselow, E. E., & Nicolelis, M. A. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07603.1999 · Cited by 345 · see citing works
Thalamic control of cortical states
Poulet, J. F. A., Fernandez, L. M. J., Crochet, S., & Petersen, C. C. H. (2012) · Nature Neuroscience · doi:10.1038/nn.3035 · Cited by 312 · see citing works
Steriade, M., Amzica, F., & Nunez, A. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.4.1385 · Cited by 302 · see citing works
Neurotransmitter Control of Neocortical Neuronal Activity and Excitability
McCormick, D. A., Wang, Z., & Huguenard, J. R. (1993) · Cerebral Cortex · doi:10.1093/cercor/3.5.387 · Cited by 289 · see citing works
Self-citationA Cortical Substrate for Memory-Guided Orienting in the Rat
Erlich, J. C., Bialek, M., & Brody, C. D. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.010 · Cited by 275 · see citing works
Larkum, M. E., & Zhu, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-16-06991.2002 · Cited by 249 · see citing works
Layer I of primary sensory neocortex: where top-down converges upon bottom-up
Cauller, L. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00032-1 · Cited by 225 · see citing works
Egner (2005) · doi:10.1038/nn1591 · Cited by 207 · see citing works
State changes rapidly modulate cortical neuronal responsiveness
Hasenstaub, A., Sachdev, R. N. S., & McCormick, D. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2184-07.2007 · Cited by 196 · see citing works
Self-citationInvited Review Anatomical loops and their electrical dynamics in relation to whisking by rat
KLEINFELD, D., BERG, R. W., & O'CONNOR, S. M. (1999) · Somatosensory & Motor Research · doi:10.1080/08990229970528 · Cited by 191 · see citing works
Primary motor cortex reports efferent control of vibrissa motion on multiple time scales
Hill, D. N., Curtis, J., Moore, J. D., & Kleinfeld, D. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.020 · Cited by 187 · see citing works
Input-output organization of the rat vibrissal motor cortex
Miyashita, E., Keller, A., & Asanuma, H. (1994) · Experimental Brain Research · doi:10.1007/bf00239589 · Cited by 174 · see citing works
Effect of Subthreshold Up and Down States on the Whisker-Evoked Response in Somatosensory Cortex
Sachdev, R. N. S., Ebner, F. F., & Wilson, C. J. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00347.2004 · Cited by 168 · see citing works
Self-citationMotor modulation of afferent somatosensory circuits
Lee, S., Carvell, G. E., & Simons, D. J. (2008) · Nature Neuroscience · doi:10.1038/nn.2227 · Cited by 155 · see citing works
Cauller, L., & Kulics, A. T. (1991) · Experimental Brain Research · doi:10.1007/bf00230973 · Cited by 147 · see citing works
Thalamocortical optimization of tactile processing according to behavioral state
Nicolelis, M. A. L., & Fanselow, E. E. (2002) · Nature Neuroscience · doi:10.1038/nn0602-517 · Cited by 143 · see citing works
Laminar analysis of extracellular field potentials in rat vibrissa/barrel cortex
Di, S., Baumgartner, C., & Barth, D. S. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.63.4.832 · Cited by 140 · see citing works
Single‐cell study of motor cortex projections to the barrel field in rats
Veinante, P., & Deschênes, M. (2003) · The Journal of comparative neurology · doi:10.1002/cne.10769 · Cited by 134 · see citing works
Afferent and efferent pathways of the vibrissal region of primary motor cortex in the mouse
Porter, L. L., & White, E. L. (1983) · Journal of Comparative Neurology · doi:10.1002/cne.902140306 · Cited by 131 · see citing works
Enhancement of visual responsiveness by spontaneous local network activity in vivo
Haider, B., Duque, A., Hasenstaub, A. R., Yu, Y., & McCormick, D. A. (2007) · Journal of Neurophysiology · doi:10.1152/jn.01114.2006 · Cited by 130 · see citing works
Self-citationDringenberg, H. C., & Vanderwolf, C. H. (1997) · Experimental Brain Research · doi:10.1007/pl00005736 · Cited by 112 · see citing works
Central Signals Rapidly Switch Tactile Processing in Rat Barrel Cortex during Whisker Movements
Hentschke, H., Haiss, F., & Schwarz, C. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj056 · Cited by 110 · see citing works
Layer-Specific Somatosensory Cortical Activation During Active Tactile Discrimination
Krupa, D. J., Wiest, M., Shuler, M. G. H., Laubach, M., & Nicolelis, M. (2004) · Science · doi:10.1126/science.1093318 · Cited by 99 · see citing works
State-Dependent Representation of Amplitude-Modulated Noise Stimuli in Rat Auditory Cortex
Marguet, S. L., & Harris, K. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5773-10.2011 · Cited by 98 · see citing works
The relationship of vibrissal motor cortex unit activity to whisking in the awake rat
Carvell, G. E., Miller, S. A., & Simons, D. J. (1996) · Somatosensory & Motor Research · doi:10.3109/08990229609051399 · Cited by 82 · see citing works
Sharp, F. R., & Evans, K. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902080305 · Cited by 73 · see citing works
Rocco, M. M., & Brumberg, J. C. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.01.002 · Cited by 46 · see citing works
Vibrissae motor cortex unit activity during whisking
Friedman, W. A., Zeigler, H. P., & Keller, A. (2011) · Journal of Neurophysiology · doi:10.1152/jn.01132.2010 · Cited by 32 · see citing works
Movement, Confusion, and Orienting in Frontal Cortices
Brecht, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.10.002 · Cited by 21 · see citing works
Borisovska, M., McGinley, M. J., Bensen, A. L., & Westbrook, G. L. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.206276 · Cited by 20 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Pupil fluctuations track rapid changes in adrenergic and cholinergic activity in cortex
Reimer, J., McGinley, M. J., Liu, Y., Rodenkirch, C., Wang, Q., McCormick, D. A., & Tolias, A. S. (2016) · Nature Communications · doi:10.1038/ncomms13289 · Cited by 926 · see citing works
Self-citationArousal and Locomotion Make Distinct Contributions to Cortical Activity Patterns and Visual Encoding
Vinck, M., Batista-Brito, R., Knoblich, U., & Cardin, J. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.028 · Cited by 819 · see citing works
Waking state: rapid variations modulate neural and behavioral responses
McGinley, M. J., Vinck, M., Reimer, J., Batista-Brito, R., Zagha, E., Cadwell, C. R., Tolias, A. S., Cardin, J. A., & McCormick, D. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.012 · Cited by 801 · see citing works
“…auditory cortical neurons are frequently observed, and these oscillations are strongly suppressed by the initiation of whisking or locomotion (Bennett et al., 2013; Crochet and Petersen, 2006; Gentet et al., 2010; McGinley et al., 2015; Polack et al., 2013; Reimer et al., 2014; Zagha et al., 2013).”
InfluentialSelf-citationCortical membrane potential signature of optimal states for sensory signal detection
McGinley, M. J., David, S. V., & McCormick, D. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.038 · Cited by 728 · see citing works
Self-citationPupil fluctuations track fast switching of cortical states during quiet wakefulness
Reimer, J., Froudarakis, E., Cadwell, C. R., Yatsenko, D., Denfield, G. H., & Tolias, A. S. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.033 · Cited by 717 · see citing works
“…with previous studies (Bennett et al., 2013; Crochet and Petersen, 2006; Niell and Stryker, 2010; Polack et al., 2013; Poulet and Petersen, 2008; Zagha et al., 2013), we found that during exploratory behaviors (running and/or whisking), V m in both S1 and V1 was desynchronized (red horizontal…”
InfluentialDiverse coupling of neurons to populations in sensory cortex
Okun, M., Steinmetz, N. A., Cossell, L., Iacaruso, M. F., Ko, H., Barthó, P., Moore, T., Hofer, S. B., Mrsic‐Flogel, T. D., Carandini, M., et al. (2015) · Nature · doi:10.1038/nature14273 · Cited by 428 · see citing works
Astrocytes regulate cortical state switching in vivo
Poskanzer, K. E., & Yuste, R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520759113 · Cited by 377 · see citing works
Scaling down of balanced excitation and inhibition by active behavioral states in auditory cortex
Zhou, M., Liang, F., Xiong, X. R., Li, L., Li, H., Xiao, Z., Tao, H. W., & Zhang, L. I. (2014) · Nature Neuroscience · doi:10.1038/nn.3701 · Cited by 316 · see citing works
Behavior needs neural variability
Waschke, L., Kloosterman, N. A., Obleser, J., & Garrett, D. D. (2021) · Neuron · doi:10.1016/j.neuron.2021.01.023 · Cited by 301 · see citing works
Neuromodulation of brain state and behavior
McCormick, D. A., Nestvogel, D. B., & He, B. J. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-100219-105424 · Cited by 303 · see citing works
Self-citationIbrahim, L. A., Mesik, L., Ji, X., Fang, Q., Li, H.-F., Li, Y.-T., Zingg, B., Zhang, L. I., & Tao, H. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.027 · Cited by 299 · see citing works
Luhmann, H. J., Sinning, A., Yang, J., Reyes‐Puerta, V., Stüttgen, M. C., Kirischuk, S., & Kilb, W. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00040 · Cited by 275 · see citing works
Tuning pathological brain oscillations with neurofeedback: a systems neuroscience framework
Ros, T., Baars, B. J., Lanius, R. A., & Vuilleumier, P. O. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.01008 · Cited by 263 · see citing works
Cholinergic signals in mouse barrel cortex during active whisker sensing
Eggermann, E., Kremer, Y., Crochet, S., & Petersen, C. C. H. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.005 · Cited by 234 · see citing works
Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei
Collins, D. P., Anastasiades, P. G., Marlin, J. J., & Carter, A. G. (2018) · Neuron · doi:10.1016/j.neuron.2018.03.024 · Cited by 231 · see citing works
Motor contributions to the temporal precision of auditory attention
Morillon, B., Schroeder, C. E., & Wyart, V. (2014) · Nature Communications · doi:10.1038/ncomms6255 · Cited by 226 · see citing works
Gao, Y., Ma, Y., Zhang, Q., Winder, A. T., Liang, Z., Antinori, L., Drew, P. J., & Zhang, N. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.11.069 · Cited by 216 · see citing works
Thalamic reticular nucleus induces fast and local modulation of arousal state
Lewis, L. D., Voigts, J., Flores, F. J., Schmitt, L. I., Wilson, M. A., Halassa, M. M., & Brown, E. N. (2015) · eLife · doi:10.7554/elife.08760 · Cited by 204 · see citing works
Selective modulation of cortical state during spatial attention
Engel, T. A., Steinmetz, N. A., Gieselmann, M. A., Thiele, A., Moore, T., & Boahen, K. A. (2016) · Science · doi:10.1126/science.aag1420 · Cited by 207 · see citing works
Brain state dependent activity in the cortex and thalamus
McCormick, D. A., McGinley, M. J., & Salkoff, D. B. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.10.003 · Cited by 189 · see citing works
Self-citationZagha, E., & McCormick, D. A. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.09.010 · Cited by 184 · see citing works
Self-citationSiclari, F., Bernardi, G., Riedner, B. A., LaRocque, J. J., Benca, R. M., & Tononi, G. (2014) · Sleep · doi:10.5665/sleep.4070 · Cited by 181 · see citing works
Origins of choice-related activity in mouse somatosensory cortex
Yang, H., Kwon, S. E., Severson, K. S., & O'Connor, D. H. (2016) · Nature Neuroscience · doi:10.1038/nn.4183 · Cited by 180 · see citing works
“Additional long-range inputs to S1 may also play a role, for instance neuromodulatory 40 axons, projections from the higher-order posteromedial thalamic nucleus 41 , or top-down projections from other motor-sensory areas 34,42,43 .”
Pathway-specific reorganization of projection neurons in somatosensory cortex during learning
Chen, J. L., Margolis, D. J., Stankov, A. D., Sumanovski, L. T., Schneider, B. L., & Helmchen, F. (2015) · Nature Neuroscience · doi:10.1038/nn.4046 · Cited by 175 · see citing works
Membrane Potential Dynamics of Neocortical Projection Neurons Driving Target-Specific Signals
Yamashita, T., Pala, A., Pedrido, L., Kremer, Y., Welker, E., & Petersen, C. C. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.059 · Cited by 172 · see citing works
Neuronal circuits in barrel cortex for whisker sensory perception
Staiger, J. F., & Petersen, C. C. H. (2021) · Physiological Reviews · doi:10.1152/physrev.00019.2019 · Cited by 165 · see citing works
Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task
Salkoff, D. B., Zagha, E., McCarthy, E., & McCormick, D. A. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz206 · Cited by 153 · see citing works
Self-citationSleep, recovery, and metaregulation: explaining the benefits of sleep
Vyazovskiy, V. V. (2015) · Nature and Science of Sleep · doi:10.2147/nss.s54036 · Cited by 151 · see citing works
The integrated brain network that controls respiration
Krohn, F., Novello, M., van der Giessen, R. S., Zeeuw, C. I. D., Pel, J. J. M., & Bosman, L. W. J. (2023) · eLife · doi:10.7554/elife.83654 · Cited by 155 · see citing works
Urbain, N., Salin, P. A., Libourel, P., Comte, J., Gentet, L. J., & Petersen, C. C. H. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.029 · Cited by 136 · see citing works
Klink, P. C., Dagnino, B., Gariel-Mathis, M.-A., & Roelfsema, P. R. (2017) · Neuron · doi:10.1016/j.neuron.2017.05.033 · Cited by 135 · see citing works
The somatosensory cortex receives information about motor output
Umeda, T., Isa, T., & Nishimura, Y. (2019) · Science Advances · doi:10.1126/sciadv.aaw5388 · Cited by 133 · see citing works
Inhibitory Circuits in Cortical Layer 5
Naka, A., & Adesnik, H. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00035 · Cited by 130 · see citing works
Long-range population dynamics of anatomically defined neocortical networks
Chen, J. L., Voigt, F. F., Javadzadeh, M., Krueppel, R., & Helmchen, F. (2016) · eLife · doi:10.7554/elife.14679 · Cited by 128 · see citing works
The Cortical States of Wakefulness
Poulet, J. F. A., & Crochet, S. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2018.00064 · Cited by 119 · see citing works
Sleep slow oscillation and plasticity
Timofeev, I., & Chauvette, S. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.03.019 · Cited by 118 · see citing works
Zhang, E., & Bruno, R. M. (2019) · eLife · doi:10.7554/elife.44158 · Cited by 111 · see citing works
Bottom-up and top-down modulation of multisensory integration
Choi, I., Lee, J. Y., & Lee, S. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.05.002 · Cited by 110 · see citing works
Pfeffer, T. A., Keitel, C., Kluger, D. S., Keitel, A., Russmann, A., Thut, G., Donner, T. H., & Groß, J. (2022) · eLife · doi:10.7554/elife.71890 · Cited by 112 · see citing works
Waschke, L., Tune, S., & Obleser, J. (2019) · eLife · doi:10.7554/elife.51501 · Cited by 105 · see citing works
Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations
Nestvogel, D., & McCormick, D. A. (2021) · Neuron · doi:10.1016/j.neuron.2021.10.005 · Cited by 103 · see citing works
Self-citationMore than Just a “Motor”: Recent Surprises from the Frontal Cortex
Ebbesen, C. L., Insanally, M. N., Kopec, C. D., Murakami, M., Saiki, A., & Erlich, J. C. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1671-18.2018 · Cited by 90 · see citing works
Sensory-Evoked and Spontaneous Gamma and Spindle Bursts in Neonatal Rat Motor Cortex
An, S., Kilb, W., & Luhmann, H. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4539-13.2014 · Cited by 94 · see citing works
Arce‐McShane, F. I., Ross, C. F., Takahashi, K., Sessle, B. J., & Hatsopoulos, N. G. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600788113 · Cited by 88 · see citing works
Optogenetic activation of neocortical neurons in vivo with a sapphire-based micro-scale LED probe
McAlinden, N., Gu, E., Dawson, M. D., Sakata, S., & Mathieson, K. (2015) · Frontiers in Neural Circuits · doi:10.3389/fncir.2015.00025 · Cited by 87 · see citing works
Neural activity in the mouse claustrum in a cross-modal sensory selection task
Chevée, M., Finkel, E. A., Kim, S.-J., O’Connor, D. H., & Brown, S. P. (2021) · Neuron · doi:10.1016/j.neuron.2021.11.013 · Cited by 86 · see citing works
Veldman, M. P., Maffiuletti, N. A., Hallett, M., Zijdewind, I., & Hortobágyi, T. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.013 · Cited by 86 · see citing works
Reznik, D., Henkin, Y., Schadel, N., & Mukamel, R. (2014) · Nature Communications · doi:10.1038/ncomms5059 · Cited by 83 · see citing works
Kral, A., Yusuf, P., & Land, R. (2017) · Hearing Research · doi:10.1016/j.heares.2016.08.017 · Cited by 81 · see citing works
Itokazu, T., Hasegawa, M., Kimura, R., Osaki, H., Albrecht, U.-R., Sohya, K., Chakrabarti, S., Itoh, H., Ito, T., Sato, T. K., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02501-4 · Cited by 81 · see citing works
A human-specific modifier of cortical connectivity and circuit function
Schmidt, E. R. E., Zhao, H. T., Park, J. M., Dipoppa, M., Monsalve-Mercado, M. M., Dahan, J. B., Rodgers, C. C., Lejeune, A., Hillman, E. M. C., Miller, K. D., et al. (2021) · Nature · doi:10.1038/s41586-021-04039-4 · Cited by 82 · see citing works
Human Somatosensory Cortex Is Modulated during Motor Planning
Gale, D. J., Flanagan, J. R., & Gallivan, J. P. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0342-21.2021 · Cited by 78 · see citing works
Competing Neural Ensembles in Motor Cortex Gate Goal-Directed Motor Output
Zagha, E., Ge, X., & McCormick, D. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.044 · Cited by 78 · see citing works
Self-citationModulation of Neocortical Development by Early Neuronal Activity: Physiology and Pathophysiology
Kirischuk, S., Sinning, A., Blanquie, O., Yang, J., Luhmann, H. J., & Kilb, W. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00379 · Cited by 79 · see citing works
Cortical State Fluctuations during Sensory Decision Making
Jacobs, E. A. K., Steinmetz, N. A., Peters, A. J., Carandini, M., & Harris, K. D. (2020) · Current Biology · doi:10.1016/j.cub.2020.09.067 · Cited by 69 · see citing works
Cortical Control of Whisker Movement
Petersen, C. C. H. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062012-170344 · Cited by 73 · see citing works
Lindeman, S., Hong, S., Kros, L., Mejías, J. F., Romano, V., Oostenveld, R., Negrello, M., Bosman, L. W. J., & Zeeuw, C. I. D. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2015292118 · Cited by 73 · see citing works
Precise movement-based predictions in the mouse auditory cortex
Audette, N. J., Zhou, W., Chioma, A. L., & Schneider, D. M. (2022) · Current Biology · doi:10.1016/j.cub.2022.09.064 · Cited by 70 · see citing works
Onorato, I., Neuenschwander, S., Hoy, J. L., Lima, B., Rocha, K.-S., Broggini, A. C., Uran, C., Spyropoulos, G., Klon-Lipok, J., Womelsdorf, T., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.039 · Cited by 63 · see citing works
Three brain states in the hippocampus and cortex
Kay, K., & Frank, L. M. (2018) · Hippocampus · doi:10.1002/hipo.22956 · Cited by 63 · see citing works
Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion
West, S. L., Aronson, J. D., Popa, L. S., Feller, K. D., Carter, R. E., Chiesl, W. M., Gerhart, M. L., Shekhar, A. C., Ghanbari, L., Kodandaramaiah, S. B., et al. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab373 · Cited by 61 · see citing works
Wang, H.-Y., Eguchi, K., Yamashita, T., & Takahashi, T. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2946-19.2020 · Cited by 59 · see citing works
Neves, R. M., van Keulen, S., Yang, M., Logothetis, N. K., & Eschenko, O. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00552.2017 · Cited by 66 · see citing works
Delta rhythm in wakefulness: evidence from intracranial recordings in human beings
Sachdev, R. N. S., Gaspard, N., Gerrard, J. L., Hirsch, L. J., Spencer, D. D., & Zaveri, H. P. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00249.2015 · Cited by 60 · see citing works
Self-citationVinck, M. A., Bos, J. J., Mourik-Donga, L. A. V., Oplaat, K. T., Klein, G. A., Jackson, J. C., Gentet, L. J., & Pennartz, C. M. A. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00187 · Cited by 56 · see citing works
Neske, G. T., Nestvogel, D., Steffan, P. J., & McCormick, D. A. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1226-18.2019 · Cited by 57 · see citing works
Self-citationTop-down coordination of local cortical state during selective attention
van Kempen, J., Gieselmann, M. A., Boyd, M., Steinmetz, N. A., Moore, T., Engel, T. A., & Thiele, A. (2021) · Neuron · doi:10.1016/j.neuron.2020.12.013 · Cited by 61 · see citing works
Modulation of cortical circuits by top-down processing and arousal state in health and disease
Batista‐Brito, R., Zagha, E., Ratliff, J. M., & Vinck, M. A. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.06.008 · Cited by 57 · see citing works
Self-citationFast and accurate edge orientation processing during object manipulation
Pruszynski, J. A., Flanagan, J. R., & Johansson, R. S. (2018) · eLife · doi:10.7554/elife.31200 · Cited by 56 · see citing works
Bauer, C. C. C., Díaz, J.-L., Concha, L., & Barrios, F. A. (2014) · Brain and Cognition · doi:10.1016/j.bandc.2014.03.009 · Cited by 56 · see citing works
Information Coding through Adaptive Gating of Synchronized Thalamic Bursting
Whitmire, C. J., Waiblinger, C., Schwarz, C., & Stanley, G. B. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.068 · Cited by 55 · see citing works
Rahimi, M. D., Fadardi, J. S., Saeidi, M., Bigdeli, I., & Kashiri, R. (2020) · Brain stimulation · doi:10.1016/j.brs.2020.02.012 · Cited by 53 · see citing works
Sensory-evoked synaptic integration in cerebellar and cerebral cortical neurons
Chadderton, P. T., Schaefer, A. T., Williams, S. R., & Margrie, T. W. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3648 · Cited by 50 · see citing works
Ohashi, H., Gribble, P. L., & Ostry, D. J. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00383.2019 · Cited by 54 · see citing works
Becoming a mother — circuit plasticity underlying maternal behavior
Elyada, Y. M., & Mizrahi, A. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.06.007 · Cited by 52 · see citing works
Parallel and Serial Sensory Processing in Developing Primary Somatosensory and Motor Cortex
Gómez, L. J., Dooley, J. C., Sokoloff, G., & BLUMBERG, M. S. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.2614-20.2021 · Cited by 52 · see citing works
Enhanced brainstem and cortical encoding of sound during synchronized movement
Nozaradan, S., Schönwiesner, M., Caron-Desrochers, L., & Lehmann, A. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.07.015 · Cited by 52 · see citing works
Olcese, U., Lohuis, M. N. O., & Pennartz, C. M. A. (2018) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2018.00049 · Cited by 49 · see citing works
Reflections of action in sensory cortex
Schneider, D. M. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.02.004 · Cited by 51 · see citing works
Cortical signatures of wakeful somatosensory processing
Song, C., Piscopo, D. M., Niell, C. M., & Knöpfel, T. (2018) · Scientific Reports · doi:10.1038/s41598-018-30422-9 · Cited by 49 · see citing works
Durá-Bernal, S., Neymotin, S. A., Suter, B. A., Dacre, J., Moreira, J. V. S., Urdapilleta, E., Schiemann, J. M., Duguid, I., Shepherd, G. M., & Lytton, W. W. (2022) · Cell Reports · doi:10.1016/j.celrep.2023.112574 · Cited by 46 · see citing works
Vyazovskiy, V. V., Cui, N., Rodriguez, A. V., Funk, C. M., Cirelli, C., & Tononi, G. (2014) · SLEEP · doi:10.5665/sleep.3926 · Cited by 45 · see citing works
Thalamic Relay or Cortico-Thalamic Processing? Old Question, New Answers
Ahissar, E., & Oram, T. B. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht296 · Cited by 47 · see citing works
Schultheiss, N. W., Schlecht, M., Jayachandran, M., Brooks, D. R., McGlothan, J. L., Guilarte, T. R., & Allen, T. A. (2020) · Behavioral Neuroscience · doi:10.1037/bne0000409 · Cited by 45 · see citing works
Rasmussen, R. N., Jensen, M. H., & Heltberg, M. L. (2017) · Cell Systems · doi:10.1016/j.cels.2017.11.011 · Cited by 43 · see citing works
Fazlali, Z., Ranjbar‐Slamloo, Y., Adibi, M., & Arabzadeh, E. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00014 · Cited by 39 · see citing works
Fernandez, L. M. J., Comte, J., Merre, P. L., Lin, J., Salin, P. A., & Crochet, S. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw311 · Cited by 37 · see citing works
Pennartz, C. M. A., Oude Lohuis, M. N., & Olcese, U. (2023) · Philosophical Transactions of the Royal Society B · doi:10.1098/rstb.2022.0336 · Cited by 38 · see citing works
Target-specific M1 inputs to infragranular S1 pyramidal neurons
Kinnischtzke, A. K., Fanselow, E. E., & Simons, D. J. (2016) · Journal of Neurophysiology · doi:10.1152/jn.01032.2015 · Cited by 38 · see citing works
Neural basis of somatosensory target detection independent of uncertainty, relevance, and reports
Schröder, P., Schmidt, T. T., & Blankenburg, F. (2019) · eLife · doi:10.7554/elife.43410 · Cited by 36 · see citing works
Omer, D. B., Fekete, T., Ulchin, Y., Hildesheim, R., & Grinvald, A. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy099 · Cited by 34 · see citing works
Multisensory task demands temporally extend the causal requirement for visual cortex in perception
Lohuis, M. N. O., Pie, J. L., Marchesi, P., Montijn, J. S., de Kock, C. P. J., Pennartz, C. M. A., & Olcese, U. (2022) · Nature Communications · doi:10.1038/s41467-022-30600-4 · Cited by 32 · see citing works
A valuable and promising method for recording brain activity in behaving newborn rodents
BLUMBERG, M. S., Sokoloff, G., Tiriac, A., & Rio‐Bermudez, C. D. (2015) · Developmental Psychobiology · doi:10.1002/dev.21305 · Cited by 35 · see citing works
Layer 1 of somatosensory cortex: an important site for input to a tiny cortical compartment
Ledderose, J. M. T., Zolnik, T. A., Toumazou, M., Trimbuch, T., Rosenmund, C., Eickholt, B. J., Jaeger, D., Larkum, M. E., & Sachdev, R. N. S. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad371 · Cited by 37 · see citing works
Self-citationNashaat, M. A., Oraby, H., Peña, L. B., Dominiak, S. E., Larkum, M. E., & Sachdev, R. N. S. (2017) · eNeuro · doi:10.1523/eneuro.0245-16.2017 · Cited by 34 · see citing works
Self-citationMetastability of Neuronal Dynamics during General Anesthesia: Time for a Change in Our Assumptions?
Hudson, A. E. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00058 · Cited by 34 · see citing works
Shaping the Cortical Landscape: Functions and Mechanisms of Top-Down Cortical Feedback Pathways
Zagha, E. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.00033 · Cited by 39 · see citing works
Self-citationCorrelation of Synaptic Inputs in the Visual Cortex of Awake, Behaving Mice
Arroyo, S., Bennett, C., & Hestrin, S. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.008 · Cited by 33 · see citing works
Rosenthal, Z. P., Raut, R. V., Yan, P., Koko, D., Kraft, A. W., Czerniewski, L. R., Acland, B. T., Mitra, A., Snyder, L. H., Bauer, A. Q., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz314 · Cited by 33 · see citing works
Perspective on the Multiple Pathways to Changing Brain States
Tantirigama, M. L. S., Zolnik, T. A., Judkewitz, B., Larkum, M. E., & Sachdev, R. N. S. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.00023 · Cited by 32 · see citing works
Self-citation
- Authors
- Zagha, E., Casale, A. E., Sachdev, R. N. S., McGinley, M. J., & McCormick, D. A.
- Affiliations
- Yale University (US)
- Corresponding author
- McCormick, David A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 79
- Issue
- 3
- Pages
- 567-578
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3742632
- OpenAlex
- W2075073129
- Cited by
- 268
- References
- 65
- Citations by year
- 2026: 8 · 2025: 26 · 2024: 11 · 2023: 20 · 2022: 13 · 2021: 26 · 2020: 20 · 2019: 24 · 2018: 20 · 2017: 21 · 2016: 28 · 2015: 23 · 2014: 22 · 2013: 6
- FWCI
- 14.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 371 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders (F32DC012449)
- National Institute of Neurological Disorders and Stroke (F32NS077816, NS-007224, NS026143, R01NS026143, R37NS026143, T32NS007224)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Keywords
- motor cortex, somatosensory cortex, network state, whisker system, sensory coding, sensory discrimination, active exploration, cortical oscillations, mice
- MeSH terms
- Channelrhodopsins, Empty Spiracles Homeobox Proteins, Action Potentials, Anesthesia, Animals, Brain Mapping, Electromyography, Mice, Inbred C57BL, Mice, Transgenic, Motor Cortex, Nerve Net, Sensation, Somatosensory Cortex, Transcription Factors, Vibrissae, Nonlinear Dynamics, Homeodomain Proteins, Feedback, Physiological, Mice, Optogenetics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review