Cited by 268Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchMultisensory perception and integration

Motor cortex feedback influences sensory processing by modulating network state

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Zagha, Edward, Casale, Amanda E., Sachdev, Robert N.S., McGinley, Matthew J., McCormick, David A.·2013·Neuron

Abstract

Long-range corticocortical communication may have important roles in context-dependent sensory processing, yet we know very little about how these pathways influence their target regions. We studied the influence of primary motor cortex activity on primary somatosensory cortex in the mouse whisker system. We show that primary motor and somatosensory cortices undergo coherent, context-dependent changes in network state. Moreover, we show that motor cortex activity can drive changes in somatosensory cortex network state. A series of experiments demonstrate the involvement of the direct corticocortical feedback pathway, providing temporally precise and spatially targeted modulation of network dynamics. Cortically mediated changes in network state significantly impact sensory coding, with activated states increasing the reliability of responses to complex stimuli. By influencing network state, corticocortical communication from motor cortex may ensure that during active exploration the relevant sensory region is primed for enhanced sensory discrimination.

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Crossref · 10.1016/j.neuron.2013.06.008

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  • Motor processes themselves may also regulate low-frequency synchronization in sensory cortex, or states associated with constricting and dilating pupils are distinct even at the same pupil diameter.

    “This suggests that motor processes themselves may also regulate low-frequency synchronization in sensory cortex (Schneider et al., 2014; Zagha et al., 2013) or that states associated with constricting and dilating pupils are distinct, even at the same pupil diameter”

    From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Zagha et al., 2013

  • The ability of somatosensory cortex to accurately represent complex whisker deflections is facilitated by cortical activation.

    “However, the ability of somatosensory cortex to accurately represent complex whisker deflections is facilitated by cortical activation”

    From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Zagha et al., 2013

  • Recent studies have identified thalamocortical, corticocortical and corticothalamic pathways that can control cortical state and sensory responsiveness with high temporal and spatial specificity.

    “In addition to the modulation of cortical neuronal excitability by ascending noradrenergic and cholinergic systems, recent studies have identified thalamocortical, corticocortical and corticothalamic pathways that can control cortical state and sensory responsiveness with high temporal and spatial specificity, owing to their activation of ionotropic and metabotropic glutamate receptors (Nelson et”

    From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Zagha et al., 2013

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Authors
Zagha, E., Casale, A. E., Sachdev, R. N. S., McGinley, M. J., & McCormick, D. A.
Affiliations
Yale University (US)
Corresponding author
McCormick, David A.
Venue
Neuron
Publisher
Elsevier BV
Published
2013-08
Volume
79
Issue
3
Pages
567-578
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2075073129
Cited by
268
References
65
Citations by year
2026: 8 · 2025: 26 · 2024: 11 · 2023: 20 · 2022: 13 · 2021: 26 · 2020: 20 · 2019: 24 · 2018: 20 · 2017: 21 · 2016: 28 · 2015: 23 · 2014: 22 · 2013: 6
FWCI
14.39
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute on Deafness and Other Communication Disorders (F32DC012449)
  • National Institute of Neurological Disorders and Stroke (F32NS077816, NS-007224, NS026143, R01NS026143, R37NS026143, T32NS007224)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
Keywords
motor cortex, somatosensory cortex, network state, whisker system, sensory coding, sensory discrimination, active exploration, cortical oscillations, mice
MeSH terms
Channelrhodopsins, Empty Spiracles Homeobox Proteins, Action Potentials, Anesthesia, Animals, Brain Mapping, Electromyography, Mice, Inbred C57BL, Mice, Transgenic, Motor Cortex, Nerve Net, Sensation, Somatosensory Cortex, Transcription Factors, Vibrissae, Nonlinear Dynamics, Homeodomain Proteins, Feedback, Physiological, Mice, Optogenetics

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