Cited by 420Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Reversible memory loss in a mouse transgenic model of Alzheimer’s disease

Open access

Kotilinek, Linda A., Bacskai, Brian, Westerman, Marcus, Kawarabayashi, Takeshi, Younkin, Linda, Hyman, Bradley T., Younkin, Steven, Ashe, Karen H.·2002·The Journal of Neuroscience

DOI 10.1523/jneurosci.22-15-06331.2002PMC PMC6758140

Open this paper in CoChat — free account Open PDF

Abstract

Alzheimer's disease (AD) is a neurodegenerative condition, believed to be irreversible, characterized by inexorable deterioration of memory and intellect, with neuronal loss accompanying amyloid plaques and neurofibrillary tangles. In an amyloid precursor protein transgenic mouse model, Tg2576, little or no neuronal loss accompanies age-related memory impairment or the accumulation of Abeta, a 40-42 aa polypeptide found in plaques. Recently, we have shown inverse correlations between brain Abeta and memory in Tg2576 mice stratified by age (Westerman et al., 2002). Broadening the age range examined obscured this relationship, leading us to propose that small, soluble assemblies of Abeta disrupt cognitive function in these mice. Here we show that memory loss can be fully reversed in Tg2576 mice using intraperitoneally administered BAM-10, a monoclonal antibody recognizing the N terminus of Abeta. The beneficial effect of BAM-10 was not associated with a significant Abeta reduction, but instead eliminated the inverse relationship between brain Abeta and memory. We postulate that BAM-10 acts by neutralizing Abeta assemblies in the brain that impair cognitive function. Our results indicate that a substantial portion of memory loss in Tg2576 mice is not permanent. If these Abeta assemblies contribute significantly to memory loss in AD, then successfully targeting them might improve memory in some AD patients.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.22-15-06331.2002

Cites

13 of 13 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Developments of a water-maze procedure for studying spatial learning in the rat
Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210
Self-citation
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160
Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
Bard, F., Cannon, C., Barbour, R., Burke, R.-L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., et al. (2000) · Nature Medicine · doi:10.1038/78682 · Cited by 2,012
Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C. A., Hardy, J., Duff, K., Jantzen, P. T., DiCarlo, G., Wilcock, D. M., et al. (2000) · Nature · doi:10.1038/35050116 · Cited by 1,506
Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., et al. (2000) · Nature · doi:10.1038/35050110 · Cited by 1,431
Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
DeMattos, R. B., Bales, K. R., Cummins, D. J., Dodart, J.-C., Paul, S. M., & Holtzman, D. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151261398 · Cited by 1,298
Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease
Kawarabayashi, T., Younkin, L. H., Saido, T. C., Shoji, M., Ashe, K. H., & Younkin, S. G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00372.2001 · Cited by 1,053 · cited 10×
“A was measured by ELISA using the 3160 capture antibody described previously (Kawarabayashi et al., 2001).”
BackgroundMethodInfluentialSelf-citation
Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?
Klein, W. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01749-5 · Cited by 989
Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model
Dodart, J.-C., Bales, K. R., Gannon, K. S., Greene, S. J., DeMattos, R. B., Mathis, C., DeLong, C. A., Wu, S., Wu, X., Holtzman, D. M., et al. (2002) · Nature Neuroscience · doi:10.1038/nn842 · Cited by 858

Show all 13 references

Sorted by citations

Items 201–300 of 418

Untangling memory deficits
Duff, K., & Planel, E. (2005) · Nature Medicine · doi:10.1038/nm0805-826 · Cited by 46
Rosuvastatin Attenuates High-Salt and Cholesterol Diet Induced Neuroinflammation and Cognitive Impairment via Preventing Nuclear Factor KappaB Pathway
Husain, I., Akhtar, M., Vohora, D., Abdin, M. Z., Islamuddin, M., Akhtar, M. J., & Najmi, A. K. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2264-2 · Cited by 46
The biogenesis and biology of amyloid β oligomers in the brain
Ashe, K. H. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12084 · Cited by 50
Self-citation
Focused ultrasound as a novel strategy for Alzheimer disease therapeutics
Meng, Y., Volpini, M., Black, S. E., Lozano, A. M., Hynynen, K., & Lipsman, N. (2017) · Annals of Neurology · doi:10.1002/ana.24933 · Cited by 45
Immunotherapy of Alzheimer's disease (AD): From murine models to anti-amyloid beta (Aβ) human monoclonal antibodies
Geylis, V., & Steinitz, M. O. (2005) · Autoimmunity Reviews · doi:10.1016/j.autrev.2005.06.007 · Cited by 45
Mechanistic insight into the role of metformin in Alzheimer's disease
Sanati, M., Aminyavari, S., Afshari, A. R., & Sahebkar, A. (2022) · Life Sciences · doi:10.1016/j.lfs.2021.120299 · Cited by 44
An Update on the Amyloid Hypothesis
Eckman, C. B., & Eckman, E. A. (2007) · Neurologic Clinics · doi:10.1016/j.ncl.2007.03.007 · Cited by 43
Vaccines for Alzheimer??s Disease
Janus, C. (2003) · CNS Drugs · doi:10.2165/00023210-200317070-00001 · Cited by 42
Antibody Responses, Amyloid-β Peptide Remnants and Clinical Effects of AN-1792 Immunization in Patients with AD in an Interrupted Trial
Kokjohn, T. A., & Roher, A. E. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709787847315 · Cited by 43
Mechanisms of memory loss in Aβ and tau mouse models
Ashe, K. H. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330591 · Cited by 42
Self-citation
Antibody-conjugated, dual-modal, near-infrared fluorescent iron oxide nanoparticles for antiamyloidgenic activity and specific detection of amyloid-β fibrils
Margel, S., Skaat, H., Corem‐Salkmon, E., Grinberg, I., Last, D., Goez, D., & Mardor, Y. (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s52833 · Cited by 43
Behavioral effects of CD40–CD40L pathway disruption in aged PSAPP mice
Roach, J. T., Volmar, C., Dwivedi, S., Town, T., Crescentini, R. M., Crawford, F., Tan, J., & MULLAN, M. J. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.004 · Cited by 41
Vaccination with Aβ-Displaying Virus-Like Particles Reduces Soluble and Insoluble Cerebral Aβ and Lowers Plaque Burden in APP Transgenic Mice
Bach, P., Tschäpe, J., Kopietz, F., Braun, G., Baade, J. K., Wiederhold, K., Staufenbiel, M., Prinz, M., Deller, T., Kalinke, U., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803366 · Cited by 44
Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid β-related Behavioral Deficits in a Mouse Model of Alzheimer Disease
Basi, G. S., Feinberg, H., Oshidari, F., Anderson, J., Barbour, R., Baker, J., Comery, T. A., Diep, L., Gill, D. S., Johnson‐Wood, K., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.045187 · Cited by 45
A Lifespan Observation of a Novel Mouse Model: In Vivo Evidence Supports Aβ Oligomer Hypothesis
Zhang, Y., Lu, L., Jia, J., Jia, L., Geula, C., Pei, J.-J., Xu, Q., Qin, W., Liu, R., Li, D., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085885 · Cited by 40
Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice
Rasool, S., Albay, R., Martínez‐Coria, H., Breydo, L., Wu, J., Milton, S. C. F., Misra, S., Tran, A. T., Pensalfini, A., LaFerla, F. M., et al. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-37 · Cited by 38
The protective effect of α-crystallin against acute inflammation in mice
Masilamoni, J. G., Jesudason, E. P., Bharathi, S. N., & Rajadas, J. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.11.002 · Cited by 39
Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aß agents
Qi, Y., Klyubin, I. V., Harney, S. C., Hu, N., Cullen, W. K., Grant, M. K. O., Steffen, J., Wilson, E. N., Carmo, S. D., Remy, S., et al. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0175-x · Cited by 41
Self-citation
Abeta DNA Vaccination for Alzheimers Disease: Focus on Disease Prevention
Cribbs, D. H. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791012080 · Cited by 39
Microbubble-enhanced Focused Ultrasound-induced Blood–brain Barrier Opening for Local and Transient Drug Delivery in Central Nervous System Disease
Fan, C., & Yeh, C. (2014) · Journal of Medical Ultrasound · doi:10.1016/j.jmu.2014.11.001 · Cited by 38
Advances on the Understanding of the Origins of Synaptic Pathology in AD
Lacor, P. N. (2007) · Current Genomics · doi:10.2174/138920207783769530 · Cited by 40
Mice expressing the Swedish APP mutation on a 129 genetic background demonstrate consistent behavioral deficits and pathological markers of Alzheimer's disease
Rustay, N. R., Cronin, E. A., Curzon, P., Markosyan, S., Bitner, R. S., Ellis, T. A., Waring, J. F., Decker, M. W., Rueter, L. E., & Browman, K. E. (2009) · Brain Research · doi:10.1016/j.brainres.2009.11.040 · Cited by 38
Novel approaches for immunotherapeutic intervention in Alzheimer's disease
Vasilevko, V., & Cribbs, D. H. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.03.019 · Cited by 37
Is passive immunization for Alzheimer's disease ‘alive and well’ or ‘dead and buried’?
Jicha, G. A. (2009) · Expert Opinion on Biological Therapy · doi:10.1517/14712590902828285 · Cited by 40
The F(ab′)2 fragment of an Aβ-specific monoclonal antibody reduces Aβ deposits in the brain
Tamura, Y., Hamajima, K., Matsui, K., Yanoma, S., Narita, M., Tajima, N., Xin, K.-Q., Klinman, D. M., & Okuda, K. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.04.007 · Cited by 38
Mannan-Abeta28conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice
Petrushina, I., Ghochikyan, A., Mkrtichyan, M., Mamikonyan, G., Movsesyan, N., Ajdari, R., Vasilevko, V., Karapetyan, A., Lees, A., Agadjanyan, M. G., et al. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-42 · Cited by 37
Rosiglitazone Prevents Amyloid-β Oligomer-Induced Impairment of Synapse Formation and Plasticity via Increasing Dendrite and Spine Mitochondrial Number
Xu, S., Guilan, L., Bao, X., Wu, J., Li, S., Zheng, B., Anwyl, R., & Wang, Q. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-130680 · Cited by 35
Olfactory Functions Scale with Circuit Restoration in a Rapidly Reversible Alzheimer's Disease Model
Cheng, N., Bai, L., Steuer, E. R., & Belluscio, L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0291-13.2013 · Cited by 35
Immunotherapy in Alzheimer’s Disease: Do We Have All the Pieces of the Puzzle?
Sarazin, M., Dorothée, G., de Souza, L. C., & Aucouturier, P. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.04.011 · Cited by 37
Human single chain Fv antibodies and a complementarity determining region-derived peptide binding to amyloid-beta 1–42
Manoutcharian, K., Acero, G., Munguía, M. E., Becerril, B., Massieu, L., Govezensky, T., Ortíz, E., Marks, J. D., Cao, C., Ugen, K. E., et al. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.06.005 · Cited by 34
Extracellular and intraneuronal HMW-AbetaOs represent a molecular basis of memory loss in Alzheimer's disease model mouse
Takamura, A., Okamoto, Y., Kawarabayashi, T., Yokoseki, T., Shibata, M. S., Mouri, A., Nabeshima, T., Sun, H., Abe, K., Urisu, T., et al. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-20 · Cited by 34
Self-citation
Naturally occurring autoantibodies interfere with β-amyloid metabolism and improve cognition in a transgenic mouse model of Alzheimer’s disease 24 h after single treatment
Mengel, D., Röskam, S., Neff, F., Balakrishnan, K., Deuster, O., Gold, M., Oertel, W. H., Bacher, M., Bach, J.-P., & Dodel, R. C. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.151 · Cited by 34
Unintended Effects of Cardiovascular Drugs on the Pathogenesis of Alzheimer’s Disease
Wang, J., Zhao, Z., Lin, E., Zhao, W., Qian, X., Freire, D., Bilski, A. E., Cheng, A., Vempati, P., Ho, L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065232 · Cited by 35
Investigating the efficacy of a combination Aβ-targeted treatment in a mouse model of Alzheimer’s disease
Liu, M., Jevtic, S. D., Markham-Coultes, K., Ellens, N. P. K., O’Reilly, M. A., Hynynen, K., Aubert, I., & McLaurin, J. (2017) · Brain Research · doi:10.1016/j.brainres.2017.10.015 · Cited by 35
39-Week Toxicity and Toxicokinetic Study of Ponezumab (PF-04360365) in Cynomolgus Monkeys with 12-Week Recovery Period
Freeman, G. B., Lin, J. C.-Y., Pons, J., & Raha, N. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110869 · Cited by 33
Anti‐Aβ: The good, the bad, and the unforeseen
Broytman, O., & Malter, J. S. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10876 · Cited by 34
X11 rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice
Mitchell, J. C., Ariff, B. B., Yates, D. M., Lau, K., Perkinton, M. S., Rogelj, B., Stephenson, J. D., Miller, C. C. J., & McLoughlin, D. M. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp408 · Cited by 33
Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease
Zhou, J., Fonseca, M. I., Kayed, R., Hernandez, I., Webster, S. D., Yazan, O., Cribbs, D. H., Glabe, C. G., & Tenner, A. J. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-28 · Cited by 34
Proteolytic Antibody Light Chains Alter β-Amyloid Aggregation and Prevent Cytotoxicity
Liu, R., McAllister, C., Lyubchenko, Y. L., & Sierks, M. R. (2004) · Biochemistry · doi:10.1021/bi0492354 · Cited by 34
Immunotherapy as treatment for Alzheimer’s disease
Hawkes, C. A., & McLaurin, J. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.11.1535 · Cited by 33
Immune responses against Aβ1–42 in HLA class II transgenic mice: implications for Aβ1–42 immune-mediated therapies
Das, P., Chapoval, S. P., HOWARD, V. G., David, C. S., & Golde, T. E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00036-8 · Cited by 33
Nanomedicine-based immunotherapy for Alzheimer's disease
Hoque, M., Samanta, A., Alam, S. S. M., Zughaibi, T. A., Kamal, M. A., & Tabrez, S. S. M. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104973 · Cited by 31
Rationale for Peptide and DNA Based Epitope Vaccines for Alzheimers Disease Immunotherapy
Ghochikyan, A. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709787847298 · Cited by 32
AICD and its Adaptors – In Search of New Players
Raychaudhuri, M., & Mukhopadhyay, D. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-11311 · Cited by 30
Production of an anti-Aβ antibody fragment in Pichia pastoris and in vitro and in vivo validation of its therapeutic effect
Montoliu‐Gaya, L., Esquerda-Canals, G., Bronsoms, S., & Villegas, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181480 · Cited by 31
Intact spatial learning in adult Tg2576 mice
Bizon, J., Prescott, S., & Nicolle, M. M. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.01.004 · Cited by 23
Administration of Amyloid-β42 Oligomer-Specific Monoclonal Antibody Improved Memory Performance in SAMP8 Mice
Zhang, Y., He, J., Wang, X., Wang, J., Bao, F.-X., Pang, S., Yin, F., Hu, H., Peng, X.-L., Sun, W., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091195 · Cited by 31
Emerging Promise of Immunotherapy for Alzheimer’s Disease: A New Hope for the Development of Alzheimer’s Vaccine
Kabir, M. T., Uddin, M. S., Mathew, B., Das, P. K., Perveen, A., & Ashraf, G. M. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200422105156 · Cited by 32
Amyloid β and Alzheimer disease therapeutics: the devil may be in the details
Cirrito, J. R., & Holtzman, D. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19420 · Cited by 33
Targeting Generation of Antibodies Specific to Conformational Epitopes of Amyloid β-Derived Neurotoxins
Lambert, M., Velasco, P., Viola, K., & Klein, W. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709787601876 · Cited by 29
Immunoreactivity of Phage Library-derived Human Single-Chain Antibodies to Amyloid Beta Conformers In Vitro
Yoshihara, T., Takiguchi, S., Kyuno, A., Tanaka, K., Kuba, S., Hashiguchi, S., Ito, Y., Hashimoto, T., Iwatsubo, T., Tsuyama, S., et al. (2007) · The Journal of Biochemistry · doi:10.1093/jb/mvm239 · Cited by 29
Neuroprotective Effect of SLM, a Novel Carbazole-Based Fluorophore, on SH-SY5Y Cell Model and 3xTg-AD Mouse Model of Alzheimer’s Disease
Wu, X., Kosaraju, J., Zhou, W., & Tam, K. Y. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00388 · Cited by 28
Detection of Amyloid Beta (Aβ) Oligomeric Composition Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS)
Wang, J. S.-H., Whitehead, S. N., & Yeung, K. K. ‐. (2018) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-018-1896-z · Cited by 31
Prevention of age-associated dementia
Mohajeri, M. H., & Leuba, G. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.06.014 · Cited by 31
Immunotherapy in Alzheimer's Disease: Where Do We Stand? Where Should We Go?
Rommy von Bernhardi, M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1248 · Cited by 28
Does Aβ 42 Have a Function Related to Blood Homeostasis?
Hardy, J. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9221-9 · Cited by 28
Novel Aβ Immunogens: Is Shorter Better?
Lemere, C. A., Maier, M., Peng, Y., Jiang, L., & Seabrook, T. J. (2007) · Current Alzheimer Research · doi:10.2174/156720507781788800 · Cited by 28
Metallothionein-3 and neuronal nitric oxide synthase levels in brains from the Tg2576 mouse model of Alzheimer's disease
Martin, B. L., Tokheim, A. M., McCarthy, P. T., Doms, B. S., Davis, A. A., & Armitage, I. M. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-006-2390-7 · Cited by 28
APP transgenic mice: The effect of active and passive immunotherapy in cognitive tasks
Röskam, S., Neff, F., Schwarting, R. K. W., Bacher, M., & Dodel, R. C. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.10.006 · Cited by 29
Vaccine Development to Treat Alzheimer’s Disease Neuropathology in APP/PS1 Transgenic Mice
Carrera, I., Etcheverrı́a, I., Fernández‐Novoa, L., Lombardi, V., Cacabelos, R., & Vigo, C. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/376138 · Cited by 27
Intramaze and Extramaze Cue Processing in Adult APPSWE Tg2576 Transgenic Mice.
Barnes, P., Hale, G., & Good, M. A. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.6.1184 · Cited by 28
Evidence supporting a role for anti-Aβ antibodies in the treatment of Alzheimer’s disease
Morgan, D., & Gitter, B. D. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.005 · Cited by 27
Chronic Zinc Exposure Decreases the Surface Expression of NR2A-Containing NMDA Receptors in Cultured Hippocampal Neurons
Zhu, J., Shao, C., Yang, W., Zhang, X., Wu, Z., Zhou, L., Wang, X., Li, Y., Xia, J., Luo, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046012 · Cited by 26
Novel amyloid-beta specific scFv and VH antibody fragments from human and mouse phage display antibody libraries
Medecigo, M., Manoutcharian, K., Vasilevko, V., Govezensky, T., Munguía, M. E., Becerril, B., Luz-Madrigal, A., Vaca, L. A., Cribbs, D. H., & Gevorkian, G. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.03.023 · Cited by 26
Current Concepts and Future Prospects for Alzheimer Disease Vaccines
Heppner, F. L., Gandy, S., & McLaurin, J. (2004) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200401000-00008 · Cited by 26
Toward modeling hemorrhagic and encephalitic complications of Alzheimer amyloid-β vaccination in nonhuman primates
Gandy, S., & Walker, L. C. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.08.002 · Cited by 27
Preventive immunization of aged and juvenile non-human primates to beta-amyloid
Kofler, J., Lopresti, B. J., Janssen, C., Trichel, A. M., Masliah, E., Finn, O. J., Salter, R. D., MURDOCH, G. H., Mathis, C. A., & Wiley, C. A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-84 · Cited by 26
A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model
Rozkalne, A., Spires‐Jones, T. L., Stern, E. A., & Hyman, B. T. (2009) · Brain Research · doi:10.1016/j.brainres.2009.05.045 · Cited by 27
Self-citation
Amyloid-Beta Immunization in Alzheimer's Disease Transgenic Mouse Models and Wildtype Mice
Lemere, C. A., Spooner, E. T., Leverone, J. F., Mori, C., Iglesias, M., Bloom, J. K., & Seabrook, T. J. (2003) · Neurochemical Research · doi:10.1023/a:1023203122036 · Cited by 26
Animal Models of Alzheimer’s Disease
Newman, M., Kretzschmar, D., Khan, I., Chen, M., Verdile, G., & Lardelli, M. T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809468-6.00040-1 · Cited by 25
Brain amyloid β protein and memory disruption in Alzheimer’s disease
Xia, W. (2010) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s7460 · Cited by 24
Vaccination Strategies for Alzheimer???s Disease
Woodhouse, A., Dickson, T. C., & Vickers, J. C. (2007) · Drugs & Aging · doi:10.2165/00002512-200724020-00003 · Cited by 24
Lethal weapon: amyloid β-peptide, role in the oxidative stress and neurodegeneration of Alzheimer’s disease
Lahiri, D. K., & Greig, N. H. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.002 · Cited by 26
Epitope mapping and neuroprotective properties of a human single chain FV antibody that binds an internal epitope of amyloid-beta 1-42
Solórzano-Vargas, R. S., Vasilevko, V., Acero, G., Ugen, K. E., Martinez, R., Govezensky, T., Vázquez‐Ramírez, R., Kubli‐Garfias, C., Cribbs, D. H., Manoutcharian, K., et al. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.08.008 · Cited by 24
Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression
Krezowski, J. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh210 · Cited by 26
Molecules that Disrupt Memory Circuits in Alzheimer’s Disease: The Attack on Synapses by Aβ Oligomers (ADDLs)
Klein, W. L., Lacor, P. N., Felice, F. G. D., & Ferreira, S. T. (2007) · Research and perspectives in neurosciences · doi:10.1007/978-3-540-45702-2_11 · Cited by 23
Limited Clearance of Pre-Existing Amyloid Plaques After Intracerebral Injection of Aβ Antibodies in Two Mouse Models of Alzheimer Disease
Tucker, S. M. F., Borchelt, D., & Troncoso, J. C. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31815f38d2 · Cited by 22
Mapping of immune responses following wild-type and mutant ABeta42 plasmid or peptide vaccination in different mouse haplotypes and HLA Class II transgenic mice
Kutzler, M. A., Cao, C., Bai, Y., Dong, H., Choe, P. Y., Saulino, V., McLaughlin, L., Whelan, A., Choo, A. Y., Weiner, D. B., et al. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.08.036 · Cited by 22
An antibody to the β-secretase cleavage site on amyloid-β-protein precursor inhibits amyloid-β production
Thomas, R. S., Liddell, J. E., Murphy, L. S., Pache, D. M., & Kidd, E. J. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-10406 · Cited by 21
The regulation of AβPP expression by RNA-binding proteins
Westmark, C. J., & Malter, J. S. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.03.005 · Cited by 21
Amyloid β and impairment in multiple memory systems in older transgenic APP TgCRND8 mice
Hanna, A., Horne, P., Yager, D., Eckman, C., Eckman, E., & Janus, C. (2009) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2009.00510.x · Cited by 20
Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin
Park, T. Y., Kim, S., Shin, Y.-C., Lee, N.-H., Lee, R.-K. C., Shim, J., Glimcher, L. H., Mook‐Jung, I., Cheong, E., Kim, W.-K., et al. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.12.022 · Cited by 20
Soluble Aβ and cognitive function in aged F-344 rats and Tg2576 mice
Lindner, M. D., Hogan, J. B., KRAUSE, R., Machet, F., Bourin, C., HODGESJR, D., Corsa, J. A., Barten, D. M., Toyn, J. H., & Stock, D. A. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.06.003 · Cited by 19
Immunization with fibrillar Aβ1–42 in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Aβ
Head, E., Barrett, E. G., Murphy, M. P., Das, P., Nistor, M., Sarsoza, F. M., Glabe, C. C., Kayed, R., Milton, S. C. F., & Vasilevko, V. (2006) · Vaccine · doi:10.1016/j.vaccine.2005.12.058 · Cited by 19
Differences in the immune response to long term A? vaccination in C57BL/6 and B6D2F1 mice
Seabrook, T. J. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.03.061 · Cited by 19
Immunocytochemical Characterization of Alzheimer Disease Hallmarks in APP/PS1 Transgenic Mice Treated with a New Anti-Amyloid-βVaccine
Carrera, I., Etcheverrı́a, I., Li, Y., Fernández‐Novoa, L., Lombardi, V., Vigo, C., Palacios, H. H., Benberin, V. V., Cacabelos, R., & Aliev, G. (2013) · BioMed Research International · doi:10.1155/2013/709145 · Cited by 19
Therapeutic Interventions Targeting Beta Amyloid Pathogenesis in an Aging Dog Model
Martin, S. B., Dowling, A. L. S., & Head, E. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376217 · Cited by 19
Beneficial Catalytic Immunity to Aβ Peptide
Paul, S., Planque, S. A., & Nishiyama, Y. (2010) · Rejuvenation Research · doi:10.1089/rej.2009.0958 · Cited by 18
Envisaging the Structural Elevation in the Early Event of Oligomerization of Disordered Amyloid β Peptide
Roy, A., Chandra, K., Dolui, S., & Maiti, N. C. (2017) · ACS Omega · doi:10.1021/acsomega.7b00522 · Cited by 18
Interactions of Volatile Anesthetics with Neurodegenerative-Disease-Associated Proteins
Carnini, A., Eckenhoff, M. F., & Eckenhoff, R. G. (2006) · Anesthesiology Clinics of North America · doi:10.1016/j.atc.2006.02.002 · Cited by 18
Optimized Protocol for Amyloid-β Extraction from the Brain
Izco, M., Pesini, P., Pérez‐Grijalba, V., Fandos, N., & Sarasa, M. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121798 · Cited by 17
Tg2576 Cortical Neurons That Express Human Ab Are Susceptible to Extracellular Aβ-Induced, K+ Efflux Dependent Neurodegeneration
Ray, S., Howells, C., Eaton, E. D., Butler, C., Shabala, L., Adlard, P. A., West, A. K., Bennett, W. R., Guillemin, G. J., & Chung, R. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019026 · Cited by 16
Elevation of BACE in an Aβ rat model of Alzheimer's disease: exacerbation by chronic stress and prevention by nicotine
Alkadhi, K. A., Alzoubi, K. H., Srivareerat, M., & Tran, T. T. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000162 · Cited by 16
Alzheimer Disease
Savonenko, A. V., Melnikova, T., Li, T., Price, D. L., & Wong, P. C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-398270-4.00021-5 · Cited by 20
Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice
Balakrishnan, K., Upadhaya, A. R., Steinmetz, J. L., Reichwald, J., Abramowski, D., Fändrich, M., Kumar, S., Yamaguchi, H., Walter, J., Staufenbiel, M., et al. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0217-z · Cited by 15
DNA Vaccine Therapy for Alzheimer's Disease: Present Status and Future Direction
Okura, Y., & Matsumoto, Y. (2008) · Rejuvenation Research · doi:10.1089/rej.2007.0638 · Cited by 17
Recognition Memory and β-amyloid Plaques in Adult Tg2576 Mice are not Modified After Oral Exposure to Aluminum
Ribes, D., Torrente, M., Vicens, P., Colomina, M. T., Gómez, M., & Domingo, J. L. (2011) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3182211ab1 · Cited by 17
Novel antibody against oligomeric amyloid-β: Insight into factors for effectively reducing the aggregation and cytotoxicity of amyloid-β aggregates
Zhang, X., Huai, Y., Cai, J., Song, C., & Zhang, Y. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.12.014 · Cited by 16
Amyloid-β Immunotherapies in Mice and Men
Brendza, R. P., & Holtzman, D. M. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000213810.89681.a5 · Cited by 16
Alzheimer's disease and immunotherapy.
Madeo, J., & Frieri, M. (2013) · Europe PMC (PubMed Central) · Cited by 15

Authors: Kotilinek, L. A., Bacskai, B., Westerman, M., Kawarabayashi, T., Younkin, L., Hyman, B. T., Younkin, S., & Ashe, K. H.
Affiliations: University of Minnesota (US)
Harvard University (US)
Mayo Clinic (US)
Mayo Clinic in Florida (US)
ORCID: Bacskai, Brian
Kawarabayashi, Takeshi
Hyman, Bradley T.
Ashe, Karen H.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2002-08-01
Volume: 22
Issue: 15
Pages: 6331-6335
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.22-15-06331.2002
PMC: PMC6758140
OpenAlex: W1705725530
Cited by: 420
References: 13
Citations by year: 2026: 1 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 12 · 2016: 7 · 2015: 10 · 2014: 15 · 2013: 28 · 2012: 14
FWCI: 18.41
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Alzheimer's Association
National Institutes of Health
National Institute on Aging (P01AG015453)
National Institute of Mental Health (R01MH065465)
National Institute of Neurological Disorders and Stroke (R01NS033249)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, memory loss, amyloid-beta, monoclonal antibodies, Tg2576 mice, amyloid precursor protein, cognitive function, age-related memory impairment
MeSH terms: Aging, Alzheimer Disease, Animals, Antibodies, Monoclonal, Behavior, Animal, Brain Chemistry, Cognition, Disease Models, Animal, Female, Immunization, Passive, Injections, Intraperitoneal, Male, Memory, Memory Disorders, Mice, Transgenic, Remission Induction, Spatial Behavior, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Reversible memory loss in a mouse transgenic model of Alzheimer’s disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks