Cited by 138Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

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Rewarding and Psychomotor Stimulant Effects of Endomorphin-1: Anteroposterior Differences within the Ventral Tegmental Area and Lack of Effect in Nucleus Accumbens

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Zangen, Abraham, Ikemoto, Satoshi, Zadina, James E., Wise, Roy A.·2002·The Journal of Neuroscience

DOI 10.1523/jneurosci.22-16-07225.2002PMC PMC6757872

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Abstract

Endomorphin-1 (EM-1) is a recently isolated endogenous peptide having potent analgesic activity and high affinity and selectivity for the mu-opioid receptor. The present study was designed to investigate the rewarding and psychomotor stimulant effects of EM-1 in specific brain regions. We found that rats would learn without priming or response shaping to lever-press for microinjections of EM-1 into the ventral tegmental area (VTA); responding was most vigorous for high-dose injections into the posterior VTA. Rats did not learn to lever-press for microinjections of EM-1 into the nucleus accumbens (NAS) or regions just dorsal to the VTA. Lever-pressing for EM-1 in the VTA was extinguished when vehicle was substituted for the peptide and was reinstated when EM-1 reinforcement was re-established. Conditioned place preference was established by EM-1 injections into the posterior but not the anterior VTA or the NAS. Injection of EM-1 (0.1-1.0 nmol) into the posterior VTA induced robust increases in locomotor activity, whereas injections into the anterior VTA had very weak locomotor-stimulating effects. When injected into the NAS, EM-1 (0.1-10.0 nmol) did not affect locomotor activity. The present findings implicate the posterior VTA as a highly specific and sensitive site for opioid reward and suggest a role for EM-1-containing projections to the posterior VTA in the rewarding effects of other reinforcers.

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Authors: Zangen, A., Ikemoto, S., Zadina, J. E., & Wise, R. A.
Affiliations: National Institutes of Health (US)
Tulane University (US)
ORCID: Zangen, Abraham
Ikemoto, Satoshi
Zadina, James E.
Wise, Roy A.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2002-08-15
Volume: 22
Issue: 16
Pages: 7225-7233
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.22-16-07225.2002
PMC: PMC6757872
OpenAlex: W1888155279
Cited by: 138
References: 47
Citations by year: 2026: 4 · 2025: 2 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 9 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 11
FWCI: 3.15
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: endomorphin-1, opioid reward, ventral tegmental area, nucleus accumbens, mu-opioid receptor, conditioned place preference, locomotor activity, reinstatement, opioid analgesia
MeSH terms: Animals, Behavior, Animal, Choice Behavior, Dose-Response Relationship, Drug, Drug Administration Routes, Male, Microinjections, Motor Activity, Nucleus Accumbens, Oligopeptides, Reinforcement, Psychology, Reward, Self Administration, Spatial Behavior, Rats, Sprague-Dawley, Receptors, Opioid, mu, Ventral Tegmental Area, Rats

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Rewarding and Psychomotor Stimulant Effects of Endomorphin-1: Anteroposterior Differences within the Ventral Tegmental Area and Lack of Effect in Nucleus Accumbens

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