Basal ganglia circuit loops, dopamine and motivation: a review and enquiry
Open accessAbstract
Dopamine neurons located in the midbrain play a role in motivation that regulates approach behavior (approach motivation). In addition, activation and inactivation of dopamine neurons regulate mood and induce reward and aversion, respectively. Accumulating evidence suggests that such motivational role of dopamine neurons is not limited to those located in the ventral tegmental area, but also in the substantia nigra. The present paper reviews previous rodent work concerning dopamine's role in approach motivation and the connectivity of dopamine neurons, and proposes two working models: One concerns the relationship between extracellular dopamine concentration and approach motivation. High, moderate and low concentrations of extracellular dopamine induce euphoric, seeking and aversive states, respectively. The other concerns circuit loops involving the cerebral cortex, basal ganglia, thalamus, epithalamus, and midbrain through which dopaminergic activity alters approach motivation. These models should help to generate hypothesis-driven research and provide insights for understanding altered states associated with drugs of abuse and affective disorders.
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The caudate nucleus receives projections from midbrain DA and is part of the nigrostriatal DA system, which plays a role in reward and motivation.
“Intriguingly, the caudate nucleus receives projections from midbrain DA and is part of the nigrostriatal DA system, which, like the mesolimbic DA system, plays a role in reward and motivation (Ikemoto et al., 2015).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Ikemoto et al., 2015
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“Before discussing motivational state in relation to these strucures, it is important to clearly define the terms: approach ies further indicate that of psychostimulant drugs preferentially act on the medial, rather than the lateral, part of the VTA–VStr DA system with respect to reward [2,53].”
Deep Brain Stimulation of the Subthalamic Nucleus Enhances Emotional Processing in Parkinson Disease
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“While positive reinforcement involves learning about the relationship between environment and behavior in the interest of procuring rewards [41], reward concerns not only reinforcement, but also the aroused, motivated state that drives approach behavior.”
Preferential localization of self-stimulation sites in striosomes/patches in the rat striatum
White, N. M., & Hiroi, N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6486 · Cited by 131 · cited 3× · see citing works
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Cell configurations in the olfactory tubercle of the rat
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Subthalamic nucleus: A key structure for emotional component synchronization in humans
Péron, J., Frühholz, S., Vérin, M., & Grandjean, D. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.001 · Cited by 124 · see citing works
Efferent connections of the caudal part of the globus pallidus in the rat
Shammah‐Lagnado, S. J., Alheid, G. F., & Heimer, L. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961216)376:3 · Cited by 123 · see citing works
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Dopamine Invigorates Reward Seeking by Promoting Cue-Evoked Excitation in the Nucleus Accumbens
du Hoffmann, J., & Nicola, S. M. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3492-14.2014 · Cited by 122 · cited 3× · see citing works
“Intra-VStr DA antagonists do ot disrupt movement processes per se, but the integration of envionmental stimuli for approach behavior [67,68].”
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The connectome of an insect brain
Winding, M., Pedigo, B. D., Barnes, C. L., Patsolic, H. G., Park, Y., Kazimiers, T., Fushiki, A., Andrade, I. V., Khandelwal, A., Valdes-Aleman, J., et al. (2023) · Science · doi:10.1126/science.add9330 · Cited by 435 · see citing works
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Secondary negative symptoms — A review of mechanisms, assessment and treatment
Kirschner, M., Aleman, A., & Kaiser, S. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.05.003 · Cited by 215 · see citing works
Brief optogenetic inhibition of dopamine neurons mimics endogenous negative reward prediction errors
Chang, C. Y., Esber, G. R., Marrero-Garcia, Y., Yau, H., Bonci, A., & Schoenbaum, G. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4191 · Cited by 211 · see citing works
“This makes the task an excellent vehicle with which to dissociate effects of dopaminergic manipulation on learning from less specific effects dopamine may have on vigor or motivational level 29, 30 , attention or salience 11, 31 , or even aversiveness 32 .”
The basal ganglia and the cerebellum in human emotion
Pierce, J. E., & Péron, J. (2020) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsaa076 · Cited by 189 · see citing works
Rapid effects of ovarian hormones in dorsal striatum and nucleus accumbens
Yoest, K. E., Quigley, J. A., & Becker, J. B. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.04.002 · Cited by 160 · see citing works
“DA projections from the VTA to the NAc are implicated in approach and avoidance behaviors (Ikemoto et al., 2015), reward learning (Schultz et al.”
Wang, S., Leri, F., & Rizvi, S. J. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110289 · Cited by 164 · see citing works
Dong, G., Wang, L., Du, X., & Potenza, M. N. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy084 · Cited by 141 · see citing works
“Activity in the ventral striatum may influence motivated or goal-directed behaviors (Ikemoto et al., 2015; Sayette, 2016) and reward processing including in addictions (Balodis and Potenza, 2015; Cheng et al.”
BackgroundGaming Increases Craving to Gaming-Related Stimuli in Individuals With Internet Gaming Disorder
Dong, G., Wang, L., Du, X., & Potenza, M. N. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.01.002 · Cited by 126 · see citing works
Intranasal oxytocin, but not vasopressin, augments neural responses to toddlers in human fathers
Li, T., Chen, X., Mascaro, J., Haroon, E., & Rilling, J. K. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.01.006 · Cited by 105 · see citing works
“However, the caudate is part of another midbrain DA system, the nigrostriatal system, which is also involved in reward andmotivation (Ikemoto et al., 2015) and commonly activated in neuroimaging studies of parental brain function (Rilling, 2013).”
Ely, B. A., Xu, J., Goodman, W. K., Lapidus, K. A. B., Gabbay, V., & Stern, E. R. (2016) · Human Brain Mapping · doi:10.1002/hbm.23179 · Cited by 95 · see citing works
“Our detection of significant Hb-thalamic functional connectivity likewise accords with past research [Ikemoto et al., 2015; Morley, 1986], including task-related coactivation of these regions in a high resolution fMRI study [Lawson et al.”
BackgroundResultInfluentialNeural mechanisms of the nucleus accumbens circuit in reward and aversive learning
Hikida, T., Morita, M., & Macpherson, T. (2016) · Neuroscience Research · doi:10.1016/j.neures.2016.01.004 · Cited by 92 · see citing works
Consolidating the Circuit Model for Addiction
Lüscher, C., & Janak, P. H. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-092920-123905 · Cited by 88 · see citing works
“Reversal learning tasks allow for the investigation of these functions (Izquierdo & Jentsch 2012).”
BackgroundDopamine Circuit Mechanisms of Addiction-Like Behaviors
Poisson, C. L., Engel, L., & Saunders, B. T. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.752420 · Cited by 75 · see citing works
Riederer, P. F., Nagatsu, T., Youdim, M. B. H., Wulf, M., Dijkstra, J. M., & Sian‐Hülsmann, J. (2023) · Journal of Neural Transmission · doi:10.1007/s00702-023-02630-9 · Cited by 68 · see citing works
“The loss of dopamine elicits a disbalance of the direct pathway and the indirect pathway in PD (Alexander et al. 1986; Ikemoto et al. 2015; Fieblinger et al. 2014).”
BackgroundExplaining individual variation in paternal brain responses to infant cries
Li, T., Horta, M., Mascaro, J. S., Bijanki, K. R., Arnal, L. H., Adams, M. K., Barr, R. G., & Rilling, J. K. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.12.033 · Cited by 66 · see citing works
“The caudate nucleus may also have a role in parental motivation given that it receives midbrain DA projections that are involved in reward and motivation (Ikemoto et al. 2015).”
BackgroundAmbrosi, E., Arciniegas, D. B., Curtis, K. N., Patriquin, M. A., Spalletta, G., Sani, G., Frueh, B. C., Fowler, J. C., Madan, A., & Salas, R. (2018) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.17120351 · Cited by 67 · see citing works
Pribiag, H., Shin, S., Wang, E. H.-J., Sun, F., Datta, P., Okamoto, A., Guss, H., Jain, A., Wang, X.-Y., Freitas, B. D., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.05.002 · Cited by 63 · see citing works
“Elevated activity in this loop interlinking the NAc, VP, LHb, and midbrain may sustain an appetitive motivational state that drives cocaine seeking (Ikemoto et al., 2015).”
Borgonovo, J. E., Allende-Castro, C., Laliena, A., Guerrero, N., Hernán Silva, I., & Concha, M. L. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.11.009 · Cited by 64 · see citing works
Abnormal large-scale resting-state functional networks in drug-free major depressive disorder
Luo, L., Wu, H., Xu, J., Chen, F., Wu, F., Wang, C., & Wang, J. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00236-y · Cited by 62 · see citing works
Simola, N., & Brudzyński, S. M. (2018) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2018.06.018 · Cited by 57 · see citing works
Kamagata, K., Zalesky, A., Hatano, T., Biase, M. A. D., Samad, O. E., Saiki, S., Shimoji, K., Kumamaru, K. K., Kamiya, K., Hori, M., et al. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.11.007 · Cited by 53 · see citing works
“Connections comprising significant components (subnetworks) were assigned to motor, associative, or limbic circuits that constitute the cortico–basal ganglia–thalamocortical network (Galvan et al., 2015; Ikemoto et al., 2015).”
BackgroundSeeking motivation and reward: Roles of dopamine, hippocampus, and supramammillo-septal pathway
Kesner, A. J., Calva, C. B., & Ikemoto, S. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102252 · Cited by 56 · see citing works
“participate in producing seeking behavior toward goals by interacting with the thalamo-cortico-basal ganglia system (Ikemoto et al., 2015).”
Glasper, E. R., Kenkel, W. M., Bick, J. R., & Rilling, J. K. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.02.005 · Cited by 54 · see citing works
Cromwell, H. C., Abe, N., Barrett, K. C., Caldwell‐Harris, C. L., Gendolla, G. H. E., Koncz, R., & Sachdev, P. S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.032 · Cited by 54 · see citing works
Updating the role of dopamine in human motivation and apathy
Chong, T. T. ‐. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2017.12.010 · Cited by 50 · see citing works
Chen, Y., Hu, Y., Talishinsky, A., Potter, C. T., Calva, C. B., Ramsey, L. A., Kesner, A. J., Don, R. F., Junn, S., Tan, A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28892-7 · Cited by 50 · see citing works
Rappeneau, V., & Castillo Díaz, F. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105675 · Cited by 51 · see citing works
“Intriguingly, the caudate nucleus receives projections from midbrain DA and is part of the nigrostriatal DA system, which, like the mesolimbic DA system, plays a role in reward and motivation (Ikemoto et al., 2015).”
BackgroundWei, C., Zhang, F., Chen, L., Ma, X., Zhang, N., & Hao, J. (2015) · Journal of Neurology · doi:10.1007/s00415-015-7958-2 · Cited by 49 · see citing works
“Still other findings identified circuit loops involving the cerebral cortex, basal ganglia, thalamus, epithalamus, and midbrain through which dopaminergic activity affected motivation [29].”
BackgroundRetractedBoekhoudt, L., Wijbrans, E. C., Man, J. H. K., Luijendijk, M. C. M., de Jong, J. W., Plasse, G., Vanderschuren, L. J. M. J., & Adan, R. A. H. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.11.005 · Cited by 49 · see citing works
“However, it has been suggested that also the nigrostriatal DA pathway, from SNc towards dorsal striatum, may play an important role in motivational processes (Ikemoto et al., 2015; Palmiter, 2008; Wise, 2009).”
Corticostriatal Circuits Encode the Subjective Value of Perceived Control
Wang, K. S., & Delgado, M. R. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz045 · Cited by 42 · see citing works
“We leveraged the differences in the 2 baseline trial types where control was always presented in one (i.e., controllable trials) and always absent in the other (i.e., uncontrollable trials) to find that the ventral striatum (i.e., NAcc) and the aMCC were engaged when there was an opportunity for control in the control…”
BackgroundInfluentialFontanesi, C., & DeSouza, J. F. X. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.600440 · Cited by 48 · see citing works
Howard‐Jones, P. A., & Jay, T. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.04.015 · Cited by 48 · see citing works
“Also, both phasic and tonic DA activity appear to be involved in motivational state [21], and both contribute to the extra-cellular DA levels that regulate conditioned responding.”
Kennedy, J. T., Collins, P. F., & Luciana, M. M. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00413 · Cited by 45 · see citing works
“Manual edits weremade to the graymatter mask to ensure proper hemispheric and gray and white matter tissue separation.”
BackgroundMethodPredominant Striatal Input to the Lateral Habenula in Macaques Comes from Striosomes
Hong, S., Amemori, S., Chung, E., Gibson, D. J., Amemori, K., & Graybiel, A. M. (2018) · Current Biology · doi:10.1016/j.cub.2018.11.008 · Cited by 43 · see citing works
After the Honeymoon: Neural and Genetic Correlates of Romantic Love in Newlywed Marriages
Acevedo, B. P., Poulin, M. J., Collins, N. L., & Brown, L. L. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00634 · Cited by 43 · see citing works
Wang, D. V., Viereckel, T., Zell, V., Konradsson‐Geuken, Å., Broker, C. J., Talishinsky, A., Yoo, J. H., Galinato, M. H., Arvidsson, E., Kesner, A. J., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.062 · Cited by 40 · see citing works
“Therefore, reduced DA concentrations in the cKO may cause mice to administer cocaine with shorter intervals (Ikemoto et al., 2015).”
BackgroundGlutamate homeostasis and dopamine signaling: Implications for psychostimulant addiction behavior
Fischer, K. D., Knackstedt, L. A., & Rosenberg, P. A. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104896 · Cited by 40 · see citing works
Basal ganglia lateralization in different types of reward
Arsalidou, M., Vijayarajah, S., & Sharaev, M. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00215-3 · Cited by 42 · see citing works
Song, J., Hou, X., Hu, X., Lu, C., Liu, C., Wang, J., Liu, W., Teng, L., & Wang, D. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.10.001 · Cited by 40 · see citing works
Stievenard, A., Méquinion, M., Andrews, Z. B., Destée, A., Chartier-Harlin, M.-C., Viltart, O., & Vanbesien-Mailliot, C. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.021 · Cited by 39 · see citing works
“…system ave been implicated in various psychiatric disorders such as chizophrenia, manic depressive disorder or addiction (Hyman t al., 2006; Ikemoto et al., 2015; Simpson et al., 2012), as well as n neurodegenerative diseases like PD (Albin et al., 1989; DeLong, 990; Wichmann and DeLong,…”
BackgroundGrasing, K. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.06.022 · Cited by 38 · see citing works
Jaspers, E., Balsters, J. H., Kassraian, P., Mantini, D., & Wenderoth, N. (2016) · Human Brain Mapping · doi:10.1002/hbm.23466 · Cited by 37 · see citing works
“…[Albin et al., 1989; DeLong and Wichmann, 2007; Hoshi et al., 2005; Wichmann and DeLong, 1996] and psychiatric disorders [Hyman et al., 2006; Ikemoto et al., 2015; Simpson et al., 2010], as well as by healthy aging [Coxon et al., 2016; Coxon et al., 2010; Goble et al., 2011; Goble et al.,…”
BackgroundWei, L., Hu, X., Yuan, Y., Liu, W., & Chen, H. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.03.011 · Cited by 37 · see citing works
Wei, W., Ding, S., & Zhou, F.-M. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00683.2016 · Cited by 35 · see citing works
“…habit learning and formation (Graybiel and Grafton 2015), multisensory integration (Coffey et al. 2016; Reig and Silberberg 2014), and emotional and motivational regulation (Francis et al. 2015; Haber and Knutson 2010; Ikemoto et al. 2015; Lobo et al. 2013, Révy et al. 2014; Sesack and Grace 2010).”
BackgroundDong, G., Wang, M., Zhang, J., Du, X., & Potenza, M. N. (2019) · Journal of Behavioral Addictions · doi:10.1556/2006.8.2019.75 · Cited by 35 · see citing works
Orendain-Jaime, E. N., Ortega‐Ibarra, J., & López‐Pérez, S. J. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.09.001 · Cited by 33 · see citing works
“…A8), and project to the nucleus accumbens, related with regulation of emotional, social and reward-associated behaviors, motivation and feeding (Ikemoto et al., 2015; O’Connell and Hofmann, 2011); and 3) the mesocortical pathway, starting in the medial cell group A10 of the ventro-tegmental…”
BackgroundResting state functional connectivity underlying musical creativity
Bashwiner, D., Bacon, D., Wertz, C. J., Flores, R. A., Chohan, M. O., & Jung, R. E. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116940 · Cited by 32 · see citing works
Avchalumov, Y., Trenet, W., Piña-Crespo, J., & Mandyam, C. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186491 · Cited by 30 · see citing works
“Dopamine affects many physiological functions, such as the control of coordinated movements, as well as motivated and emotional behaviors by altering the neuroplasticity in the striatum [13,14].”
BackgroundHuman moral decision-making through the lens of Parkinson’s disease
Ponsi, G., Scattolin, M., Villa, R., & Aglioti, S. M. (2021) · npj Parkinson s Disease · doi:10.1038/s41531-021-00167-w · Cited by 31 · see citing works
Holloway, Z. R., Freels, T. G., Comstock, J. F., Nolen, H. G., Sable, H. J. K., & Lester, D. B. (2018) · Synapse · doi:10.1002/syn.22074 · Cited by 29 · see citing works
Why Do Birds Flock? A Role for Opioids in the Reinforcement of Gregarious Social Interactions
Riters, L. V., Kelm-Nelson, C., & Spool, J. A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00421 · Cited by 26 · see citing works
Yang, X., Guo, Z., Lü, J., Zhao, B., Fei, Y., Li, J., Jiang, H., Sun, L., Wang, Y., Sun, Y., et al. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/2357653 · Cited by 27 · see citing works
“Although Th and DAT are not significantly different in Western blot validation, the involvement of brain dopaminergic system including Th and DAT has been noted in major depressive patients [66, 67].”
BackgroundAdult forebrain NMDA receptors gate social motivation and social memory
Jacobs, S., & Tsien, J. Z. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.08.019 · Cited by 26 · see citing works
“Social interaction is thought to produce an internal reward state which will, in turn, reinforce and promote approach behaviors (Ikemoto et al. 2015).”
BackgroundAlteration of Neural Pathways and Its Implications in Alzheimer’s Disease
Kim, S., Nam, Y., Kim, H. S., Jung, H., Jeon, S. G., Hong, S. B., & Moon, M. (2022) · Biomedicines · doi:10.3390/biomedicines10040845 · Cited by 28 · see citing works
Winkelmeier, L., Filosa, C., Hartig, R., Scheller, M. F., Sack, M., Reinwald, J., Becker, R., Wolf, D., Gerchen, M. F., Sartorius, A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30978-1 · Cited by 24 · see citing works
Ávila, G., Picazo, O., Chuc-Meza, E., & Garcı́a-Ramı́rez, M. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112589 · Cited by 25 · see citing works
Heinzel, S., Kaufmann, C., Grützmann, R., Klawohn, J., Riesel, A., Bey, K., Heilmann-Heimbach, S., Weinhold, L., Ramirez, A., Wagner, M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-98333-w · Cited by 23 · see citing works
Pluck, G. C., Mancero, P. C. B., Encalada, P. A. O., Alcivar, A. M. U., Gavilánez, C. E. M., & Chacon, P. (2019) · Trends in Neuroscience and Education · doi:10.1016/j.tine.2019.100124 · Cited by 25 · see citing works
The Neural Bases of Disgust for Cheese: An fMRI Study
Royet, J., David Meunier, A., Torquet, N., Mouly, A., & Jiang, T. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00511 · Cited by 24 · see citing works
Listening to Rhythmic Music Reduces Connectivity within the Basal Ganglia and the Reward System
Brodal, H. P., Osnes, B., & Specht, K. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00153 · Cited by 23 · see citing works
“…this respect, the nucleus accumbens, which is part of the dopaminergic system, is seen as part of the reward processing system which is mainly active during experiencing reward, and its activity may correlate with the reward value (Salimpoor et al., 2013, 2015; Ikemoto et al., 2015; Zatorre, 2015).”
BackgroundMethodUsing Functional Analysis as a Framework to Guide Individualized Treatment for Negative Symptoms
Lincoln, T. M., Riehle, M., Pillny, M., Helbig‐Lang, S., Fladung, A.-K., Hartmann-Riemer, M. N., & Kaiser, S. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.02108 · Cited by 23 · see citing works
“Finally, antipsychotics have been suggested to directly cause amotivation and subsequent impairments in goal-directed behavior by the reduction of dopaminergic transmission (Ikemoto et al., 2015).”
BackgroundSakayori, N., Katakura, M., Hamazaki, K., Higuchi, O., Fujii, K., Fukabori, R., Iguchi, Y., Setogawa, S., Takao, K., Miyazawa, T., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-01209-4 · Cited by 23 · see citing works
Striatal Activity and Reward Relativity: Neural Signals Encoding Dynamic Outcome Valuation
Webber, E. S., Mankin, D. E., & Cromwell, H. C. (2016) · eNeuro · doi:10.1523/eneuro.0022-16.2016 · Cited by 23 · see citing works
“Introduction Stable neural representations have been important components of motivational neuroscience (Hikosaka et al., 2014; Bowman et al., 1996; Ikemoto et al., 2015; Morita and Kawaguchi, 2015) and historically helped strengthen the idea that a hierarchy of incentives can reliably guide behavior and brain function…”
BackgroundGómez‐A, A., Fiorenza, A. M., Boschen, S. L., Sugi, A. H., Beckman, D., Ferreira, S. T., Lee, K., Blaha, C. D., & Cunha, C. D. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00358 · Cited by 23 · see citing works
Unravelling the Link Between Prenatal Stress, Dopamine and Substance Use Disorder
Pastor, V. E., Antonelli, M. C., & Pallarés, M. E. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9674-9 · Cited by 22 · see citing works
“cocaine, amphetamine, cannabis, ecstasy, opiates such as heroin and opium and alcohol among others) is known to increase DA signalling in mesocorticolimbic circuit and it had long been accepted that rewarding effects of drugs are related to dopamine transmission (Ikemoto et al. 2015; Volkow Nora and Morales 2015).”
BackgroundDetecting stable individual differences in the functional organization of the human basal ganglia
García-García, M., Nikolaidis, A., Bellec, P., Craddock, R. C., Cheung, B., Castellanos, F. X., & Milham, M. P. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.07.029 · Cited by 22 · see citing works
Holloway, Z. R., Hawkey, A. B., Torres, A. K., Evans, J., Pippen, E., White, H., Katragadda, V., Kenou, B., Wells, C., Murphy, S. K., et al. (2020) · NeuroToxicology · doi:10.1016/j.neuro.2020.10.007 · Cited by 22 · see citing works
Increased alcohol consumption in sleep-restricted rats is mediated by delta FosB induction
García‐García, F., Priego-Fernández, S., López-Muciño, L. A., Acosta-Hernández, M. E., & Peña-Escudero, C. (2021) · Alcohol · doi:10.1016/j.alcohol.2021.02.004 · Cited by 21 · see citing works
Fransquet, P., Hutchinson, D. M., Olsson, C. A., Wilson, J., ALLSOP, S. J., Najman, J. M., Elliott, E. J., Mattick, R. P., Saffery, R., & Ryan, J. L. (2016) · Current Zoology · doi:10.1093/eep/dvw023 · Cited by 21 · see citing works
McLaughlin, T., Blum, K., Steinberg, B., Modestino, E. J., Fried, L., Baron, D. A., Siwicki, D., Braverman, E. R., & Badgaiyan, R. D. (2018) · Journal of Behavioral Addictions · doi:10.1556/2006.6.2017.081 · Cited by 21 · see citing works
“While much of this evidence points to the loci of this effect of DA being the ventral tegmental area (VTA), other evidence suggests that the motivational and other effects of DA on behavior may also derive from the substantia nigra (Ikemoto et al., 2015; Krawczyk et al., 2013).”
BackgroundMolecular Plasticity of the Nucleus Accumbens Revisited—Astrocytic Waves Shall Rise
Kardos, J., Dobolyi, Á., Szabó, Z. M., Simon, Á., Lourmet, G. S., Palkovits, M., & Héja, L. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1641-z · Cited by 21 · see citing works
Troshev, D. V., Berezhnoy, D. S., Игоревна, К. О., Абаимов, Д. А., Muzychuk, O. A., Nalobin, D. S., Stvolinsky, S. L., & Федорова, Т. Н. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.04.006 · Cited by 21 · see citing works
Blázquez, G., Castañé, A., Saavedra, A., Masana, M., Alberch, J., & Pérez‐Navarro, E. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00317 · Cited by 20 · see citing works
Janíčková, H., Kljakic, O., Rosborough, K., Raulic, S., Matovic, S., Gros, R., Saksida, L. M., Bussey, T. J., Inoue, W., Prado, V. F., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802108r · Cited by 21 · see citing works
“It is also important to note that PPT/LDT cholinergic neurons critically influence activity of midbrain dopaminergic neurons (96–99), known to be involved in the modulation of stress responsiveness (100) and motivation (101).”
BackgroundLi, R., Wang, X., Lin, F., Song, T., Zhu, X., & Lei, H. C. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116588 · Cited by 19 · see citing works
Selley, D. E., Lazenka, M. F., Sim‐Selley, L. J., McVoy, J. R. S., Potter, D. N., Chartoff, E. H., Carlezon, W. A., & Negus, S. S. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.107935 · Cited by 19 · see citing works
Hu, S., Wu, H., Xu, C., Wang, A., Wang, Y., Shen, T., Huang, F., Kan, H., & Li, C. (2019) · Frontiers in Neural Circuits · doi:10.3389/fncir.2019.00025 · Cited by 18 · see citing works
Extracellular Vesicles in Psychiatry Research in the Context of RDoC Criteria
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Sanchez, W. N., Pochapski, J. A., Jessen, L. F., Ellenberger, M., Schwarting, R. K. W., Robinson, D. L., Andreatini, R., & Cunha, C. D. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15658 · Cited by 15 · see citing works
Batton, A. D., Blaha, C. D., Bieber, A. J., et al. (2018) · Synapse · doi:10.1002/syn.22073 · Cited by 15 · see citing works
Single-dose L-dopa increases upper brainstem GABA in Parkinson's disease: A preliminary study
Song, Y., Gong, T., Xiang, Y., Mikkelsen, M. E., Wang, G., & Edden, R. A. E. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.117309 · Cited by 16 · see citing works
Glueck, E., Ginder, D. E., Hyde, J., North, K., & Grimm, J. W. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4516-2 · Cited by 15 · see citing works
“One possibility is that EE or loss of EE produces a state of low motivation, perhaps reflecting decreased dopamine signaling (Ikemoto et al. 2015; Salamone et al. 2016).”
Baldi, P., Alhassen, W., Chen, S., Nguyen, H. N., Khoudari, M., & Alachkar, A. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24919 · Cited by 12 · see citing works
Fuenzalida‐Uribe, N., & Campusano, J. M. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.12.032 · Cited by 12 · see citing works
Dopamine modulates the optomotor response to unreliable visual stimuli in Drosophila melanogaster
Akiba, M., Sugimoto, K., Aoki, R., Murakami, R., Miyashita, T., Hashimoto, R., Hiranuma, A., Yamauchi, J., Ueno, T., & Morimoto, T. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14648 · Cited by 13 · see citing works
Group independent components underpin responses to items from a depression scale
Stoyanov, D., Khorev, V. S., Paunova, R., Kandilarova, S., Kurkin, S., & Calhoun, V. D. (2023) · Acta Neuropsychiatrica · doi:10.1017/neu.2023.22 · Cited by 13 · see citing works
Systematic review on resting-state fMRI in people with AUD and people who binge drink
Rodríguez, G. C., Russell, M. A., & Claus, E. D. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02796-y · Cited by 12 · see citing works
Modeling of Neurodegenerative Diseases Using Discrete Chaotic Systems
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“Caudate (Ca), putamen (Pu), and nucleus accumbens (NAcc) are important hubs of cognition and motivation in the basal ganglia [18].”
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“…with previous work showing that Δ FosB accumulation in D1R(+) MSNs plays a major role in cocaine reward (Kelz et al., 1999; Colby et al., 2003; Grueter et al., 2013) and that the activation of D1R(+) cells in the striatum produces reinforcing effects (Kravitz et al., 2012; Ikemoto et al., 2015).”
InfluentialNeurophysiological correlates of stereotypic behaviour in a model carnivore species
Díez‐León, M., Kitchenham, L., Duprey, R., Bailey, C. D. C., Choleris, E., Lewis, M. H., & Mason, G. J. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112056 · Cited by 12 · see citing works
Gemikonakli, G., Keay, K. A., Kendig, M. D., Kang, J. W. M., Corbit, L. H., & Mor, D. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14518 · Cited by 12 · see citing works
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Relapse to cocaine seeking in an invertebrate
Amaning-Kwarteng, A. O., Asif-Malik, A., Pei, Y., & Canales, J. J. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.04.008 · Cited by 11 · see citing works
“…with common brain substrates, one of which is the dopaminergic system and its affiliated basal ganglia thalamo-cortical systems in mammals (Ikemoto et al., 2015, Volkow and Morales, 2015), and therefore it could be argued that such drugs can prime one another by reactivating…”
Cilia in the Striatum Mediate Timing-Dependent Functions
Alhassen, W., Alhassen, S., Chen, J., Monfared, R. V., & Alachkar, A. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03095-9 · Cited by 11 · see citing works
Limbic-Basal Ganglia Circuits Parallel and Integrative Aspects
Groenewegen, H. J., Voorn, P., & Scheel‐Krüger, J. (2016) · Innovations in cognitive neuroscience · doi:10.1007/978-3-319-42743-0_2 · Cited by 11 · see citing works
Bao, D., Zhou, J., Ying, H., Yang, X., Jiao, W., Hu, Y., & Wang, X. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00654 · Cited by 11 · see citing works
Takeuchi, E., Yamada, D., Suzuki, S., Saitoh, A., Itoh, M., Hayashi, T., Yamada, M., Wada, K., & Sekiguchi, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230647 · Cited by 11 · see citing works
“Since dopaminergic neurotransmission from the VTA to the NAc is known to play an important role in emotional arousal and reward [38], we speculated that this pathway was activated after the ingestion of a diet high in ω-3 PUFAs to reduce FST-immobility.”
Background
- Authors
- Ikemoto, S., Yang, C., & Tan, A.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Ikemoto, Satoshi
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 290
- Pages
- 17-31
- ISSN
- 0166-4328 (ISSN-L)
- PMC
- PMC4447603
- OpenAlex
- W2081845928
- Semantic Scholar
- bb06782b6fb20361735cf21f960fea754adbcf67
- Cited by
- 226
- References
- 255
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 14 · 2023: 15 · 2022: 21 · 2021: 25 · 2020: 29 · 2019: 22 · 2018: 22 · 2017: 21 · 2016: 26 · 2015: 3
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Behavioural Brain Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (ZIADA000575, ZIADA000439, ZIADA000550)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine, approach motivation, substantia nigra, ventral tegmental area, reward, aversion, thalamus, epithalamus, drugs of abuse, mood disorders
- MeSH terms
- Animals, Basal Ganglia, Motivation, Nerve Net, Reward, Dopaminergic Neurons
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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