The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
The Aromatase Knock-Out Mouse Provides New Evidence That Estradiol Is Required during Development in the Female for the Expression of Sociosexual Behaviors in Adulthood
Open accessAbstract
We used estrogen-deficient aromatase knock-out (ArKO) mice to determine whether estrogens contribute to the development of the brain and behavior in females. Female mice of three different genotypes [i.e., wild type (WT), heterozygous (HET), and homozygous (ArKO)] were ovariectomized in adulthood and subsequently tested for odor preferences (choice: intact male vs estrous female) in a Y-maze. When treated with testosterone, ArKO females spent significantly less time sniffing odors (both volatile and nonvolatile) from either male or female stimuli compared with WT and HET females. When given direct access to anesthetized stimulus animals or when given a choice between odor and visual cues from both stimulus animals, ArKO females continued to spend less time investigating the stimuli compared with WT and HET females. These defects in olfactory investigation of ArKO females were partially corrected with estradiol treatment in adulthood. Estradiol-treated ArKO females no longer differed from WT and HET females in the time spent investigating either nonvolatile odors or the anogenital region of anesthetized animals. However, ArKO females still investigated volatile odors and/or visual cues less than WT and HET females. Sexual receptivity was severely impaired in ArKO females after treatments with estradiol and progesterone that successfully induced receptivity in WT and HET females. Furthermore, ArKO females showed diminished levels of male sexual behaviors, whereas WT and HET females readily mounted an estrous female. Together, these findings demonstrate that estrogen is required for normal female development. The concept that the female brain develops in the absence of any hormonal stimulation should therefore be reconsidered.
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“masculinization of the male brain may in part be dependent on the effects of androgens on androgen receptors (Auger, Tetel, & McCarthy, 2000;Bakker, Honda, Harada, & Balthazart, 2002;Meaney & McEwen, 1986;Morris, Jordan, Dugger, & Breedlove, 2005).”
From Play fighting in androgen-insensitivetfm rats: Evidence that androgen receptors are necessary for the development of adult playful attack and defense (2006) · cites this paper as Bakker, Honda, Harada, & Balthazart, 2002
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PHOENIX, C. H., GOY, R. W., GERALL, A. A., & YOUNG, W. C. (1959) · Endocrinology · doi:10.1210/endo-65-3-369 · Cited by 1,934
Sexual Differentiation of the Central Nervous System
MacLusky, N. J., & Naftolin, F. (1981) · Science · doi:10.1126/science.6163211 · Cited by 1,469
Fisher, C. R., Graves, K. H., Parlow, A. F., & Simpson, E. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6965 · Cited by 867
The Formation of Estrogens by Central Neuroendocrine Tissues
NAFTOLIN, F., RYAN, K. J., DAVIES, I. J., REDDY, V. V., FLORES, F., PETRO, Z., KUHN, M., WHITE, R. J., TAKAOKA, Y., & WOLIN, L. (1975) · Proceedings of the 1974 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571131-9.50012-8 · Cited by 793
Aromatization: Important for sexual differentiation of the neonatal rat brain
McEwen, B. S., Lieberburg, I., Chaptal, C., & Krey, L. C. (1977) · Hormones and Behavior · doi:10.1016/0018-506x(77)90060-5 · Cited by 443
Toran‐Allerand, C. D. (1976) · Brain Research · doi:10.1016/0006-8993(76)91038-6 · Cited by 373
Differentiation of coital behavior in mammals: A comparative analysis
Baum, M. J. (1979) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(79)90013-7 · Cited by 321
Mammalian Social Odors: A Critical Review
Brown, R. E. (1979) · Advances in the study of behavior · doi:10.1016/s0065-3454(08)60094-7 · Cited by 293
Disruption of Sexual Behavior in Male Aromatase-Deficient Mice Lacking Exons 1 and 2 of thecyp19Gene
Honda, S., Harada, N., Ito, S., Takagi, Y., & Maeda, S. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9672 · Cited by 290
Self-citationEfferent control of stimulus access to the hamster vomeronasal organ.
Meredith, M. J., & O’Connell, R. J. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012620 · Cited by 260
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Papes, F., Nakahara, T. S., & Camargo, A. P. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4466-9_15
Gonzales, K. L. (2010) · Scholars Archive - University at Albany (University at Albany, State University of New York) · doi:10.54014/kgr7-heec
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Malone, C. A., Zhao, X., Xu, S. B., & Tschida, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.01.662591
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Masoumparast, M., Fiset, J.-P., Nasri, N., & Silva, M. S. B. (2026) · Endocrinology · doi:10.1210/endocr/bqag036
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Devillers, M. M. (2021) · theses.fr (ABES) · doi:10.70675/66ce6604zc759z4b30z8361z93a93c0f2deb
Sex influences gliovascular unit assembly and function in the developing mouse brainPreprint
Lemale, L., Abioui-Mourgues, M., Naulé, L., Alvear‐Perez, R., Rubio, M., Vivien, D., Lefebvre, M., Hourcade, T., Boulay, A.-C., Mhaouty‐Kodja, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.13.718096
Metadata
- Authors
- Bakker, J., Honda, S.-I., Harada, N., & Balthazart, J.
- Affiliations
- University of Liège (BE)
- Fujita Health University (JP)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-10-15
- Volume
- 22
- Issue
- 20
- Pages
- 9104-9112
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6757696
- OpenAlex
- W1904569017
- Cited by
- 209
- References
- 31
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 10 · 2016: 10 · 2015: 10 · 2014: 8 · 2013: 11 · 2012: 11
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion)
- Funders
- Fédération Wallonie-Bruxelles
- National Institutes of Health
- National Institute of Mental Health (MH-50388, R01MH050388)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- estradiol, estrogen, sociosexual behavior, odor preference, sexual receptivity, estrous cycle, testosterone, estradiol treatment, progesterone, female sexual behavior
- MeSH terms
- Animals, Aromatase, Choice Behavior, Cues, Estradiol, Female, Heterozygote, Homozygote, Male, Ovariectomy, Photic Stimulation, Progesterone, Reaction Time, Sexual Behavior, Animal, Smell, Social Behavior, Testosterone, Mice, Knockout, Gene Targeting, Mice
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