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The Aromatase Knock-Out Mouse Provides New Evidence That Estradiol Is Required during Development in the Female for the Expression of Sociosexual Behaviors in Adulthood
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We used estrogen-deficient aromatase knock-out (ArKO) mice to determine whether estrogens contribute to the development of the brain and behavior in females. Female mice of three different genotypes [i.e., wild type (WT), heterozygous (HET), and homozygous (ArKO)] were ovariectomized in adulthood and subsequently tested for odor preferences (choice: intact male vs estrous female) in a Y-maze. When treated with testosterone, ArKO females spent significantly less time sniffing odors (both volatile and nonvolatile) from either male or female stimuli compared with WT and HET females. When given direct access to anesthetized stimulus animals or when given a choice between odor and visual cues from both stimulus animals, ArKO females continued to spend less time investigating the stimuli compared with WT and HET females. These defects in olfactory investigation of ArKO females were partially corrected with estradiol treatment in adulthood. Estradiol-treated ArKO females no longer differed from WT and HET females in the time spent investigating either nonvolatile odors or the anogenital region of anesthetized animals. However, ArKO females still investigated volatile odors and/or visual cues less than WT and HET females. Sexual receptivity was severely impaired in ArKO females after treatments with estradiol and progesterone that successfully induced receptivity in WT and HET females. Furthermore, ArKO females showed diminished levels of male sexual behaviors, whereas WT and HET females readily mounted an estrous female. Together, these findings demonstrate that estrogen is required for normal female development. The concept that the female brain develops in the absence of any hormonal stimulation should therefore be reconsidered.
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“masculinization of the male brain may in part be dependent on the effects of androgens on androgen receptors (Auger, Tetel, & McCarthy, 2000;Bakker, Honda, Harada, & Balthazart, 2002;Meaney & McEwen, 1986;Morris, Jordan, Dugger, & Breedlove, 2005).”
From Play fighting in androgen-insensitivetfm rats: Evidence that androgen receptors are necessary for the development of adult playful attack and defense (2006) · cites this paper as Bakker, Honda, Harada, & Balthazart, 2002
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Pierman, S., Douhard, Q., & Bakker, J. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.06016.x · Cited by 37
Self-citationEffects of estradiol on kisspeptin neurons during puberty
Clarkson, J. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.02.002 · Cited by 38
Alternative 5′-untranslated first exons of the mouse Cyp19A1 (aromatase) gene
Chow, J. D. Y., Simpson, E. R., & Boon, W. C. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.03.010 · Cited by 36
RETRACTED: Neurological effects of aromatase deficiency in the mouse
Μatsumoto, T., Honda, S., & Harada, N. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00345-5 · Cited by 36
Self-citationRetractedDevillers, M. M., Mhaouty‐Kodja, S., & Guigon, C. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213695 · Cited by 38
Brockman, R., Bunick, D., & Mahoney, M. M. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.07.011 · Cited by 34
Bonthuis, P. J., Patteson, J. K., & Rissman, E. F. (2011) · Endocrinology · doi:10.1210/en.2010-1001 · Cited by 37
McCarthy, E. A., Kunkhyen, T., Korzan, W. J., Naik, A. S., Maqsudlu, A., Cherry, J. A., & Baum, M. J. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.12.011 · Cited by 31
Metadata
- Authors
- Bakker, J., Honda, S.-I., Harada, N., & Balthazart, J.
- Affiliations
- University of Liège (BE)
- Fujita Health University (JP)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-10-15
- Volume
- 22
- Issue
- 20
- Pages
- 9104-9112
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6757696
- OpenAlex
- W1904569017
- Cited by
- 209
- References
- 31
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 10 · 2016: 10 · 2015: 10 · 2014: 8 · 2013: 11 · 2012: 11
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion)
- Funders
- Fédération Wallonie-Bruxelles
- National Institutes of Health
- National Institute of Mental Health (MH-50388, R01MH050388)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- estradiol, estrogen, sociosexual behavior, odor preference, sexual receptivity, estrous cycle, testosterone, estradiol treatment, progesterone, female sexual behavior
- MeSH terms
- Animals, Aromatase, Choice Behavior, Cues, Estradiol, Female, Heterozygote, Homozygote, Male, Ovariectomy, Photic Stimulation, Progesterone, Reaction Time, Sexual Behavior, Animal, Smell, Social Behavior, Testosterone, Mice, Knockout, Gene Targeting, Mice
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