Cited by 209Sexual Differentiation and DisordersNeuroendocrine regulation and behaviorEstrogen and related hormone effects

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The Aromatase Knock-Out Mouse Provides New Evidence That Estradiol Is Required during Development in the Female for the Expression of Sociosexual Behaviors in Adulthood

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Bakker, Julie, Honda, Shin-Ichiro, Harada, Nobuhiro, Balthazart, Jacques·2002·The Journal of Neuroscience

DOI 10.1523/jneurosci.22-20-09104.2002PMC PMC6757696

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Abstract

We used estrogen-deficient aromatase knock-out (ArKO) mice to determine whether estrogens contribute to the development of the brain and behavior in females. Female mice of three different genotypes [i.e., wild type (WT), heterozygous (HET), and homozygous (ArKO)] were ovariectomized in adulthood and subsequently tested for odor preferences (choice: intact male vs estrous female) in a Y-maze. When treated with testosterone, ArKO females spent significantly less time sniffing odors (both volatile and nonvolatile) from either male or female stimuli compared with WT and HET females. When given direct access to anesthetized stimulus animals or when given a choice between odor and visual cues from both stimulus animals, ArKO females continued to spend less time investigating the stimuli compared with WT and HET females. These defects in olfactory investigation of ArKO females were partially corrected with estradiol treatment in adulthood. Estradiol-treated ArKO females no longer differed from WT and HET females in the time spent investigating either nonvolatile odors or the anogenital region of anesthetized animals. However, ArKO females still investigated volatile odors and/or visual cues less than WT and HET females. Sexual receptivity was severely impaired in ArKO females after treatments with estradiol and progesterone that successfully induced receptivity in WT and HET females. Furthermore, ArKO females showed diminished levels of male sexual behaviors, whereas WT and HET females readily mounted an estrous female. Together, these findings demonstrate that estrogen is required for normal female development. The concept that the female brain develops in the absence of any hormonal stimulation should therefore be reconsidered.

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ORIGINAL ARTICLE Estradiol-induced neurogenesis in the female accessory olfactory bulb is required for the learning of the male odor
Trouillet, A., Hellier, V., & Bakker, J. (2016)
Self-citation
Gonadal Hormonal Influences on the Adolescent Brain and Trajectories of Behavioral Development
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Authors: Bakker, J., Honda, S.-I., Harada, N., & Balthazart, J.
Affiliations: University of Liège (BE)
Fujita Health University (JP)
ORCID: Bakker, Julie
Balthazart, Jacques
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2002-10-15
Volume: 22
Issue: 20
Pages: 9104-9112
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.22-20-09104.2002
PMC: PMC6757696
OpenAlex: W1904569017
Cited by: 209
References: 31
Citations by year: 2026: 2 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 10 · 2016: 10 · 2015: 10 · 2014: 8 · 2013: 11 · 2012: 11
FWCI: 2.79
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Open Repository and Bibliography (University of Liège) (submittedVersion)
Funders: Fédération Wallonie-Bruxelles
National Institutes of Health
National Institute of Mental Health (MH-50388, R01MH050388)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: estradiol, estrogen, sociosexual behavior, odor preference, sexual receptivity, estrous cycle, testosterone, estradiol treatment, progesterone, female sexual behavior
MeSH terms: Animals, Aromatase, Choice Behavior, Cues, Estradiol, Female, Heterozygote, Homozygote, Male, Ovariectomy, Photic Stimulation, Progesterone, Reaction Time, Sexual Behavior, Animal, Smell, Social Behavior, Testosterone, Mice, Knockout, Gene Targeting, Mice

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The Aromatase Knock-Out Mouse Provides New Evidence That Estradiol Is Required during Development in the Female for the Expression of Sociosexual Behaviors in Adulthood

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