The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Genome-Wide Expression Analysis in Drosophila Reveals Genes Controlling Circadian Behavior
Open accessAbstract
In Drosophila, a number of key processes such as emergence from the pupal case, locomotor activity, feeding, olfaction, and aspects of mating behavior are under circadian regulation. Although we have a basic understanding of how the molecular oscillations take place, a clear link between gene regulation and downstream biological processes is still missing. To identify clock-controlled output genes, we have used an oligonucleotide-based high-density array that interrogates gene expression changes on a whole genome level. We found genes regulating various physiological processes to be under circadian transcriptional regulation, ranging from protein stability and degradation, signal transduction, heme metabolism, detoxification, and immunity. By comparing rhythmically expressed genes in the fly head and body, we found that the clock has adapted its output functions to the needs of each particular tissue, implying that tissue-specific regulation is superimposed on clock control of gene expression. Finally, taking full advantage of the fly as a model system, we have identified and characterized a cycling potassium channel protein as a key step in linking the transcriptional feedback loop to rhythmic locomotor behavior.
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Cites
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. B., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,290
Self-citationOrchestrated Transcription of Key Pathways in Arabidopsis by the Circadian Clock
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Self-citationExtensive and divergent circadian gene expression in liver and heart
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Time zones: a comparative genetics of circadian clocks
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double-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation
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A Component of Calcium-activated Potassium Channels Encoded by the Drosophila slo Locus
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Cited by
Loboda, A., Damulewicz, M., Pyza, E., Jozkowicz, A., & Dulak, J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2223-0 · Cited by 2,632
Molecular mechanisms and physiological importance of circadian rhythms
Patke, A., Young, M. W., & Axelrod, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0179-2 · Cited by 1,388
Mammalian circadian biology: elucidating genome-wide levels of temporal organization
Lowrey, P. L., & Takahashi, J. S. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.175925 · Cited by 976
Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways
Yin, L., Wu, N., Curtin, J. C., Qatanani, M., Szwergold, N. R., Reid, R. A., Waitt, G. M., Parks, D. J., Pearce, K. H., Wisely, G. B., et al. (2007) · Science · doi:10.1126/science.1150179 · Cited by 707
Extensive and divergent effects of sleep and wakefulness on brain gene expression
Cirelli, C., Gutierrez, C. M., & Tononi, G. (2004) · Neuron · doi:10.1016/s0896-6273(03)00814-6 · Cited by 627
Metadata
- Authors
- Ceriani, M. F., Hogenesch, J. B., Yanovsky, M., Panda, S., Straume, M., & Kay, S. A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-11-01
- Volume
- 22
- Issue
- 21
- Pages
- 9305-9319
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1982442428
- Cited by
- 352
- References
- 39
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ceriani, M. F., Hogenesch, J. B., Yanovsky, M., Panda, S., Straume, M., & Kay, S. A. (2002). Genome-Wide Expression Analysis in Drosophila Reveals Genes Controlling Circadian Behavior. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.22-21-09305.2002
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