Cited by 201Hypothalamic control of reproductive hormonesNeuroscience and Neuropharmacology ResearchNeuroendocrine regulation and behavior

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Dual-Phenotype GABA/Glutamate Neurons in Adult Preoptic Area: Sexual Dimorphism and Function

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Ottem, Erich N., Godwin, Jonathan G., Krishnan, Sudha, Petersen, Sandra L.·2004·The Journal of Neuroscience

DOI 10.1523/jneurosci.2267-04.2004PMC PMC6729791

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Abstract

It is generally assumed that the inhibitory neurotransmitter GABA and the stimulatory neurotransmitter glutamate are released from different neurons in adults. However, this tenet has made it difficult to explain how the same afferent signals can cause opposite changes in GABA and glutamate release. Such reciprocal release is a central mechanism in the neural control of many physiological processes including activation of gonadotropin-releasing hormone (GnRH) neurons, the neural signal for ovulation. Activation of GnRH neurons requires simultaneous suppression of GABA and stimulation of glutamate release, each of which occurs in response to a daily photoperiodic signal, but only in the presence of estradiol (E 2). In rodents, E 2 and photoperiodic signals converge in the anteroventral periventricular nucleus (AVPV), but it is unclear how these signals differentially regulate GABA and glutamate secretion. We now report that nearly all neurons in the AVPV of female rats express both vesicular glutamate transporter 2 (VGLUT2), a marker of hypothalamic glutamatergic neurons, as well as glutamic acid decarboxylase and vesicular GABA transporter (VGAT), markers of GABAergic neurons. These dual-phenotype neurons are the main targets of E 2 in the region and are more than twice as numerous in females as in males. Moreover, dual-phenotype synaptic terminals contact GnRH neurons, and at the time of the surge, VGAT-containing vesicles decrease and VGLUT2-containing vesicles increase in these terminals. Thus, we propose a new model for ovulation that includes dual-phenotype GABA/glutamate neurons as central transducers of hormonal and neural signals to GnRH neurons.

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Styne, D. M., Grumbach, M. M., Dennis, M., Styne, J., & Melvin, M. N. (1998) · Time to knit · doi:10.1016/b978-1-4160-2911-3.50026-1 · Cited by 546
Sexual Differentiation of Kiss1 Gene Expression in the Brain of the Rat
Kauffman, A. S., Gottsch, M. L., Roa, J., Byquist, A. C., Crown, A., Clifton, D. K., Hoffman, G. E., Steiner, R. A., & Tena‐Sempere, M. (2007) · Endocrinology · doi:10.1210/en.2006-1540 · Cited by 504
From glutamate co-release to vesicular synergy: vesicular glutamate transporters
El Mestikawy, S., Wallén-Mackenzie, Å., Fortin, G. M., Descarries, L., & Trudeau, L.-E. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2969 · Cited by 385
Estrogen positive feedback to gonadotropin-releasing hormone (GnRH) neurons in the rodent: The case for the rostral periventricular area of the third ventricle (RP3V)
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Characterization of Kiss1 neurons using transgenic mouse models
Cravo, R. M., Margatho, L. O., Osborne-Lawrence, S., Donato, J., Atkin, S., Bookout, A. L., Rovinsky, S., Frazão, R., Lee, C. E., Gautron, L., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.022 · Cited by 353

See all 201

Authors: Ottem, E. N., Godwin, J. G., Krishnan, S., & Petersen, S. L.
Affiliations: University of Massachusetts Amherst (US)
Harvard University (US)
ORCID: Petersen, Sandra L.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2004-09-15
Volume: 24
Issue: 37
Pages: 8097-8105
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.2267-04.2004
PMC: PMC6729791
OpenAlex: W2133423309
Cited by: 201
References: 87
Citations by year: 2026: 3 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 10 · 2017: 5 · 2016: 11 · 2015: 9 · 2014: 5 · 2013: 11 · 2012: 7
FWCI: 10.07
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5t32mh020051-09, HD27305)
National Institute of Mental Health (MH20051, T32-MH020051)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-27305, R01HD027305)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: GABAergic neurons, glutamatergic neurons, preoptic area, anteroventral periventricular nucleus, sexual dimorphism, estradiol, photoperiod, GnRH neurons, ovulation, vesicular glutamate transporter 2, vesicular GABA transporter, glutamic acid decarboxylase, synaptic terminals
MeSH terms: Animals, Castration, Circadian Rhythm, Drug Implants, Estradiol, Female, gamma-Aminobutyric Acid, Gene Expression Regulation, Glutamate Decarboxylase, Gonadotropin-Releasing Hormone, Male, Models, Biological, Nerve Endings, Nerve Tissue Proteins, Neurons, Ovulation, Phenotype, Preoptic Area, Sex Characteristics, Biomarkers, Rats, Sprague-Dawley, In Situ Hybridization, Glutamic Acid, Estrogen Receptor Modulators, Membrane Transport Proteins, Amino Acid Transport Systems, Estrogen Receptor alpha, Vesicular Inhibitory Amino Acid Transport Proteins, Vesicular Glutamate Transport Protein 2, Rats

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Dual-Phenotype GABA/Glutamate Neurons in Adult Preoptic Area: Sexual Dimorphism and Function

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