Distribution of vesicular glutamate transporter mRNA in rat hypothalamus
Abstract
Two isoforms of the vesicular glutamate transporter, VGLUT1 and VGLUT2, were recently cloned and biophysically characterized. Both VGLUT1 and VGLUT2 specifically transport glutamate into synaptic vesicles, making them definitive markers for neurons using glutamate as a neurotransmitter. The present study takes advantage of the specificity of the vesicular transporters to afford the first detailed map of putative glutamatergic neurons in the rat hypothalamus. In situ hybridization analysis was used to map hypothalamic distributions of VGLUT1 and VGLUT2 mRNAs. VGLUT2 is clearly the predominant vesicular transporter mRNA found in the hypothalamus; rich expression can be documented in regions regulating energy balance (ventromedial hypothalamus), neuroendocrine function (preoptic nuclei), autonomic tone (posterior hypothalamus), and behavioral/homeostatic integration (lateral hypothalamus, mammillary nuclei). Expression of VGLUT1 is decidedly more circumspect and is confined to relatively weak labeling in lateral hypothalamic regions, neuroendocrine nuclei, and the suprachiasmatic nucleus. Importantly, dual-label analysis revealed no incidence of colocalization of VGLUT1 or VGLUT2 mRNAs in glutamic acid decarboxylase (GAD) 65-positive neurons, indicating that GABA neurons do not express either transporter. Our data support a major role for hypothalamic glutamatergic neurons in regulation of all aspects of hypothalamic function.
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VGLUT2 is highly expressed in the hypothalamus, including OX neurons.
“It is known that glutamate transporters, particularity VGLUT2, are highly expressed in the hypothalamus, including OX neurons (Ziegler et al., 2002, Rosin et al., 2003)”
From A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance (2016) · cites this paper as Ziegler et al., 2002
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270 · see citing works
Brain Maps: Structure of the Rat Brain
Swanson, L. W. (1992) · Medical Entomology and Zoology · Cited by 1,851 · see citing works
Localization of neuronal and glial glutamate transporters
Rothstein, J. D., Martin, L. J., Levey, A. I., Dykes‐Hoberg, M., Jin, L., Wu, D. M., Nash, N. R., & Kuncl, R. W. (1994) · Neuron · doi:10.1016/0896-6273(94)90038-8 · Cited by 1,703 · see citing works
Brain maps: structure of the rat brain
Guillery, R. W. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90187-q · Cited by 1,677 · see citing works
The Expression of Vesicular Glutamate Transporters Defines Two Classes of Excitatory Synapse
Fremeau, R. T., Troyer, M. D., Pahner, I., Nygaard, G. O., Tran, C. H., Reimer, R. J., Bellocchio, E. E., Fortin, D. L., Storm‐Mathisen, J., & Edwards, R. H. (2001) · Neuron · doi:10.1016/s0896-6273(01)00344-0 · Cited by 1,266 · see citing works
Takamori, S., Rhee, J. S., Rosenmund, C., & Jahn, R. (2000) · Nature · doi:10.1038/35025070 · Cited by 862 · see citing works
Cerebral hemisphere regulation of motivated behavior
Swanson, L. W. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02905-x · Cited by 846 · see citing works
Hisano, S., Hoshi, K., Ikeda, Y., Maruyama, D., Kanemoto, M., Ichijo, H., Kojima, I., Takeda, J., & Nogami, H. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00194-7 · Cited by 806 · see citing works
Uptake of Glutamate into Synaptic Vesicles by an Inorganic Phosphate Transporter
Bellocchio, E. E., Reimer, R. J., Fremeau, R. T., & Edwards, R. H. (2000) · Science · doi:10.1126/science.289.5481.957 · Cited by 795 · see citing works
Feldmeyer, D., Lübke, J., Silver, R. A., & Sakmann, B. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.012959 · Cited by 656 · see citing works
Chemoarchitecture of the Brain
Nieuwenhuys, R. (1985) · Springer eBooks · doi:10.1007/978-3-642-70426-0 · Cited by 500 · see citing works
Chemoarchitecture of the brain
(1987) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(87)90305-7 · Cited by 416 · see citing works
Luiten, P. G. M., Horst, G. J. T., & Steffens, A. B. (1987) · Progress in Neurobiology · doi:10.1016/0301-0082(87)90004-9 · Cited by 385 · see citing works
Fujiyama, F., Furuta, T., & Kaneko, T. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1037 · Cited by 374 · see citing works
Viau, V., & Meaney, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-05-01866.1996 · Cited by 347 · see citing works
Bellocchio, E. E., Hu, H., Pohorille, A., Chan, J., Pickel, V. M., & Edwards, R. H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-21-08648.1998 · Cited by 337 · see citing works
Ni, B., Rosteck, P. R., Nadi, N. S., & Paul, S. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5607 · Cited by 316 · see citing works
The dorsomedial hypothalamic nucleus revisited: 1986 update
Bernardis, L. L., & Bellinger, L. L. (1987) · Brain Research Reviews · doi:10.1016/0165-0173(87)90004-x · Cited by 309 · see citing works
The suprachiasmatic nucleus and the circadian time-keeping system revisited
van Esseveldt, L. E., Lehman, M. N., & Boer, G. J. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00025-4 · Cited by 296 · see citing works
Molecular Cloning of a Novel Brain‐Type Na+‐Dependent Inorganic Phosphate Cotransporter
Aihara, Y., Mashima, H., Onda, H., Hisano, S., Kasuya, H., Hori, T., Yamada, S., Tomura, H., Yamada, Y., Inoue, I., et al. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0742622.x · Cited by 281 · see citing works
Local circuit regulation of paraventricular nucleus stress integration
Herman, J. P., Tasker, J. G., Ziegler, D. R., & Cullinan, W. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00681-5 · Cited by 274 · see citing works
Sleep–waking discharge of neurons in the posterior lateral hypothalamus of the albino rat
Steininger, T. L., Alam, M. N., Gong, H., Szymusiak, R. S., & McGinty, D. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01648-0 · Cited by 257 · see citing works
Bowers, G., Cullinan, W. E., & Herman, J. P. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-15-05938.1998 · Cited by 250 · see citing works
Hermes, M. L., Coderre, E. M., Buijs, R. M., & Renaud, L. P. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021724 · Cited by 184 · see citing works
The Dorsomedial Hypothalamic Nucleus Revisited: 1998 Update
Bernardis, L. L., & Bellinger, L. L. (1998) · Experimental Biology and Medicine · doi:10.3181/00379727-218-44296 · Cited by 179 · see citing works
Chastrette, N., Pfaff, D. W., & Gibbs, R. B. (1991) · Brain Research · doi:10.1016/0006-8993(91)91559-j · Cited by 165 · see citing works
Daftary, S. S., Boudaba, C., Szabó, K., & Tasker, J. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10619.1998 · Cited by 145 · see citing works
The medial supramammillary nucleus, spatial learning and the frequency of hippocampal theta activity
Pan, W. X., & McNaughton, N. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00431-9 · Cited by 142 · see citing works
Ni, B., Wu, X., Yan, G., Wang, J., & Paul, S. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-08-05789.1995 · Cited by 137 · see citing works
Hayashi, M., Otsuka, M., Morimoto, R., Hirota, S., Yatsushiro, S., Takeda, J., Yamamoto, A., & Moriyama, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106244200 · Cited by 119 · see citing works
Chemical stimulation of the dorsomedial hypothalamus elevates plasma ACTH in conscious rats
Bailey, T. W., & DiMicco, J. A. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.1.r8 · Cited by 113 · see citing works
Neurochemistry : a practical approach
Turner, A. J., & Bachelard, H. S. (1997) · Cited by 107 · see citing works
CNS Neurotransmitters and Neuromodulators: Glutamate
Stone, T. W. (1995) · Medical Entomology and Zoology · Cited by 104 · see citing works
Glutamate Transport and Storage in Synaptic Vesicles
Özkan, E. D., & Ueda, T. (1998) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.77.1 · Cited by 101 · see citing works
Cui, L.-N., Coderre, E., & Renaud, L. P. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.4.r1283 · Cited by 99 · see citing works
The supramammillary nucleus: Is it necessary for the mediation of hippocampal theta rhythm?
Thinschmidt, J. S., Kinney, G. G., & Kocsis, B. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00045-k · Cited by 96 · see citing works
Kapsimali, M., Vidal, B., González, A., Dufour, S., & Vernier, P. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000410)419:3 · Cited by 91 · see citing works
MEMORY AND THE REGION OF THE MAMMILLARY BODIES
Sziklas, V. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00064-6 · Cited by 88 · see citing works
Human retinohypothalamic tract as revealed by in vitro postmortem tracing
Dai, J., van der Vliet, J., Swaab, D. F., & Buijs, R. M. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980803)397:3 · Cited by 83 · see citing works
Injection of muscimol into posterior hypothalamus blocks stress-induced tachycardia
Lisa, M., Marmo, E., Wible, J. H., & DiMicco, J. A. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.257.1.r246 · Cited by 64 · see citing works
Hormonal integration of neurochemical and sensory signals governing female reproductive behavior
Etgen, A. M., Chu, H.-P., Fiber, J. M., Karkanias, G. B., & Morales, J. M. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00085-6 · Cited by 51 · see citing works
Morin, S. M., Stotz‐Potter, E. H., & DiMicco, J. A. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.5.r1276 · Cited by 51 · see citing works
Sun, X., Rusak, B., & Semba, K. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00170-6 · Cited by 38 · see citing works
SPECT tracer [123I]IBZM has similar affinity to dopamine D2 and D3 receptors
Videb�k, C., Toska, K., Scheideler, M. A., Paulson, O. B., & Knudsen, G. M. (2000) · Synapse · doi:10.1002/1098-2396(20001201)38:3 · Cited by 38 · see citing works
Amir, S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90145-2 · Cited by 34 · see citing works
GABA exerts opposite influence on warm and cold sensitive neurons in medial preoptic area in rats
Jha, S. K., Islam, F., & Mallick, B. N. (2001) · Journal of Neurobiology · doi:10.1002/neu.1058 · Cited by 32 · see citing works
Ishiwata, T., Hasegawa, H., Yasumatsu, M., Akano, F., Yazawa, T., Otokawa, M., & Aihara, Y. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01865-1 · Cited by 31 · see citing works
Wisden, W., Seeburg, P. H., & Monyer, H. (2000) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(00)80045-7 · Cited by 19 · see citing works
Suárez, M. M., & Ni, P. (1988) · PubMed · Cited by 13 · see citing works
The amino acid neurotransmitters and histamine
Feldman, R. (1997) · Neuropsychopharmacology · Cited by 7 · see citing works
Developmental and Hormonal Regulation of Thermosensitive Neuron Potential Activity in Rat Brain
Belugin, S., Akino, K., Takamura, N., Mine, M., Romanovsky, D., FEDOSEEV, V., Кубарко, А. И., Kosaka, M., & Yamashita, S. (1999) · Thyroid · doi:10.1089/thy.1999.9.837 · Cited by 2 · see citing works
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Sorted by citations
Neural regulation of endocrine and autonomic stress responses
Ulrich-Lai, Y. M., & Herman, J. P. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2647 · Cited by 3,318 · see citing works
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586 · see citing works
Saper, C. B., Fuller, P. M., Pedersen, N. P., Lu, J., & Scammell, T. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.032 · Cited by 1,404 · see citing works
Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons
Vong, L., Ye, C., Yang, Z., Choi, B. J., Chua, S. C., & Lowell, B. B. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.028 · Cited by 1,238 · see citing works
Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791 · see citing works
Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms
Chou, T. C., Scammell, T. E., Gooley, J. J., Gaus, S. E., Saper, C. B., & Lu, J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-33-10691.2003 · Cited by 576 · see citing works
Jones, B. E. (2003) · Frontiers in bioscience · doi:10.2741/1074 · Cited by 532 · see citing works
Regulation of affect by the lateral septum: implications for neuropsychiatry
Sheehan, T. P., Chambers, R. A., & Russell, D. S. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.04.009 · Cited by 514 · see citing works
Lateral hypothalamic circuits for feeding and reward
Stuber, G. D., & Wise, R. A. (2016) · Nature Neuroscience · doi:10.1038/nn.4220 · Cited by 519 · see citing works
Santana, N. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh070 · Cited by 486 · see citing works
Li, Y., Gao, X., Sakurai, T., & van den Pol, A. N. (2002) · Neuron · doi:10.1016/s0896-6273(02)01132-7 · Cited by 476 · see citing works
Tong, Q., Ye, C., McCrimmon, R. J., Dhillon, H., Choi, B., Kramer, M. D., Yu, J., Yang, Z., Christiansen, L. M., Lee, C. E., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.04.001 · Cited by 413 · see citing works
Characterization of Kiss1 neurons using transgenic mouse models
Cravo, R. M., Margatho, L. O., Osborne-Lawrence, S., Donato, J., Atkin, S., Bookout, A. L., Rovinsky, S., Frazão, R., Lee, C. E., Gautron, L., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.022 · Cited by 353 · see citing works
Fast Feedback Inhibition of the HPA Axis by Glucocorticoids Is Mediated by Endocannabinoid Signaling
Evanson, N. K., Tasker, J. G., Hill, M. N., Hillard, C. J., & Herman, J. P. (2010) · Endocrinology · doi:10.1210/en.2010-0285 · Cited by 324 · see citing works
Han, K.-S., Kim, L., & Shim, I. (2012) · Experimental Neurobiology · doi:10.5607/en.2012.21.4.141 · Cited by 290 · see citing works
Hur, E. E., & Záborszky, L. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20444 · Cited by 305 · see citing works
Álvarez, F. J., Villalba, R. M., Zerda, R., & Schneider, S. P. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20012 · Cited by 290 · see citing works
Role of GABA and Glutamate Circuitry in Hypothalamo‐Pituitary‐Adrenocortical Stress Integration
HERMAN, J. P., MUELLER, N. K., & FIGUEIREDO, H. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.004 · Cited by 282 · see citing works
Self-citationNeurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight
Meister, B. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.05.021 · Cited by 284 · see citing works
Radley, J. J., Gosselink, K. L., & Sawchenko, P. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5924-08.2009 · Cited by 268 · see citing works
Functional role of local GABAergic influences on the HPA axis
Cullinan, W. E., Ziegler, D. R., & Herman, J. P. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0192-2 · Cited by 255 · see citing works
Dual-phenotype GABA/glutamate neurons in adult preoptic area: sexual dimorphism and function
Ottem, E. N., Godwin, J. G., Krishnan, S., & Petersen, S. L. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2267-04.2004 · Cited by 201 · see citing works
Direct and Indirect Regulation of Gonadotropin-Releasing Hormone Neurons by Estradiol1
Petersen, S. L., Ottem, E. N., & Carpenter, C. D. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.103.019745 · Cited by 201 · see citing works
Functional identification of a neurocircuit regulating blood glucose
Meek, T. H., Nelson, J. T., Matsen, M. E., Dorfman, M. D., Guyenet, S. J., Damian, V. M., Allison, M. B., Scarlett, J. M., Hồng, N. T., Thaler, J. P., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521160113 · Cited by 178 · see citing works
Dabrowska, J., Hazra, R., Guo, J., DeWitt, S., & Rainnie, D. G. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00156 · Cited by 163 · see citing works
In Vivo Excitation of GABA Interneurons in the Medial Prefrontal Cortex through 5-HT3 Receptors
Puig, M. V. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh097 · Cited by 153 · see citing works
Homma, T., SAKAKIBARA, M., Yamada, S., Kinoshita, M., Iwata, K., Tomikawa, J., Kanazawa, T., Matsui, H., Takatsu, Y., Ohtaki, T., et al. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.109.078311 · Cited by 153 · see citing works
Balcita‐Pedicino, J. J., & Sesack, S. R. (2007) · Journal of Comparative Neurology · doi:10.1002/cne.21420 · Cited by 150 · see citing works
Landry, M., Bouali‐Benazzouz, R., Mestikawy, S. E., Ravassard, P., & Nagy, F. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10988 · Cited by 150 · see citing works
Chronic stress plasticity in the hypothalamic paraventricular nucleus
Herman, J. P., Flak, J. N., & Jankord, R. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00429-9 · Cited by 149 · see citing works
Myers, B., Dolgas, C. M., Kasckow, J., Cullinan, W. E., & Herman, J. P. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0566-y · Cited by 146 · see citing works
Chronic stress‐induced neurotransmitter plasticity in the PVN
Flak, J. N., Ostrander, M. M., Tasker, J. G., & Herman, J. P. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22142 · Cited by 143 · see citing works
A neural network for intermale aggression to establish social hierarchy
Stagkourakis, S., Spigolon, G., Williams, P., Protzmann, J., Fisone, G., & Broberger, C. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0153-x · Cited by 135 · see citing works
Steroid‐induced sexual differentiation of the developing brain: multiple pathways, one goal
Schwarz, J. M., & McCarthy, M. M. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05384.x · Cited by 136 · see citing works
Corticotropin-releasing factor in the dorsal raphe nucleus: Linking stress coping and addiction
Valentino, R. J., Lucki, I., & Bockstaele, E. V. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.100 · Cited by 135 · see citing works
Lin, W., McKinney, K., Liu, L., Lakhlani, S., & Jennes, L. (2003) · Endocrinology · doi:10.1210/en.2002-220908 · Cited by 133 · see citing works
Glutamate and GABA in Appetite Regulation
Delgado, T. C. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00103 · Cited by 128 · see citing works
Stocker, S. D., Simmons, J. R., Stornetta, R. L., Toney, G. M., & Guyenet, P. G. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20835 · Cited by 130 · see citing works
A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance
Martins, L., Seoane-Collazo, P., Contreras, C., González-García, I., Martínez-Sánchez, N., González, F., Zalvide, J., Gallego, R., Diéguez, C., Nogueiras, R., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.045 · Cited by 154 · see citing works
Lindberg, D., Chen, P., & Li, C. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23338 · Cited by 125 · see citing works
Collin, M., Bäckberg, M., Ovesjö, M., Fisone, G., Edwards, R. H., Fujiyama, F., & Meister, B. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02840.x · Cited by 127 · see citing works
Neural circuits underlying the generation of theta oscillations
Pignatelli, M., Beyeler, A., & Leinekugel, X. (2011) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2011.09.007 · Cited by 124 · see citing works
Omelchenko, N., & Sesack, S. R. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.016 · Cited by 121 · see citing works
Li, J., Fujiyama, F., Kaneko, T., & Mizuno, N. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10556 · Cited by 122 · see citing works
Zhang, L., Hernández, V. S., Swinny, J. D., Verma, A. K., Giesecke, T., Emery, A. C., Mutig, K., García‐Segura, L. M., & Eiden, L. E. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0099-5 · Cited by 121 · see citing works
Neural basis for fasting activation of the hypothalamic–pituitary–adrenal axis
Douglass, A. M., Resch, J. M., Madara, J. C., Kucukdereli, H., Yizhar, O., Grama, A., Yamagata, M., Yang, Z., & Lowell, B. B. (2023) · Nature · doi:10.1038/s41586-023-06358-0 · Cited by 121 · see citing works
Multiple convergent hypothalamus–brainstem circuits drive defensive behavior
Lovett-Barron, M., Chen, R., Bradbury, S., Andalman, A. S., Wagle, M. D., Guo, S., & Deisseroth, K. A. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0655-1 · Cited by 110 · see citing works
de Almeida, J., & Mengod, G. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04768.x · Cited by 109 · see citing works
Méndez, J. A. T., Bourque, M.-J., Bo, G. D., Bourdeau, M. L., Danik, M., Williams, S., Lacaille, J., & Trudeau, L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1331-08.2008 · Cited by 108 · see citing works
Turrin, N. P., & Rivest, S. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422901003 · Cited by 107 · see citing works
Enkephalin co‐expression with classic neurotransmitters in the amygdaloid complex of the rat
Poulin, J., Castonguay-Lebel, Z., Laforest, S., & Drolet, G. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21587 · Cited by 104 · see citing works
Kalsbeek, A., Verhagen, L. A. W., Schalij, I., Foppen, E., Saboureau, M., Bothorel, B., Buijs, R. M., & Pévet, P. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06057.x · Cited by 100 · see citing works
Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity
Lee, S. J., Sanchez-Watts, G., Krieger, J.-P., Pignalosa, A., Norell, P. N., Cortella, A., Pettersen, K. G., Vrdoljak, D., Hayes, M. R., Kanoski, S. E., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.03.008 · Cited by 95 · see citing works
Zhang, L., & Hernández, V. S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.10.010 · Cited by 96 · see citing works
Ziegler, D. R., Cullinan, W. E., & Herman, J. P. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20445 · Cited by 97 · see citing works
Glutamatergic drive of the dorsal raphe nucleus
Soiza‐Reilly, M., & Commons, K. G. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.04.004 · Cited by 95 · see citing works
Novel Aspects of Glutamatergic Signalling in the Neuroendocrine System
Hrabovszky, E., & Liposits, Z. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01719.x · Cited by 91 · see citing works
Programmed and Induced Phenotype of the Hippocampal Granule Cells
Gómez-Lira, G., Lamas, M., Romo-Parra, H., & Gutiérrez, R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1674-05.2005 · Cited by 99 · see citing works
Macroscale intrinsic network architecture of the hypothalamus
Hahn, J. D., Sporns, O., Watts, A. G., & Swanson, L. W. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1819448116 · Cited by 87 · see citing works
Wittmann, G., Hrabovszky, E., & Lechan, R. M. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23350 · Cited by 87 · see citing works
Fu, L., & van den Pol, A. N. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0749-08.2008 · Cited by 85 · see citing works
Hrabovszky, E., Wittmann, G., Turi, G. F., Liposits, Z., & Fekete, C. (2005) · Endocrinology · doi:10.1210/en.2004-0856 · Cited by 82 · see citing works
Medial preoptic circuit induces hunting-like actions to target objects and prey
Park, S.-G., Jeong, Y., Kim, D., Lee, M.-H., Shin, A., Park, G., Ryoo, J., Hong, J., Bae, S., Kim, C.-H., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0072-x · Cited by 82 · see citing works
Stressor-Selective Role of the Ventral Subiculum in Regulation of Neuroendocrine Stress Responses
Mueller, N. K., Dolgas, C. M., & Herman, J. P. (2004) · Endocrinology · doi:10.1210/en.2004-0097 · Cited by 81 · see citing works
The Central Effects of Thyroid Hormones on Appetite
Amin, A., Dhillo, W. S., & Murphy, K. G. (2011) · Journal of Thyroid Research · doi:10.4061/2011/306510 · Cited by 82 · see citing works
Ulrich‐Lai, Y. M., Jones, K. R., Ziegler, D. R., Cullinan, W. E., & Herman, J. P. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22571 · Cited by 79 · see citing works
Zhang, L., Hernández, V. S., Vázquez‐Juárez, E., Chay, F. K., & Barrio, R. A. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00013 · Cited by 76 · see citing works
Hrabovszky, E., Halász, J., Meelis, W., Kruk, M. R., Liposits, Z., & Haller, J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.042 · Cited by 78 · see citing works
Hrabovszky, E., Turi, G. F., Kalló, I., & Liposits, Z. (2004) · Endocrinology · doi:10.1210/en.2004-0589 · Cited by 72 · see citing works
Zheng, H., Stornetta, R. L., Agassandian, K., & Rinaman, L. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0841-6 · Cited by 67 · see citing works
Torterolo, P., Sampogna, S. L., Morales, F. R., & Chase, M. H. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.100 · Cited by 70 · see citing works
Connections of the juxtaventromedial region of the lateral hypothalamic area in the male rat
Hahn, J. D., & Swanson, L. W. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00066 · Cited by 68 · see citing works
Johnson, J., Fremeau, R. T., Duncan, J. L., Renterı́a, R. C., Yang, H., Hua, Z., Liu, X., LaVail, M. M., Edwards, R. H., & Copenhagen, D. R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0815-07.2007 · Cited by 65 · see citing works
VGLUT1 and VGLUT2 innervation in autonomic regions of intact and transected rat spinal cord
Llewellyn‐Smith, I., Martin, C. L., Fenwick, N. M., DiCarlo, S. E., Lujan, H. L., & Schreihofer, A. M. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21414 · Cited by 67 · see citing works
Resch, J. M., Boisvert, J. P., Hourigan, A. E., Mueller, C. R., Yi, S. S., & Choi, S. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00334.2011 · Cited by 67 · see citing works
Different Neuronal Phenotypes in the Lateral Hypothalamus and Their Role in Sleep and Wakefulness
Gerashchenko, D., & Shiromani, P. J. (2004) · Molecular Neurobiology · doi:10.1385/mn:29:1:41 · Cited by 67 · see citing works
Li, J., Xiong, K., Dong, Y., Fujiyama, F., Kaneko, T., & Mizuno, N. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10755 · Cited by 67 · see citing works
Pompolo, S., Pereira, A., Scott, C., Fujiyma, F., & Clarke, I. J. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10805 · Cited by 65 · see citing works
Ventromedial Nucleus of the Hypothalamus Neurons Under the Magnifying Glass
Khodai, T., & Luckman, S. M. (2021) · Endocrinology · doi:10.1210/endocr/bqab141 · Cited by 62 · see citing works
Larriva-Sahd, J. A. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21011 · Cited by 61 · see citing works
Danik, M., Cassoly, E., Manseau, F., Sotty, F., Mouginot, D., & Williams, S. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20500 · Cited by 61 · see citing works
Wallén‐Mackenzie, Å., Wootz, H., & Englund, H. (2010) · Upsala Journal of Medical Sciences · doi:10.3109/03009730903572073 · Cited by 59 · see citing works
Yilmazer‐Hanke, D. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-374236-0.10022-7 · Cited by 60 · see citing works
Wang, G., Coleman, C. G., Chan, J., Faraco, G., Marques-Lopes, J., Milner, T. A., Guruju, M. R., Anrather, J., Davisson, R. L., Iadecola, C., et al. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00367.2012 · Cited by 58 · see citing works
Herb, B. R., Glover, H. J., Bhaduri, A., Colantuoni, C., Bale, T. L., Siletti, K., Linnarsson, S., Hodge, R. D., Lein, E. S., Kriegstein, A. R., et al. (2023) · Science Advances · doi:10.1126/sciadv.adf6251 · Cited by 55 · see citing works
Otake, K. (2005) · Neuroscience Research · doi:10.1016/j.neures.2004.12.009 · Cited by 56 · see citing works
Wu, M. V., & Tollkühn, J. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.07.001 · Cited by 55 · see citing works
Pompolo, S., Pereira, A. Z., Kaneko, T., & Clarke, I. J. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01030.x · Cited by 55 · see citing works
Brainstem origins of glutamatergic innervation of the rat hypothalamic paraventricular nucleus
Ziegler, D. R., Edwards, M., Ulrich‐Lai, Y. M., Herman, J. P., & Cullinan, W. E. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23043 · Cited by 54 · see citing works
Kocsis, K. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00180-1 · Cited by 54 · see citing works
Mom doesn’t care: When increased brain CRF system activity leads to maternal neglect in rodents
Klampfl, S. M., & Bosch, O. J. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.01.001 · Cited by 51 · see citing works
Nunzi, M. G., Russo, M. J., & Mugnaini, E. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00568-2 · Cited by 53 · see citing works
Stern, J. E., & Zhang, W. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.077735 · Cited by 52 · see citing works
Role of paraventricular nucleus glutamate signaling in regulation of HPA axis stress responses
EVANSON, N. K., & HERMAN, J. P. (2015) · Interdisciplinary Information Sciences · doi:10.4036/iis.2015.b.10 · Cited by 48 · see citing works
Expression of VGLUTs contributes to degeneration and acquisition of learning and memory
Cheng, X., Yang, Y. G., Zhou, W., & Zhang, Y. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.01.010 · Cited by 51 · see citing works
Intrinsic properties and neuropharmacology of midline paraventricular thalamic nucleus neurons
Kolaj, M., Zhang, L., Hermes, M. L. H. J., & Renaud, L. P. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00132 · Cited by 51 · see citing works
Halasy, K., Hajszán, T., Kovács, É. G., Lâm, T., & Léránth, C. (2004) · Hippocampus · doi:10.1002/hipo.20006 · Cited by 50 · see citing works
Cheung, C. C., Krause, W. C., Edwards, R. H., Yang, C. F., Shah, N. M., Hnasko, T. S., & Ingraham, H. A. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.09.001 · Cited by 50 · see citing works
Sleep & metabolism: The multitasking ability of lateral hypothalamic inhibitory circuitries
Herrera, C. G., Ponomarenko, A. A., Korotkova, T. M., Burdakov, D., & Adamantidis, A. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.11.002 · Cited by 49 · see citing works
Girardet, C., Blanchard, M., Ferracci, G., Lévêque, C., Moreno, M., François‐Bellan, A., Becquet, D., & Bosler, O. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07071.x · Cited by 48 · see citing works
- Authors
- Ziegler, D. R., Cullinan, W. E., & Herman, J. P.
- Affiliations
- University of Kentucky (US)
- Marquette University (US)
- Corresponding author
- Herman, James P.
- ORCID
- Herman, James P.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2002-05-21
- Volume
- 448
- Issue
- 3
- Pages
- 217-229
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W1977741133
- Cited by
- 241
- References
- 53
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 10 · 2022: 8 · 2021: 10 · 2020: 5 · 2019: 12 · 2018: 14 · 2017: 10 · 2016: 11 · 2015: 11 · 2014: 9 · 2013: 12 · 2012: 9
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29mh056577-05, 5f31mh011980-02, 5r03mh060819-03)
- National Institute of Mental Health (MH 60819, MH49698, MH56577, MH 11980)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- vesicular glutamate transporter, VGLUT1, VGLUT2, hypothalamus, glutamatergic neurons, glutamatergic neurotransmission, mRNA distribution, ventromedial hypothalamus, suprachiasmatic nucleus, lateral hypothalamus, mammillary nuclei, GABAergic neurons, energy balance, neuroendocrine function, autonomic regulation
- MeSH terms
- Animals, Carrier Proteins, Gene Expression Regulation, Glutamate Decarboxylase, Hypothalamus, Male, Synaptic Transmission, Neurons, RNA, Messenger, Synaptic Vesicles, Biomarkers, Rats, Sprague-Dawley, In Situ Hybridization, Glutamic Acid, Membrane Transport Proteins, Vesicular Transport Proteins, Vesicular Glutamate Transport Protein 1, Vesicular Glutamate Transport Protein 2, Rats
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