The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Maternal Influenza Infection Causes Marked Behavioral and Pharmacological Changes in the Offspring
Open accessAbstract
Maternal viral infection is known to increase the risk for schizophrenia and autism in the offspring. Using this observation in an animal model, we find that respiratory infection of pregnant mice (both BALB/c and C57BL/6 strains) with the human influenza virus yields offspring that display highly abnormal behavioral responses as adults. As in schizophrenia and autism, these offspring display deficits in prepulse inhibition (PPI) in the acoustic startle response. Compared with control mice, the infected mice also display striking responses to the acute administration of antipsychotic (clozapine and chlorpromazine) and psychomimetic (ketamine) drugs. Moreover, these mice are deficient in exploratory behavior in both open-field and novel-object tests, and they are deficient in social interaction. At least some of these behavioral changes likely are attributable to the maternal immune response itself. That is, maternal injection of the synthetic double-stranded RNA polyinosinic-polycytidylic acid causes a PPI deficit in the offspring in the absence of virus. Therefore, maternal viral infection has a profound effect on the behavior of adult offspring, probably via an effect of the maternal immune response on the fetus.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“MIA models have ASD-like social, vocalization, ritualistic, exploration and other behavioral deficits [123–125].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [123]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Altering the postnatal gut microbiota by early life treatment with the human gut bacterium Bacteroides fragilis sufficiently ameliorated deficits in the frequency and quality of adult ultrasonic vocalizations and reduced stereotypic burying behavior exhibited by the ASD-like mice.”
From Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder (2017) · cites this paper as [31]
Experimental — accuracy not yet measuredIn the citing paper
“evidence from neuroanatomical, animal, and epidemiologic studies support the prenatal and early postnatal origins of autism.19–24”
From Environmental Chemical Exposures and Autism Spectrum Disorders: A Review of the Epidemiological Evidence (2014) · cites this paper as [23]
In the citing paper
“it has now been demonstrated through animal models that merely an activated immune response in the mother, absent any infection, is sufficient to lead to changes in the offspring”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Shi et al, 2003
In the citing paper
“Shi et al (2003) infected two strains of pregnant mice with human influenza virus and observed abnormal behavior, exploration, and social interaction in their offspring.”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Shi et al, 2003
In the citing paper
“the authors observed similar aberrant phenotypes in the same mice when using only poly(I:C) treatment rather than infection, suggesting that it was the maternal immune response rather than the infection itself that was responsible”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Shi et al, 2003
In the citing paper
“The consequences of MIA include behavioral deficits of broad relevance to ASD33, 34, 35”
From Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder (2018) · cites this paper as [33]
In the citing paper
“In a mouse model of maternal immune activation, a principal environmental risk factor for autism, mice develop core behavioral features of ASD (impaired social communication and stereotyped behaviors), as well as several neuropathologies and co-morbid gastrointestinal and immunological symptoms relevant to the human disorder (30–32).”
From Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder (2017) · cites this paper as [31]
In the citing paper
“Similarly, mice and/or non-human primates that are exposed to maternal immune activation (MIA) through maternal infection with the viral mimetic, polyinosinic: polycitidylic acid (poly (I:C)), or maternal influenza infection, have offspring that develop abnormal social behaviors 646566, deficits in their immune profiles and anxiety-like phenotypes 67.”
From Gastrointestinal Issues and Autism Spectrum Disorder (2020) · cites this paper as [66]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Koch, M. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00098-7 · Cited by 1,287
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
Mednick, S. A. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800260109013 · Cited by 1,203
A decrease of reelin expression as a putative vulnerability factor in schizophrenia
Impagnatiello, F., Guidotti, A. R., Pesold, C., Dwivedi, Y., Caruncho, H. J., Pisu, M. G., Uzunov, D. P., Smalheiser, N. R., Davis, J. M., Pandey, G. N., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15718 · Cited by 762
Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA
Cella, M., Salio, M., Sakakibara, Y., Langen, H., Julkunen, I., & Lanzavecchia, A. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.5.821 · Cited by 709
Malhotra, A. K. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00036-5 · Cited by 681
Swerdlow, N. R., & Geyer, M. A. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033326 · Cited by 626
Postmortem brain abnormalities of the glutamate neurotransmitter system in autism
Purcell, A. E., Jeon, O. H., Zimmerman, A. W., Blue, M. E., & Pevsner, J. (2001) · Neurology · doi:10.1212/wnl.57.9.1618 · Cited by 518
Marenco, S., & Weinberger, D. R. (2000) · Development and Psychopathology · doi:10.1017/s0954579400003138 · Cited by 485
Brain anatomy and sensorimotor gating in Asperger's syndrome
McAlonan, G. M. (2002) · Brain · doi:10.1093/brain/awf150 · Cited by 447
Jyonouchi, H., Sun, S., & Le, H. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00421-0 · Cited by 396
Research works printed but not linked: 1
- Shahab SZ, Glezen WP (1994) Influenza virus. In: Viral diseases in preg- nancy (Gonik B, ed), pp 215-223. New York: Springer.
Cited by
Sorted by citations
Items 501–600 of 996
Weber‐Stadlbauer, U., & Meyer, U. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.02.006 · Cited by 32
Overview of Animal Models of Schizophrenia
Powell, S. B., & Geyer, M. A. (2007) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0924s39 · Cited by 35
Behavioral and Molecular Biomarkers in Translational Animal Models for Neuropsychiatric Disorders
Sarnyai, Z., Alsaif, M., Bahn, S., Ernst, A., Guest, P. C., Hradetzky, E., Kluge, W. F., Stelzhammer, V., & Wesseling, H. (2011) · International review of neurobiology · doi:10.1016/b978-0-12-387718-5.00008-0 · Cited by 35
Asp, L., Beraki, S., Kristensson, K., Ögren, S. O., & Karlsson, H. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.04.004 · Cited by 33
Kleeman, E. A., Reisinger, S. N., Adithya, P., Houston, B. J., Stathatos, G. G., Garnham, A. L., McLaughlin, S., O’Bryan, M. K., Gubert, C., & Hannan, A. J. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.10.005 · Cited by 34
Hemmerle, A. M., Ahlbrand, R., Bronson, S. L., Lundgren, K. H., Richtand, N. M., & Seroogy, K. B. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.07.006 · Cited by 33
Behavioral Phenotypes for Negative Symptoms in Animal Models of Schizophrenia
Miyamoto, Y., & Nitta, A. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.14r02cr · Cited by 32
Animal Models of Autism: An Epigenetic and Environmental Viewpoint
Iwata, K., Matsuzaki, H., Takei, N., Manabe, T., & Mori, N. (2010) · Journal of Central Nervous System Disease · doi:10.4137/jcnsd.s6188 · Cited by 35
Hu, Y., Hong, X.-Y., Yang, X., Ma, R.-H., Wang, X., Zhang, J., Feng, Q., Li, X., Sun, D., Li, X. M., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.02.020 · Cited by 35
Saffari, A., Arno, M. J., Nasser, E. E., Ronald, A., Wong, C. C. Y., Schalkwyk, L. C., Mill, J. S., Dudbridge, F., & Meaburn, E. L. (2019) · Molecular Autism · doi:10.1186/s13229-019-0285-1 · Cited by 32
Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study
Fajardo, V. M., Zhang, D., Paiola, S. G., Mok, T., Cambou, M. C., Kerin, T., Rao, R., Brasil, P., Ferreira, F., Fuller, T. L., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-069194 · Cited by 33
Neonatal bacterial infection alters fever to live and simulated infections in adulthood
Bilbo, S. D., Wieseler, J. L., Barrientos, R. M., Tsang, V., Watkins, L. R., & Maier, S. F. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.07.014 · Cited by 33
Prenatal LPS exposure reduces olfactory perception in neonatal and adult rats
Kirsten, T. B., Chaves, G. P., Taricano, M., Martins, D. O., Flório, J. C., de Britto, L. R. G., Torrão, A. D. S., Palermo‐Neto, J., & Bernardi, M. M. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.049 · Cited by 33
Airway inflammation and central respiratory control: Results from in vivo and in vitro neonatal rat
Gresham, K. S., Boyer, B., Mayer, C. A., Foglyano, R., Martin, R. J., & Wilson, C. G. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.05.008 · Cited by 33
Schizophrenia: an integrative approach to modelling a complex disorder
Robertson, G. S., Hori, S. E., & Powell, K. J. (2006) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0619 · Cited by 34
Antonson, A. M., Kenney, A. D., Chen, H. J., Corps, K. N., Yount, J. S., & Gur, T. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.05.004 · Cited by 33
Yates, E. F., & Mulkey, S. B. (2024) · Pediatric Research · doi:10.1038/s41390-024-03145-z · Cited by 35
Tsukada, T., Simamura, E., Shimada, H., Arai, T., Higashi, N., Akai, T., Iizuka, H., & Hatta, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129011 · Cited by 31
Computerized assessment of social approach behavior in mouse
Page, D. T. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.048.2009 · Cited by 32
Landreau, F., Galeano, P., Caltana, L. R., Masciotra, L., Chertcoff, A. V., Pontoriero, A., Baumeister, E. G., Amoroso, M., Brusco, H. A., Tous, M. I., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051068 · Cited by 34
Sal-Sarria, S., Conejo, N. M., & González‐Pardo, H. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105844 · Cited by 34
Reelin-mediated Signaling during Normal and Pathological Forms of Aging.
Doehner, J., & Knuesel, I. (2010) · Europe PMC (PubMed Central) · Cited by 32
Aluminum and Neurodegenerative Diseases
Bondy, S. C., & Campbell, A. (2017) · Advances in neurotoxicology · doi:10.1016/bs.ant.2017.07.008 · Cited by 31
Ibi, D., Nakasai, G., Koide, N., Sawahata, M., Kohno, T., Takaba, R., Nagai, T., Hattori, M., Nabeshima, T., Yamada, K., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00285 · Cited by 31
Critical Role of the Maternal Immune System in the Pathogenesis of Autism Spectrum Disorder
Ravaccia, D., & Ghafourian, T. (2020) · Biomedicines · doi:10.3390/biomedicines8120557 · Cited by 32
Frontal-Subcortical Protein Expression following Prenatal Exposure to Maternal Inflammation
Deng, M., Lam, S., Meyer, U., Feldon, J., Li, Q., Wei, R., Luk, L. H. F., Chua, S. E., Sham, P. C., Wang, Y., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016638 · Cited by 31
Reid, G. (2004) · Clinical Infectious Diseases · doi:10.1086/423387 · Cited by 30
Strøm, M., Granström, C., Lyall, K., Ascherio, A., & Olsen, S. F. (2017) · Psychological Medicine · doi:10.1017/s0033291717002410 · Cited by 33
Neuroinflammation in Autism Spectrum Disorders: Role of High Mobility Group Box 1 Protein.
Dipasquale, V., Cutrupi, M. C., Colavita, L., Manti, S., Cuppari, C., & Salpietro, C. D. (2017) · Europe PMC (PubMed Central) · doi:10.22088/acadpub.bums.6.3.148 · Cited by 31
Berkiks, I., Garcia-Segura, L. M., Nassiri, A., Mesfioui, A., Ouichou, A., Boulbaroud, S., Bahbiti, Y., Lopez-Rodriguez, A. B., Hasnaoui, E., & El Hessni, A. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.11.037 · Cited by 30
Ben‐Reuven, L., & Reiner, O. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0594-y · Cited by 29
Cohort-guided insights into gene–environment interactions in autism spectrum disorders
Lipkin, W. I., Bresnahan, M. A., & Susser, E. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-022-00764-0 · Cited by 35
Viruses and autism: A Bi-mutual cause and effect
Al‐Beltagi, M., Saeed, N. K., Elbeltagi, R. M., Bediwy, A. S., Aftab, S. A. S., & Alhawamdeh, R. (2023) · World Journal of Virology · doi:10.5501/wjv.v12.i3.172 · Cited by 32
Prenatal lipopolysaccharide treatment enhances MK-801-induced psychotomimetic effects in rats
Basta‐Kaim, A., Fijał, K., Budziszewska, B., Regulska, M., Leśkiewicz, M., Kubera, M., Gołembiowska, K., Lasoń, W., & Wędzony, K. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.12.026 · Cited by 30
Serotonin and dopamine interactions in psychosis prevention
Richtand, N. M., & McNamara, R. K. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00907-2 · Cited by 28
Łukasz, B., O’Sullivan, N. C., Loscher, J. S., Pickering, M., Regan, C. M., & Murphy, K. J. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.09.011 · Cited by 31
Buschert, J., Sakalem, M. E., Saffari, R., Hohoff, C., Rothermundt, M., Arolt, V., Zhang, W., & Ambrée, O. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.01.005 · Cited by 29
Immune activation state modulates infant engram expression across development
Power, S. D., Stewart, E., Zielke, L. G., Byrne, E. P., Douglas, A., Luis, C. O. S., Lynch, L., & Ryan, T. J. (2023) · Science Advances · doi:10.1126/sciadv.adg9921 · Cited by 29
Coe, C. L., Lubach, G. R., Crispen, H. R., Shirtcliff, E. A., & Schneider, M. L. (2010) · Developmental Psychobiology · doi:10.1002/dev.20489 · Cited by 29
Exploring causal mechanisms of psychosis risk
Oliver, D., Chesney, E., Cullen, A. E., Davies, C., Englund, A., Gifford, G., Kerins, S., Lalousis, P. A., Logeswaran, Y., Merritt, K., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105699 · Cited by 33
Handbook of Schizophrenia Spectrum Disorders, Volume II
Ritsner, M. S. (2011) · Springer eBooks · doi:10.1007/978-94-007-0831-0 · Cited by 28
Month of Conception and Learning Disabilities: A Record-Linkage Study of 801,592 Children
Mackay, D., Smith, G. C. S., Cooper, S., Wood, R., King, A., Clark, D. N., & Pell, J. P. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kww096 · Cited by 28
Gentile, I., Zappulo, E., Riccio, M. P., Binda, S., Bubba, L., Pellegrinelli, L., Scognamiglio, D., Operto, F. F., Margari, L., Borgia, G., et al. (2017) · In Vivo · doi:10.21873/invivo.11085 · Cited by 27
Aria, F., Bonini, S. A., Cattaneo, V., Premoli, M., Mastinu, A., Maccarinelli, G., & Memo, M. (2020) · Brain Sciences · doi:10.3390/brainsci10090620 · Cited by 28
Deslauriers, J., Racine, W., Sarret, P., & Grignon, S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.061 · Cited by 29
Astrocytes as Pharmacological Targets in the Treatment of Schizophrenia
Pocivavsek, A., Notarangelo, F. M., Wu, H., Bruno, J. P., & Schwarcz, R. M. (2015) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-800981-9.00025-0 · Cited by 30
Enstrom, A. M., Onore, C. E., Tarver, A., Hertz‐Picciotto, I., Hansen, R. L., Croen, L., de Water, J. V., & Ashwood, P. (2008) · American journal of biochemistry & biotechnology/American journal of biochemistry and biotechnology · doi:10.3844/ajbbsp.2008.121.129 · Cited by 28
Developing New Drugs for Schizophrenia: From Animals to the Clinic
Jones, D. N. C., Gartlon, J. E., Minassian, A., Perry, W., & Geyer, M. A. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373861-5.00008-4 · Cited by 30
Developmental Neurobiology and Clinical Disorders: Lost in Translation?
Levitt, P. R. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.015 · Cited by 28
Impact of Maternal Stress in Pregnancy on Brain Function of the Offspring
Udagawa, J., & Hino, K. (2016) · Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) · doi:10.1265/jjh.71.188 · Cited by 29
Li, Y., Dugyala, S., Ptacek, T., Gilmore, J. H., & Frӧhlich, F. (2018) · eNeuro · doi:10.1523/eneuro.0313-18.2018 · Cited by 27
SARS-CoV-2 Spike protein alters microglial purinergic signaling
Alves, V. S., Santos, S. A. C. S., Leite-Aguiar, R., Paiva-Pereira, E., dos Reis, R. R., Calazans, M. L., Fernandes, G. G., Antonio, L. S., de Lima, E. V., Kurtenbach, E., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1158460 · Cited by 28
Bilbo, S. D., Nevison, C. D., & Parker, W. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26253 · Cited by 28
Tsukada, T., Shimada, H., Sakata‐Haga, H., Iizuka, H., & Hatta, T. (2018) · Congenital Anomalies · doi:10.1111/cga.12323 · Cited by 27
McLellan, J., Kim, D. H. J., Bruce, M. R., Ramirez-Celis, A., & de Water, J. V. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.834910 · Cited by 30
McDonald, C. R., Elphinstone, R. E., & Kain, K. C. (2013) · Trends in Parasitology · doi:10.1016/j.pt.2013.03.005 · Cited by 27
Ornaghi, S., Hsieh, L. S., Bordey, A., Vergani, P., Paidas, M. J., & van den Pol, A. N. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0970-17.2017 · Cited by 25
Gray, A., Tattoli, R., Dunn, A. L., Hodgson, D. M., Michie, P. T., & Harms, L. R. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.08.016 · Cited by 26
Campen, H. V., Bishop, J. V., Abrahams, V. M., Bielefeldt‐Ohmann, H., Mathiason, C. K., Bouma, G. J., Winger, Q. A., Mayo, C. E., Bowen, R. A., & Hansen, T. R. (2020) · Viruses · doi:10.3390/v12091003 · Cited by 26
Autism and EMF? Plausibility of a pathophysiological link part II
Herbert, M. R., & Sage, C. (2013) · Pathophysiology · doi:10.1016/j.pathophys.2013.08.002 · Cited by 28
Debnath, M., & Chaudhuri, T. K. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.06.033 · Cited by 26
Dopaminergic hypofunctions and prepulse inhibition deficits in mice lacking midkine
Ohgake, S., Shimizu, E., Hashimoto, K., Okamura, N., Koike, K., Koizumi, H., Fujisaki, M., Kanahara, N., Matsuda, S., Sutoh, C., et al. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.02.005 · Cited by 26
Cassella, S. N., Hemmerle, A. M., Lundgren, K. H., Kyser, T. L., Ahlbrand, R., Bronson, S. L., Richtand, N. M., & Seroogy, K. B. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.01.041 · Cited by 27
Kaminski, V. D. L., Michita, R. T., Ellwanger, J. H., Veit, T. D., Schuch, J. B., Riesgo, R. D. S., Roman, T., & Chies, J. A. B. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15593 · Cited by 29
[Association between HSV-2 infection and serum anti-rat brain antibodies in patients with autism].
Mora, M., Quintero, L., Cardenas, R., Suárez-Roca, H., Zavala, M. D. M., & Montiel, N. (2009) · PubMed · Cited by 25
Neurons Preferentially Respond to Self-MHC Class I Allele Products Regardless of Peptide Presented
Escande‐Beillard, N., Washburn, L. R., Zekzer, D., Wu, Z.-P., Eitan, S., Ivković, S., Lu, Y., Dang, H. N., Middleton, B., Bilousova, T. V., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902159 · Cited by 25
Yu, J. H., Zhang, H., Wolff, A. R., Bilkey, D. K., & Liu, P. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.06.001 · Cited by 24
Soto, A. M. S., Kirsten, T. B., Reis-Silva, T. M., Martins, M. D. F. M., Teodorov, E., Flório, J. C., Palermo‐Neto, J., Bernardi, M. M., & Bondan, E. F. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.03.003 · Cited by 25
McAlonan, G. M., Li, Q., & Cheung, C. (2010) · Neurosignals · doi:10.1159/000321080 · Cited by 24
Effect of polybrominated diphenyl ether congeners on placental cytokine production
Arita, Y., Yeh, C., Thoma, T., Getahun, D., Menon, R., & Peltier, M. R. (2017) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2017.12.002 · Cited by 25
Can we use mice to study schizophrenia?
Canetta, S., & Kellendonk, C. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0032 · Cited by 25
Tohmi, M., Tsuda, N., Zheng, Y., Mizuno, M., Sotoyama, H., Shibuya, M., Kawamura, M., Kakita, A., Takahashi, H., & Nawa, H. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.08.034 · Cited by 25
Kawa, R., & E.*, P. (2010) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2010-1785 · Cited by 26
Ibi, D., & Yamada, K. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226092 · Cited by 24
Sheu, J., Hsieh, C., Jayakumar, T., Tseng, M.-F., Lee, H.-N., Huang, S.-W., Manubolu, M., & Yang, C. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00635 · Cited by 24
Böhmwald, K., Andrade, C. A., & Kalergis, A. M. (2021) · Pharmaceuticals · doi:10.3390/ph14040340 · Cited by 28
Ryan, A. M., & Bauman, M. D. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.02.012 · Cited by 24
The Immune System and the Developing Brain
Schwarz, J. M., & Bilbo, S. D. (2011) · Colloquium Series on The Developing Brain · doi:10.4199/c00045ed1v01y201110dbr004 · Cited by 25
Flow cytometric characterization of microglia in the offspring of PolyI:C treated mice
Manitz, M. P., Plümper, J., Demir, S., Ahrens, M., Eßlinger, M., Wachholz, S., Eisenacher, M., Juckel, G., & Friebe, A. (2016) · Brain Research · doi:10.1016/j.brainres.2016.02.004 · Cited by 25
Song, C. H., Clark, S. M., Vaughn, C. N., Nicholson, J. D., Murphy, K. J., Mou, T.-C. M., Schwarcz, R. M., Hoffman, G. E., & Tonelli, L. H. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.11.001 · Cited by 24
Crosstalk Between the Microbiome and Gestational Immunity in Autism-Related Disorders
Paysour, M. J., Bolte, A. C., & Lukens, J. R. (2019) · DNA and Cell Biology · doi:10.1089/dna.2019.4653 · Cited by 25
Quinlan, S., Merino‐Serrais, P., Grande, A. D., Düßmann, H., Prehn, J. H. M., Chonghaile, T. N., Henshall, D. C., & Jimenez-Mateos, E. M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01752 · Cited by 24
Brain Autoantibodies in Autism Spectrum Disorder
Elamin, N. E., & AL-Ayadhi, L. Y. (2014) · Biomarkers in Medicine · doi:10.2217/bmm.14.1 · Cited by 24
Gene expression changes in brains of mice exposed to a maternal virus infection
Asp, L., Beraki, S., Aronsson, F. S., Rosvall, L., Ögren, S. O., Kristensson, K., & Karlsson, H. (2005) · Neuroreport · doi:10.1097/00001756-200507130-00016 · Cited by 23
Targeting Cognition in Schizophrenia Research: From Etiology to Treatment
Goldberg, T. E., & Gomar, J. J. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09040497 · Cited by 24
Dera, H. S. A. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112688 · Cited by 26
Walle, K. M., Askeland, R. B., Gustavson, K., Mjaaland, S., Ystrøm, E., Lipkin, W. I., Magnus, P. M., Stoltenberg, C., Susser, E., Bresnahan, M. A., et al. (2022) · JCPP Advances · doi:10.1002/jcv2.12070 · Cited by 23
Richtand, N. M., Ahlbrand, R., Horn, P. S., Tambyraja, R., Grainger, M., Bronson, S. L., & McNamara, R. K. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.02.004 · Cited by 24
Innate immune system regulation of nuclear hormone receptors in metabolic diseases
Chow, E. K., Razani, B., & Cheng, G. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.1206741 · Cited by 23
Chou, S., Jones, S., & Li, M. (2015) · Brain Research · doi:10.1016/j.brainres.2015.05.036 · Cited by 23
Developmental dysfunction of prefrontal–hippocampal networks in mouse models of mental illness
Oberlander, V. C., Xu, X., Chini, M., & Hanganu‐Opatz, I. L. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14436 · Cited by 23
Qi, F., Zuo, Z., Hu, S., Xia, Y., Song, D., Kong, J., Yang, Y., Wu, Y., Wang, X., Yang, J., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.04.003 · Cited by 21
Velloso, F. J., Wadhwa, A., Kumari, E., Carcea, I., Bozdagi-Gunal, O., & Levison, S. W. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.12.015 · Cited by 24
Potential Neurocognitive Symptoms Due to Respiratory Syncytial Virus Infection
Andrade, C. A., Kalergis, A. M., & Böhmwald, K. (2021) · Pathogens · doi:10.3390/pathogens11010047 · Cited by 21
Prenatal and Childhood Immuno-Metabolic Risk Factors for Adult Depression and Psychosis
Kappelmann, N., Perry, B. I., & Khandaker, G. M. (2022) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000322 · Cited by 22
Sotoyama, H., Namba, H., Tohmi, M., & Nawa, H. (2023) · Biomolecules · doi:10.3390/biom13020372 · Cited by 24
Perez-Palomar, B., Erdozain, A. M., Erkizia-Santamaría, I., Ortega, J. E., & Meana, J. J. (2023) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-023-10070-1 · Cited by 22
Patrich, E., Piontkewitz, Y., Peretz, A. S., Weiner, I., & Attali, B. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.08.021 · Cited by 27
Effects of Exogenous Agents on Brain Development: Stress, Abuse and Therapeutic Compounds
Archer, T. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00171.x · Cited by 23
Vanders, R. L., Murphy, V. E., Gibson, P. G., Hansbro, P. M., & Wark, P. A. B. (2014) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2014.09.051 · Cited by 22
Metadata
- Authors
- Shi, L., Fatemi, S. H., Sidwell, R. W., & Patterson, P. H.
- Affiliations
- California Institute of Technology (US)
- University of Minnesota (US)
- Utah State University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-01-01
- Volume
- 23
- Issue
- 1
- Pages
- 297-302
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6742135
- OpenAlex
- W2143217444
- Cited by
- 1,025
- References
- 43
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 34 · 2023: 29 · 2022: 48 · 2021: 45 · 2020: 42 · 2019: 35 · 2018: 47 · 2017: 46 · 2016: 47 · 2015: 59 · 2014: 57 · 2013: 57 · 2012: 66
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion, cc-by)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health (n01ai065291-009)
- National Institute of Allergy and Infectious Diseases (N01 AI 65291)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- maternal influenza infection, prenatal viral infection, offspring behavior, prepulse inhibition, acoustic startle response, clozapine, chlorpromazine, ketamine, exploratory behavior, social interaction deficits, maternal immune response, polyinosinic-polycytidylic acid, schizophrenia, autism spectrum disorder, mouse strain differences
- MeSH terms
- Acoustic Stimulation, Animals, Animals, Newborn, Antiviral Agents, Anxiety, Behavior, Animal, Chlorpromazine, Clozapine, Exploratory Behavior, Female, Immunity, Ketamine, Mice, Inbred BALB C, Mice, Inbred C57BL, Motor Activity, Orthomyxoviridae Infections, Poly I-C, Pregnancy, Social Behavior, Antipsychotic Agents, Maternal-Fetal Relations, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
