The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Maternal Influenza Infection Causes Marked Behavioral and Pharmacological Changes in the Offspring
Open accessAbstract
Maternal viral infection is known to increase the risk for schizophrenia and autism in the offspring. Using this observation in an animal model, we find that respiratory infection of pregnant mice (both BALB/c and C57BL/6 strains) with the human influenza virus yields offspring that display highly abnormal behavioral responses as adults. As in schizophrenia and autism, these offspring display deficits in prepulse inhibition (PPI) in the acoustic startle response. Compared with control mice, the infected mice also display striking responses to the acute administration of antipsychotic (clozapine and chlorpromazine) and psychomimetic (ketamine) drugs. Moreover, these mice are deficient in exploratory behavior in both open-field and novel-object tests, and they are deficient in social interaction. At least some of these behavioral changes likely are attributable to the maternal immune response itself. That is, maternal injection of the synthetic double-stranded RNA polyinosinic-polycytidylic acid causes a PPI deficit in the offspring in the absence of virus. Therefore, maternal viral infection has a profound effect on the behavior of adult offspring, probably via an effect of the maternal immune response on the fetus.
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In the citing paper
“MIA models have ASD-like social, vocalization, ritualistic, exploration and other behavioral deficits [123–125].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [123]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The consequences of MIA include behavioral deficits of broad relevance to ASD33, 34, 35”
From Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder (2018) · cites this paper as [33]
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In the citing paper
“Altering the postnatal gut microbiota by early life treatment with the human gut bacterium Bacteroides fragilis sufficiently ameliorated deficits in the frequency and quality of adult ultrasonic vocalizations and reduced stereotypic burying behavior exhibited by the ASD-like mice.”
From Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder (2017) · cites this paper as [31]
Experimental — accuracy not yet measuredIn the citing paper
“evidence from neuroanatomical, animal, and epidemiologic studies support the prenatal and early postnatal origins of autism.19–24”
From Environmental Chemical Exposures and Autism Spectrum Disorders: A Review of the Epidemiological Evidence (2014) · cites this paper as [23]
In the citing paper
“it has now been demonstrated through animal models that merely an activated immune response in the mother, absent any infection, is sufficient to lead to changes in the offspring”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Shi et al, 2003
In the citing paper
“Shi et al (2003) infected two strains of pregnant mice with human influenza virus and observed abnormal behavior, exploration, and social interaction in their offspring.”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Shi et al, 2003
In the citing paper
“the authors observed similar aberrant phenotypes in the same mice when using only poly(I:C) treatment rather than infection, suggesting that it was the maternal immune response rather than the infection itself that was responsible”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Shi et al, 2003
In the citing paper
“In a mouse model of maternal immune activation, a principal environmental risk factor for autism, mice develop core behavioral features of ASD (impaired social communication and stereotyped behaviors), as well as several neuropathologies and co-morbid gastrointestinal and immunological symptoms relevant to the human disorder (30–32).”
From Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder (2017) · cites this paper as [31]
In the citing paper
“Similarly, mice and/or non-human primates that are exposed to maternal immune activation (MIA) through maternal infection with the viral mimetic, polyinosinic: polycitidylic acid (poly (I:C)), or maternal influenza infection, have offspring that develop abnormal social behaviors 646566, deficits in their immune profiles and anxiety-like phenotypes 67.”
From Gastrointestinal Issues and Autism Spectrum Disorder (2020) · cites this paper as [66]
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Citations
Cites
Koch, M. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00098-7 · Cited by 1,287
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
Mednick, S. A. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800260109013 · Cited by 1,203
A decrease of reelin expression as a putative vulnerability factor in schizophrenia
Impagnatiello, F., Guidotti, A. R., Pesold, C., Dwivedi, Y., Caruncho, H. J., Pisu, M. G., Uzunov, D. P., Smalheiser, N. R., Davis, J. M., Pandey, G. N., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15718 · Cited by 762
Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA
Cella, M., Salio, M., Sakakibara, Y., Langen, H., Julkunen, I., & Lanzavecchia, A. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.5.821 · Cited by 709
Malhotra, A. K. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00036-5 · Cited by 681
Swerdlow, N. R., & Geyer, M. A. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033326 · Cited by 626
Postmortem brain abnormalities of the glutamate neurotransmitter system in autism
Purcell, A. E., Jeon, O. H., Zimmerman, A. W., Blue, M. E., & Pevsner, J. (2001) · Neurology · doi:10.1212/wnl.57.9.1618 · Cited by 518
Marenco, S., & Weinberger, D. R. (2000) · Development and Psychopathology · doi:10.1017/s0954579400003138 · Cited by 485
Brain anatomy and sensorimotor gating in Asperger's syndrome
McAlonan, G. M. (2002) · Brain · doi:10.1093/brain/awf150 · Cited by 447
Jyonouchi, H., Sun, S., & Le, H. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00421-0 · Cited by 396
Research works printed but not linked: 1
- Shahab SZ, Glezen WP (1994) Influenza virus. In: Viral diseases in preg- nancy (Gonik B, ed), pp 215-223. New York: Springer.
Cited by
Sorted by citations
Items 401–500 of 996
A question of balance: a proposal for new mouse models of autism
Murcia, C. L., Gulden, F. O., & Herrup, K. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.07.001 · Cited by 50
Neonatal BCG vaccination of mice improves neurogenesis and behavior in early life
Yang, J., Qi, F., Gu, H., Zou, J., Yang, Y., Yuan, Q., & Yao, Z. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.10.012 · Cited by 48
Animal Models of Maternal Immune Activation in Depression Research
Ronovsky, M., Berger, S., Molz, B., Berger, A., & Pollak, D. D. (2015) · Current Neuropharmacology · doi:10.2174/1570159x14666151215095359 · Cited by 49
Hartung, H., Cichon, N., Feo, V. D., Riemann, S., Schildt, S., Lindemann, C., Mulert, C., Gogos, J. A., & Hanganu‐Opatz, I. L. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw274 · Cited by 47
Chen, K., Fu, Y., Wang, Y., Liao, L., Xu, H., Zhang, A., Zhang, J., Fan, L., Ren, J., & Fang, B. (2020) · Microbial Ecology · doi:10.1007/s00248-020-01494-w · Cited by 53
Allard, M., Bergeron, J. D., Baharnoori, M., Srivastava, L. K., Fortier, L., Poyart, C., & Sébire, G. (2017) · Autism Research · doi:10.1002/aur.1647 · Cited by 48
Human Endogenous Retrovirus as Therapeutic Targets in Neurologic Disease
Giménez-Orenga, K., Perron, H., & Oltra, E. (2021) · Pharmaceuticals · doi:10.3390/ph14060495 · Cited by 50
Ratnayake, U., Quinn, T., LaRosa, D. A., Dickinson, H., & Walker, D. W. (2014) · Developmental Neuroscience · doi:10.1159/000362205 · Cited by 49
Immune Therapy in Autism: Historical Experience and Future Directions with Immunomodulatory Therapy
Chez, M. G., & Guido-Estrada, N. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.008 · Cited by 48
Carpentier, P. A., Haditsch, U., Braun, A. E., Cantu, A., Moon, H. M., Price, R. O., Anderson, M. P., Saravanapandian, V., Ismail, K., Rivera, M., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4654-12.2013 · Cited by 51
Peripheral Somatosensory Neuron Dysfunction: Emerging Roles in Autism Spectrum Disorders
Orefice, L. L. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.01.039 · Cited by 51
Sharma, A. R., Batra, G., Saini, L. K., Sharma, S., Mishra, A., Singla, R., Singh, A. K., Singh, R. S., Jain, A., Bansal, S., et al. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210806165430 · Cited by 49
Infection-Induced Vulnerability of Perinatal Brain Injury
Mallard, C. E., & Wang, X. (2011) · Neurology Research International · doi:10.1155/2012/102153 · Cited by 48
Association between maternal fever and psychological/behavior outcomes: A hypothesis
Dombrowski, S. C., Martin, R. P., & HUTTUNEN, M. O. (2003) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.10096 · Cited by 49
Viviani, B., Boraso, M., Valero, M., Gardoni, F., Marco, E. M., Llorente, R., Corsini, E., Galli, C. L., Luca, M. D., Marinovich, M., et al. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.09.008 · Cited by 47
Nagai, T., Kitahara, Y., Ibi, D., Nabeshima, T., Sawa, A., & Yamada, K. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.049 · Cited by 49
Allergic fetal priming leads to developmental, behavioral and neurobiological changes in mice
Schwartzer, J. J., Careaga, M., Chang, C., Onore, C. E., & Ashwood, P. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.40 · Cited by 48
A systematic review of gut‐immune‐brain mechanisms in Autism Spectrum Disorder
Azhari, A., Azizan, F., & Esposito, G. (2018) · Developmental Psychobiology · doi:10.1002/dev.21803 · Cited by 52
Ding, S., Hu, Y., Luo, B., Cai, Y., Hao, K., Yang, Y., Zhang, Y., Wang, X., Ding, M., Zhang, H., et al. (2019) · Behavioral and Brain Functions · doi:10.1186/s12993-019-0154-2 · Cited by 48
Examining the Causes of Autism.
Amaral, D. G. (2017) · PubMed Central · Cited by 48
Airborne inflammatory factors from the nose to the brain
Tonelli, L. H. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s52 · Cited by 47
Cortical interneurons, immune factors and oxidative stress as early targets for schizophrenia
O’Donnell, P. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08130.x · Cited by 47
DISC1 mouse models as a tool to decipher gene-environment interactions in psychiatric disorders
Cash-Padgett, T. V., & Jaaro-Peled, H. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00113 · Cited by 47
Aavani, T., Rana, S. A., Hawkes, R. B., & Pittman, Q. J. (2015) · The Cerebellum · doi:10.1007/s12311-015-0669-5 · Cited by 50
Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models
Moran, P. M., Stokes, J., Marr, J., Bock, G., Desbonnet, L., Waddington, J. L., & O’Tuathaigh, C. M. P. (2016) · Neural Plasticity · doi:10.1155/2016/2173748 · Cited by 55
Pioglitazone abolishes autistic-like behaviors via the IL-6 pathway
Kirsten, T. B., Casarin, R. C. V., Bernardi, M. M., & Felício, L. F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197060 · Cited by 46
Fatemi, S. H., Folsom, T. D., Reutiman, T. J., Huang, H., Oishi, K., & Mori, S. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.03.004 · Cited by 45
Self-citationAutism spectrum disorder in children born preterm—role of exposure to perinatal inflammation
Meldrum, S. J., Strunk, T., Currie, A. J., Prescott, S. L., Simmer, K. N., & Whitehouse, A. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00123 · Cited by 48
Schizophrenia associated sensory gating deficits develop after adolescent microglia activation
Eßlinger, M., Wachholz, S., Manitz, M. P., Plümper, J., Sommer, R., Juckel, G., & Friebe, A. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.05.018 · Cited by 45
Meta-analyses of RELN variants in neuropsychiatric disorders
Chen, N., Bao, Y., Xue, Y., Sun, Y., Hu, D., Meng, S., Lu, L., & Shi, J. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.05.028 · Cited by 44
Between Dysbiosis, Maternal Immune Activation and Autism: Is There a Common Pathway?
Suprunowicz, M., Tomaszek, N., Urbaniak, A., Zackiewicz, K., Modzelewski, S., & Waszkiewicz, N. (2024) · Nutrients · doi:10.3390/nu16040549 · Cited by 44
Tzanoulinou, S., Musardo, S., Contestabile, A., Bariselli, S., Casarotto, G., Magrinelli, E., Jiang, Y., Jabaudon, D., & Bellone, C. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01427-0 · Cited by 43
Xia, Y., Qi, F., Zou, J., Yang, J., & Yao, Z. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.202 · Cited by 43
Millan, M. J., & Brocco, M. (2008) · Therapies · doi:10.2515/therapie:2008041 · Cited by 44
Perinatal Influences of Valproate on Brain and Behaviour: An Animal Model for Autism
Ranger, P., & Ellenbroek, B. A. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_404 · Cited by 43
Prenatal inflammation and risk for schizophrenia: A role for immune proteins in neurodevelopment
Allswede, D. M., & Cannon, T. D. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000317 · Cited by 46
The Endocannabinoid System as a Window Into Microglial Biology and Its Relationship to Autism
Araujo, D. J., Tjoa, K., & Saijo, K. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00424 · Cited by 47
BDNF increases homotypic olivocerebellar reinnervation and associated fine motor and cognitive skill
Willson, M. L., McElnea, C., Mariani, J., Lohof, A. M., & Sherrard, R. M. (2008) · Brain · doi:10.1093/brain/awn024 · Cited by 44
Macêdo, D. S., de Araújo, D. P., Sampaio, L. R. L., Vasconcelos, S. M. M., Sales, P. M. G., de Sousa, F. C. F., Hallak, J. E. C., Crippa, J. A., & Carvalho, A. F. (2012) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2012007500031 · Cited by 46
Influenza Virus Infection during Pregnancy as a Trigger of Acute and Chronic Complications
Oseghale, O., Vlahos, R., O’Leary, J. J., Brooks, R. D., Brooks, D. A., Liong, S., & Selemidis, S. (2022) · Viruses · doi:10.3390/v14122729 · Cited by 45
Etiopathogenesis of autism spectrum disorders: Fitting the pieces of the puzzle together
Gentile, I., Zappulo, E., Militerni, R., Pascotto, A., Borgia, G., & Bravaccio, C. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.04.002 · Cited by 44
Chua, J. S. C., Cowley, C. J., Manavis, J., Rofe, A. M., & Coyle, P. V. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.10.002 · Cited by 43
Yang, G., & Shcheglovitov, A. (2019) · Developmental Dynamics · doi:10.1002/dvdy.100 · Cited by 46
Tohmi, M., Tsuda, N., Mizuno, M., Takei, N., Frankland, P. W., & Nawa, H. (2005) · Behavior Genetics · doi:10.1007/s10519-005-5357-7 · Cited by 43
Neonatal impact of leukemia inhibitory factor on neurobehavioral development in rats
Watanabe, Y., Hashimoto, S., Kakita, A., Takahashi, H., Ko, J., Mizuno, M., Someya, T., Patterson, P. H., & Nawa, H. (2004) · Neuroscience Research · doi:10.1016/j.neures.2003.12.001 · Cited by 43
Self-citationMicroglia and Sensitive Periods in Brain Development
Dziabis, J. E., & Bilbo, S. D. (2021) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2021_242 · Cited by 42
Induction of the kynurenine pathway by neurotropic influenza a virus infection
Holtze, M., Asp, L., Schwieler, L., Engberg, G., & Karlsson, H. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21799 · Cited by 42
Soumiya, H., Fukumitsu, H., & Furukawa, S. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22636 · Cited by 44
Sensorimotor gating deficits in “two-hit” models of schizophrenia risk factors
Khan, A., & Powell, S. B. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.10.009 · Cited by 47
Modeling Autism-Related Disorders in Mice with Maternal Immune Activation (MIA)
Lammert, C. R., & Lukens, J. R. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9167-9_20 · Cited by 42
Zhao, X., Mohammed, R., Tran, H., Erickson, M., & Kentner, A. C. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.03.018 · Cited by 44
Decreased survival of newborn neurons in the dorsal hippocampus after neonatal LPS exposure in mice
Järlestedt, K., Naylor, A. S., Dean, J. M., Hagberg, H., & Mallard, C. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.040 · Cited by 42
Elmore, M. R. P., Burton, M. D., Conrad, M. S., Rytych, J. L., Alstine, W. G. V., & Johnson, R. W. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2180-13.2014 · Cited by 41
Glass, R. M., Norton, S. A., Fox, N. W., & Kusnecov, A. W. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.05.005 · Cited by 37
McGarry, N., Murray, C., Garvey, S., Wilkinson, A., Tortorelli, L. S., Ryan, L., Hayden, L., Healy, D., Griffin, É. W., Hennessy, E., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.04.016 · Cited by 44
Sato, A., Kotajima‐Murakami, H., Tanaka, M., Katoh, Y., & Ikeda, K. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.821455 · Cited by 44
Yui, K., Sato, A., & Imataka, G. (2015) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557515666150324122930 · Cited by 41
Morais, L. H., Felice, D., Golubeva, A. V., Moloney, G. M., Dinan, T. G., & Cryan, J. F. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000374 · Cited by 40
Beyond the brain: A multi-system inflammatory subtype of autism spectrum disorder
Thom, R. P., Keary, C. J., Palumbo, M. L., Ravichandran, C. T., Mullett, J. E., Hazen, E. P., Neumeyer, A. M., & McDougle, C. J. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05280-6 · Cited by 44
Fatemi, S. H. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00175-0 · Cited by 40
Self-citationPregnancy and infection: using disease pathogenesis to inform vaccine strategy
Vermillion, M. S., & Klein, S. L. (2018) · npj Vaccines · doi:10.1038/s41541-017-0042-4 · Cited by 39
Girardi, C. E. N., Zanta, N. C., & Suchecki, D. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00319 · Cited by 39
MacRae, M., Macrina, T., Khoury, A., Migliore, M. M., & Kentner, A. C. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.04.048 · Cited by 39
Perinatal complications and schizophrenia: involvement of the immune system
Jenkins, T. A. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00110 · Cited by 42
Mahic, M., Che, X., Susser, E., Levin, B. L., Reichborn‐Kjennerud, T., Magnus, P. M., Stoltenberg, C., Chauhan, L. S., Briese, T., Bresnahan, M. A., et al. (2017) · mSphere · doi:10.1128/msphere.00159-17 · Cited by 43
Laird, E. J., Thurston, S. W., van Wijngaarden, E., Shamlaye, C. F., MYERS, G. J., Davidson, P. W., Watson, G. E., McSorley, E. M., Mulhern, M. S., Yeates, A. J., et al. (2017) · Nutrients · doi:10.3390/nu9111235 · Cited by 39
Endogenous Retroviruses Activity as a Molecular Signature of Neurodevelopmental Disorders
Balestrieri, E., Matteucci, C., Cipriani, C., Grelli, S., Ricceri, L., Calamandrei, G., & Vallebona, P. S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236050 · Cited by 38
Role of environmental factors and epigenetics in autism spectrum disorders
Saxena, R., Babadi, M., Namvarhaghighi, H., & Roullet, F. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.05.002 · Cited by 40
Kleeman, E. A., Gubert, C., & Hannan, A. J. (2022) · Trends in Genetics · doi:10.1016/j.tig.2022.03.006 · Cited by 41
Stolp, H. B., Ek, C. J., Johansson, P. A., Dzięgielewska, K. M., Potter, A., Habgood, M. D., & Saunders, N. R. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05973.x · Cited by 39
Sequential perturbations to mouse corticogenesis following in utero maternal immune activation
Canales, C. P., Estes, M. L., Cichewicz, K., Angara, K., Aboubechara, J. P., Cameron, S., Prendergast, K., Su-Feher, L., Zdilar, I., Kreun, E. J., et al. (2021) · eLife · doi:10.7554/elife.60100 · Cited by 43
Sun, L., Tian, Z., & Wang, J. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.09.016 · Cited by 38
Animal models for autism in 2017 and the consequential implications to drug discovery
Chadman, K. K. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1383982 · Cited by 39
Openshaw, R. L., Kwon, J., McColl, A., Penninger, J. M., Cavanagh, J., Pratt, J. A., & MORRIS, B. J. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1408-5 · Cited by 36
Avian influenza and the brain—Comments on the occasion of resurrection of the Spanish flu virus
Kristensson, K. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.11.022 · Cited by 38
Richtand, N. M., Ahlbrand, R., Horn, P. S., Stanford, K. E., Bronson, S. L., & McNamara, R. K. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.02.007 · Cited by 41
Neonatally measured immunoglobulins and risk of autism
Grether, J. K., Croen, L., Anderson, M., Nelson, K. B., & Yolken, R. H. (2010) · Autism Research · doi:10.1002/aur.160 · Cited by 39
Ron‐Harel, N., Cardon, M., & Schwartz, M. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.011 · Cited by 37
Liu, Y., Lai, W., Tsay, H.-J., Wang, T., & Yu, J. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.09.007 · Cited by 37
Dickerson, D. D., & Bilkey, D. K. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00217 · Cited by 40
Metabolic consequences of interleukin-6 challenge in developing neurons and astroglia
Brown, J. A., Sherrod, S. D., Goodwin, C. R., Brewer, B. M., Yang, L., Garbett, K. A., Li, D., MCLEAN, J. A. J., Wikswo, J. P., & Mirnics, K. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0183-6 · Cited by 37
Genes and sex hormones interaction in neurodevelopmental disorders
Romano, E., Cosentino, L., Laviola, G., & Filippis, B. D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.019 · Cited by 42
Ruggiero, R. N., Rossignoli, M. T., Ross, J. B. D., Hallak, J. E. C., Leite, J. P., & Bueno-Júnior, L. S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00399 · Cited by 39
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Metadata
- Authors
- Shi, L., Fatemi, S. H., Sidwell, R. W., & Patterson, P. H.
- Affiliations
- California Institute of Technology (US)
- University of Minnesota (US)
- Utah State University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-01-01
- Volume
- 23
- Issue
- 1
- Pages
- 297-302
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6742135
- OpenAlex
- W2143217444
- Cited by
- 1,025
- References
- 43
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 34 · 2023: 29 · 2022: 48 · 2021: 45 · 2020: 42 · 2019: 35 · 2018: 47 · 2017: 46 · 2016: 47 · 2015: 59 · 2014: 57 · 2013: 57 · 2012: 66
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion, cc-by)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health (n01ai065291-009)
- National Institute of Allergy and Infectious Diseases (N01 AI 65291)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- maternal influenza infection, prenatal viral infection, offspring behavior, prepulse inhibition, acoustic startle response, clozapine, chlorpromazine, ketamine, exploratory behavior, social interaction deficits, maternal immune response, polyinosinic-polycytidylic acid, schizophrenia, autism spectrum disorder, mouse strain differences
- MeSH terms
- Acoustic Stimulation, Animals, Animals, Newborn, Antiviral Agents, Anxiety, Behavior, Animal, Chlorpromazine, Clozapine, Exploratory Behavior, Female, Immunity, Ketamine, Mice, Inbred BALB C, Mice, Inbred C57BL, Motor Activity, Orthomyxoviridae Infections, Poly I-C, Pregnancy, Social Behavior, Antipsychotic Agents, Maternal-Fetal Relations, Mice
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